Michelle P. Hudspeth

TitleDirector, Division of Pediatric Hematology/Oncology
InstitutionMedical University of South Carolina
DepartmentPediatric Hematology/Oncology
AddressP.O. Box MSC 561
RN 520F
Roper Medical Office Bldg - 125 Doughty St., Charl
Phone843-792-2957
Fax843-792-8912
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    Whether it’s on the floors of the hospital or Congress, Michelle Hudspeth, M.D., shows her passion for children.

    Voted as one of the 2013 Best Doctors, Hudspeth fights to find and get funding for the best possible treatments for children. Immune reconstitution after bone marrow transplant is one of her specialty areas. On average it takes a patient about six months to a year to have a normal immune system after transplant and the subsequent revaccination. In her research, Hudspeth looks for clues to determine the best timing for vaccination after transplant. Based on the quality of that research, Hudspeth was invited to speak at the 2013 American Society of Pediatric Hematology/Oncology combined with the Pediatric Blood and Marrow Transplant Consortium about revaccination strategies after allogeneic hematopoietic stem cell transplant.

    Hudspeth earned her medical degree from MUSC in 1999, completing her residency at Johns Hopkins Hospital, followed by a fellowship there in conjunction with the National Cancer Institute. Hudspeth was recruited back to her home state and MUSC in 2007 to lead the stem cell transplant program, the only one of its kind in the state. In just one year the number of pediatric transplants increased by 125 percent, with children not having to leave their home state to receive the best care, an important cause for her.

    Research shows that socioeconomic status is the biggest determinant of survival after transplant. Looking at the children of South Carolina based on zip code and income, MUSC takes care of children who are in the lowest quartile, which should predict a lower survival rate. But that’s not what’s happening in the Palmetto state. The outcomes are actually just as good as or better than national standards despite all these adverse factors.

    “I want people to know that our program here at MUSC is committed to delivering the best possible care for our children and so our unofficial slogan is: Make it happen. Give us the worst of odds and our goal is to turn that around.”

    Hudspeth, who testified about the drug shortage crisis at the Subcommittee on Health Care, District of Columbia, Census, and the National Archives November 2011 hearing, makes time for legislative advocacy work despite her busy schedule. Hudspeth provides blood or marrow transplants to approximately 30 patients a year, with her team treating patients from almost every county in the state.

    “Our goal everyday is to defy the odds. We are typically dealing with children who are in the worst of worst situations and who are facing a massive amount of obstacles. Our job every day is to get past that and make the impossible possible. There is nothing more gratifying than seeing kids walk through the door who never should’ve made it. And, that’s why our team is here. That’s what we focus on.”
    Collapse keywords
    Cancer/Leukemia, Children-s Health, Pediatrics, Cancer/Lymphoma, Cancer/Other, Drug Studies, Men-s Health, Pulmonary, Transplant, Adolescents, Cancer, Immune System, Infant, Women-s Health

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Diorio C, Vatsayan A, Talleur AC, Annesley C, Jaroscak JJ, Shalabi H, Ombrello AK, Hudspeth M, Maude SL, Gardner RA, Shah NN. Anakinra utilization in refractory pediatric CAR T-cell associated toxicities. Blood Adv. 2022 06 14; 6(11):3398-3403. PMID: 35395068.
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    2. McCoy NC, Hay EL, Romeo DA, Doty JW, Wolf BJ, Hudspeth MP. Decreased Opioid Consumption in Bone Marrow Harvest Patients Using Quadratus Lumborum Blocks in a Standardized Protocol. Front Med (Lausanne). 2022; 9:862309. PMID: 35559351.
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    3. Bhatt ND, Heh JL, Hudspeth MP, Williams KW, Twombley KE. Teriparatide Therapy in a 4-Month-Old With Severe Hypoparathyroidism. J Pediatr Pharmacol Ther. 2022; 27(1):80-84. PMID: 35002563.
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    4. Picca A, Wahlquist AE, Hudspeth M. Incorporating Absolute Phagocyte Count With Absolute Neutrophil Count as a Measure for Safe Discharge for Pediatric Oncology Febrile Neutropenia: A Pilot Study. J Pediatr Hematol Oncol. 2021 10 01; 43(7):e1000-e1002. PMID: 33065712.
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    5. Sharma A, Huang S, Li Y, Brooke RJ, Ahmed I, Allewelt HB, Amrolia P, Bertaina A, Bhatt NS, Bierings MB, Bies J, Brisset C, Brondon JE, Dahlberg A, Dalle JH, Eissa H, Fahd M, Gassas A, Gloude NJ, Goebel WS, Goeckerman ES, Harris K, Ho R, Hudspeth MP, Huo JS, Jacobsohn D, Kasow KA, Katsanis E, Kaviany S, Keating AK, Kernan NA, Ktena YP, Lauhan CR, López-Hernandez G, Martin PL, Myers KC, Naik S, Olaya-Vargas A, Onishi T, Radhi M, Ramachandran S, Ramos K, Rangarajan HG, Roehrs PA, Sampson ME, Shaw PJ, Skiles JL, Somers K, Symons HJ, de Tersant M, Uber AN, Versluys B, Cheng C, Triplett BM. Outcomes of pediatric patients with therapy-related myeloid neoplasms. Bone Marrow Transplant. 2021 12; 56(12):2997-3007. PMID: 34480120.
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    6. Traube C, Gerber LM, Mauer EA, Small K, Broglie L, Chopra YR, Duncan CN, Ebens CL, Fitzgerald JC, Freedman JL, Hudspeth MP, Hurley C, Mahadeo KM, McArthur J, Shapiro MC, Sharron MP, Wall DA, Zinter MS, Greenwald BM, Silver G, Boulad F. Delirium in Children Undergoing Hematopoietic Cell Transplantation: A Multi-Institutional Point Prevalence Study. Front Oncol. 2021; 11:627726. PMID: 33968727.
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    7. Snyder AN, Wine Lee L, Jaroscak JJ, Donahoo LB, Hudspeth M. Outcomes Using Narrowband UVB Phototherapy for Acute Cutaneous Graft Versus Host Disease in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients. J Pediatr Hematol Oncol. 2021 01; 43(1):e151-e153. PMID: 33315852.
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    8. Stone JM, Savage A, Hudspeth M, Twombley K, Kasi N, Quiros JA, Arbizu RA, Curry S. Multi-organism gastrointestinal polymerase chain reaction positivity among pediatric transplant vs non-transplant populations: A single-center experience. Pediatr Transplant. 2020 09; 24(6):e13771. PMID: 32639105.
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    9. Fabrizio V, Wahlquist A, Hill E, Williams E, Kramer C, Jaroscak J, Duong A, Garrett-Mayer E, Hudspeth M. The effect of bone marrow graft composition on pediatric bone marrow transplantation outcomes. Pediatr Transplant. 2018 12; 22(8):e13287. PMID: 30159974.
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    10. Om A, Cathey SS, Gathings RM, Hudspeth M, Lee JA, Marzolf S, Wine Lee L. Phacomatosis Pigmentokeratotica: A Mosaic RASopathy with Malignant Potential. Pediatr Dermatol. 2017 May; 34(3):352-355. PMID: 28523882.
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    11. Lewis K, Butts R, Antonio Quiros J, Hudspeth M, Twombley K, Savage A, Self S, Burnette A, Sun S. Autoimmune enteropathy and hepatitis in pediatric heart transplant recipient. Pediatr Transplant. 2017 Mar; 21(2). PMID: 28097735.
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    12. Dumitriu A, Armeson K, Hudspeth M. Limited Role of Sinus CT in the Management of Febrile Pediatric HSCT Recipients. J Pediatr Hematol Oncol. 2016 08; 38(6):e186-8. PMID: 26535772.
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    13. Huenerberg K, Hudspeth M, Bergmann S, Pai S, Singh B, Duong A. Two cases of Vici syndrome associated with Idiopathic Thrombocytopenic Purpura (ITP) with a review of the literature. Am J Med Genet A. 2016 May; 170A(5):1343-6. PMID: 26854214.
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    14. Hudspeth M, Sun T, Parab N, Guo Z, Fezzaa K, Luo S, Chen W. Simultaneous X-ray diffraction and phase-contrast imaging for investigating material deformation mechanisms during high-rate loading. J Synchrotron Radiat. 2015 Jan; 22(1):49-58. PMID: 25537588.
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    15. Wagner JE, Eapen M, Carter S, Wang Y, Schultz KR, Wall DA, Bunin N, Delaney C, Haut P, Margolis D, Peres E, Verneris MR, Walters M, Horowitz MM, Kurtzberg J. One-unit versus two-unit cord-blood transplantation for hematologic cancers. N Engl J Med. 2014 Oct 30; 371(18):1685-94. PMID: 25354103.
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    16. Boles EE, Chiuzan C, Ragucci D, Hudspeth MP. Analysis of factors affecting immune recovery and initial response to tetanus after DTaP vaccination in pediatric allogeneic HSCT patients. Pediatr Transplant. 2014 Dec; 18(8):882-8. PMID: 25243374.
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    17. Hudspeth M, Turner A, Miller N, Lazarchick J. Pancytopenia after allogeneic bone marrow transplant due to copper deficiency. J Pediatr Hematol Oncol. 2014 May; 36(4):316-8. PMID: 23652881.
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    18. Hudspeth MP, Heath TS, Chiuzan C, Garrett-Mayer E, Nista E, Burton L, Ragucci D. Folinic acid administration after MTX GVHD prophylaxis in pediatric allo-SCT. Bone Marrow Transplant. 2013 Jan; 48(1):46-9. PMID: 22609886.
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    19. Post GR, Lewis JA, Hudspeth MP, Caplan MJ, Lazarchick J. Disseminated neuroendocrine carcinoma in a pediatric patient: a rare case and diagnostic challenge. J Pediatr Hematol Oncol. 2012 Apr; 34(3):200-3. PMID: 22134610.
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    20. Brown E, Hebra A, Jenrette J, Hudspeth M. Successful treatment of late, recurrent wilms tumor with high-dose chemotherapy and autologous stem cell rescue in third complete response. J Pediatr Hematol Oncol. 2010 Aug; 32(6):e241-3. PMID: 20628317.
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    21. Hudspeth MP, Hill TN, Lewis JA, Van Meter E, Ragucci D. Post-hematopoietic stem cell transplant immunization practices in the Pediatric Blood and Marrow Transplant Consortium. Pediatr Blood Cancer. 2010 Jul 01; 54(7):970-5. PMID: 20135703.
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    22. Hudspeth MP, Joseph S, Holden KR. A novel mutation in type II methemoglobinemia. J Child Neurol. 2010 Jan; 25(1):91-3. PMID: 19471045.
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    23. Angotti LB, Post GR, Robinson NS, Lewis JA, Hudspeth MP, Lazarchick J. Pancytopenia with myelodysplasia due to copper deficiency. Pediatr Blood Cancer. 2008 Nov; 51(5):693-5. PMID: 18623212.
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    24. Hudspeth MP, Raymond GV. Immunopathogenesis of adrenoleukodystrophy: current understanding. J Neuroimmunol. 2007 Jan; 182(1-2):5-12. PMID: 17125847.
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    25. Hudspeth MP, Holden KR, Crawford TO. The "slurp" test: bedside evaluation of bulbar muscle fatigue. Pediatrics. 2006 Aug; 118(2):e530-3. PMID: 16847079.
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    26. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 29933069.
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