Michael R. Zile

TitleEndowed Chair, Charles Ezra Daniel for Cardiology
InstitutionMedical University of South Carolina
DepartmentMedicine
AddressP.O. Box MSC 592
BM 323
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-6866
Fax843-876-4809
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    Heart, Cardiovascular

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Butt JH, Petrie MC, Jhund PS, Sattar N, Desai AS, K?ber L, Rouleau JL, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJV. Anthropometric measures and adverse outcomes in heart failure with reduced ejection fraction: revisiting the obesity paradox. Eur Heart J. 2023 Mar 22. PMID: 36944496.
      Citations:    Fields:    Translation:Humans
    2. Litwin SE, Komtebedde J, Hu M, Burkhoff D, Hasenfu? G, Borlaug BA, Solomon SD, Zile MR, Mohan RC, Khawash R, Sverdlov AL, Fail P, Chung ES, Kaye DM, Blair J, Eicher JC, Hummel SL, Zirlik A, Westenfeld R, Hayward C, Gorter TM, Demers C, Shetty R, Lewis G, Starling RC, Patel S, Gupta DK, Morsli H, Penicka M, Cikes M, Gustafsson F, Silvestry FE, Rowin EJ, Cutlip DE, Leon MB, Kitzman DW, Kleber FX, Shah SJ, REDUCE LAP-HF Investigators and Research Staff. Exercise-Induced Left Atrial Hypertension?in Heart?Failure With Preserved Ejection Fraction. JACC Heart Fail. 2023 Mar 14. PMID: 36939661.
      Citations:    Fields:    
    3. Curtain JP, Adamson C, Kondo T, Butt JH, Desai AS, Zannad F, Rouleau JL, Rohde LE, Kober L, Anand IS, van Veldhuisen DJ, Zile MR, Lefkowitz MP, Solomon SD, Packer M, Petrie MC, Jhund PS, McMurray JJV. Investigator-reported ventricular arrhythmias and mortality in heart failure with mildly reduced or preserved ejection fraction. Eur Heart J. 2023 02 21; 44(8):668-677. PMID: 36632831.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    4. Chatur S, Claggett BL, McCausland FR, Rouleau J, Zile MR, Packer M, Pfeffer MA, Lefkowitz M, McMurray JJ, Solomon SD, Vaduganathan M. Variation in Renal Function Following Transition to Sacubitril/Valsartan in Patients with Heart Failure. J Am Coll Cardiol. 2023 Feb 09. PMID: 36812948.
      Citations:    Fields:    Translation:Humans
    5. Rohde LE, Zimerman A, Vaduganathan M, Claggett BL, Packer M, Desai AS, Zile M, Rouleau J, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. Associations Between New York Heart Association Classification, Objective Measures, and Long-term Prognosis in Mild Heart Failure: A Secondary Analysis of the PARADIGM-HF Trial. JAMA Cardiol. 2023 02 01; 8(2):150-158. PMID: 36477809; PMCID: PMC9857149.
      Citations:    Fields:    Translation:Humans
    6. Butt JH, Ibrahim W, Dewan P, Desai AS, K?ber L, Prescott MF, Lefkowitz MP, Rouleau JL, Solomon SD, Zile MR, Packer M, Jhund PS, McMurray JJV. Urinary cGMP (Cyclic Guanosine Monophosphate)/BNP (B-Type Natriuretic Peptide) Ratio, Sacubitril/Valsartan, and Outcomes in Heart Failure With Reduced Ejection Fraction: An Analysis of the PARADIGM-HF Trial. Circ Heart Fail. 2023 03; 16(3):e010111. PMID: 36943907; PMCID: PMC10022671.
      Citations:    Fields:    Translation:Humans
    7. Coeyman SJ, Zhang Y, Baicu CF, Zile MR, Bradshaw AD, Richardson WJ. In vitro bioreactor for mechanical control and characterization of tissue constructs. J Biomech. 2023 01; 147:111458. PMID: 36682211; PMCID: PMC9946176.
      Citations:    Fields:    Translation:AnimalsCells
    8. Zile MR, Kahwash R, Sarkar S, Koehler J, Butler J. Temporal Characteristics of Device-Based Individual and Integrated?Risk Metrics in Patients With?Chronic?Heart?Failure. JACC Heart Fail. 2023 Feb; 11(2):143-156. PMID: 36752485.
      Citations:    Fields:    Translation:Humans
    9. Chandra A, Polanczyk CA, Claggett BL, Vaduganathan M, Packer M, Lefkowitz MP, Rouleau JL, Liu J, Shi VC, Schwende H, Zile MR, Desai AS, Pfeffer MA, McMurray JJV, Solomon SD, Lewis EF. Health-Related Quality of Life Outcomes in PARAGON-HF. Eur J Heart Fail. 2022 Nov 17. PMID: 36394533.
      Citations:    Fields:    
    10. Kondo T, Abdul-Rahim AH, Talebi A, Abraham WT, Desai AS, Dickstein K, Inzucchi SE, K?ber L, Kosiborod MN, Martinez FA, Packer M, Petrie M, Ponikowski P, Rouleau JL, Sabatine MS, Swedberg K, Zile MR, Solomon SD, Jhund PS, McMurray JJV. Predicting stroke in heart failure and reduced ejection fraction without atrial fibrillation. Eur Heart J. 2022 11 07; 43(42):4469-4479. PMID: 36017729; PMCID: PMC9637422.
      Citations: 1     Fields:    Translation:Humans
    11. Zile MR, Mehra MR, Ducharme A, Sears SF, Desai AS, Maisel A, Paul S, Smart F, Grafton G, Kumar S, Nossuli TO, Johnson N, Henderson J, Adamson PB, Costanzo MR, Lindenfeld J. Hemodynamically-Guided Management of Heart?Failure Across the Ejection?Fraction Spectrum: The GUIDE-HF Trial. JACC Heart Fail. 2022 Dec; 10(12):931-944. PMID: 36456066.
      Citations:    Fields:    Translation:Humans
    12. Butt JH, Dewan P, Jhund PS, Anand IS, Atar D, Ge J, Desai AS, Echeverria LE, K?ber L, Lam CSP, Maggioni AP, Martinez F, Packer M, Rouleau JL, Sim D, Van Veldhuisen DJ, Vrtovec B, Zannad F, Zile MR, Gong J, Lefkowitz MP, Rizkala AR, Solomon SD, McMurray JJV. Sacubitril/Valsartan and Frailty in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2022 09 20; 80(12):1130-1143. PMID: 36050227.
      Citations: 2     Fields:    Translation:Humans
    13. Zhang L, Cunningham JW, Claggett BL, Jacob J, Mendelson MM, Serrano-Fernandez P, Kaiser S, Yates DP, Healey M, Chen CW, Turner GM, Patel-Murray NL, Zhao F, Beste MT, Laramie JM, Abraham WT, Jhund PS, Kober L, Packer M, Rouleau J, Zile MR, Prescott MF, Lefkowitz M, McMurray JJV, Solomon SD, Chutkow W. Aptamer Proteomics for Biomarker Discovery in Heart Failure With Reduced Ejection Fraction. Circulation. 2022 Nov; 146(18):1411-1414. PMID: 36029463.
      Citations:    Fields:    Translation:Humans
    14. Dusi V, Angelini F, Zile MR, De Ferrari GM. Neuromodulation devices for heart failure. Eur Heart J Suppl. 2022 Sep; 24(Suppl E):E12-E27. PMID: 35991619; PMCID: PMC9385122.
      Citations:    
    15. Zile MR, Bradshaw AD, Zile MR, Bradshaw AD. And the band played on: persistent fibrosis after unbanding reveals sex-dependent differences in rats. Am J Physiol Heart Circ Physiol. 2022 08 01; 323(2):H358-H359. PMID: 35839155; PMCID: PMC9342134.
      Citations:    Fields:    Translation:Animals
    16. Zile MR, Desai AS, Costanzo MR, Ducharme A, Maisel A, Mehra MR, Paul S, Sears SF, Smart F, Chien C, Guha A, Guichard JL, Hall S, Jonsson O, Johnson N, Sood P, Henderson J, Adamson PB, Lindenfeld J, Zile MR, Desai AS, Costanzo MR, Ducharme A, Maisel A, Mehra MR, Paul S, Sears SF, Smart F, Chien C, Guha A, Guichard JL, Hall S, Jonsson O, Johnson N, Sood P, Henderson J, Adamson PB, Lindenfeld J. The GUIDE-HF trial of pulmonary artery pressure monitoring in heart failure: impact of the COVID-19 pandemic. Eur Heart J. 2022 07 14; 43(27):2603-2618. PMID: 35266003; PMCID: PMC8992324.
      Citations:    
    17. Coats AJS, Abraham WT, Zile MR, Lindenfeld JA, Weaver FA, Fudim M, Bauersachs J, Duval S, Galle E, Zannad F, Coats AJS, Abraham WT, Zile MR, Lindenfeld JA, Weaver FA, Fudim M, Bauersachs J, Duval S, Galle E, Zannad F. Baroreflex activation therapy with the Barostim? device in patients with heart failure with reduced ejection fraction: a patient level meta-analysis of randomized controlled trials. Eur J Heart Fail. 2022 09; 24(9):1665-1673. PMID: 35713888.
      Citations: 3     Fields:    Translation:Humans
    18. Wijkman MO, Claggett B, Vaduganathan M, Cunningham JW, Rørth R, Jackson A, Packer M, Zile M, Rouleau J, Swedberg K, Lefkowitz M, Shah SJ, Pfeffer MA, McMurray JJV, Solomon SD, Wijkman MO, Claggett B, Vaduganathan M, Cunningham JW, R?rth R, Jackson A, Packer M, Zile M, Rouleau J, Swedberg K, Lefkowitz M, Shah SJ, Pfeffer MA, McMurray JJV, Solomon SD. Effects of sacubitril/valsartan on glycemia in patients with diabetes and heart failure: the PARAGON-HF and PARADIGM-HF trials. Cardiovasc Diabetol. 2022 06 18; 21(1):110. PMID: 35717169; PMCID: PMC9206286.
      Citations: 2     Fields:    Translation:Humans
    19. Neff LS, Zhang Y, Van Laer AO, Baicu CF, Karavan M, Zile MR, Bradshaw AD, Neff LS, Zhang Y, Van Laer AO, Baicu CF, Karavan M, Zile MR, Bradshaw AD. Mechanisms that limit regression of myocardial fibrosis following removal of left ventricular pressure overload. Am J Physiol Heart Circ Physiol. 2022 07 01; 323(1):H165-H175. PMID: 35657618; PMCID: PMC9236876.
      Citations: 1     Fields:    Translation:HumansAnimals
    20. Cikes M, Planinc I, Claggett B, Cunningham J, Milicic D, Sweitzer N, Senni M, Gori M, Linssen G, Shah SJ, Packer M, Pfeffer M, Zile MR, Anand I, Chiang LM, Lam CSP, Redfield M, Desai AS, McMurray JJV, Solomon SD, Cikes M, Planinc I, Claggett B, Cunningham J, Milicic D, Sweitzer N, Senni M, Gori M, Linssen G, Shah SJ, Packer M, Pfeffer M, Zile MR, Anand I, Chiang LM, Lam CSP, Redfield M, Desai AS, McMurray JJV, Solomon SD. Atrial Fibrillation in Heart?Failure With Preserved Ejection Fraction: The PARAGON-HF Trial. JACC Heart Fail. 2022 05; 10(5):336-346. PMID: 35483796.
      Citations: 2     Fields:    Translation:Humans
    21. Curtain JP, Campbell RT, Petrie MC, Jackson AM, Abraham WT, Desai AS, Dickstein K, Køber L, Rouleau JL, Swedberg K, Zile MR, Solomon SD, Jhund PS, McMurray JJV, Curtain JP, Campbell RT, Petrie MC, Jackson AM, Abraham WT, Desai AS, Dickstein K, K?ber L, Rouleau JL, Swedberg K, Zile MR, Solomon SD, Jhund PS, McMurray JJV. Clinical Outcomes Related to Background Diuretic Use and New Diuretic Initiation in Patients With HFrEF. JACC Heart Fail. 2022 06; 10(6):415-427. PMID: 35654526.
      Citations: 1     Fields:    Translation:Humans
    22. Ward M, Yeganegi A, Baicu CF, Bradshaw AD, Spinale FG, Zile MR, Richardson WJ, Ward M, Yeganegi A, Baicu CF, Bradshaw AD, Spinale FG, Zile MR, Richardson WJ. Ensemble machine learning model identifies patients with HFpEF from matrix-related plasma biomarkers. Am J Physiol Heart Circ Physiol. 2022 05 01; 322(5):H798-H805. PMID: 35275763; PMCID: PMC8993521.
      Citations:    
    23. Pabón MA, Cunningham JW, Claggett BL, Packer M, Zile M, Pfeffer MA, Lefkowitz M, Shi V, Rizkala A, McMurray JJV, Solomon SD, Vaduganathan M, Pab?n MA, Cunningham JW, Claggett BL, Packer M, Zile M, Pfeffer MA, Lefkowitz M, Shi V, Rizkala A, McMurray JJV, Solomon SD, Vaduganathan M. Natriuretic peptide-based inclusion criteria in heart failure with preserved ejection fraction clinical trials: insights from PARAGON-HF. Eur J Heart Fail. 2022 04; 24(4):672-677. PMID: 35080787.
      Citations:    
    24. Curtain JP, Jackson AM, Shen L, Jhund PS, Docherty KF, Petrie MC, Castagno D, Desai AS, Rohde LE, Lefkowitz MP, Rouleau JL, Zile MR, Solomon SD, Swedberg K, Packer M, McMurray JJV, Curtain JP, Jackson AM, Shen L, Jhund PS, Docherty KF, Petrie MC, Castagno D, Desai AS, Rohde LE, Lefkowitz MP, Rouleau JL, Zile MR, Solomon SD, Swedberg K, Packer M, McMurray JJV. Effect of sacubitril/valsartan on investigator-reported ventricular arrhythmias in PARADIGM-HF. Eur J Heart Fail. 2022 03; 24(3):551-561. PMID: 34969175; PMCID: PMC9542658.
      Citations:    
    25. Mc Causland FR, Lefkowitz MP, Claggett B, Packer M, Senni M, Gori M, Jhund PS, McGrath MM, Rouleau JL, Shi V, Swedberg K, Vaduganathan M, Zannad F, Pfeffer MA, Zile M, McMurray JJV, Solomon SD, Mc Causland FR, Lefkowitz MP, Claggett B, Packer M, Senni M, Gori M, Jhund PS, McGrath MM, Rouleau JL, Shi V, Swedberg K, Vaduganathan M, Zannad F, Pfeffer MA, Zile M, McMurray JJV, Solomon SD. Angiotensin-neprilysin inhibition and renal outcomes across the spectrum of ejection fraction in heart failure. Eur J Heart Fail. 2022 09; 24(9):1591-1598. PMID: 34989105; PMCID: PMC9253196.
      Citations:    
    26. Chowdhury SM, Graham EM, Taylor CL, Savage A, McHugh KE, Gaydos S, Nutting AC, Zile MR, Atz AM, Chowdhury SM, Graham EM, Taylor CL, Savage A, McHugh KE, Gaydos S, Nutting AC, Zile MR, Atz AM. Diastolic Dysfunction With Preserved Ejection Fraction After the Fontan Procedure. J Am Heart Assoc. 2022 01 18; 11(2):e024095. PMID: 35023347; PMCID: PMC9238510.
      Citations:    
    27. Zhang Y, Van Laer AO, Baicu CF, Neff LS, Hoffman S, Katz MR, Zeigler SM, Zile MR, Bradshaw AD, Zhang Y, Van Laer AO, Baicu CF, Neff LS, Hoffman S, Katz MR, Zeigler SM, Zile MR, Bradshaw AD. Phenotypic characterization of primary cardiac fibroblasts from patients with HFpEF. PLoS One. 2022; 17(1):e0262479. PMID: 35015787; PMCID: PMC8752005.
      Citations:    
    28. Albayram MS, Smith G, Tufan F, Tuna IS, Bostanciklioglu M, Zile M, Albayram O, Albayram MS, Smith G, Tufan F, Tuna IS, Bostanciklioglu M, Zile M, Albayram O. Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes. Nat Commun. 2022 01 11; 13(1):203. PMID: 35017525; PMCID: PMC8752739.
      Citations:    
    29. Jackson AM, Rørth R, Liu J, Kristensen SL, Anand IS, Claggett BL, Cleland JGF, Chopra VK, Desai AS, Ge J, Gong J, Lam CSP, Lefkowitz MP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rizkala AR, Rouleau JL, Seferovic PM, Tromp J, Van Veldhuisen DJ, Yilmaz MB, Zannad F, Zile MR, Køber L, Petrie MC, Jhund PS, Solomon SD, McMurray JJV, Jackson AM, R?rth R, Liu J, Kristensen SL, Anand IS, Claggett BL, Cleland JGF, Chopra VK, Desai AS, Ge J, Gong J, Lam CSP, Lefkowitz MP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rizkala AR, Rouleau JL, Seferovic PM, Tromp J, Van Veldhuisen DJ, Yilmaz MB, Zannad F, Zile MR, K?ber L, Petrie MC, Jhund PS, Solomon SD, McMurray JJV, PARAGON-HF Committees and Investigators. Diabetes and pre-diabetes in patients with heart failure and preserved ejection fraction. Eur J Heart Fail. 2022 03; 24(3):497-509. PMID: 34918855; PMCID: PMC9542636.
      Citations:    
    30. Mooney L, Hawkins NM, Jhund PS, Redfield MM, Vaduganathan M, Desai AS, Rouleau JL, Minamisawa M, Shah AM, Lefkowitz MP, Zile MR, Van Veldhuisen DJ, Pfeffer MA, Anand IS, Maggioni AP, Senni M, Claggett BL, Solomon SD, McMurray JJV, Mooney L, Hawkins NM, Jhund PS, Redfield MM, Vaduganathan M, Desai AS, Rouleau JL, Minamisawa M, Shah AM, Lefkowitz MP, Zile MR, Van Veldhuisen DJ, Pfeffer MA, Anand IS, Maggioni AP, Senni M, Claggett BL, Solomon SD, McMurray JJV. Impact of Chronic Obstructive Pulmonary Disease in Patients With Heart Failure With Preserved Ejection Fraction: Insights From PARAGON-HF. J Am Heart Assoc. 2021 12 07; 10(23):e021494. PMID: 34796742; PMCID: PMC9075384.
      Citations:    
    31. El Hajj EC, El Hajj MC, Sykes B, Lamicq M, Zile MR, Malcolm R, O'Neil PM, Litwin SE, El Hajj EC, El Hajj MC, Sykes B, Lamicq M, Zile MR, Malcolm R, O'Neil PM, Litwin SE. Pragmatic Weight Management Program for Patients With Obesity and Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2021 11 02; 10(21):e022930. PMID: 34713711; PMCID: PMC8751835.
      Citations:    
    32. Meyer M, LeWinter MM, Zile MR, Meyer M, LeWinter MM, Zile MR. A Targeted Treatment Opportunity for HFpEF: Taking Advantage of Diastolic Tone. Circulation. 2021 10 19; 144(16):1269-1271. PMID: 34662157.
      Citations:    
    33. Jackson AM, Jhund PS, Anand IS, Düngen HD, Lam CSP, Lefkowitz MP, Linssen G, Lund LH, Maggioni AP, Pfeffer MA, Rouleau JL, Saraiva JFK, Senni M, Vardeny O, Wijkman MO, Yilmaz MB, Saito Y, Zile MR, Solomon SD, McMurray JJV, Jackson AM, Jhund PS, Anand IS, D?ngen HD, Lam CSP, Lefkowitz MP, Linssen G, Lund LH, Maggioni AP, Pfeffer MA, Rouleau JL, Saraiva JFK, Senni M, Vardeny O, Wijkman MO, Yilmaz MB, Saito Y, Zile MR, Solomon SD, McMurray JJV. Sacubitril-valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction. Eur Heart J. 2021 09 21; 42(36):3741-3752. PMID: 34392331; PMCID: PMC8455346.
      Citations:    
    34. Lindenfeld J, Zile MR, Desai AS, Bhatt K, Ducharme A, Horstmanshof D, Krim SR, Maisel A, Mehra MR, Paul S, Sears SF, Sauer AJ, Smart F, Zughaib M, Castaneda P, Kelly J, Johnson N, Sood P, Ginn G, Henderson J, Adamson PB, Costanzo MR, Lindenfeld J, Zile MR, Desai AS, Bhatt K, Ducharme A, Horstmanshof D, Krim SR, Maisel A, Mehra MR, Paul S, Sears SF, Sauer AJ, Smart F, Zughaib M, Castaneda P, Kelly J, Johnson N, Sood P, Ginn G, Henderson J, Adamson PB, Costanzo MR. Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial. Lancet. 2021 09 11; 398(10304):991-1001. PMID: 34461042.
      Citations:    
    35. Shin SH, Claggett B, Inciardi RM, Santos ABS, Shah SJ, Zile MR, Pfeffer MA, Shah AM, Solomon SD, Shin SH, Claggett B, Inciardi RM, Santos ABS, Shah SJ, Zile MR, Pfeffer MA, Shah AM, Solomon SD. Prognostic Value of Minimal Left Atrial Volume in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2021 08 03; 10(15):e019545. PMID: 34325519; PMCID: PMC8475710.
      Citations:    
    36. Gori M, Senni M, Claggett B, Liu J, Maggioni AP, Zile M, Prescott MF, Van Veldhuisen DJ, Zannad F, Pieske B, Lam CSP, Rouleau J, Jhund P, Packer M, Pfeffer MA, Lefkowitz M, Shi V, McMurray JJV, Solomon SD, Gori M, Senni M, Claggett B, Liu J, Maggioni AP, Zile M, Prescott MF, Van Veldhuisen DJ, Zannad F, Pieske B, Lam CSP, Rouleau J, Jhund P, Packer M, Pfeffer MA, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. Integrating High-Sensitivity Troponin T and?Sacubitril/Valsartan Treatment in?HFpEF: The PARAGON-HF Trial. JACC Heart Fail. 2021 09; 9(9):627-635. PMID: 34246603.
      Citations:    
    37. Suzuki K, Claggett B, Minamisawa M, Packer M, Zile MR, Pfeffer MA, Chiang LM, Lefkowitz M, McMurray JJV, Solomon SD, Desai AS, Suzuki K, Claggett B, Minamisawa M, Packer M, Zile MR, Pfeffer MA, Chiang LM, Lefkowitz M, McMurray JJV, Solomon SD, Desai AS. Influence of study discontinuation during the run-in period on the estimated efficacy of sacubitril/valsartan in the PARAGON-HF trial. Eur J Heart Fail. 2021 12; 23(12):2085-2090. PMID: 34114720.
      Citations:    
    38. Bhatt AS, Vaduganathan M, Claggett BL, Liu J, Packer M, Desai AS, Lefkowitz MP, Rouleau JL, Shi VC, Zile MR, Swedberg K, Vardeny O, McMurray JJV, Solomon SD, Bhatt AS, Vaduganathan M, Claggett BL, Liu J, Packer M, Desai AS, Lefkowitz MP, Rouleau JL, Shi VC, Zile MR, Swedberg K, Vardeny O, McMurray JJV, Solomon SD. Effect of sacubitril/valsartan vs. enalapril on changes in heart failure therapies over time: the PARADIGM-HF trial. Eur J Heart Fail. 2021 09; 23(9):1518-1524. PMID: 34101308; PMCID: PMC9291580.
      Citations:    
    39. Bhatt AS, Claggett BL, Packer M, Lefkowitz MP, Zile MR, McMurray JJV, Solomon SD, Vaduganathan M, Bhatt AS, Claggett BL, Packer M, Lefkowitz MP, Zile MR, McMurray JJV, Solomon SD, Vaduganathan M. Treatment Effects of Sacubitril/Valsartan Compared With Valsartan by Ejection Fraction in Patients With Recent Hospitalization. J Card Fail. 2021 09; 27(9):1027-1030. PMID: 34133969.
      Citations:    
    40. Shen L, Claggett BL, Jhund PS, Abraham WT, Desai AS, Dickstein K, Gong J, Køber LV, Lefkowitz MP, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, McMurray JJV, Shen L, Claggett BL, Jhund PS, Abraham WT, Desai AS, Dickstein K, Gong J, K?ber LV, Lefkowitz MP, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, McMurray JJV. Development and external validation of prognostic models to predict sudden and pump-failure death in patients with HFrEF from PARADIGM-HF and ATMOSPHERE. Clin Res Cardiol. 2021 Aug; 110(8):1334-1349. PMID: 34101002; PMCID: PMC8318968.
      Citations:    
    41. Paulus WJ, Zile MR, Paulus WJ, Zile MR. From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure With Preserved Ejection Fraction Paradigm Revisited. Circ Res. 2021 05 14; 128(10):1451-1467. PMID: 33983831; PMCID: PMC8351796.
      Citations:    
    42. Litwin SE, Zile MR, Litwin SE, Zile MR. The Vexing Problem of HFpEF?Therapeutics: Inching Toward Success. JACC Heart Fail. 2021 05; 9(5):371-373. PMID: 33926730.
      Citations:    
    43. Shen L, Jhund PS, Anand IS, Bhatt AS, Desai AS, Maggioni AP, Martinez FA, Pfeffer MA, Rizkala AR, Rouleau JL, Swedberg K, Vaduganathan M, Vardeny O, van Veldhuisen DJ, Zannad F, Zile MR, Packer M, Solomon SD, McMurray JJV, Shen L, Jhund PS, Anand IS, Bhatt AS, Desai AS, Maggioni AP, Martinez FA, Pfeffer MA, Rizkala AR, Rouleau JL, Swedberg K, Vaduganathan M, Vardeny O, van Veldhuisen DJ, Zannad F, Zile MR, Packer M, Solomon SD, McMurray JJV. Incidence and Outcomes of Pneumonia in Patients With Heart?Failure. J Am Coll Cardiol. 2021 04 27; 77(16):1961-1973. PMID: 33888245.
      Citations:    
    44. Tromp J, Claggett BL, Liu J, Jackson AM, Jhund PS, Køber L, Widimský J, Boytsov SA, Chopra VK, Anand IS, Ge J, Chen CH, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, Van Veldhuisen DJ, Zannad F, Zile MR, Rizkala AR, Inubushi-Molessa A, Lefkowitz MP, Shi VC, McMurray JJV, Solomon SD, Lam CSP, Tromp J, Claggett BL, Liu J, Jackson AM, Jhund PS, K?ber L, Widimsk? J, Boytsov SA, Chopra VK, Anand IS, Ge J, Chen CH, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, Van Veldhuisen DJ, Zannad F, Zile MR, Rizkala AR, Inubushi-Molessa A, Lefkowitz MP, Shi VC, McMurray JJV, Solomon SD, Lam CSP, PARAGON-HF Investigators. Global Differences in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Trial. Circ Heart Fail. 2021 04; 14(4):e007901. PMID: 33866828.
      Citations:    
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    314. Bourge RC, Abraham WT, Adamson PB, Aaron MF, Aranda JM, Magalski A, Zile MR, Smith AL, Smart FW, O'Shaughnessy MA, Jessup ML, Sparks B, Naftel DL, Stevenson LW, Bourge RC, Abraham WT, Adamson PB, Aaron MF, Aranda JM, Magalski A, Zile MR, Smith AL, Smart FW, O'Shaughnessy MA, Jessup ML, Sparks B, Naftel DL, Stevenson LW, COMPASS-HF Study Group. Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: the COMPASS-HF study. J Am Coll Cardiol. 2008 Mar 18; 51(11):1073-9. PMID: 18342224.
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    315. Cheng G, Zile MR, Takahashi M, Baicu CF, Bonnema DD, Cabral F, Menick DR, Cooper G, Cheng G, Zile MR, Takahashi M, Baicu CF, Bonnema DD, Cabral F, Menick DR, Cooper G. A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart. Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2231-41. PMID: 18344371.
      Citations:    
    316. McMurray JJ, Carson PE, Komajda M, McKelvie R, Zile MR, Ptaszynska A, Staiger C, Donovan JM, Massie BM, McMurray JJ, Carson PE, Komajda M, McKelvie R, Zile MR, Ptaszynska A, Staiger C, Donovan JM, Massie BM. Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial. Eur J Heart Fail. 2008 Feb; 10(2):149-56. PMID: 18279770.
      Citations:    
    317. Jang IK, Weissman NJ, Picard MH, Zile MR, Pettigrew V, Shen S, Tatsuno J, Hibberd MG, Tzivoni D, Wackers FJ, Jang IK, Weissman NJ, Picard MH, Zile MR, Pettigrew V, Shen S, Tatsuno J, Hibberd MG, Tzivoni D, Wackers FJ, EVOLVE Investigators. A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular salvage in acute myocardial infarction (EVOLVE). Am Heart J. 2008 Jan; 155(1):113.e1-8. PMID: 18082500.
      Citations:    
    318. Spruill LS, Baicu CF, Zile MR, McDermott PJ, Spruill LS, Baicu CF, Zile MR, McDermott PJ. Selective translation of mRNAs in the left ventricular myocardium of the mouse in response to acute pressure overload. J Mol Cell Cardiol. 2008 Jan; 44(1):69-75. PMID: 18036610; PMCID: PMC2246077.
      Citations:    
    319. Bonnema DD, Webb CS, Pennington WR, Stroud RE, Leonardi AE, Clark LL, McClure CD, Finklea L, Spinale FG, Zile MR, Bonnema DD, Webb CS, Pennington WR, Stroud RE, Leonardi AE, Clark LL, McClure CD, Finklea L, Spinale FG, Zile MR. Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs). J Card Fail. 2007 Sep; 13(7):530-40. PMID: 17826643; PMCID: PMC2698433.
      Citations:    
    320. Solomon SD, Janardhanan R, Verma A, Bourgoun M, Daley WL, Purkayastha D, Lacourcière Y, Hippler SE, Fields H, Naqvi TZ, Mulvagh SL, Arnold JM, Thomas JD, Zile MR, Aurigemma GP, Solomon SD, Janardhanan R, Verma A, Bourgoun M, Daley WL, Purkayastha D, Lacourci?re Y, Hippler SE, Fields H, Naqvi TZ, Mulvagh SL, Arnold JM, Thomas JD, Zile MR, Aurigemma GP, Valsartan In Diastolic Dysfunction (VALIDD) Investigators. Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: a randomised trial. Lancet. 2007 Jun 23; 369(9579):2079-87. PMID: 17586303.
      Citations:    
    321. Zile MR, Lewinter MM, Zile MR, Lewinter MM. Left ventricular end-diastolic volume is normal in patients with heart failure and a normal ejection fraction: a renewed consensus in diastolic heart failure. J Am Coll Cardiol. 2007 Mar 06; 49(9):982-5. PMID: 17336722.
      Citations:    
    322. Goodroe R, Bonnema DD, Lunsford S, Anderson P, Ryan-Baille B, Uber W, Ikonomidis J, Crumbley AJ, VanBakel A, Zile MR, Pereira N, Goodroe R, Bonnema DD, Lunsford S, Anderson P, Ryan-Baille B, Uber W, Ikonomidis J, Crumbley AJ, VanBakel A, Zile MR, Pereira N. Severe left ventricular hypertrophy 1 year after transplant predicts mortality in cardiac transplant recipients. J Heart Lung Transplant. 2007 Feb; 26(2):145-51. PMID: 17258148.
      Citations:    
    323. Orr RK, Hoehn JL, Col NF, Ahmed A, Zile MR, Rich MW, Fleg JL, Adams KF, Love TE, Young JB, Aronow WS, Kitzman DW, Gheorghiade M, Dell'Italia LJ. Hospitalizations due to unstable angina pectoris in diastolic and systolic heart failure. Am J Cardiol. 2007 Feb 15; 99(4):460-4. PMID: 17293184; PMCID: PMC2659173.
      Citations:    
    324. Ahmed A, Rich MW, Sanders PW, Perry GJ, Bakris GL, Zile MR, Love TE, Aban IB, Shlipak MG, Ahmed A, Rich MW, Sanders PW, Perry GJ, Bakris GL, Zile MR, Love TE, Aban IB, Shlipak MG. Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched study. Am J Cardiol. 2007 Feb 01; 99(3):393-8. PMID: 17261405; PMCID: PMC2708087.
      Citations:    
    325. Pereira NL, Zile MR, Harley RA, Van Bakel AB, Pereira NL, Zile MR, Harley RA, Van Bakel AB. Myocardial mechanisms causing heart failure early after cardiac transplantation. Transplant Proc. 2006 Nov; 38(9):2999-3003. PMID: 17112884.
      Citations:    
    326. Xu L, Renaud L, Müller JG, Baicu CF, Bonnema DD, Zhou H, Kappler CS, Kubalak SW, Zile MR, Conway SJ, Menick DR, Xu L, Renaud L, M?ller JG, Baicu CF, Bonnema DD, Zhou H, Kappler CS, Kubalak SW, Zile MR, Conway SJ, Menick DR. Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation. J Biol Chem. 2006 Nov 10; 281(45):34430-40. PMID: 16966329; PMCID: PMC3096005.
      Citations:    
    327. Webb CS, Bonnema DD, Ahmed SH, Leonardi AH, McClure CD, Clark LL, Stroud RE, Corn WC, Finklea L, Zile MR, Spinale FG, Webb CS, Bonnema DD, Ahmed SH, Leonardi AH, McClure CD, Clark LL, Stroud RE, Corn WC, Finklea L, Zile MR, Spinale FG. Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling. Circulation. 2006 Sep 05; 114(10):1020-7. PMID: 16923753.
      Citations:    
    328. Janardhanan R, Daley WL, Naqvi TZ, Mulvagh SL, Aurigemma G, Zile M, Arnold JM, Artis E, Purkayastha D, Thomas JD, Solomon SD, Janardhanan R, Daley WL, Naqvi TZ, Mulvagh SL, Aurigemma G, Zile M, Arnold JM, Artis E, Purkayastha D, Thomas JD, Solomon SD, VALIDD Investigators. Rationale and design: the VALsartan In Diastolic Dysfunction (VALIDD) Trial: evolving the management of diastolic dysfunction in hypertension. Am Heart J. 2006 Aug; 152(2):246-52. PMID: 16875904.
      Citations:    
    329. Ahmed A, Rich MW, Fleg JL, Zile MR, Young JB, Kitzman DW, Love TE, Aronow WS, Adams KF, Gheorghiade M, Ahmed A, Rich MW, Fleg JL, Zile MR, Young JB, Kitzman DW, Love TE, Aronow WS, Adams KF, Gheorghiade M. Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial. Circulation. 2006 Aug 01; 114(5):397-403. PMID: 16864724; PMCID: PMC2628473.
      Citations:    
    330. Bland AM, D'Eugenio LR, Dugan MA, Janech MG, Almeida JS, Zile MR, Arthur JM, Bland AM, D'Eugenio LR, Dugan MA, Janech MG, Almeida JS, Zile MR, Arthur JM. Comparison of variability associated with sample preparation in two-dimensional gel electrophoresis of cardiac tissue. J Biomol Tech. 2006 Jul; 17(3):195-9. PMID: 16870710; PMCID: PMC2291783.
      Citations:    
    331. Little WC, Zile MR, Klein A, Appleton CP, Kitzman DW, Wesley-Farrington DJ, Little WC, Zile MR, Klein A, Appleton CP, Kitzman DW, Wesley-Farrington DJ. Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction. Am J Cardiol. 2006 Aug 01; 98(3):383-5. PMID: 16860028.
      Citations:    
    332. Quiñones MA, Zile MR, Massie BM, Kass DA, Qui?ones MA, Zile MR, Massie BM, Kass DA, Writing Committee of the Dartmouth Diastolic Discourses. Chronic heart failure: a report from the Dartmouth Diastole Discourses. Congest Heart Fail. 2006 May-Jun; 12(3):162-5. PMID: 16760702.
      Citations:    
    333. Katz AM, Zile MR, Katz AM, Zile MR. New molecular mechanism in diastolic heart failure. Circulation. 2006 Apr 25; 113(16):1922-5. PMID: 16636184.
      Citations:    
    334. Ahmed SH, Clark LL, Pennington WR, Webb CS, Bonnema DD, Leonardi AH, McClure CD, Spinale FG, Zile MR, Ahmed SH, Clark LL, Pennington WR, Webb CS, Bonnema DD, Leonardi AH, McClure CD, Spinale FG, Zile MR. Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease. Circulation. 2006 May 02; 113(17):2089-96. PMID: 16636176.
      Citations:    
    335. Lindsey ML, Goshorn DK, Comte-Walters S, Hendrick JW, Hapke E, Zile MR, Schey K, Lindsey ML, Goshorn DK, Comte-Walters S, Hendrick JW, Hapke E, Zile MR, Schey K. A multidimensional proteomic approach to identify hypertrophy-associated proteins. Proteomics. 2006 Apr; 6(7):2225-35. PMID: 16493702.
      Citations:    
    336. Clark LL, Ikonomidis JS, Crawford FA, Crumbley A, Kratz JM, Stroud MR, Woolson RF, Bruce JJ, Nicholas JS, Lackland DT, Zile MR, Spinale FG, Clark LL, Ikonomidis JS, Crawford FA, Crumbley A, Kratz JM, Stroud MR, Woolson RF, Bruce JJ, Nicholas JS, Lackland DT, Zile MR, Spinale FG. Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: an 8-year retrospective cohort study. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):679-85. PMID: 16515923.
      Citations:    
    337. Aurigemma GP, Zile MR, Gaasch WH, Aurigemma GP, Zile MR, Gaasch WH. Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function. Circulation. 2006 Jan 17; 113(2):296-304. PMID: 16418449.
      Citations:    
    338. Jang IK, Pettigrew V, Picard MH, Kowey PR, Demmel V, Zile MR, Tatsuno J, Wackers FJ, Hibberd M, Jang IK, Pettigrew V, Picard MH, Kowey PR, Demmel V, Zile MR, Tatsuno J, Wackers FJ, Hibberd M. A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: rationale and design of the evaluation of MCC-135 for left ventricular salvage in acute MI (EVOLVE) study. J Thromb Thrombolysis. 2005 Dec; 20(3):147-53. PMID: 16261287.
      Citations:    
    339. Konstam MA, Czerska B, Böhm M, Oren RM, Sadowski J, Khanal S, Abraham WT, Wasler A, Dahm JB, Gavazzi A, Gradinac S, Legrand V, Mohacsi P, Poelzl G, Radovancevic B, Van Bakel AB, Zile MR, Cabuay B, Bartus K, Jansen P, Konstam MA, Czerska B, B?hm M, Oren RM, Sadowski J, Khanal S, Abraham WT, Wasler A, Dahm JB, Gavazzi A, Gradinac S, Legrand V, Mohacsi P, Poelzl G, Radovancevic B, Van Bakel AB, Zile MR, Cabuay B, Bartus K, Jansen P. Continuous aortic flow augmentation: a pilot study of hemodynamic and renal responses to a novel percutaneous intervention in decompensated heart failure. Circulation. 2005 Nov 15; 112(20):3107-14. PMID: 16275867.
      Citations:    
    340. Peura JL, Zile MR, Feldman DS, VanBakel AB, McClure C, Uber W, Haynes H, Pereira NL, Peura JL, Zile MR, Feldman DS, VanBakel AB, McClure C, Uber W, Haynes H, Pereira NL. Effects of conversion from cyclosporine to tacrolimus on left ventricular structure in cardiac allograft recipients. J Heart Lung Transplant. 2005 Nov; 24(11):1969-72. PMID: 16297806.
      Citations:    
    341. Carson P, Massie BM, McKelvie R, McMurray J, Komajda M, Zile M, Ptaszynska A, Frangin G, Carson P, Massie BM, McKelvie R, McMurray J, Komajda M, Zile M, Ptaszynska A, Frangin G, I-PRESERVE Investigators. The irbesartan in heart failure with preserved systolic function (I-PRESERVE) trial: rationale and design. J Card Fail. 2005 Oct; 11(8):576-85. PMID: 16230259.
      Citations:    
    342. Zile MR, Zile MR. Treating diastolic heart failure with statins: "phat" chance for pleiotropic benefits. Circulation. 2005 Jul 19; 112(3):300-3. PMID: 16027268.
      Citations:    
    343. Baicu CF, Zile MR, Aurigemma GP, Gaasch WH, Baicu CF, Zile MR, Aurigemma GP, Gaasch WH. Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure. Circulation. 2005 May 10; 111(18):2306-12. PMID: 15851588.
      Citations:    
    344. Little WC, Zile MR, Kitzman DW, Hundley WG, O'Brien TX, Degroof RC, Little WC, Zile MR, Kitzman DW, Hundley WG, O'Brien TX, Degroof RC. The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. J Card Fail. 2005 Apr; 11(3):191-5. PMID: 15812746.
      Citations:    
    345. Stroud RE, Deschamps AM, Lowry AS, Hardin AE, Mukherjee R, Lindsey ML, Ramamoorthy S, Zile MR, Spencer WH, Spinale FG, Stroud RE, Deschamps AM, Lowry AS, Hardin AE, Mukherjee R, Lindsey ML, Ramamoorthy S, Zile MR, Spencer WH, Spinale FG. Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4 after alcohol septal ablation in hypertrophic obstructive cardiomyopathy. J Card Fail. 2005 Mar; 11(2):124-30. PMID: 15732032.
      Citations:    
    346. Zile MR, Baicu CF, Bonnema DD, Zile MR, Baicu CF, Bonnema DD. Diastolic heart failure: definitions and terminology. Prog Cardiovasc Dis. 2005 Mar-Apr; 47(5):307-13. PMID: 16003645.
      Citations:    
    347. Ikonomidis JS, Hendrick JW, Parkhurst AM, Herron AR, Escobar PG, Dowdy KB, Stroud RE, Hapke E, Zile MR, Spinale FG, Ikonomidis JS, Hendrick JW, Parkhurst AM, Herron AR, Escobar PG, Dowdy KB, Stroud RE, Hapke E, Zile MR, Spinale FG. Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H149-58. PMID: 15598866.
      Citations:    
    348. Aurigemma GP, Zile MR, Gaasch WH, Aurigemma GP, Zile MR, Gaasch WH. Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure. Am Heart J. 2004 Sep; 148(3):E12. PMID: 15389248.
      Citations:    
    349. Zile M, Gaasch W, Little W, Francis G, Tavazzi L, Cleland J, Davies M, Zile M, Gaasch W, Little W, Francis G, Tavazzi L, Cleland J, Davies M, MCC-135 GO1 Investigators. A phase II, double-blind, randomized, placebo-controlled, dose comparative study of the efficacy, tolerability, and safety of MCC-135 in subjects with chronic heart failure, NYHA class II/III (MCC-135-GO1 study): rationale and design. J Card Fail. 2004 Jun; 10(3):193-9. PMID: 15190528.
      Citations:    
    350. Zile MR, Baicu CF, Gaasch WH, Zile MR, Baicu CF, Gaasch WH. Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med. 2004 May 06; 350(19):1953-9. PMID: 15128895.
      Citations:    
    351. Gaasch WH, Zile MR, Gaasch WH, Zile MR. Left ventricular diastolic dysfunction and diastolic heart failure. Annu Rev Med. 2004; 55:373-94. PMID: 14746527.
      Citations: 89     Fields:    Translation:Humans
    352. Yost MJ, Baicu CF, Stonerock CE, Goodwin RL, Price RL, Davis JM, Evans H, Watson PD, Gore CM, Sweet J, Creech L, Zile MR, Terracio L, Yost MJ, Baicu CF, Stonerock CE, Goodwin RL, Price RL, Davis JM, Evans H, Watson PD, Gore CM, Sweet J, Creech L, Zile MR, Terracio L. A novel tubular scaffold for cardiovascular tissue engineering. Tissue Eng. 2004 Jan-Feb; 10(1-2):273-84. PMID: 15009952.
      Citations: 15     Fields:    Translation:Cells
    353. Domanski MJ, Krause-Steinrauf H, Massie BM, Deedwania P, Follmann D, Kovar D, Murray D, Oren R, Rosenberg Y, Young J, Zile M, Eichhorn E, Domanski MJ, Krause-Steinrauf H, Massie BM, Deedwania P, Follmann D, Kovar D, Murray D, Oren R, Rosenberg Y, Young J, Zile M, Eichhorn E, BEST Investigators. A comparative analysis of the results from 4 trials of beta-blocker therapy for heart failure: BEST, CIBIS-II, MERIT-HF, and COPERNICUS. J Card Fail. 2003 Oct; 9(5):354-63. PMID: 14583895.
      Citations: 48     Fields:    Translation:Humans
    354. Ishibashi Y, Takahashi M, Isomatsu Y, Qiao F, Iijima Y, Shiraishi H, Simsic JM, Baicu CF, Robbins J, Zile MR, Cooper G, Ishibashi Y, Takahashi M, Isomatsu Y, Qiao F, Iijima Y, Shiraishi H, Simsic JM, Baicu CF, Robbins J, Zile MR, Cooper G. Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytes. Am J Physiol Heart Circ Physiol. 2003 Sep; 285(3):H1270-85. PMID: 12750067.
      Citations: 10     Fields:    Translation:AnimalsCells
    355. Zile MR, Zile MR. Heart failure with preserved ejection fraction: is this diastolic heart failure? J Am Coll Cardiol. 2003 May 07; 41(9):1519-22. PMID: 12742292.
      Citations: 15     Fields:    Translation:Humans
    356. Zile MR, Gaasch WH, Zile MR, Gaasch WH. Heart failure in aortic stenosis - improving diagnosis and treatment. N Engl J Med. 2003 May 01; 348(18):1735-6. PMID: 12724478.
      Citations: 4     Fields:    Translation:Humans
    357. Zile MR, Zile MR. Diastolic heart failure. Diagnosis, prognosis, treatment. Minerva Cardioangiol. 2003 Apr; 51(2):131-42. PMID: 12783069.
      Citations: 2     Fields:    Translation:Humans
    358. Zile MR, Zile MR. Peter C. Gazes: physician, teacher, scholar. Clin Cardiol. 2003 Mar; 26(3):158-9. PMID: 12685625; PMCID: PMC6653979.
      Citations:    Fields:    
    359. Orr RK, Hoehn JL, Col NF, King MK, Coker ML, Goldberg A, McElmurray JH, Gunasinghe HR, Mukherjee R, Zile MR, O'Neill TP, Spinale FG. Selective matrix metalloproteinase inhibition with developing heart failure: effects on left ventricular function and structure. Circ Res. 2003 Feb 07; 92(2):177-85. PMID: 12574145.
      Citations: 29     Fields:    Translation:Animals
    360. Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Baskin JM, Deschamps AM, Lowry AS, Escobar GP, Lucas DG, Yarbrough WM, Zile MR, Spinale FG, Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Baskin JM, Deschamps AM, Lowry AS, Escobar GP, Lucas DG, Yarbrough WM, Zile MR, Spinale FG. Myocardial infarct expansion and matrix metalloproteinase inhibition. Circulation. 2003 Feb 04; 107(4):618-25. PMID: 12566376.
      Citations: 89     Fields:    Translation:AnimalsCells
    361. Baicu CF, Stroud JD, Livesay VA, Hapke E, Holder J, Spinale FG, Zile MR, Baicu CF, Stroud JD, Livesay VA, Hapke E, Holder J, Spinale FG, Zile MR. Changes in extracellular collagen matrix alter myocardial systolic performance. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H122-32. PMID: 12485818.
      Citations: 46     Fields:    Translation:AnimalsCells
    362. Zile MR, Zile MR. Structural components of cardiomyocyte remodeling: summation. J Card Fail. 2002 Dec; 8(6 Suppl):S311-3. PMID: 12555137.
      Citations:    Fields:    Translation:HumansAnimalsCells
    363. Harris TS, Baicu CF, Conrad CH, Koide M, Buckley JM, Barnes M, Cooper G, Zile MR, Harris TS, Baicu CF, Conrad CH, Koide M, Buckley JM, Barnes M, Cooper G, Zile MR. Constitutive properties of hypertrophied myocardium: cellular contribution to changes in myocardial stiffness. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2173-82. PMID: 12003826.
      Citations: 12     Fields:    Translation:AnimalsCells
    364. Stroud JD, Baicu CF, Barnes MA, Spinale FG, Zile MR, Stroud JD, Baicu CF, Barnes MA, Spinale FG, Zile MR. Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2324-35. PMID: 12003843.
      Citations: 21     Fields:    Translation:AnimalsCells
    365. Yun KL, Sintek CF, Miller DC, Pfeffer TA, Kochamba GS, Khonsari S, Zile MR, Yun KL, Sintek CF, Miller DC, Pfeffer TA, Kochamba GS, Khonsari S, Zile MR. Randomized trial comparing partial versus complete chordal-sparing mitral valve replacement: effects on left ventricular volume and function. J Thorac Cardiovasc Surg. 2002 Apr; 123(4):707-14. PMID: 11986599.
      Citations: 24     Fields:    Translation:HumansCTClinical Trials
    366. Zile MR, Brutsaert DL, Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment. Circulation. 2002 Mar 26; 105(12):1503-8. PMID: 11914262.
      Citations: 174     Fields:    Translation:HumansAnimalsCells
    367. Zile MR, Brutsaert DL, Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function. Circulation. 2002 Mar 19; 105(11):1387-93. PMID: 11901053.
      Citations: 276     Fields:    Translation:Humans
    368. Walker CA, Ergul A, Grubbs A, Zile MR, Zellner JL, Crumbley AJ, Spinale FG, Walker CA, Ergul A, Grubbs A, Zile MR, Zellner JL, Crumbley AJ, Spinale FG. beta-Adrenergic and endothelin receptor interaction in dilated human cardiomyopathic myocardium. J Card Fail. 2001 Jun; 7(2):129-37. PMID: 11420764.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    369. Zile MR, Green GR, Schuyler GT, Aurigemma GP, Miller DC, Cooper G, Zile MR, Green GR, Schuyler GT, Aurigemma GP, Miller DC, Cooper G. Cardiocyte cytoskeleton in patients with left ventricular pressure overload hypertrophy. J Am Coll Cardiol. 2001 Mar 15; 37(4):1080-4. PMID: 11263612.
      Citations: 28     Fields:    Translation:Humans
    370. Ishibashi Y, Rembert JC, Carabello BA, Nemoto S, Hamawaki M, Zile MR, Greenfield JC, Cooper G, Ishibashi Y, Rembert JC, Carabello BA, Nemoto S, Hamawaki M, Zile MR, Greenfield JC, Cooper G. Normal myocardial function in severe right ventricular volume overload hypertrophy. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H11-6. PMID: 11123212.
      Citations: 1     Fields:    Translation:Animals
    371. Gramling-Babb PM, Zile MR, Reeves ST, Gramling-Babb PM, Zile MR, Reeves ST. Preliminary report on high thoracic epidural analgesia: relationship between its therapeutic effects and myocardial blood flow as assessed by stress thallium distribution. J Cardiothorac Vasc Anesth. 2000 Dec; 14(6):657-61. PMID: 11139104.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    372. Laser M, Willey CD, Jiang W, Cooper G, Menick DR, Zile MR, Kuppuswamy D, Laser M, Willey CD, Jiang W, Cooper G, Menick DR, Zile MR, Kuppuswamy D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. 2000 Nov 10; 275(45):35624-30. PMID: 10958798.
      Citations: 38     Fields:    Translation:AnimalsCells
    373. Zile MR, Nappi J, Zile MR, Nappi J. Diastolic Heart Failure. Curr Treat Options Cardiovasc Med. 2000 Oct; 2(5):439-450. PMID: 11096548.
      Citations: 2     
    374. Koide M, Hamawaki M, Narishige T, Sato H, Nemoto S, DeFreyte G, Zile MR, Cooper G IV, Carabello BA, Koide M, Hamawaki M, Narishige T, Sato H, Nemoto S, DeFreyte G, Zile MR, Cooper G IV, Carabello BA. Microtubule depolymerization normalizes in vivo myocardial contractile function in dogs with pressure-overload left ventricular hypertrophy. Circulation. 2000 Aug 29; 102(9):1045-52. PMID: 10961971.
      Citations: 31     Fields:    Translation:AnimalsCells
    375. Ghatpande S, Ghatpande A, Zile M, Evans T, Ghatpande S, Ghatpande A, Zile M, Evans T. Anterior endoderm is sufficient to rescue foregut apoptosis and heart tube morphogenesis in an embryo lacking retinoic acid. Dev Biol. 2000 Mar 01; 219(1):59-70. PMID: 10677255.
      Citations: 12     Fields:    Translation:Animals
    376. Maden M, Graham A, Zile M, Gale E, Maden M, Graham A, Zile M, Gale E. Abnormalities of somite development in the absence of retinoic acid. Int J Dev Biol. 2000; 44(1):151-9. PMID: 10761860.
      Citations: 6     Fields:    Translation:Animals
    377. Roten L, Nemoto S, Simsic J, Coker ML, Rao V, Baicu S, Defreyte G, Soloway PJ, Zile MR, Spinale FG, Roten L, Nemoto S, Simsic J, Coker ML, Rao V, Baicu S, Defreyte G, Soloway PJ, Zile MR, Spinale FG. Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. J Mol Cell Cardiol. 2000 Jan; 32(1):109-20. PMID: 10652195.
      Citations: 33     Fields:    Translation:Animals
    378. Yun KL, Sintek CF, Miller DC, Schuyler GT, Fletcher AD, Pfeffer TA, Kochamba GS, Khonsari S, Zile MR, Yun KL, Sintek CF, Miller DC, Schuyler GT, Fletcher AD, Pfeffer TA, Kochamba GS, Khonsari S, Zile MR. Randomized trial of partial versus complete chordal preservation methods of mitral valve replacement: A preliminary report. Circulation. 1999 Nov 09; 100(19 Suppl):II90-4. PMID: 10567284.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    379. McElmurray JH, Mukherjee R, New RB, Sampson AC, King MK, Hendrick JW, Goldberg A, Peterson TJ, Hallak H, Zile MR, Spinale FG, McElmurray JH, Mukherjee R, New RB, Sampson AC, King MK, Hendrick JW, Goldberg A, Peterson TJ, Hallak H, Zile MR, Spinale FG. Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: comparative effects on left ventricular function and geometry. J Pharmacol Exp Ther. 1999 Nov; 291(2):799-811. PMID: 10525103.
      Citations: 11     Fields:    Translation:Animals
    380. Spinale FG, Coker ML, Krombach SR, Mukherjee R, Hallak H, Houck WV, Clair MJ, Kribbs SB, Johnson LL, Peterson JT, Zile MR, Spinale FG, Coker ML, Krombach SR, Mukherjee R, Hallak H, Houck WV, Clair MJ, Kribbs SB, Johnson LL, Peterson JT, Zile MR. Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function. Circ Res. 1999 Aug 20; 85(4):364-76. PMID: 10455065.
      Citations: 54     Fields:    Translation:AnimalsCells
    381. Nagai T, Laser M, Baicu CF, Zile MR, Cooper G, Kuppuswamy D, Nagai T, Laser M, Baicu CF, Zile MR, Cooper G, Kuppuswamy D. Beta3-integrin-mediated focal adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices. Am J Cardiol. 1999 Jun 17; 83(12A):38H-43H. PMID: 10750585.
      Citations: 7     Fields:    Translation:AnimalsCells
    382. Stratford T, Logan C, Zile M, Maden M, Stratford T, Logan C, Zile M, Maden M. Abnormal anteroposterior and dorsoventral patterning of the limb bud in the absence of retinoids. Mech Dev. 1999 Mar; 81(1-2):115-25. PMID: 10330489.
      Citations: 12     Fields:    Translation:AnimalsCells
    383. Kostetskii I, Jiang Y, Kostetskaia E, Yuan S, Evans T, Zile M, Kostetskii I, Jiang Y, Kostetskaia E, Yuan S, Evans T, Zile M. Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation. Dev Biol. 1999 Feb 15; 206(2):206-18. PMID: 9986733.
      Citations: 18     Fields:    Translation:AnimalsCells
    384. Koide M, Carabello BA, Conrad CC, Buckley JM, DeFreyte G, Barnes M, Tomanek RJ, Wei CC, Dell'Italia LJ, Cooper G, Zile MR, Koide M, Carabello BA, Conrad CC, Buckley JM, DeFreyte G, Barnes M, Tomanek RJ, Wei CC, Dell'Italia LJ, Cooper G, Zile MR. Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation. Am J Physiol. 1999 Feb; 276(2 Pt 2):H350-8. PMID: 9950833.
      Citations: 6     Fields:    Translation:Animals
    385. Zile MR, Koide M, Sato H, Ishiguro Y, Conrad CH, Buckley JM, Morgan JP, Cooper G, Zile MR, Koide M, Sato H, Ishiguro Y, Conrad CH, Buckley JM, Morgan JP, Cooper G. Role of microtubules in the contractile dysfunction of hypertrophied myocardium. J Am Coll Cardiol. 1999 Jan; 33(1):250-60. PMID: 9935038.
      Citations: 20     Fields:    Translation:AnimalsCells
    386. Kostetskii I, Yuan SY, Kostetskaia E, Linask KK, Blanchet S, Seleiro E, Michaille JJ, Brickell P, Zile M, Kostetskii I, Yuan SY, Kostetskaia E, Linask KK, Blanchet S, Seleiro E, Michaille JJ, Brickell P, Zile M. Initial retinoid requirement for early avian development coincides with retinoid receptor coexpression in the precardiac fields and induction of normal cardiovascular development. Dev Dyn. 1998 Oct; 213(2):188-98. PMID: 9786419.
      Citations: 6     Fields:    Translation:Animals
    387. Zile MR, Richardson K, Cowles MK, Buckley JM, Koide M, Cowles BA, Gharpuray V, Cooper G, Zile MR, Richardson K, Cowles MK, Buckley JM, Koide M, Cowles BA, Gharpuray V, Cooper G. Constitutive properties of adult mammalian cardiac muscle cells. Circulation. 1998 Aug 11; 98(6):567-79. PMID: 9714115.
      Citations: 18     Fields:    Translation:AnimalsCells
    388. Matsuo T, Carabello BA, Nagatomo Y, Koide M, Hamawaki M, Zile MR, McDermott PJ, Matsuo T, Carabello BA, Nagatomo Y, Koide M, Hamawaki M, Zile MR, McDermott PJ. Mechanisms of cardiac hypertrophy in canine volume overload. Am J Physiol. 1998 Jul; 275(1 Pt 2):H65-74. PMID: 9688897.
      Citations: 8     Fields:    Translation:AnimalsCells
    389. Zile MR, Cowles MK, Buckley JM, Richardson K, Cowles BA, Baicu CF, Cooper G IV, Gharpuray V, Zile MR, Cowles MK, Buckley JM, Richardson K, Cowles BA, Baicu CF, Cooper G IV, Gharpuray V. Gel stretch method: a new method to measure constitutive properties of cardiac muscle cells. Am J Physiol. 1998 Jun; 274(6 Pt 2):H2188-202. PMID: 9841544.
      Citations: 6     Fields:    Translation:Animals
    390. Tagawa H, Koide M, Sato H, Zile MR, Carabello BA, Cooper G, Tagawa H, Koide M, Sato H, Zile MR, Carabello BA, Cooper G. Cytoskeletal role in the transition from compensated to decompensated hypertrophy during adult canine left ventricular pressure overloading. Circ Res. 1998 Apr 20; 82(7):751-61. PMID: 9562434.
      Citations: 44     Fields:    Translation:AnimalsCells
    391. Hamawaki M, Coffman TM, Lashus A, Koide M, Zile MR, Oliverio MI, DeFreyte G, Cooper G, Carabello BA, Hamawaki M, Coffman TM, Lashus A, Koide M, Zile MR, Oliverio MI, DeFreyte G, Cooper G, Carabello BA. Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. Am J Physiol. 1998 03; 274(3):H868-73. PMID: 9530198.
      Citations: 10     Fields:    Translation:Animals
    392. Goldfine H, Aurigemma GP, Zile MR, Gaasch WH, Goldfine H, Aurigemma GP, Zile MR, Gaasch WH. Left ventricular length-force-shortening relations before and after surgical correction of chronic mitral regurgitation. J Am Coll Cardiol. 1998 Jan; 31(1):180-5. PMID: 9426038.
      Citations: 4     Fields:    Translation:Humans
    393. Gramling-Babb P, Miller MJ, Reeves ST, Roy RC, Zile MR, Gramling-Babb P, Miller MJ, Reeves ST, Roy RC, Zile MR. Treatment of medically and surgically refractory angina pectoris with high thoracic epidural analgesia: initial clinical experience. Am Heart J. 1997 Jun; 133(6):648-55. PMID: 9200392.
      Citations: 4     Fields:    Translation:Humans
    394. Koide M, Nagatsu M, Zile MR, Hamawaki M, Swindle MM, Keech G, DeFreyte G, Tagawa H, Cooper G, Carabello BA, Koide M, Nagatsu M, Zile MR, Hamawaki M, Swindle MM, Keech G, DeFreyte G, Tagawa H, Cooper G, Carabello BA. Premorbid determinants of left ventricular dysfunction in a novel model of gradually induced pressure overload in the adult canine. Circulation. 1997 Mar 18; 95(6):1601-10. PMID: 9118531.
      Citations: 16     Fields:    Translation:Animals
    395. Tagawa H, Wang N, Narishige T, Ingber DE, Zile MR, Cooper G, Tagawa H, Wang N, Narishige T, Ingber DE, Zile MR, Cooper G. Cytoskeletal mechanics in pressure-overload cardiac hypertrophy. Circ Res. 1997 Feb; 80(2):281-9. PMID: 9012750.
      Citations: 43     Fields:    Translation:AnimalsCells
    396. Kato S, Koide M, Cooper G, Zile MR, Kato S, Koide M, Cooper G, Zile MR. Effects of pressure- or volume-overload hypertrophy on passive stiffness in isolated adult cardiac muscle cells. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2575-83. PMID: 8997318.
      Citations: 3     Fields:    Translation:Animals
    397. Wada H, Zile MR, Ivester CT, Cooper G, McDermott PJ, Wada H, Zile MR, Ivester CT, Cooper G, McDermott PJ. Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Am J Physiol. 1996 Jul; 271(1 Pt 2):H29-37. PMID: 8760154.
      Citations: 7     Fields:    Translation:AnimalsCells
    398. Tanaka R, Barnes MA, Cooper G, Zile MR, Tanaka R, Barnes MA, Cooper G, Zile MR. Effects of anisosmotic stress on cardiac muscle cell length, diameter, area, and sarcomere length. Am J Physiol. 1996 Apr; 270(4 Pt 2):H1414-22. PMID: 8967384.
      Citations: 1     Fields:    Translation:AnimalsCells
    399. Kato S, Spinale FG, Tanaka R, Johnson W, Cooper G, Zile MR, Kato S, Spinale FG, Tanaka R, Johnson W, Cooper G, Zile MR. Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function. Am J Physiol. 1995 Sep; 269(3 Pt 2):H863-8. PMID: 7573529.
      Citations: 21     Fields:    Translation:AnimalsCells
    400. Kato S, Ivester CT, Cooper G, Zile MR, McDermott PJ, Kato S, Ivester CT, Cooper G, Zile MR, McDermott PJ. Growth effects of electrically stimulated contraction on adult feline cardiocytes in primary culture. Am J Physiol. 1995 Jun; 268(6 Pt 2):H2495-504. PMID: 7611500.
      Citations: 13     Fields:    Translation:AnimalsCells
    401. Zile MR, Mukherjee R, Clayton C, Kato S, Spinale FG, Zile MR, Mukherjee R, Clayton C, Kato S, Spinale FG. Effects of chronic supraventricular pacing tachycardia on relaxation rate in isolated cardiac muscle cells. Am J Physiol. 1995 May; 268(5 Pt 2):H2104-13. PMID: 7771561.
      Citations: 1     Fields:    Translation:AnimalsCells
    402. Rozich JD, Barnes MA, Schmid PG, Zile MR, McDermott PJ, Cooper G, Rozich JD, Barnes MA, Schmid PG, Zile MR, McDermott PJ, Cooper G. Load effects on gene expression during cardiac hypertrophy. J Mol Cell Cardiol. 1995 Jan; 27(1):485-99. PMID: 7760368.
      Citations: 8     Fields:    Translation:AnimalsCells
    403. Walker JD, Crawford FA, Mukherjee R, Zile MR, Spinale FG, Walker JD, Crawford FA, Mukherjee R, Zile MR, Spinale FG. Direct effects of acute administration of 3, 5, 3' triiodo-L-thyronine on myocyte function. Ann Thorac Surg. 1994 Sep; 58(3):851-6. PMID: 7944715.
      Citations: 2     Fields:    Translation:Animals
    404. Spinale FG, Tempel GE, Mukherjee R, Eble DM, Brown R, Vacchiano CA, Zile MR, Spinale FG, Tempel GE, Mukherjee R, Eble DM, Brown R, Vacchiano CA, Zile MR. Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia. Cardiovasc Res. 1994 Aug; 28(8):1243-50. PMID: 7954628.
      Citations: 7     Fields:    Translation:Animals
    405. Hird RB, Crawford FA, Mukherjee R, Zile MR, Spinale FG, Hird RB, Crawford FA, Mukherjee R, Zile MR, Spinale FG. Effects of protamine on myocyte contractile function and beta-adrenergic responsiveness. Ann Thorac Surg. 1994 May; 57(5):1066-74; discussion 1074-5. PMID: 8179366.
      Citations: 1     Fields:    Translation:Animals
    406. Nagatsu M, Zile MR, Tsutsui H, Schmid PG, DeFreyte G, Cooper G, Carabello BA, Nagatsu M, Zile MR, Tsutsui H, Schmid PG, DeFreyte G, Cooper G, Carabello BA. Native beta-adrenergic support for left ventricular dysfunction in experimental mitral regurgitation normalizes indexes of pump and contractile function. Circulation. 1994 Feb; 89(2):818-26. PMID: 8313571.
      Citations: 11     Fields:    Translation:Animals
    407. Nagatsu M, Ishihara K, Zile MR, Tsutsui H, Tagawa H, DeFreyte G, Tanaka R, Cooper G, Carabello BA, Nagatsu M, Ishihara K, Zile MR, Tsutsui H, Tagawa H, DeFreyte G, Tanaka R, Cooper G, Carabello BA. The effects of complete versus incomplete mitral valve repair in experimental mitral regurgitation. J Thorac Cardiovasc Surg. 1994 Feb; 107(2):416-23. PMID: 8302060.
      Citations: 2     Fields:    Translation:Animals
    408. Assey ME, Zile MR, Usher BW, Karavan MP, Carabello BA, Assey ME, Zile MR, Usher BW, Karavan MP, Carabello BA. Effect of catheter positioning on the variability of measured gradient in aortic stenosis. Cathet Cardiovasc Diagn. 1993 Dec; 30(4):287-92. PMID: 8287452.
      Citations: 1     Fields:    Translation:Humans
    409. Spinale FG, Ishihra K, Zile M, DeFryte G, Crawford FA, Carabello BA, Spinale FG, Ishihra K, Zile M, DeFryte G, Crawford FA, Carabello BA. Structural basis for changes in left ventricular function and geometry because of chronic mitral regurgitation and after correction of volume overload. J Thorac Cardiovasc Surg. 1993 Dec; 106(6):1147-57. PMID: 8246553.
      Citations: 15     Fields:    Translation:Animals
    410. Tanaka R, Fulbright BM, Mukherjee R, Burchell SA, Crawford FA, Zile MR, Spinale FG, Tanaka R, Fulbright BM, Mukherjee R, Burchell SA, Crawford FA, Zile MR, Spinale FG. The cellular basis for the blunted response to beta-adrenergic stimulation in supraventricular tachycardia-induced cardiomyopathy. J Mol Cell Cardiol. 1993 Oct; 25(10):1215-33. PMID: 8263955.
      Citations: 9     Fields:    Translation:AnimalsCells
    411. Tsutsui H, Urabe Y, Mann DL, Tagawa H, Carabello BA, Cooper G, Zile MR, Tsutsui H, Urabe Y, Mann DL, Tagawa H, Carabello BA, Cooper G, Zile MR. Effects of chronic mitral regurgitation on diastolic function in isolated cardiocytes. Circ Res. 1993 May; 72(5):1110-23. PMID: 8477523.
      Citations: 4     Fields:    Translation:AnimalsCells
    412. Zile MR, Tomita M, Ishihara K, Nakano K, Lindroth J, Spinale F, Swindle M, Carabello BA, Zile MR, Tomita M, Ishihara K, Nakano K, Lindroth J, Spinale F, Swindle M, Carabello BA. Changes in diastolic function during development and correction of chronic LV volume overload produced by mitral regurgitation. Circulation. 1993 Apr; 87(4):1378-88. PMID: 8462159.
      Citations: 8     Fields:    Translation:Animals
    413. Spinale FG, Mukherjee R, Fulbright BM, Hu J, Crawford FA, Zile MR, Spinale FG, Mukherjee R, Fulbright BM, Hu J, Crawford FA, Zile MR. Contractile properties of isolated porcine ventricular myocytes. Cardiovasc Res. 1993 Feb; 27(2):304-11. PMID: 8472283.
      Citations: 2     Fields:    Translation:AnimalsCells
    414. Ishihara K, Zile MR, Nagatsu M, Nakano K, Tomita M, Kanazawa S, Clamp L, DeFreyte G, Carabello BA, Ishihara K, Zile MR, Nagatsu M, Nakano K, Tomita M, Kanazawa S, Clamp L, DeFreyte G, Carabello BA. Coronary blood flow after the regression of pressure-overload left ventricular hypertrophy. Circ Res. 1992 Dec; 71(6):1472-81. PMID: 1423939.
      Citations: 4     Fields:    Translation:Animals
    415. Rozich JD, Carabello BA, Usher BW, Kratz JM, Bell AE, Zile MR, Rozich JD, Carabello BA, Usher BW, Kratz JM, Bell AE, Zile MR. Mitral valve replacement with and without chordal preservation in patients with chronic mitral regurgitation. Mechanisms for differences in postoperative ejection performance. Circulation. 1992 Dec; 86(6):1718-26. PMID: 1451243.
      Citations: 19     Fields:    Translation:Humans
    416. Cannon JD, Zile MR, Crawford FA, Carabello BA, Cannon JD, Zile MR, Crawford FA, Carabello BA. Aortic valve resistance as an adjunct to the Gorlin formula in assessing the severity of aortic stenosis in symptomatic patients. J Am Coll Cardiol. 1992 Dec; 20(7):1517-23. PMID: 1452925.
      Citations: 13     Fields:    Translation:Humans
    417. Tanaka R, Spinale FG, Crawford FA, Zile MR, Tanaka R, Spinale FG, Crawford FA, Zile MR. Effect of chronic supraventricular tachycardia on left ventricular function and structure in newborn pigs. J Am Coll Cardiol. 1992 Dec; 20(7):1650-60. PMID: 1452940.
      Citations: 11     Fields:    Translation:Animals
    418. Ishihara K, Zile MR, Kanazawa S, Tsutsui H, Urabe Y, DeFreyte G, Carabello BA, Ishihara K, Zile MR, Kanazawa S, Tsutsui H, Urabe Y, DeFreyte G, Carabello BA. Left ventricular mechanics and myocyte function after correction of experimental chronic mitral regurgitation by combined mitral valve replacement and preservation of the native mitral valve apparatus. Circulation. 1992 Nov; 86(5 Suppl):II16-25. PMID: 1423995.
      Citations: 1     Fields:    Translation:Animals
    419. Burchell SA, Spinale FG, Crawford FA, Tanaka R, Zile MR, Burchell SA, Spinale FG, Crawford FA, Tanaka R, Zile MR. Effects of chronic tachycardia-induced cardiomyopathy on the beta-adrenergic receptor system. J Thorac Cardiovasc Surg. 1992 Oct; 104(4):1006-12. PMID: 1328769.
      Citations: 5     Fields:    Translation:Animals
    420. Zile MR, Tanaka R, Lindroth JR, Spinale F, Carabello BA, Mirsky I, Zile MR, Tanaka R, Lindroth JR, Spinale F, Carabello BA, Mirsky I. Left ventricular volume determined echocardiographically by assuming a constant left ventricular epicardial long-axis/short-axis dimension ratio throughout the cardiac cycle. J Am Coll Cardiol. 1992 Oct; 20(4):986-93. PMID: 1388183.
      Citations: 4     Fields:    Translation:Animals
    421. Carabello BA, Zile MR, Tanaka R, Cooper G, Carabello BA, Zile MR, Tanaka R, Cooper G. Left ventricular hypertrophy due to volume overload versus pressure overload. Am J Physiol. 1992 Oct; 263(4 Pt 2):H1137-44. PMID: 1415762.
      Citations: 11     Fields:    Translation:Animals
    422. Spinale FG, Fulbright BM, Mukherjee R, Tanaka R, Hu J, Crawford FA, Zile MR, Spinale FG, Fulbright BM, Mukherjee R, Tanaka R, Hu J, Crawford FA, Zile MR. Relation between ventricular and myocyte function with tachycardia-induced cardiomyopathy. Circ Res. 1992 Jul; 71(1):174-87. PMID: 1606661.
      Citations: 11     Fields:    Translation:Animals
    423. Ishihara K, Zile MR, Tomita M, Tanaka R, Kanazawa S, Carabello BA, Ishihara K, Zile MR, Tomita M, Tanaka R, Kanazawa S, Carabello BA. Left ventricular hypertrophy in a canine model of reversible pressure overload. Cardiovasc Res. 1992 Jun; 26(6):580-5. PMID: 1451137.
      Citations: 1     Fields:    Translation:Animals
    424. Gwinn N, Leman R, Kratz J, White JK, Zile MR, Gillette P, Gwinn N, Leman R, Kratz J, White JK, Zile MR, Gillette P. Chronotropic incompetence: a common and progressive finding in pacemaker patients. Am Heart J. 1992 May; 123(5):1216-9. PMID: 1575136.
      Citations: 10     Fields:    Translation:Humans
    425. Spinale FG, Mukherjee R, Tanaka R, Zile MR, Spinale FG, Mukherjee R, Tanaka R, Zile MR. The effects of valvular regurgitation on thermodilution ejection fraction measurements. Chest. 1992 Mar; 101(3):723-31. PMID: 1541138.
      Citations: 9     Fields:    
    426. Spinale FG, Clayton C, Tanaka R, Fulbright BM, Mukherjee R, Schulte BA, Crawford FA, Zile MR, Spinale FG, Clayton C, Tanaka R, Fulbright BM, Mukherjee R, Schulte BA, Crawford FA, Zile MR. Myocardial Na+,K(+)-ATPase in tachycardia induced cardiomyopathy. J Mol Cell Cardiol. 1992 Mar; 24(3):277-94. PMID: 1320703.
      Citations: 12     Fields:    Translation:Animals
    427. Spinale FG, Tanaka R, Crawford FA, Zile MR, Spinale FG, Tanaka R, Crawford FA, Zile MR. Changes in myocardial blood flow during development of and recovery from tachycardia-induced cardiomyopathy. Circulation. 1992 Feb; 85(2):717-29. PMID: 1735164.
      Citations: 18     Fields:    Translation:Animals
    428. Spinale FG, Grine RC, Tempel GE, Crawford FA, Zile MR, Spinale FG, Grine RC, Tempel GE, Crawford FA, Zile MR. Alterations in the myocardial capillary vasculature accompany tachycardia-induced cardiomyopathy. Basic Res Cardiol. 1992 Jan-Feb; 87(1):65-79. PMID: 1567354.
      Citations: 11     Fields:    Translation:Animals
    429. Zile MR, Tomita M, Nakano K, Mirsky I, Usher B, Lindroth J, Carabello BA, Zile MR, Tomita M, Nakano K, Mirsky I, Usher B, Lindroth J, Carabello BA. Effects of left ventricular volume overload produced by mitral regurgitation on diastolic function. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1471-80. PMID: 1951734.
      Citations: 13     Fields:    Translation:Animals
    430. Spinale FG, Zellner JL, Tomita M, Crawford FA, Zile MR, Spinale FG, Zellner JL, Tomita M, Crawford FA, Zile MR. Relation between ventricular and myocyte remodeling with the development and regression of supraventricular tachycardia-induced cardiomyopathy. Circ Res. 1991 Oct; 69(4):1058-67. PMID: 1934334.
      Citations: 19     Fields:    Translation:Animals
    431. Zile MR, Gaasch WH, Zile MR, Gaasch WH. Load-dependent left ventricular relaxation in conscious dogs. Am J Physiol. 1991 Sep; 261(3 Pt 2):H691-9. PMID: 1887917.
      Citations: 6     Fields:    Translation:Animals
    432. Izzi G, Zile MR, Gaasch WH, Izzi G, Zile MR, Gaasch WH. Myocardial oxygen consumption and the left ventricular pressure-volume area in normal and hypertrophic canine hearts. Circulation. 1991 Sep; 84(3):1384-92. PMID: 1832096.
      Citations: 6     Fields:    Translation:Animals
    433. Spinale FG, Tomita M, Zellner JL, Cook JC, Crawford FA, Zile MR, Spinale FG, Tomita M, Zellner JL, Cook JC, Crawford FA, Zile MR. Collagen remodeling and changes in LV function during development and recovery from supraventricular tachycardia. Am J Physiol. 1991 Aug; 261(2 Pt 2):H308-18. PMID: 1877659.
      Citations: 41     Fields:    Translation:Animals
    434. Spinale FG, Zellner JL, Tomita M, Tempel GE, Crawford FA, Zile MR, Spinale FG, Zellner JL, Tomita M, Tempel GE, Crawford FA, Zile MR. Tachycardia-induced cardiomyopathy: effects on blood flow and capillary structure. Am J Physiol. 1991 Jul; 261(1 Pt 2):H140-8. PMID: 1858914.
      Citations: 8     Fields:    Translation:Animals
    435. Gaasch WH, Zile MR, Gaasch WH, Zile MR. Left ventricular function after surgical correction of chronic mitral regurgitation. Eur Heart J. 1991 Jul; 12 Suppl B:48-51. PMID: 1936024.
      Citations: 5     Fields:    Translation:Humans
    436. Nakano K, Swindle MM, Spinale F, Ishihara K, Kanazawa S, Smith A, Biederman RW, Clamp L, Hamada Y, Zile MR, Nakano K, Swindle MM, Spinale F, Ishihara K, Kanazawa S, Smith A, Biederman RW, Clamp L, Hamada Y, Zile MR, et al. Depressed contractile function due to canine mitral regurgitation improves after correction of the volume overload. J Clin Invest. 1991 Jun; 87(6):2077-86. PMID: 1828252; PMCID: PMC296964.
      Citations: 12     Fields:    Translation:Animals
    437. Zile MR, Zile MR. Chronic aortic and mitral regurgitation. Choosing the optimal time for surgical correction. Cardiol Clin. 1991 May; 9(2):239-53. PMID: 2054815.
      Citations: 1     Fields:    Translation:Humans
    438. Rozich JD, Smith B, Thomas JD, Zile MR, Kaiser J, Mann DL, Rozich JD, Smith B, Thomas JD, Zile MR, Kaiser J, Mann DL. Dialysis-induced alterations in left ventricular filling: mechanisms and clinical significance. Am J Kidney Dis. 1991 Mar; 17(3):277-85. PMID: 1996569.
      Citations: 1     Fields:    Translation:Humans
    439. Zile MR, Izzi G, Gaasch WH, Zile MR, Izzi G, Gaasch WH. Left ventricular diastolic dysfunction limits use of maximum systolic elastance as an index of contractile function. Circulation. 1991 Feb; 83(2):674-80. PMID: 1825039.
      Citations: 6     Fields:    Translation:Animals
    440. Tomita M, Spinale FG, Crawford FA, Zile MR, Tomita M, Spinale FG, Crawford FA, Zile MR. Changes in left ventricular volume, mass, and function during the development and regression of supraventricular tachycardia-induced cardiomyopathy. Disparity between recovery of systolic versus diastolic function. Circulation. 1991 Feb; 83(2):635-44. PMID: 1991381.
      Citations: 33     Fields:    Translation:Animals
    441. Swindle MM, Spinale FG, Smith AC, Schumann RE, Green CT, Nakano K, Kanasawa S, Ishihara K, Zile MR, Carabello BA, Swindle MM, Spinale FG, Smith AC, Schumann RE, Green CT, Nakano K, Kanasawa S, Ishihara K, Zile MR, Carabello BA. Anesthetic and postoperative protocols for a canine model of reversible left ventricular volume overload. J Invest Surg. 1991; 4(3):339-46. PMID: 1832953.
      Citations:    Fields:    Translation:Animals
    442. Gaasch WH, Zile MR, Hoshino PK, Weinberg EO, Rhodes DR, Apstein CS, Gaasch WH, Zile MR, Hoshino PK, Weinberg EO, Rhodes DR, Apstein CS. Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy. Circulation. 1990 May; 81(5):1644-53. PMID: 2139593.
      Citations: 14     Fields:    Translation:Animals
    443. Zile MR, Gaasch WH, Zile MR, Gaasch WH. Mechanical loads and the isovolumic and filling indices of left ventricular relaxation. Prog Cardiovasc Dis. 1990 Mar-Apr; 32(5):333-46. PMID: 2179994.
      Citations: 3     Fields:    Translation:HumansAnimals
    444. Zile MR, Conrad CH, Gaasch WH, Robinson KG, Bing OH, Zile MR, Conrad CH, Gaasch WH, Robinson KG, Bing OH. Preload does not affect relaxation rate in normal, hypoxic, or hypertrophic myocardium. Am J Physiol. 1990 Jan; 258(1 Pt 2):H191-7. PMID: 2137298.
      Citations: 3     Fields:    Translation:Animals
    445. Zile MR, Blaustein AS, Gaasch WH, Zile MR, Blaustein AS, Gaasch WH. The effect of acute alterations in left ventricular afterload and beta-adrenergic tone on indices of early diastolic filling rate. Circ Res. 1989 Aug; 65(2):406-16. PMID: 2546696.
      Citations: 3     Fields:    Translation:Animals
    446. Gaasch WH, Zile MR, Hoshino PK, Apstein CS, Blaustein AS, Gaasch WH, Zile MR, Hoshino PK, Apstein CS, Blaustein AS. Stress-shortening relations and myocardial blood flow in compensated and failing canine hearts with pressure-overload hypertrophy. Circulation. 1989 Apr; 79(4):872-83. PMID: 2522357.
      Citations: 26     Fields:    Translation:Animals
    447. Zile MR, Neill WA, Gaasch WH, Oxendine J, Apstein CS, Weinberg E, Bing OH, Zile MR, Neill WA, Gaasch WH, Oxendine J, Apstein CS, Weinberg E, Bing OH. Distribution of a neutral cardioplegic vehicle during the development of ischemic myocardial contracture. J Mol Cell Cardiol. 1987 Oct; 19(10):977-89. PMID: 2449532.
      Citations:    Fields:    Translation:Animals
    448. Zile MR, Blaustein AS, Shimizu G, Gaasch WH, Zile MR, Blaustein AS, Shimizu G, Gaasch WH. Right ventricular pacing reduces the rate of left ventricular relaxation and filling. J Am Coll Cardiol. 1987 Sep; 10(3):702-9. PMID: 3624674.
      Citations: 16     Fields:    Translation:Animals
    449. Zile MR, Gaasch WH, Wiegner AW, Robinson KG, Bing OH, Zile MR, Gaasch WH, Wiegner AW, Robinson KG, Bing OH. Mechanical determinants of maximum isotonic lengthening rate in rat left ventricular myocardium. Circ Res. 1987 Jun; 60(6):815-23. PMID: 3594754.
      Citations: 3     Fields:    Translation:Animals
    450. Konstam MA, Weiland DS, Conlon TP, Martin TT, Cohen SR, Eichhorn EJ, Isner JM, Zile MR, Salem DN, Konstam MA, Weiland DS, Conlon TP, Martin TT, Cohen SR, Eichhorn EJ, Isner JM, Zile MR, Salem DN. Hemodynamic correlates of left ventricular versus right ventricular radionuclide volumetric responses to vasodilator therapy in congestive heart failure secondary to ischemic or dilated cardiomyopathy. Am J Cardiol. 1987 May 01; 59(12):1131-7. PMID: 3578055.
      Citations: 1     Fields:    Translation:Humans
    451. Weiland DS, Konstam MA, Salem DN, Martin TT, Cohen SR, Zile MR, Das D, Weiland DS, Konstam MA, Salem DN, Martin TT, Cohen SR, Zile MR, Das D. Contribution of reduced mitral regurgitant volume to vasodilator effect in severe left ventricular failure secondary to coronary artery disease or idiopathic dilated cardiomyopathy. Am J Cardiol. 1986 Nov 01; 58(10):1046-50. PMID: 3776843.
      Citations: 6     Fields:    Translation:Humans
    452. Zile MR, Gaasch WH, Levine HJ, Zile MR, Gaasch WH, Levine HJ. Left ventricular stress-dimension-shortening relations before and after correction of chronic aortic and mitral regurgitation. Am J Cardiol. 1985 Jul 01; 56(1):99-105. PMID: 3160230.
      Citations: 3     Fields:    Translation:Humans
    453. Konstam MA, Cohen SR, Salem DN, Conlon TP, Isner JM, Das D, Zile MR, Levine HJ, Kahn PC, Konstam MA, Cohen SR, Salem DN, Conlon TP, Isner JM, Das D, Zile MR, Levine HJ, Kahn PC. Comparison of left and right ventricular end-systolic pressure-volume relations in congestive heart failure. J Am Coll Cardiol. 1985 Jun; 5(6):1326-34. PMID: 3923077.
      Citations: 4     Fields:    Translation:Humans
    454. Shimizu G, Zile MR, Blaustein AS, Gaasch WH, Shimizu G, Zile MR, Blaustein AS, Gaasch WH. Left ventricular chamber filling and midwall fiber lengthening in patients with left ventricular hypertrophy: overestimation of fiber velocities by conventional midwall measurements. Circulation. 1985 Feb; 71(2):266-72. PMID: 3155498.
      Citations: 19     Fields:    Translation:Humans
    455. Gaasch WH, Zile MR, Gaasch WH, Zile MR. Evaluation of myocardial function in cardiomyopathic states. Prog Cardiovasc Dis. 1984 Sep-Oct; 27(2):115-32. PMID: 6382437.
      Citations: 2     Fields:    Translation:Humans
    456. Konstam MA, Salem DN, Isner JM, Zile MR, Kahn PC, Bonin JD, Cohen SR, Levine HJ, Konstam MA, Salem DN, Isner JM, Zile MR, Kahn PC, Bonin JD, Cohen SR, Levine HJ. Vasodilator effect on right ventricular function in congestive heart failure and pulmonary hypertension: end-systolic pressure--volume relation. Am J Cardiol. 1984 Jul 01; 54(1):132-6. PMID: 6430055.
      Citations: 3     Fields:    Translation:Humans
    457. Zile MR, Gaasch WH, Carroll JD, Levine HJ, Zile MR, Gaasch WH, Carroll JD, Levine HJ. Chronic mitral regurgitation: predictive value of preoperative echocardiographic indexes of left ventricular function and wall stress. J Am Coll Cardiol. 1984 Feb; 3(2 Pt 1):235-42. PMID: 6693615.
      Citations: 14     Fields:    Translation:Humans
    458. Carroll JD, Gaasch WH, Zile MR, Levine HJ, Carroll JD, Gaasch WH, Zile MR, Levine HJ. Serial changes in left ventricular function after correction of chronic aortic regurgitation. Dependence on early changes in preload and subsequent regression of hypertrophy. Am J Cardiol. 1983 Feb; 51(3):476-82. PMID: 6218744.
      Citations: 2     Fields:    Translation:Humans
    459. Coffey RL, Zile MR, Luskin AT, Coffey RL, Zile MR, Luskin AT. Immunologic tests of value in diagnosis. 1. Acute phase reactants and autoantibodies. Postgrad Med. 1981 Aug; 70(2):163-78. PMID: 7019872.
      Citations: 1     Fields:    Translation:Humans
    460. Coffey RL, Zile MR, Luskin AT, Coffey RL, Zile MR, Luskin AT. Immunologic tests of value in diagnosis. 2. Complement. Postgrad Med. 1981 Aug; 70(2):183-8. PMID: 7019873.
      Citations:    Fields:    Translation:Humans
    461. Ito YL, Zile M, Ahrens H, DeLuca HF, Ito YL, Zile M, Ahrens H, DeLuca HF. Liquid-gel partition chromatography of vitamin A compounds; formation of retinoic acid from retinyl acetate in vivo. J Lipid Res. 1974 Sep; 15(5):517-24. PMID: 4414497.
      Citations: 10     Fields:    Translation:Animals
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