Avtar K. Singh

Title
InstitutionMedical University of South Carolina
DepartmentPathology and Laboratory Medicine
AddressP.O. Box MSC 908
CR513
173 Ashley Ave.
Phone843-577-5011
Fax843-792-7130
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Khan M, Qiao F, Islam SMT, Dhammu TS, Kumar P, Won J, Singh AK, Singh I. GSNOR and ALDH2 alleviate traumatic spinal cord injury. Brain Res. 2021 May 01; 1758:147335. PMID: 33545099.
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    2. Islam SMT, Won J, Kim J, Qiao F, Singh AK, Khan M, Singh I. Detoxification of Reactive Aldehydes by Alda-1 Treatment Ameliorates Experimental Autoimmune Encephalomyelitis in Mice. Neuroscience. 2021 03 15; 458:31-42. PMID: 33493617.
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    3. Khan M, Kumar P, Qiao F, Islam SMT, Singh AK, Won JS, Feng W, Singh I. Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke. Brain Res. 2020 08 15; 1741:146879. PMID: 32418890.
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    4. Choi S, Singh I, Singh AK, Khan M, Won J. Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathology. FASEB J. 2020 05; 34(5):6808-6823. PMID: 32239698.
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    5. Khan M, Dhammu TS, Qiao F, Kumar P, Singh AK, Singh I. S-Nitrosoglutathione Mimics the Beneficial Activity of Endothelial Nitric Oxide Synthase-Derived Nitric Oxide in a Mouse Model of Stroke. J Stroke Cerebrovasc Dis. 2019 Dec; 28(12):104470. PMID: 31680031.
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    6. Feldman D, Singh A, Schmid-Burgk JL, Carlson RJ, Mezger A, Garrity AJ, Zhang F, Blainey PC. Optical Pooled Screens in Human Cells. Cell. 2019 10 17; 179(3):787-799.e17. PMID: 31626775.
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    7. Choi S, Saxena N, Dhammu T, Khan M, Singh AK, Singh I, Won J. Regulation of endothelial barrier integrity by redox-dependent nitric oxide signaling: Implication in traumatic and inflammatory brain injuries. Nitric Oxide. 2019 02 01; 83:51-64. PMID: 30590116.
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    8. Khan M, Dhammu TS, Singh I, Singh AK. Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity. BMC Neurosci. 2018 08 13; 19(1):50. PMID: 30103682.
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    9. Khan M, Shunmugavel A, Dhammu TS, Khan H, Singh I, Singh AK. Combined treatment with GSNO and CAPE accelerates functional recovery via additive antioxidant activities in a mouse model of TBI. J Neurosci Res. 2018 12; 96(12):1900-1913. PMID: 30027580.
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    10. Singh I, Nath N, Saxena N, Singh AK, Won JS. Regulation of IL-10 and IL-17 mediated experimental autoimmune encephalomyelitis by S-nitrosoglutathione. Immunobiology. 2018 10; 223(10):549-554. PMID: 29960806.
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    11. Choi S, Won JS, Carroll SL, Annamalai B, Singh I, Singh AK. Pathology of nNOS-Expressing GABAergic Neurons in Mouse Model of Alzheimer's Disease. Neuroscience. 2018 08 01; 384:41-53. PMID: 29782905.
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    12. Saxena N, Won J, Choi S, Singh AK, Singh I. S-nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis. Free Radic Biol Med. 2018 06; 121:57-68. PMID: 29694854.
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    13. Singh I, Samuvel DJ, Choi S, Saxena N, Singh AK, Won J. Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model. Immunology. 2018 07; 154(3):434-451. PMID: 29331024.
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    14. Khan M, Khan H, Singh I, Singh AK. Hypoxia inducible factor-1 alpha stabilization for regenerative therapy in traumatic brain injury. Neural Regen Res. 2017 May; 12(5):696-701. PMID: 28616019.
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    15. Kim J, Choi S, Saxena N, Singh AK, Singh I, Won JS. Regulation of STAT3 and NF-?B activations by S-nitrosylation in multiple myeloma. Free Radic Biol Med. 2017 05; 106:245-253. PMID: 28232202.
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    16. Won JS, Singh AK, Singh I. Biochemical, cell biological, pathological, and therapeutic aspects of Krabbe's disease. J Neurosci Res. 2016 11; 94(11):990-1006. PMID: 27638584.
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    17. Khan M, Dhammu TS, Baarine M, Kim J, Paintlia MK, Singh I, Singh AK. GSNO promotes functional recovery in experimental TBI by stabilizing HIF-1a. Behav Brain Res. 2018 03 15; 340:63-70. PMID: 27780722.
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    18. Samuvel DJ, Shunmugavel A, Singh AK, Singh I, Khan M. S-Nitrosoglutathione ameliorates acute renal dysfunction in a rat model of lipopolysaccharide-induced sepsis. J Pharm Pharmacol. 2016 Oct; 68(10):1310-9. PMID: 27484743.
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    19. Khan M, Dhammu TS, Dhaindsa TS, Khan H, Singh AK, Singh I. An NO/GSNO-based Neuroregeneration Strategy for Stroke Therapy. J Neurol Neurosci. 2015; 6(4). PMID: 27668143.
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    20. Singh I, Kim J, Singh AK, Sharma AK, Won JS. STAT3 Regulation By S-Nitrosylation: Implication In Cancer. Redox Biol. 2015 08; 5:416-417. PMID: 28162277.
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    21. Baarine M, Khan M, Singh A, Singh I. Functional Characterization of IPSC-Derived Brain Cells as a Model for X-Linked Adrenoleukodystrophy. PLoS One. 2015; 10(11):e0143238. PMID: 26581106.
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    22. Khan M, Dhammu TS, Matsuda F, Annamalai B, Dhindsa TS, Singh I, Singh AK. Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI. Brain Res. 2016 Jan 01; 1630:159-70. PMID: 26596859.
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    23. Samuvel DJ, Saxena N, Dhindsa JS, Singh AK, Gill GS, Grobelny DW, Singh I. AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis. PLoS One. 2015; 10(10):e0141781. PMID: 26513477.
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    24. Won JS, Annamalai B, Choi S, Singh I, Singh AK. S-nitrosoglutathione reduces tau hyper-phosphorylation and provides neuroprotection in rat model of chronic cerebral hypoperfusion. Brain Res. 2015 Oct 22; 1624:359-369. PMID: 26271717.
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    25. Khan M, Dhammu TS, Matsuda F, Singh AK, Singh I. Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy. BMC Neurosci. 2015 Jul 15; 16:42. PMID: 26174015.
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    26. Kaliyaperumal K, Sharma AK, McDonald DG, Dhindsa JS, Yount C, Singh AK, Won JS, Singh I. S-Nitrosoglutathione-mediated STAT3 regulation in efficacy of radiotherapy and cisplatin therapy in head and neck squamous cell carcinoma. Redox Biol. 2015 Dec; 6:41-50. PMID: 26177470.
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    27. Khan M, Shunmugavel A, Dhammu TS, Matsuda F, Singh AK, Singh I. Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats. J Neuroinflammation. 2015 May 15; 12:94. PMID: 25971887.
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    28. Khan M, Dhammu TS, Matsuda F, Baarine M, Dhindsa TS, Singh I, Singh AK. Promoting endothelial function by S-nitrosoglutathione through the HIF-1a/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats. Drug Des Devel Ther. 2015; 9:2233-47. PMID: 25945035.
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    29. Annamalai B, Won JS, Choi S, Singh I, Singh AK. Role of S-nitrosoglutathione mediated mechanisms in tau hyper-phosphorylation. Biochem Biophys Res Commun. 2015 Feb 27; 458(1):214-9. PMID: 25640839.
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    30. Baarine M, Beeson C, Singh A, Singh I. ABCD1 deletion-induced mitochondrial dysfunction is corrected by SAHA: implication for adrenoleukodystrophy. J Neurochem. 2015 May; 133(3):380-96. PMID: 25393703.
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    31. Paintlia MK, Singh I, Singh AK. Effect of vitamin D3 intake on the onset of disease in a murine model of human Krabbe disease. J Neurosci Res. 2015 Jan; 93(1):28-42. PMID: 25236689.
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    32. Shunmugavel A, Khan M, Hughes FM, Purves JT, Singh A, Singh I. S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling. Neurourol Urodyn. 2015 Aug; 34(6):519-26. PMID: 24853799.
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    33. Kim J, Won JS, Singh AK, Sharma AK, Singh I. STAT3 regulation by S-nitrosylation: implication for inflammatory disease. Antioxid Redox Signal. 2014 Jun 01; 20(16):2514-27. PMID: 24063605.
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    34. Contreras MA, Alzate O, Singh AK, Singh I. PPARa activation induces N(e)-Lys-acetylation of rat liver peroxisomal multifunctional enzyme type 1. Lipids. 2014 Feb; 49(2):119-31. PMID: 24092543.
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    35. Paintlia AS, Paintlia MK, Singh AK, Singh I. Modulation of Rho-Rock signaling pathway protects oligodendrocytes against cytokine toxicity via PPAR-a-dependent mechanism. Glia. 2013 Sep; 61(9):1500-1517. PMID: 23839981.
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    36. Paintlia AS, Paintlia MK, Mohan S, Singh AK, Singh I. AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model. Am J Pathol. 2013 Aug; 183(2):526-41. PMID: 23759513.
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    37. Won JS, Kim J, Paintlia MK, Singh I, Singh AK. Role of endogenous psychosine accumulation in oligodendrocyte differentiation and survival: implication for Krabbe disease. Brain Res. 2013 May 01; 1508:44-52. PMID: 23438514.
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    38. Won JS, Kim J, Annamalai B, Shunmugavel A, Singh I, Singh AK. Protective role of S-nitrosoglutathione (GSNO) against cognitive impairment in rat model of chronic cerebral hypoperfusion. J Alzheimers Dis. 2013; 34(3):621-35. PMID: 23254638.
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    39. Paintlia MK, Paintlia AS, Singh AK, Singh I. S-nitrosoglutathione induces ciliary neurotrophic factor expression in astrocytes, which has implications to protect the central nervous system under pathological conditions. J Biol Chem. 2013 Feb 08; 288(6):3831-43. PMID: 23264628.
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    40. Khan M, Dhammu TS, Sakakima H, Shunmugavel A, Gilg AG, Singh AK, Singh I. The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke. J Neurochem. 2012 Nov; 123 Suppl 2:86-97. PMID: 23050646.
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    41. Paintlia AS, Paintlia MK, Hollis BW, Singh AK, Singh I. Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. Am J Pathol. 2012 Sep; 181(3):993-1006. PMID: 22796435.
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    42. Sakakima H, Khan M, Dhammu TS, Shunmugavel A, Yoshida Y, Singh I, Singh AK. Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion. Restor Neurol Neurosci. 2012; 30(5):383-96. PMID: 22717646.
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    43. Khan M, Sakakima H, Dhammu TS, Shunmugavel A, Im YB, Gilg AG, Singh AK, Singh I. S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats. J Neuroinflammation. 2011 Jul 06; 8:78. PMID: 21733162.
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    44. Paintlia MK, Paintlia AS, Singh AK, Singh I. Synergistic activity of interleukin-17 and tumor necrosis factor-a enhances oxidative stress-mediated oligodendrocyte apoptosis. J Neurochem. 2011 Feb; 116(4):508-21. PMID: 21143599.
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    45. Paintlia AS, Paintlia MK, Singh AK, Orak JK, Singh I. Activation of PPAR-? and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. Glia. 2010 Nov 01; 58(14):1669-85. PMID: 20578043.
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    46. Won JS, Im YB, Kim J, Singh AK, Singh I. Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis. Biochem Biophys Res Commun. 2010 Sep 03; 399(4):487-91. PMID: 20659426.
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    47. Contreras MA, Ries WL, Shanmugarajan S, Arboleda G, Singh I, Singh AK. Factors that affect postnatal bone growth retardation in the twitcher murine model of Krabbe disease. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):601-8. PMID: 20441793.
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    48. Khan M, Im YB, Shunmugavel A, Gilg AG, Dhindsa RK, Singh AK, Singh I. Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact. J Neuroinflammation. 2009 Nov 04; 6:32. PMID: 19889224.
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    49. Hoda MN, Singh I, Singh AK, Khan M. Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat. J Neuroinflammation. 2009 Aug 13; 6:21. PMID: 19678934.
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    50. Singh I, Singh AK, Contreras MA. Peroxisomal dysfunction in inflammatory childhood white matter disorders: an unexpected contributor to neuropathology. J Child Neurol. 2009 Sep; 24(9):1147-57. PMID: 19605772.
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    51. Paintlia AS, Paintlia MK, Singh I, Skoff RB, Singh AK. Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis. Glia. 2009 Jan 15; 57(2):182-93. PMID: 18720408.
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    52. Paintlia MK, Paintlia AS, Singh AK, Singh I. Attenuation of lipopolysaccharide-induced inflammatory response and phospholipids metabolism at the feto-maternal interface by N-acetyl cysteine. Pediatr Res. 2008 Oct; 64(4):334-9. PMID: 18552708.
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    53. Prasad R, Giri S, Singh AK, Singh I. 15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases. J Inflamm (Lond). 2008 Aug 08; 5:14. PMID: 18691416.
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    54. Paintlia AS, Paintlia MK, Singh I, Singh AK. Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis. Exp Neurol. 2008 Dec; 214(2):168-80. PMID: 18775426.
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    55. Contreras MA, Haq E, Uto T, Singh I, Singh AK. Psychosine-induced alterations in peroxisomes of twitcher mouse liver. Arch Biochem Biophys. 2008 Sep 15; 477(2):211-8. PMID: 18602885.
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    56. Lee JK, Won JS, Singh AK, Singh I. Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death. Neurosci Lett. 2008 Aug 08; 440(3):260-4. PMID: 18583044.
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    57. Markovic-Plese S, Singh AK, Singh I. Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair. Future Neurol. 2008 Mar 01; 3(2):153. PMID: 20107624.
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    58. Won JS, Im YB, Khan M, Contreras M, Singh AK, Singh I. Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts. J Neurochem. 2008 May; 105(4):1536-49. PMID: 18266936.
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    59. Giri S, Khan M, Nath N, Singh I, Singh AK. The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe disease. J Neurochem. 2008 Jun; 105(5):1820-33. PMID: 18248608.
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    60. Paintlia AS, Paintlia MK, Singh AK, Singh I. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol Pharmacol. 2008 May; 73(5):1381-93. PMID: 18239032.
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    61. Paintlia MK, Paintlia AS, Khan M, Singh I, Singh AK. Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures. J Neurochem. 2008 May; 105(3):956-70. PMID: 18205750.
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    62. Paintlia MK, Paintlia AS, Contreras MA, Singh I, Singh AK. Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine. Exp Neurol. 2008 Apr; 210(2):560-76. PMID: 18291369.
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    63. Won JS, Singh AK, Singh I. Lactosylceramide: a lipid second messenger in neuroinflammatory disease. J Neurochem. 2007 Nov; 103 Suppl 1:180-91. PMID: 17986153.
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    64. Khan M, Elango C, Ansari MA, Singh I, Singh AK. Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem. 2007 Jul; 102(2):365-77. PMID: 17437550.
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    65. Pannu R, Christie DK, Barbosa E, Singh I, Singh AK. Post-trauma Lipitor treatment prevents endothelial dysfunction, facilitates neuroprotection, and promotes locomotor recovery following spinal cord injury. J Neurochem. 2007 Apr; 101(1):182-200. PMID: 17217414.
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    66. Prasad R, Giri S, Nath N, Singh I, Singh AK. GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions. Glia. 2007 Jan 01; 55(1):65-77. PMID: 17019693.
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    67. Paintlia AS, Paintlia MK, Singh I, Singh AK. Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis. Am J Pathol. 2006 Sep; 169(3):1012-25. PMID: 16936274.
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    68. Prasad R, Giri S, Nath N, Singh I, Singh AK. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. J Neurosci Res. 2006 Aug 15; 84(3):614-25. PMID: 16770773.
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    69. Giri S, Rattan R, Haq E, Khan M, Yasmin R, Won JS, Key L, Singh AK, Singh I. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr Metab (Lond). 2006 Aug 10; 3:31. PMID: 16901342.
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    70. Nath N, Prasad R, Giri S, Singh AK, Singh I. T-bet is essential for the progression of experimental autoimmune encephalomyelitis. Immunology. 2006 Jul; 118(3):384-91. PMID: 16827899.
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    71. Jatana M, Giri S, Ansari MA, Elango C, Singh AK, Singh I, Khan M. Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. J Neuroinflammation. 2006 May 11; 3:12. PMID: 16689995.
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    72. Jatana M, Singh I, Singh AK, Jenkins D. Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res. 2006 May; 59(5):684-9. PMID: 16627882.
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    73. Paintlia AS, Paintlia MK, Singh I, Singh AK. IL-4-induced peroxisome proliferator-activated receptor gamma activation inhibits NF-kappaB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication for CNS-demyelinating diseases. J Immunol. 2006 Apr 01; 176(7):4385-98. PMID: 16547277.
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    74. Khan M, Jatana M, Elango C, Paintlia AS, Singh AK, Singh I. Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke. Nitric Oxide. 2006 Sep; 15(2):114-24. PMID: 16524750.
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    75. Haq E, Contreras MA, Giri S, Singh I, Singh AK. Dysfunction of peroxisomes in twitcher mice brain: a possible mechanism of psychosine-induced disease. Biochem Biophys Res Commun. 2006 Apr 28; 343(1):229-38. PMID: 16530726.
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    76. Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem. 2005 Nov 25; 280(47):39582-93. PMID: 16176927.
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    77. Ayasolla KR, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Abeta peptide-induced inflammatory mediators in astroglia. J Neuroinflammation. 2005 Sep 20; 2:21. PMID: 16174294.
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    78. Chang EY, Barbosa E, Paintlia MK, Singh A, Singh I. The use of N-acetylcysteine for the prevention of hypertension in the reduced uterine perfusion pressure model for preeclampsia in Sprague-Dawley rats. Am J Obstet Gynecol. 2005 Sep; 193(3 Pt 2):952-6. PMID: 16157093.
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    79. Paintlia AS, Paintlia MK, Khan M, Vollmer T, Singh AK, Singh I. HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis. FASEB J. 2005 Sep; 19(11):1407-21. PMID: 16126908.
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    80. Won JS, Im YB, Khan M, Singh AK, Singh I. Involvement of phospholipase A2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells. Glia. 2005 Jul; 51(1):13-21. PMID: 15779087.
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    81. Prasad R, Giri S, Nath N, Singh I, Singh AK. Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction. J Neurochem. 2005 Jul; 94(1):204-14. PMID: 15953363.
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    82. Nath N, Giri S, Prasad R, Salem ML, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis. J Immunol. 2005 Jul 01; 175(1):566-74. PMID: 15972693.
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    83. Khan M, Haq E, Giri S, Singh I, Singh AK. Peroxisomal participation in psychosine-mediated toxicity: implications for Krabbe's disease. J Neurosci Res. 2005 Jun 15; 80(6):845-54. PMID: 15898099.
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    84. Stanislaus R, Gilg AG, Singh AK, Singh I. N-acetyl-L-cysteine ameliorates the inflammatory disease process in experimental autoimmune encephalomyelitis in Lewis rats. J Autoimmune Dis. 2005 May 03; 2(1):4. PMID: 15869713.
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    85. Pannu R, Barbosa E, Singh AK, Singh I. Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats. J Neurosci Res. 2005 Feb 01; 79(3):340-50. PMID: 15605375.
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    86. Khan M, Sekhon B, Giri S, Jatana M, Gilg AG, Ayasolla K, Elango C, Singh AK, Singh I. S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke. J Cereb Blood Flow Metab. 2005 Feb; 25(2):177-92. PMID: 15647746.
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    87. Pannu R, Singh AK, Singh I. A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma. J Biol Chem. 2005 Apr 08; 280(14):13742-51. PMID: 15668227.
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    88. Lee JK, Won JS, Singh AK, Singh I. Adenosine kinase inhibitor attenuates the expression of inducible nitric oxide synthase in glial cells. Neuropharmacology. 2005 Jan; 48(1):151-60. PMID: 15617735.
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    89. Won JS, Im YB, Singh AK, Singh I. Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability. Free Radic Biol Med. 2004 Dec 01; 37(11):1834-44. PMID: 15528042.
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    90. Paintlia MK, Paintlia AS, Barbosa E, Singh I, Singh AK. N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain. J Neurosci Res. 2004 Nov 01; 78(3):347-61. PMID: 15389835.
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    91. Giri S, Rattan R, Singh AK, Singh I. The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. J Immunol. 2004 Oct 15; 173(8):5196-208. PMID: 15470065.
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    92. Singh I, Paintlia AS, Khan M, Stanislaus R, Paintlia MK, Haq E, Singh AK, Contreras MA. Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment. Brain Res. 2004 Oct 01; 1022(1-2):1-11. PMID: 15353207.
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    93. Lin A, Sekhon C, Sekhon B, Smith A, Chavin K, Orak J, Singh I, Singh A. Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation. Transplantation. 2004 Sep 15; 78(5):654-9. PMID: 15371664.
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    94. Ayasolla K, Khan M, Singh AK, Singh I. Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic Biol Med. 2004 Aug 01; 37(3):325-38. PMID: 15223066.
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    95. Paintlia AS, Paintlia MK, Singh AK, Stanislaus R, Gilg AG, Barbosa E, Singh I. Regulation of gene expression associated with acute experimental autoimmune encephalomyelitis by Lovastatin. J Neurosci Res. 2004 Jul 01; 77(1):63-81. PMID: 15197739.
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    96. Pannu R, Won JS, Khan M, Singh AK, Singh I. A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases. J Neurosci. 2004 Jun 30; 24(26):5942-54. PMID: 15229242.
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    97. Khan M, Sekhon B, Jatana M, Giri S, Gilg AG, Sekhon C, Singh I, Singh AK. Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci Res. 2004 May 15; 76(4):519-27. PMID: 15114624.
      Citations:    
    98. Won JS, Im YB, Khan M, Singh AK, Singh I. The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase. J Neurochem. 2004 Feb; 88(3):583-93. PMID: 14720208.
      Citations:    
    99. Nath N, Giri S, Prasad R, Singh AK, Singh I. Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy. J Immunol. 2004 Jan 15; 172(2):1273-86. PMID: 14707106.
      Citations:    
    100. Giri S, Nath N, Smith B, Viollet B, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci. 2004 Jan 14; 24(2):479-87. PMID: 14724246.
      Citations:    
    101. Paintlia AS, Gilg AG, Khan M, Singh AK, Barbosa E, Singh I. Correlation of very long chain fatty acid accumulation and inflammatory disease progression in childhood X-ALD: implications for potential therapies. Neurobiol Dis. 2003 Dec; 14(3):425-39. PMID: 14678759.
      Citations:    
    102. Rattan R, Giri S, Singh AK, Singh I. Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha. Free Radic Biol Med. 2003 Nov 01; 35(9):1037-50. PMID: 14572607.
      Citations:    
    103. Haq E, Giri S, Singh I, Singh AK. Molecular mechanism of psychosine-induced cell death in human oligodendrocyte cell line. J Neurochem. 2003 Sep; 86(6):1428-40. PMID: 12950451.
      Citations:    
    104. Won JS, Im YB, Key L, Singh I, Singh AK. The involvement of glucose metabolism in the regulation of inducible nitric oxide synthase gene expression in glial cells: possible role of glucose-6-phosphate dehydrogenase and CCAAT/enhancing binding protein. J Neurosci. 2003 Aug 20; 23(20):7470-8. PMID: 12930785.
      Citations:    
    105. Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I, Singh AK. N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia. Brain Res. 2003 May 02; 971(1):1-8. PMID: 12691831.
      Citations:    
    106. Sekhon CS, Sekhon BK, Singh I, Orak JK, Singh AK. Attenuation of renal ischemia/reperfusion injury by a triple drug combination therapy. J Nephrol. 2003 Jan-Feb; 16(1):63-74. PMID: 12649537.
      Citations:    
    107. Stanislaus R, Gilg AG, Singh AK, Singh I. Immunomodulation of experimental autoimmune encephalomyelitis in the Lewis rats by Lovastatin. Neurosci Lett. 2002 Nov 29; 333(3):167-70. PMID: 12429374.
      Citations:    
    108. Dobashi K, Singh I, Orak JK, Asayama K, Singh AK. Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney. Mol Cell Biochem. 2002 Nov; 240(1-2):9-17. PMID: 12487367.
      Citations:    
    109. Jatana M, Giri S, Singh AK. Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine. Neurosci Lett. 2002 Sep 20; 330(2):183-7. PMID: 12231442.
      Citations:    
    110. Giri S, Jatana M, Rattan R, Won JS, Singh I, Singh AK. Galactosylsphingosine (psychosine)-induced expression of cytokine-mediated inducible nitric oxide synthases via AP-1 and C/EBP: implications for Krabbe disease. FASEB J. 2002 May; 16(7):661-72. PMID: 11978730.
      Citations:    
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