Kenneth A Christensen

TitleAssociate Professor
InstitutionClemson University
DepartmentDepartment of Chemistry
Address223 Hunter Hall
Clemson, South Carolina 29634
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Valdoz JC, Franks NA, Cribbs CG, Jacobs DJ, Dodson EL, Knight CJ, Poulson PD, Garfield SR, Johnson BC, Hemeyer BM, Sudo MT, Saunooke JA, Kartchner BC, Saxton A, Vallecillo-Zuniga ML, Santos M, Chamberlain B, Christensen KA, Nordin GP, Narayanan AS, Raghu G, Van Ry PM. Soluble ECM promotes organotypic formation in lung alveolar model. Biomaterials. 2022 04; 283:121464. PMID: 35306229.
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    2. Cryan LM, Tsang TM, Stiles J, Bazinet L, Lee SL, Garrard S, Madrian E, Roberts C, Payne J, Jensen A, Frankel AE, Ackroyd PC, Christensen KA, Rogers MS. Capillary morphogenesis gene 2 (CMG2) mediates growth factor-induced angiogenesis by regulating endothelial cell chemotaxis. Angiogenesis. 2022 08; 25(3):397-410. PMID: 35212873.
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    3. Sanchez Noriega JL, Chartrand NA, Valdoz JC, Cribbs CG, Jacobs DA, Poulson D, Viglione MS, Woolley AT, Van Ry PM, Christensen KA, Nordin GP. Spatially and optically tailored 3D printing for highly miniaturized and integrated microfluidics. Nat Commun. 2021 09 17; 12(1):5509. PMID: 34535656.
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    4. Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Müschen M, Forostyan TV, Free S, Mercenne G, Banks CJ, Valdoz J, Whatcott CJ, Foulks JM, Bearss DJ, O'Hare T, Huang DCS, Christensen KA, Moody J, Warner SL, Tyner JW, Andersen JL. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 09 09; 12(1):5337. PMID: 34504101.
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    5. Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. Adaptive immunity induces mutualism between commensal eukaryotes. Nature. 2021 08; 596(7870):114-118. PMID: 34262174.
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    6. Johnson DK, Magoffin W, Myers SJ, Finnell JG, Hancock JC, Orton TS, Persaud SP, Christensen KA, Weber KS. CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs. Front Immunol. 2020; 11:561889. PMID: 33542711.
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    7. Warr C, Valdoz JC, Bickham BP, Knight CJ, Franks NA, Chartrand N, Van Ry PM, Christensen KA, Nordin GP, Cook AD. Biocompatible PEGDA Resin for 3D Printing. ACS Appl Bio Mater. 2020 Apr 20; 3(4):2239-2244. PMID: 32467881.
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    8. Finnell JG, Tsang TM, Cryan L, Garrard S, Lee SL, Ackroyd PC, Rogers MS, Christensen KA. A Canstatin-Derived Peptide Provides Insight into the Role of Capillary Morphogenesis Gene 2 in Angiogenic Regulation and Matrix Uptake. ACS Chem Biol. 2020 02 21; 15(2):587-596. PMID: 32003961.
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    9. G-Doyagüez E, Carrero P, Madrona A, Rodriguez-Salamanca P, Martínez-Gualda B, Camarasa MJ, Jimeno ML, Bennallack PR, Finnell JG, Tsang TM, Christensen KA, San-Félix A, Rogers MS. Galloyl Carbohydrates with Antiangiogenic Activity Mediated by Capillary Morphogenesis Gene 2 (CMG2) Protein Binding. J Med Chem. 2019 04 25; 62(8):3958-3970. PMID: 30964669.
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    10. Ortega-Villarreal AS, Hernández-Fernández E, Jensen C, Valdivia-Berroeta GA, Garrard S, López I, Smith SJ, Christensen KA, Reyes-González MA, Michaelis DJ. Synthesis and characterization of ethyl benzotriazolyl acrylate-based D-p-A fluorophores for live cell-based imaging applications. RSC Adv. 2019 Mar 15; 9(16):8759-8767. PMID: 35517661.
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    11. Voyton CM, Choi J, Qiu Y, Morris MT, Ackroyd PC, Morris JC, Christensen KA. A Microfluidic-Based Microscopy Platform for Continuous Interrogation of Trypanosoma brucei during Environmental Perturbation. Biochemistry. 2019 02 19; 58(7):875-882. PMID: 30638014.
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    12. Voyton CM, Qiu Y, Morris MT, Ackroyd PC, Suryadi J, Crowe L, Morris JC, Christensen KA. A FRET flow cytometry method for monitoring cytosolic and glycosomal glucose in living kinetoplastid parasites. PLoS Negl Trop Dis. 2018 05; 12(5):e0006523. PMID: 29851949.
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    13. Voyton CM, Morris MT, Ackroyd PC, Morris JC, Christensen KA. FRET Flow Cytometry-Based High Throughput Screening Assay To Identify Disrupters of Glucose Levels in Trypanosoma brucei. ACS Infect Dis. 2018 07 13; 4(7):1058-1066. PMID: 29741365.
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    14. Gordhan HM, Milanes JE, Qiu Y, Golden JE, Christensen KA, Morris JC, Whitehead DC. A targeted delivery strategy for the development of potent trypanocides. Chem Commun (Camb). 2017 Aug 11; 53(62):8735-8738. PMID: 28726862.
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    15. Jia Z, Ackroyd C, Han T, Agrawal V, Liu Y, Christensen K, Dominy B. Effects from metal ion in tumor endothelial marker 8 and anthrax protective antigen: BioLayer Interferometry experiment and molecular dynamics simulation study. J Comput Chem. 2017 06 05; 38(15):1183-1190. PMID: 28437008.
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    16. Lin S, Voyton C, Morris MT, Ackroyd PC, Morris JC, Christensen KA. pH regulation in glycosomes of procyclic form Trypanosoma brucei. J Biol Chem. 2017 05 12; 292(19):7795-7805. PMID: 28348078.
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    17. Schadock-Hewitt AJ, Pittman JJ, Christensen KA, Marcus RK. Head group-functionalized poly(ethyleneglycol)-lipid (PEG-lipid) surface modification for highly selective analyte extractions on capillary-channeled polymer (C-CP) fibers. Analyst. 2014 May 07; 139(9):2108-13. PMID: 24503581.
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    18. Dukes KD, Christensen KA, Chumanov G. Core-shell silver nanoparticles for optical labeling of cells. Anal Biochem. 2014 Aug 01; 458:43-8. PMID: 24755004.
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    19. Lin S, Morris MT, Ackroyd PC, Morris JC, Christensen KA. Peptide-targeted delivery of a pH sensor for quantitative measurements of intraglycosomal pH in live Trypanosoma brucei. Biochemistry. 2013 May 28; 52(21):3629-37. PMID: 23651061.
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    20. Cryan LM, Habeshian KA, Caldwell TP, Morris MT, Ackroyd PC, Christensen KA, Rogers MS. Identification of small molecules that inhibit the interaction of TEM8 with anthrax protective antigen using a FRET assay. J Biomol Screen. 2013 Jul; 18(6):714-25. PMID: 23479355.
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    21. Cryan LM, Bazinet L, Habeshian KA, Cao S, Clardy J, Christensen KA, Rogers MS. 1,2,3,4,6-Penta-O-galloyl-ß-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2. J Med Chem. 2013 Mar 14; 56(5):1940-5. PMID: 23394144.
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    22. Fernando LP, Kandel PK, Ackroyd PC, Christensen KA. The relative brightness of PEG lipid-conjugated polymer nanoparticles as fluid-phase markers in live cells. Anal Bioanal Chem. 2012 Dec; 404(10):3003-14. PMID: 23052882.
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    23. Wang F, Widejko RG, Yang Z, Nguyen KT, Chen H, Fernando LP, Christensen KA, Anker JN. Surface-enhanced raman scattering detection of pH with silica-encapsulated 4-mercaptobenzoic acid-functionalized silver nanoparticles. Anal Chem. 2012 Sep 18; 84(18):8013-9. PMID: 22881392.
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    24. Rogers MS, Cryan LM, Habeshian KA, Bazinet L, Caldwell TP, Ackroyd PC, Christensen KA. A FRET-based high throughput screening assay to identify inhibitors of anthrax protective antigen binding to capillary morphogenesis gene 2 protein. PLoS One. 2012; 7(6):e39911. PMID: 22768167.
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    25. Chaurra A, Gutzman BM, Taylor E, Ackroyd PC, Christensen KA. Lucifer Yellow as a live cell fluorescent probe for imaging water transport in subcellular organelles. Appl Spectrosc. 2011 Jan; 65(1):20-5. PMID: 21211149.
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    26. Kandel PK, Fernando LP, Ackroyd PC, Christensen KA. Incorporating functionalized polyethylene glycol lipids into reprecipitated conjugated polymer nanoparticles for bioconjugation and targeted labeling of cells. Nanoscale. 2011 Mar; 3(3):1037-45. PMID: 21152603.
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    27. Dodson HC, Lyda TA, Chambers JW, Morris MT, Christensen KA, Morris JC. Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1. Exp Parasitol. 2011 Feb; 127(2):423-8. PMID: 20971104.
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    28. Fernando LP, Kandel PK, Yu J, McNeill J, Ackroyd PC, Christensen KA. Mechanism of cellular uptake of highly fluorescent conjugated polymer nanoparticles. Biomacromolecules. 2010 Oct 11; 11(10):2675-82. PMID: 20863132.
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    29. Bhut BV, Christensen KA, Husson SM. Membrane chromatography: protein purification from E. coli lysate using newly designed and commercial anion-exchange stationary phases. J Chromatogr A. 2010 Jul 23; 1217(30):4946-57. PMID: 20554285.
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    30. Luo PG, Wang H, Gu L, Lu F, Lin Y, Christensen KA, Yang ST, Sun YP. Selective interactions of sugar-functionalized single-walled carbon nanotubes with Bacillus spores. ACS Nano. 2009 Dec 22; 3(12):3909-16. PMID: 19911831.
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    31. Wu C, Bull B, Christensen K, McNeill J. Ratiometric single-nanoparticle oxygen sensors for biological imaging. Angew Chem Int Ed Engl. 2009; 48(15):2741-5. PMID: 19253320.
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    32. Wu C, Bull B, Szymanski C, Christensen K, McNeill J. Multicolor conjugated polymer dots for biological fluorescence imaging. ACS Nano. 2008 Nov 25; 2(11):2415-23. PMID: 19206410.
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    33. Rogers MS, Christensen KA, Birsner AE, Short SM, Wigelsworth DJ, Collier RJ, D'Amato RJ. Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth. Cancer Res. 2007 Oct 15; 67(20):9980-5. PMID: 17942931.
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    34. Evanoff DD, Heckel J, Caldwell TP, Christensen KA, Chumanov G. Monitoring DPA release from a single germinating Bacillus subtilis endospore via surface-enhanced Raman scattering microscopy. J Am Chem Soc. 2006 Oct 04; 128(39):12618-9. PMID: 17002334.
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    35. Shaughnessy LM, Hoppe AD, Christensen KA, Swanson JA. Membrane perforations inhibit lysosome fusion by altering pH and calcium in Listeria monocytogenes vacuoles. Cell Microbiol. 2006 May; 8(5):781-92. PMID: 16611227.
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    36. Daniels JK, Caldwell TP, Christensen KA, Chumanov G. Monitoring the kinetics of Bacillus subtilis endospore germination via surface-enhanced Raman scattering spectroscopy. Anal Chem. 2006 Mar 01; 78(5):1724-9. PMID: 16503629.
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    37. Christensen KA, Krantz BA, Collier RJ. Assembly and disassembly kinetics of anthrax toxin complexes. Biochemistry. 2006 Feb 21; 45(7):2380-6. PMID: 16475827.
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    38. Qa'dan M, Christensen KA, Zhang L, Roberts TM, Collier RJ. Membrane insertion by anthrax protective antigen in cultured cells. Mol Cell Biol. 2005 Jul; 25(13):5492-8. PMID: 15964805.
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    39. Christensen KA, Krantz BA, Melnyk RA, Collier RJ. Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics. Biochemistry. 2005 Jan 25; 44(3):1047-53. PMID: 15654761.
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    40. Krantz BA, Trivedi AD, Cunningham K, Christensen KA, Collier RJ. Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin. J Mol Biol. 2004 Nov 26; 344(3):739-56. PMID: 15533442.
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    41. Pimental RA, Christensen KA, Krantz BA, Collier RJ. Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):258-62. PMID: 15313199.
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    42. Wigelsworth DJ, Krantz BA, Christensen KA, Lacy DB, Juris SJ, Collier RJ. Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. J Biol Chem. 2004 May 28; 279(22):23349-56. PMID: 15044490.
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    43. Christensen KA, Myers JT, Swanson JA. pH-dependent regulation of lysosomal calcium in macrophages. J Cell Sci. 2002 Feb 01; 115(Pt 3):599-607. PMID: 11861766.
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    44. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 12496132.
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