Mushfiquddin Khan

Title
InstitutionMedical University of South Carolina
DepartmentPediatrics
AddressP.O. Box MSC 515
CR 513
173 Ashley Ave.
Phone843-792-7991
Fax843-792-3653
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Khan M, Qiao F, Kumar P, Touhidul Islam SM, Singh AK, Won J, Singh I. Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms. Neural Regen Res. 2022 Jan; 17(1):185-193. PMID: 34100455.
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    2. Khan M, Singh I, Won J. Asymmetric dimethylarginine-induced oxidative damage leads to cerebrovascular dysfunction. Neural Regen Res. 2021 Sep; 16(9):1793-1794. PMID: 33510080.
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    3. Singh I, Kim J, Saxena N, Choi S, Islam SMT, Singh AK, Khan M, Won J. Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis. Immunology. 2021 11; 164(3):602-616. PMID: 34310708.
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    4. Kim J, Islam SMT, Qiao F, Singh AK, Khan M, Won J, Singh I. Regulation of B cell functions by S-nitrosoglutathione in the EAE model. Redox Biol. 2021 09; 45:102053. PMID: 34175668.
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    5. Islam SMT, Won J, Khan M, Mannie MD, Singh I. Hypoxia-inducible factor-1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseases. Immunology. 2021 09; 164(1):31-42. PMID: 33813735.
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    6. Khan M, Qiao F, Islam SMT, Dhammu TS, Kumar P, Won J, Singh AK, Singh I. GSNOR and ALDH2 alleviate traumatic spinal cord injury. Brain Res. 2021 05 01; 1758:147335. PMID: 33545099.
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    7. Islam SMT, Won J, Kim J, Qiao F, Singh AK, Khan M, Singh I. Detoxification of Reactive Aldehydes by Alda-1 Treatment Ameliorates Experimental Autoimmune Encephalomyelitis in Mice. Neuroscience. 2021 03 15; 458:31-42. PMID: 33493617.
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    8. Khan M, Kumar P, Qiao F, Islam SMT, Singh AK, Won JS, Feng W, Singh I. Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke. Brain Res. 2020 08 15; 1741:146879. PMID: 32418890.
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    9. Choi S, Singh I, Singh AK, Khan M, Won J. Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathology. FASEB J. 2020 05; 34(5):6808-6823. PMID: 32239698.
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    10. Khan M, Dhammu TS, Qiao F, Kumar P, Singh AK, Singh I. S-Nitrosoglutathione Mimics the Beneficial Activity of Endothelial Nitric Oxide Synthase-Derived Nitric Oxide in a Mouse Model of Stroke. J Stroke Cerebrovasc Dis. 2019 Dec; 28(12):104470. PMID: 31680031.
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    11. Khan M, Singh I. Therapeutic exploitation of the S-nitrosoglutathione/S-nitrosylation mechanism for the treatment of contusion spinal cord injury. Neural Regen Res. 2019 Jun; 14(6):973-974. PMID: 30762004.
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    12. Choi S, Saxena N, Dhammu T, Khan M, Singh AK, Singh I, Won J. Regulation of endothelial barrier integrity by redox-dependent nitric oxide signaling: Implication in traumatic and inflammatory brain injuries. Nitric Oxide. 2019 02 01; 83:51-64. PMID: 30590116.
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    13. Khan M, Dhammu TS, Singh I, Singh AK. Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity. BMC Neurosci. 2018 08 13; 19(1):50. PMID: 30103682.
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    14. Khan M, Shunmugavel A, Dhammu TS, Khan H, Singh I, Singh AK. Combined treatment with GSNO and CAPE accelerates functional recovery via additive antioxidant activities in a mouse model of TBI. J Neurosci Res. 2018 12; 96(12):1900-1913. PMID: 30027580.
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    15. Dasgupta S, Gomez JJ, Singh I, Khan M. S-Nitrosylation in Regulation of Inflammation and Cell Damage. Curr Drug Targets. 2018; 19(15):1831-1838. PMID: 29437005.
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    16. Khan M, Khan H, Singh I, Singh AK. Hypoxia inducible factor-1 alpha stabilization for regenerative therapy in traumatic brain injury. Neural Regen Res. 2017 May; 12(5):696-701. PMID: 28616019.
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    17. Khan M, Dhammu TS, Baarine M, Kim J, Paintlia MK, Singh I, Singh AK. GSNO promotes functional recovery in experimental TBI by stabilizing HIF-1a. Behav Brain Res. 2018 03 15; 340:63-70. PMID: 27780722.
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    18. Samuvel DJ, Shunmugavel A, Singh AK, Singh I, Khan M. S-Nitrosoglutathione ameliorates acute renal dysfunction in a rat model of lipopolysaccharide-induced sepsis. J Pharm Pharmacol. 2016 Oct; 68(10):1310-9. PMID: 27484743.
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    19. Khan M, Singh I. Inhibition of the AMPK/nNOS pathway for neuroprotection in stroke. Neural Regen Res. 2016 Mar; 11(3):398-9. PMID: 27127467.
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    20. Khan M, Dhammu TS, Dhaindsa TS, Khan H, Singh AK, Singh I. An NO/GSNO-based Neuroregeneration Strategy for Stroke Therapy. J Neurol Neurosci. 2015; 6(4). PMID: 27668143.
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    21. Baarine M, Khan M, Singh A, Singh I. Functional Characterization of IPSC-Derived Brain Cells as a Model for X-Linked Adrenoleukodystrophy. PLoS One. 2015; 10(11):e0143238. PMID: 26581106.
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    22. Khan M, Dhammu TS, Matsuda F, Annamalai B, Dhindsa TS, Singh I, Singh AK. Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI. Brain Res. 2016 Jan 01; 1630:159-70. PMID: 26596859.
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    23. Khan M, Dhammu TS, Matsuda F, Singh AK, Singh I. Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy. BMC Neurosci. 2015 Jul 15; 16:42. PMID: 26174015.
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    24. Khan M, Shunmugavel A, Dhammu TS, Matsuda F, Singh AK, Singh I. Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats. J Neuroinflammation. 2015 May 15; 12:94. PMID: 25971887.
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    25. Khan M, Dhammu TS, Matsuda F, Baarine M, Dhindsa TS, Singh I, Singh AK. Promoting endothelial function by S-nitrosoglutathione through the HIF-1a/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats. Drug Des Devel Ther. 2015; 9:2233-47. PMID: 25945035.
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    26. Shunmugavel A, Khan M, Hughes FM, Purves JT, Singh A, Singh I. S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling. Neurourol Urodyn. 2015 Aug; 34(6):519-26. PMID: 24853799.
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    27. Singh J, Khan M, Pujol A, Baarine M, Singh I. Histone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells. PLoS One. 2013; 8(7):e70712. PMID: 23923017.
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    28. Singh J, Khan M, Singh I. Caffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes. Biochim Biophys Acta. 2013 Apr; 1831(4):747-58. PMID: 23318275.
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    29. Shunmugavel A, Martin MM, Khan M, Copay AG, Subach BR, Schuler TC, Singh I. Simvastatin ameliorates cauda equina compression injury in a rat model of lumbar spinal stenosis. J Neuroimmune Pharmacol. 2013 Mar; 8(1):274-86. PMID: 23188522.
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    30. Shunmugavel A, Khan M, Martin MM, Copay AG, Subach BR, Schuler TC, Singh I. S-Nitrosoglutathione administration ameliorates cauda equina compression injury in rats. Neurosci Med. 2012 Sep 25; 3(3):294-305. PMID: 23997981.
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    31. Sakakima H, Khan M, Dhammu TS, Shunmugavel A, Yoshida Y, Singh I, Singh AK. Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion. Restor Neurol Neurosci. 2012; 30(5):383-96. PMID: 22717646.
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    32. Shunmugavel A, Khan M, Chou PC, Singh I. Spinal cord injury induced arrest in estrous cycle of rats is ameliorated by S-nitrosoglutathione: novel therapeutic agent to treat amenorrhea. J Sex Med. 2012 Jan; 9(1):148-58. PMID: 22024253.
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    33. Singh J, Khan M, Singh I. HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes. J Lipid Res. 2011 Nov; 52(11):2056-69. PMID: 21891797.
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    34. Khan M, Sakakima H, Dhammu TS, Shunmugavel A, Im YB, Gilg AG, Singh AK, Singh I. S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats. J Neuroinflammation. 2011 Jul 06; 8:78. PMID: 21733162.
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    35. Huang J, Viswakarma N, Yu S, Jia Y, Bai L, Vluggens A, Cherkaoui-Malki M, Khan M, Singh I, Yang G, Rao MS, Borensztajn J, Reddy JK. Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. Am J Pathol. 2011 Aug; 179(2):703-13. PMID: 21801867.
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    36. Chou PC, Shunmugavel A, El Sayed H, Desouki MM, Nguyen SA, Khan M, Singh I, Bilgen M. Preclinical use of longitudinal MRI for screening the efficacy of S-nitrosoglutathione in treating spinal cord injury. J Magn Reson Imaging. 2011 Jun; 33(6):1301-11. PMID: 21590998.
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    37. Shunmugavel A, Khan M, Te Chou PC, Dhindsa RK, Martin MM, Copay AG, Subach BR, Schuler TC, Bilgen M, Orak JK, Singh I. Simvastatin protects bladder and renal functions following spinal cord injury in rats. J Inflamm (Lond). 2010 Apr 19; 7:17. PMID: 20403180.
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    38. Vluggens A, Andreoletti P, Viswakarma N, Jia Y, Matsumoto K, Kulik W, Khan M, Huang J, Guo D, Yu S, Sarkar J, Singh I, Rao MS, Wanders RJ, Reddy JK, Cherkaoui-Malki M. Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Lab Invest. 2010 May; 90(5):696-708. PMID: 20195242.
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    39. Khan M, Singh J, Gilg AG, Uto T, Singh I. Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy. J Lipid Res. 2010 Jul; 51(7):1685-95. PMID: 20173212.
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    40. Khan M, Im YB, Shunmugavel A, Gilg AG, Dhindsa RK, Singh AK, Singh I. Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact. J Neuroinflammation. 2009 Nov 04; 6:32. PMID: 19889224.
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    41. Hoda MN, Singh I, Singh AK, Khan M. Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat. J Neuroinflammation. 2009 Aug 13; 6:21. PMID: 19678934.
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    42. Singh J, Khan M, Singh I. Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy. J Lipid Res. 2009 Jan; 50(1):135-47. PMID: 18723473.
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    43. Khan M, Singh J, Singh I. Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin. J Neurochem. 2008 Aug; 106(4):1766-79. PMID: 18540993.
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    44. Giri S, Khan M, Nath N, Singh I, Singh AK. The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe disease. J Neurochem. 2008 Jun; 105(5):1820-33. PMID: 18248608.
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    45. Paintlia MK, Paintlia AS, Khan M, Singh I, Singh AK. Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures. J Neurochem. 2008 May; 105(3):956-70. PMID: 18205750.
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    46. Khan M, Elango C, Ansari MA, Singh I, Singh AK. Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem. 2007 Jul; 102(2):365-77. PMID: 17437550.
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    47. Giri S, Rattan R, Haq E, Khan M, Yasmin R, Won JS, Key L, Singh AK, Singh I. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr Metab (Lond). 2006 Aug 10; 3:31. PMID: 16901342.
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    48. Jatana M, Giri S, Ansari MA, Elango C, Singh AK, Singh I, Khan M. Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. J Neuroinflammation. 2006 May 11; 3:12. PMID: 16689995.
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    49. Khan M, Jatana M, Elango C, Paintlia AS, Singh AK, Singh I. Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke. Nitric Oxide. 2006 Sep; 15(2):114-24. PMID: 16524750.
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    50. Paintlia AS, Paintlia MK, Khan M, Vollmer T, Singh AK, Singh I. HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis. FASEB J. 2005 Sep; 19(11):1407-21. PMID: 16126908.
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    51. Won JS, Im YB, Khan M, Singh AK, Singh I. Involvement of phospholipase A2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells. Glia. 2005 Jul; 51(1):13-21. PMID: 15779087.
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    52. Khan M, Haq E, Giri S, Singh I, Singh AK. Peroxisomal participation in psychosine-mediated toxicity: implications for Krabbe's disease. J Neurosci Res. 2005 Jun 15; 80(6):845-54. PMID: 15898099.
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    53. Khan M, Sekhon B, Giri S, Jatana M, Gilg AG, Ayasolla K, Elango C, Singh AK, Singh I. S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke. J Cereb Blood Flow Metab. 2005 Feb; 25(2):177-92. PMID: 15647746.
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    54. Kawada Y, Khan M, Sharma AK, Ratnayake DB, Dobashi K, Asayama K, Moser HW, Contreras MA, Singh I. Inhibition of peroxisomal functions due to oxidative imbalance induced by mistargeting of catalase to cytoplasm is restored by vitamin E treatment in skin fibroblasts from Zellweger syndrome-like patients. Mol Genet Metab. 2004 Dec; 83(4):297-305. PMID: 15589116.
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    55. Singh I, Paintlia AS, Khan M, Stanislaus R, Paintlia MK, Haq E, Singh AK, Contreras MA. Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment. Brain Res. 2004 Oct 01; 1022(1-2):1-11. PMID: 15353207.
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    56. Ayasolla K, Khan M, Singh AK, Singh I. Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic Biol Med. 2004 Aug 01; 37(3):325-38. PMID: 15223066.
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    57. Pannu R, Won JS, Khan M, Singh AK, Singh I. A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases. J Neurosci. 2004 Jun 30; 24(26):5942-54. PMID: 15229242.
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    58. Khan M, Sekhon B, Jatana M, Giri S, Gilg AG, Sekhon C, Singh I, Singh AK. Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci Res. 2004 May 15; 76(4):519-27. PMID: 15114624.
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    59. Won JS, Im YB, Khan M, Singh AK, Singh I. The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase. J Neurochem. 2004 Feb; 88(3):583-93. PMID: 14720208.
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    60. Paintlia AS, Gilg AG, Khan M, Singh AK, Barbosa E, Singh I. Correlation of very long chain fatty acid accumulation and inflammatory disease progression in childhood X-ALD: implications for potential therapies. Neurobiol Dis. 2003 Dec; 14(3):425-39. PMID: 14678759.
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    61. Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I, Singh AK. N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia. Brain Res. 2003 May 02; 971(1):1-8. PMID: 12691831.
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    62. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 31870746.
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    63. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 23050646.
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    64. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 18266936.
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