Agneta Simionescu

TitleAssistant Professor
InstitutionClemson University
DepartmentDepartment of Bioengineering
Address301 Rhodes Hall
Clemson, South Carolina 29634
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Manduteanu I, Simionescu D, Simionescu A, Simionescu M. Aortic valve disease in diabetes: Molecular mechanisms and novel therapies. J Cell Mol Med. 2021 10; 25(20):9483-9495. PMID: 34561944.
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    2. Movileanu I, Harpa M, Al Hussein H, Harceaga L, Chertes A, Al Hussein H, Lutter G, Puehler T, Preda T, Sircuta C, Cotoi O, Nistor D, Man A, Cordos B, Deac R, Suciu H, Brinzaniuc K, Casco M, Sierad L, Bruce M, Simionescu D, Simionescu A. Preclinical Testing of Living Tissue-Engineered Heart Valves for Pediatric Patients, Challenges and Opportunities. Front Cardiovasc Med. 2021; 8:707892. PMID: 34490371.
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    3. Lutter G, Bax L, Liu Y, Hansen JH, Frank D, Freitag-Wolf S, Simionescu A, Sathananthan J, Puehler T. Transcatheter mitral valve replacement: tissue in-growth after 4 weeks. Interact Cardiovasc Thorac Surg. 2021 01 01; 32(1):1-8. PMID: 33279987.
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    4. Tucureanu MM, Filippi A, Alexandru N, Ana Constantinescu C, Ciortan L, Macarie R, Vadana M, Voicu G, Frunza S, Nistor D, Simionescu A, Simionescu DT, Georgescu A, Manduteanu I. Diabetes-induced early molecular and functional changes in aortic heart valves in a murine model of atherosclerosis. Diab Vasc Dis Res. 2019 11; 16(6):562-576. PMID: 31530180.
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    5. Dhulekar J, Simionescu A. Challenges in vascular tissue engineering for diabetic patients. Acta Biomater. 2018 04 01; 70:25-34. PMID: 29396167.
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    6. Chow JP, Simionescu DT, Carter AL, Simionescu A. Immunomodulatory effects of adipose tissue-derived stem cells on elastin scaffold remodeling in diabetes. Tissue Eng Regen Med. 2016 Dec; 13(6):701-712. PMID: 30603451.
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    7. Kennamer A, Sierad L, Pascal R, Rierson N, Albers C, Harpa M, Cotoi O, Harceaga L, Olah P, Terezia P, Simionescu A, Simionescu D. Bioreactor Conditioning of Valve Scaffolds Seeded Internally with Adult Stem Cells. Tissue Eng Regen Med. 2016 Oct; 13(5):507-515. PMID: 30337944.
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    8. Harpa M, Movileanu I, Sierad L, Cotoi O, Suciu H, Preda T, Nistor D, Sircuta C, Brânzaniuc K, Deac R, Gurzu S, Harceaga L, Olah P, Simionescu D, Dandel M, Simionescu A. In Vivo Testing of Xenogeneic Acellular Aortic Valves Seeded with Stem Cells. Rev Rom Med Lab. 2016 Sep; 24(3):343-346. PMID: 31098341.
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    9. Deborde C, Simionescu DT, Wright C, Liao J, Sierad LN, Simionescu A. Stabilized Collagen and Elastin-Based Scaffolds for Mitral Valve Tissue Engineering. Tissue Eng Part A. 2016 11; 22(21-22):1241-1251. PMID: 27608885.
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    10. Chawla V, Simionescu A, Langan EM, LaBerge M. Influence of Clinically Relevant Mechanical Forces on Vascular Smooth Muscle Cells Under Chronic High Glucose: An In Vitro Dynamic Disease Model. Ann Vasc Surg. 2016 Jul; 34:212-26. PMID: 27126714.
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    11. Sierad LN, Shaw EL, Bina A, Brazile B, Rierson N, Patnaik SS, Kennamer A, Odum R, Cotoi O, Terezia P, Branzaniuc K, Smallwood H, Deac R, Egyed I, Pavai Z, Szanto A, Harceaga L, Suciu H, Raicea V, Olah P, Simionescu A, Liao J, Movileanu I, Harpa M, Simionescu DT. Functional Heart Valve Scaffolds Obtained by Complete Decellularization of Porcine Aortic Roots in a Novel Differential Pressure Gradient Perfusion System. Tissue Eng Part C Methods. 2015 Dec; 21(12):1284-96. PMID: 26467108.
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    12. Pennel T, Fercana G, Bezuidenhout D, Simionescu A, Chuang TH, Zilla P, Simionescu D. The performance of cross-linked acellular arterial scaffolds as vascular grafts; pre-clinical testing in direct and isolation loop circulatory models. Biomaterials. 2014 Aug; 35(24):6311-22. PMID: 24816365.
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    13. Schulte JB, Simionescu A, Simionescu DT. The acellular myocardial flap: a novel extracellular matrix scaffold enriched with patent microvascular networks and biocompatible cell niches. Tissue Eng Part C Methods. 2013 Jul; 19(7):518-30. PMID: 23151037.
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    14. Chow JP, Simionescu DT, Warner H, Wang B, Patnaik SS, Liao J, Simionescu A. Mitigation of diabetes-related complications in implanted collagen and elastin scaffolds using matrix-binding polyphenol. Biomaterials. 2013 Jan; 34(3):685-95. PMID: 23103157.
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    15. Simionescu A, Schulte JB, Fercana G, Simionescu DT. Inflammation in cardiovascular tissue engineering: the challenge to a promise: a minireview. Int J Inflam. 2011; 2011:958247. PMID: 21755031.
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    16. Simionescu A, Tedder ME, Chuang TH, Simionescu DT. Lectin and antibody-based histochemical techniques for cardiovascular tissue engineering. J Histotechnol. 2011 Mar; 34(1):20-28. PMID: 25620822.
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    17. Tedder ME, Simionescu A, Chen J, Liao J, Simionescu DT. Assembly and testing of stem cell-seeded layered collagen constructs for heart valve tissue engineering. Tissue Eng Part A. 2011 Jan; 17(1-2):25-36. PMID: 20673028.
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    18. Sierad LN, Simionescu A, Albers C, Chen J, Maivelett J, Tedder ME, Liao J, Simionescu DT. Design and Testing of a Pulsatile Conditioning System for Dynamic Endothelialization of Polyphenol-Stabilized Tissue Engineered Heart Valves. Cardiovasc Eng Technol. 2010 Jun; 1(2):138-153. PMID: 21340043.
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    19. Chuang TH, Stabler C, Simionescu A, Simionescu DT. Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts. Tissue Eng Part A. 2009 Oct; 15(10):2837-51. PMID: 19254115.
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    20. Tedder ME, Liao J, Weed B, Stabler C, Zhang H, Simionescu A, Simionescu DT. Stabilized collagen scaffolds for heart valve tissue engineering. Tissue Eng Part A. 2009 Jun; 15(6):1257-68. PMID: 18928400.
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    21. Simionescu A, Simionescu DT, Vyavahare NR. Osteogenic responses in fibroblasts activated by elastin degradation products and transforming growth factor-beta1: role of myofibroblasts in vascular calcification. Am J Pathol. 2007 Jul; 171(1):116-23. PMID: 17591959.
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    22. Lee JS, Basalyga DM, Simionescu A, Isenburg JC, Simionescu DT, Vyavahare NR. Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses. Am J Pathol. 2006 Feb; 168(2):490-8. PMID: 16436663.
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    23. Simionescu A, Philips K, Vyavahare N. Elastin-derived peptides and TGF-beta1 induce osteogenic responses in smooth muscle cells. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):524-32. PMID: 16005428.
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    24. Lu Q, Simionescu A, Vyavahare N. Novel capillary channel fiber scaffolds for guided tissue engineering. Acta Biomater. 2005 Nov; 1(6):607-14. PMID: 16701841.
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    25. Dobreanu M, Galateanu C, Simionescu A, Deac R. Effects of Atorvastatin on some inflammatory parameters in severe primary hypercholesterolemia. Rom J Intern Med. 2002; 40(1-4):61-73. PMID: 15526541.
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    26. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 24183699.
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