Steven D. Shapiro

Title
InstitutionMedical University of South Carolina
DepartmentPediatric Dentistry
AddressP.O. Box MSC 507
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lui A, Feldstein E, Clare K, Dicpinigaitis AJ, Reddy M, Khan F, Semaan R, Galluzzo D, Shapiro S, Kamal H, Yaghi S, Pisapia J, Muh C, Nuoman R, Overby P, Etienne M, Chong J, Mayer S, Gandhi CD, Al-Mufti F. Acute ischemic strokes in patients with developmental disabilities: A cross-sectional analysis. Interv Neuroradiol. 2022 Jul 03; 15910199221110327. PMID: 35786031.
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    2. Dicpinigaitis AJ, Feldstein E, Shapiro SD, Kamal H, Bauerschmidt A, Rosenberg J, Amuluru K, Pisapia J, Dangayach NS, Liang JW, Bowers CA, Mayer SA, Gandhi CD, Al-Mufti F. Cerebral vasospasm following arteriovenous malformation rupture: a population-based cross-sectional study. Neurosurg Focus. 2022 07; 53(1):E15. PMID: 35901745.
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    3. Chennareddy S, Kalagara R, Smith C, Matsoukas S, Bhimani A, Liang J, Shapiro S, De Leacy R, Mokin M, Fifi JT, Mocco J, Kellner CP. Portable stroke detection devices: a systematic scoping review of prehospital applications. BMC Emerg Med. 2022 06 16; 22(1):111. PMID: 35710360.
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    4. Li X, Lai Y, Lane Z, Strollo H, Tanimura K, Sembrat JC, Zou C, Myerburg MM, Rojas M, Shapiro S, Jiang Y, Nyunoya T. Cigarette smoking is a secondary cause of folliculin loss. Thorax. 2022 Mar 17. PMID: 35301243.
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    5. Dicpinigaitis AJ, Feldstein E, Damodara N, Cooper JB, Shapiro SD, Kamal H, Kinon MD, Pisapia J, Rosenberg J, Gandhi CD, Al-Mufti F. Development of cerebral vasospasm following traumatic intracranial hemorrhage: incidence, risk factors, and clinical outcomes. Neurosurg Focus. 2022 03; 52(3):E14. PMID: 35231889.
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    6. Dicpinigaitis AJ, Palumbo KE, Gandhi CD, Cooper JB, Hanft S, Kamal H, Shapiro SD, Feldstein E, Kafina M, Kurian C, Chong JY, Mayer SA, Al-Mufti F. Association of Elevated Body Mass Index with Functional Outcome and Mortality following Acute Ischemic Stroke: The Obesity Paradox Revisited. Cerebrovasc Dis. 2022; 51(5):565-569. PMID: 35158366.
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    7. Feldstein E, Zeller S, Mureb M, Kamal H, Shapiro SD, Kaur G, Al-Mufti F, Gandhi CD, Santarelli J. A novel variant of the aortic arch great vessels. Clin Neurol Neurosurg. 2022 03; 214:107172. PMID: 35158165.
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    8. Nasrazadani A, Marti JLG, Kip KE, Marroquin OC, Lemon L, Shapiro SD, Brufsky AM. Breast cancer mortality as a function of age. Aging (Albany NY). 2022 02 08; 14(3):1186-1199. PMID: 35134749.
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    9. Shapiro SD, Alkayyali M, Reynolds A, Reilly K, Selim M, Dangayach N, Mocco J, Kellner CP, Liang JW. Stereotactic IntraCerebral Underwater Blood Aspiration (SCUBA) Improves Survival Following Intracerebral Hemorrhage as Compared with Predicted Mortality. World Neurosurg. 2022 05; 161:e289-e294. PMID: 35134583.
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    10. Dicpinigaitis AJ, Gandhi CD, Shah SP, Galea VP, Cooper JB, Feldstein E, Shapiro SD, Kamal H, Kurian C, Kaur G, Tyagi R, Biswas A, Rosenberg J, Bauerschmidt A, Bowers CA, Mayer SA, Al-Mufti F. Endovascular thrombectomy with and without preceding intravenous thrombolysis for treatment of large vessel anterior circulation stroke: A cross-sectional analysis of 50,000 patients. J Neurol Sci. 2022 Mar 15; 434:120168. PMID: 35101765.
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    11. Giordano L, Gregory AD, Pérez Verdaguer M, Ware SA, Harvey H, DeVallance E, Brzoska T, Sundd P, Zhang Y, Sciurba FC, Shapiro SD, Kaufman BA. Extracellular Release of Mitochondrial DNA: Triggered by Cigarette Smoke and Detected in COPD. Cells. 2022 01 22; 11(3). PMID: 35159179.
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    12. Alder JK, Sutton RM, Iasella CJ, Nouraie M, Koshy R, Hannan SJ, Chan EG, Chen X, Zhang Y, Brown M, Popescu I, Veatch M, Saul M, Berndt A, Methé BA, Morris A, Pilewski JM, Sanchez PG, Morrell MR, Shapiro SD, Lindell KO, Gibson KF, Kass DJ, McDyer JF. Lung transplantation for idiopathic pulmonary fibrosis enriches for individuals with telomere-mediated disease. J Heart Lung Transplant. 2022 05; 41(5):654-663. PMID: 34933798.
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    13. Chu X, Sun Z, Baek DS, Li W, Mellors JW, Shapiro SD, Dimitrov DS. Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases. Int J Mol Sci. 2021 Oct 15; 22(20). PMID: 34681796.
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    14. Nighot M, Ganapathy AS, Saha K, Suchanec E, Castillo EF, Gregory A, Shapiro S, Ma T, Nighot P. Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration Across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis. J Crohns Colitis. 2021 Oct 07; 15(10):1751-1765. PMID: 33836047.
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    15. Chen D, Gregory AD, Li X, Wei J, Burton CL, Gibson G, Scott SJ, St Croix CM, Zhang Y, Shapiro SD. RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease. JCI Insight. 2021 06 22; 6(12). PMID: 34156033.
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    16. Sun F, Li L, Xiao Y, Gregory AD, Shapiro SD, Xiao G, Qu Z. Alveolar Macrophages Inherently Express Programmed Death-1 Ligand 1 for Optimal Protective Immunity and Tolerance. J Immunol. 2021 07 01; 207(1):110-114. PMID: 34135059.
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    17. Li X, Noell G, Tabib T, Gregory AD, Trejo Bittar HE, Vats R, Kaminski TW, Sembrat J, Snyder ME, Chandra D, Chen K, Zou C, Zhang Y, Sundd P, McDyer JF, Sciurba F, Rojas M, Lafyatis R, Shapiro SD, Faner R, Nyunoya T. Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD. Respir Res. 2021 Apr 06; 22(1):100. PMID: 33823868.
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    18. Carleton N, Zou J, Fang Y, Koscumb SE, Shah OS, Chen F, Beriwal S, Diego EJ, Brufsky AM, Oesterreich S, Shapiro SD, Ferris R, Emens LA, Tseng G, Marroquin OC, Lee AV, McAuliffe PF. Outcomes After Sentinel Lymph Node Biopsy and Radiotherapy in Older Women With Early-Stage, Estrogen Receptor-Positive Breast Cancer. JAMA Netw Open. 2021 04 01; 4(4):e216322. PMID: 33856473.
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    19. Li L, Sun F, Han L, Liu X, Xiao Y, Gregory AD, Shapiro SD, Xiao G, Qu Z. PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis. JCI Insight. 2021 03 08; 6(5). PMID: 33539325.
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    20. Shapiro SD, Boehme AK, Chang BP, Miller EC, Willey J, Elkind MSV. Safety and Hospital Costs Averted Using a Rapid Outpatient Management Strategy for Transient Ischemic Attack and Minor Strokes: The RAVEN Clinic. Neurohospitalist. 2021 Apr; 11(2):107-113. PMID: 33791052.
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    21. Bakalov V, Reyes-Uribe L, Deshpande R, Maloy AL, Shapiro SD, Angus DC, Chang CH, Le Moyec L, Wendell SG, Kaynar AM. Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis. PLoS One. 2020; 15(11):e0241122. PMID: 33151963.
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    22. Shapiro SD, Rothman PB. How Academic Health Systems Can Move Forward Once COVID-19 Wanes. JAMA. 2020 Jun 16; 323(23):2377-2378. PMID: 32433764.
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    23. Sun F, Guo ZS, Gregory AD, Shapiro SD, Xiao G, Qu Z. Dual but not single PD-1 or TIM-3 blockade enhances oncolytic virotherapy in refractory lung cancer. J Immunother Cancer. 2020 05; 8(1). PMID: 32461344.
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    24. Henkel M, Partyka J, Gregory AD, Forno E, Cho MH, Eddens T, Tout AR, Salamacha N, Horne W, Rao KS, Wu Y, Alcorn JF, Kostka D, Hirsch R, Celedón JC, Shapiro SD, Kolls JK, Campfield BT. FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema. Am J Respir Crit Care Med. 2020 04 15; 201(8):934-945. PMID: 31834999.
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    25. Sun F, Li L, Yan P, Zhou J, Shapiro SD, Xiao G, Qu Z. Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance. Nat Commun. 2019 11 22; 10(1):5324. PMID: 31757943.
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    26. Chang BP, Rostanski S, Willey J, Miller EC, Shapiro S, Mehendale R, Kummer B, Navi BB, Elkind MSV. Safety and Feasibility of a Rapid Outpatient Management Strategy for Transient Ischemic Attack and Minor Stroke: The Rapid Access Vascular Evaluation-Neurology (RAVEN) Approach. Ann Emerg Med. 2019 10; 74(4):562-571. PMID: 31326206.
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    27. Preston JA, Bewley MA, Marriott HM, McGarry Houghton A, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR, Craig RW, van Rooijen N, Bingle CD, Read RC, Mitchell TJ, Whyte MKB, Shapiro SD, Dockrell DH. Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia. Am J Respir Crit Care Med. 2019 07 01; 200(1):84-97. PMID: 30649895.
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    28. Radder JE, Shapiro SD. Identifying Chronic Obstructive Pulmonary Disease Genes: Shining the Light on Dark DNA. Am J Respir Cell Mol Biol. 2019 Apr; 60(4):373-374. PMID: 30376354.
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    29. Shapiro SD, Goldman J, Morgello S, Honig L, Elkind MSV, Marshall RS, Mohr JP, Gutierrez J. Pathological correlates of brain arterial calcifications. Cardiovasc Pathol. 2019 Jan - Feb; 38:7-13. PMID: 30399527.
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    30. Mallia-Milanes B, Dufour A, Philp C, Solis N, Klein T, Fischer M, Bolton CE, Shapiro S, Overall CM, Johnson SR. TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations. Am J Physiol Lung Cell Mol Physiol. 2018 12 01; 315(6):L1003-L1014. PMID: 30284925.
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    31. Kinslow CJ, Shapiro SD, Grunebaum MF, Miller EC. Acute hypertensive crisis and severe headache after concurrent use of armodafinil and tranylcypromine: Case report and review of the literature. J Neurol Sci. 2018 10 15; 393:1-3. PMID: 30077942.
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    32. Fanjul-Fernández M, Folgueras AR, Fueyo A, Balbín M, Suárez MF, Fernández-García MS, Shapiro SD, Freije JMP, López-Otín C. Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. J Biol Chem. 2018 07 27; 293(30):11970. PMID: 30054294.
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    33. Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH. Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages. Am J Respir Crit Care Med. 2017 10 01; 196(7):845-855. PMID: 28557543.
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    34. Radder JE, Gregory AD, Leme AS, Cho MH, Chu Y, Kelly NJ, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Beaty TH, Crapo JD, Silverman EK, Zhang Y, Berndt A, Shapiro SD. Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility. Am J Respir Cell Mol Biol. 2017 09; 57(3):367-375. PMID: 28441029.
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    35. Dandachi N, Kelly NJ, Wood JP, Burton CL, Radder JE, Leme AS, Gregory AD, Shapiro SD. Macrophage Elastase Induces TRAIL-mediated Tumor Cell Death through Its Carboxy-Terminal Domain. Am J Respir Crit Care Med. 2017 08 01; 196(3):353-363. PMID: 28345958.
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    36. Radder JE, Zhang Y, Gregory AD, Yu S, Kelly NJ, Leader JK, Kaminski N, Sciurba FC, Shapiro SD. Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. Am J Respir Crit Care Med. 2017 07 15; 196(2):159-171. PMID: 28199135.
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    37. Shapiro SD. Update: healthcare reform - it's getting personal. Per Med. 2017 07; 14(4):281-283. PMID: 29749829.
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    38. Kelly NJ, Radder JE, Baust JJ, Burton CL, Lai YC, Potoka KC, Agostini BA, Wood JP, Bachman TN, Vanderpool RR, Dandachi N, Leme AS, Gregory AD, Morris A, Mora AL, Gladwin MT, Shapiro SD. Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor. Am J Respir Cell Mol Biol. 2017 04; 56(4):488-496. PMID: 28085498.
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    39. Meng Q, Lai YC, Kelly NJ, Bueno M, Baust JJ, Bachman TN, Goncharov D, Vanderpool RR, Radder JE, Hu J, Goncharova E, Morris AM, Mora AL, Shapiro SD, Gladwin MT. Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction. Am J Respir Cell Mol Biol. 2017 04; 56(4):497-505. PMID: 28118022.
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    40. Shapiro SD. Refining Lung Cancer Screening Criteria in the Era of Value-Based Medicine. PLoS Med. 2017 02; 14(2):e1002226. PMID: 28170392.
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    41. Shapiro SD, Kaynar AM. Electronic cigarettes: the lesser of two evils, but how much less? Thorax. 2016 12; 71(12):1080-1081. PMID: 28441136.
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    42. Kelly NJ, Dandachi N, Goncharov DA, Pena AZ, Radder JE, Gregory AD, Lai YC, Leme AS, Gladwin MT, Goncharova EA, St Croix CM, Shapiro SD. Automated Measurement of Blood Vessels in Tissues from Microscopy Images. Curr Protoc Cytom. 2016 10 10; 78:12.44.1-12.44.13. PMID: 27723088.
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    43. Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA. HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Oct 01; 194(7):866-877. PMID: 27119551.
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    44. Shapiro SD. Transformational Healthcare Models: Medical and Specialty Medical Homes. Inflamm Bowel Dis. 2016 08; 22(8):1984-5. PMID: 27416046.
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    45. Kaynar AM, Bakalov V, Laverde SM, Cambriel AI, Lee BH, Towheed A, Gregory AD, Webb SA, Palladino MJ, Bozza FA, Shapiro SD, Angus DC. Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster. Intensive Care Med Exp. 2016 Dec; 4(1):4. PMID: 26791145.
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    46. Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH. Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. J Biol Chem. 2015 Dec 11; 290(50):29742-57. PMID: 26494620.
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    47. Shapiro SD, Karceski S. Mindfulness therapy and seizures. Neurology. 2015 Sep 29; 85(13):e101-3. PMID: 26416804.
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    48. Qu Z, Sun F, Zhou J, Li L, Shapiro SD, Xiao G. Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer. Cancer Res. 2015 Aug 15; 75(16):3209-15. PMID: 26122841.
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    49. Solleti SK, Simon DM, Srisuma S, Arikan MC, Bhattacharya S, Rangasamy T, Bijli KM, Rahman A, Crossno JT, Shapiro SD, Mariani TJ. Airway epithelial cell PPAR? modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 01; 309(3):L293-304. PMID: 26024894.
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    50. Sambamurthy N, Leme AS, Oury TD, Shapiro SD. The receptor for advanced glycation end products (RAGE) contributes to the progression of emphysema in mice. PLoS One. 2015; 10(3):e0118979. PMID: 25781626.
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    51. Tsuji T, Kelly NJ, Takahashi S, Leme AS, Houghton AM, Shapiro SD. Macrophage elastase suppresses white adipose tissue expansion with cigarette smoking. Am J Respir Cell Mol Biol. 2014 Dec; 51(6):822-9. PMID: 24914890.
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    52. Zhou J, Qu Z, Yan S, Sun F, Whitsett JA, Shapiro SD, Xiao G. Differential roles of STAT3 in the initiation and growth of lung cancer. Oncogene. 2015 Jul; 34(29):3804-3814. PMID: 25284582.
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    53. Kaynar AM, Yende S, Zhu L, Frederick DR, Chambers R, Burton CL, Carter M, Stolz DB, Agostini B, Gregory AD, Nagarajan S, Shapiro SD, Angus DC. Effects of intra-abdominal sepsis on atherosclerosis in mice. Crit Care. 2014 Sep 03; 18(5):469. PMID: 25182529.
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    54. Radder JE, Shapiro SD, Berndt A. Personalized medicine for chronic, complex diseases: chronic obstructive pulmonary disease as an example. Per Med. 2014 Sep; 11(7):669-679. PMID: 29764057.
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    55. Dandachi NG, Shapiro SD. A protean protease: MMP-12 fights viruses as a protease and a transcription factor. Nat Med. 2014 May; 20(5):470-2. PMID: 24804752.
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    56. Adler KB, Shapiro SD, Holtzman MJ, McDonald JA. The Red journal at 25 years. Looking back and looking ahead. Am J Respir Cell Mol Biol. 2014 May; 50(5):839-40. PMID: 24783952.
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    57. Kelly NJ, Shapiro SD. PPAR? in emphysema: blunts the damage and triggers repair? J Clin Invest. 2014 Mar; 124(3):978-80. PMID: 24569365.
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    58. Shapiro SD, Chin CH, Kirkness JP, McGinley BM, Patil SP, Polotsky VY, Biselli PJ, Smith PL, Schneider H, Schwartz AR. Leptin and the control of pharyngeal patency during sleep in severe obesity. J Appl Physiol (1985). 2014 May 15; 116(10):1334-41. PMID: 24557793.
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    59. Nasto LA, Ngo K, Leme AS, Robinson AR, Dong Q, Roughley P, Usas A, Sowa GA, Pola E, Kang J, Niedernhofer LJ, Shapiro S, Vo NV. Investigating the role of DNA damage in tobacco smoking-induced spine degeneration. Spine J. 2014 Mar 01; 14(3):416-23. PMID: 24211096.
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    60. Herazo-Maya JD, Noth I, Duncan SR, Kim S, Ma SF, Tseng GC, Feingold E, Juan-Guardela BM, Richards TJ, Lussier Y, Huang Y, Vij R, Lindell KO, Xue J, Gibson KF, Shapiro SD, Garcia JG, Kaminski N. Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. Sci Transl Med. 2013 Oct 02; 5(205):205ra136. PMID: 24089408.
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    61. Fanjul-Fernández M, Folgueras AR, Fueyo A, Balbín M, Suárez MF, Fernández-García MS, Shapiro SD, Freije JMP, López-Otín C. Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. J Biol Chem. 2013 May 17; 288(20):14647-14656. PMID: 23548910.
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    62. Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Lima JJ, Irvin CG, Peters SP, Kubo M, Tamari M, Nakamura Y, Litonjua AA, Tantisira KG, Raby BA, Bleecker ER, Meyers DA, London SJ, Barnes KC, Gilliland FD, Williams LK, Burchard EG, Nicolae DL, Ober C, DeMeo DL, Silverman EK, Paigen B, Churchill G, Shapiro SD, Weiss ST. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013; 8(2):e56179. PMID: 23457522.
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    63. McAuliffe PF, Danoff S, Shapiro SD, Davidson NE. Treatment for breast cancer: is time really of the essence? J Natl Cancer Inst. 2013 Jan 16; 105(2):80-2. PMID: 23264682.
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    64. Kenche H, Baty CJ, Vedagiri K, Shapiro SD, Blumental-Perry A. Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. FASEB J. 2013 Mar; 27(3):965-77. PMID: 23169770.
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    65. Berndt A, Leme AS, Shapiro SD. Emerging genetics of COPD. EMBO Mol Med. 2012 Nov; 4(11):1144-55. PMID: 23090857.
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    66. Shapiro SD, Eros Y, Abrahami Y, Leviav A. Evaluation of safety and efficacy of the TriPollar technology for treatment of wrinkles. Lasers Surg Med. 2012 Aug; 44(6):453-8. PMID: 22806630.
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    67. Shapiro SD. Healthcare reform: it is getting personal. Per Med. 2012 Jun; 9(4):405-412. PMID: 29776259.
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    68. Peter Y, Sen N, Levantini E, Keller S, Ingenito EP, Ciner A, Sackstein R, Shapiro SD. CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture. J Tissue Eng Regen Med. 2013 Jul; 7(7):572-83. PMID: 22585451.
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    69. Shapiro SD. The future of medicine is very personal. Am J Respir Crit Care Med. 2012 May 01; 185(9):903-4. PMID: 22550204.
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    70. Wilson DO, Ryan A, Fuhrman C, Schuchert M, Shapiro S, Siegfried JM, Weissfeld J. Doubling times and CT screen–detected lung cancers in the Pittsburgh Lung Screening Study. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):85-9. PMID: 21997335.
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    71. Shapiro SD. Merging personalized medicine and biology of aging in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011 Oct 15; 184(8):864-6. PMID: 22003144.
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    72. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011 Jun; 8(3):215-22. PMID: 21653526.
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    73. Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK, Zheng M. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One. 2011; 6(5):e20333. PMID: 21647421.
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    74. Bhattacharya S, Tyagi S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ. Peripheral blood gene expression profiles in COPD subjects. J Clin Bioinforma. 2011 Apr 24; 1(1):12. PMID: 21884629.
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    75. Brown RH, Kaczka DW, Fallano K, Shapiro S, Mitzner W. Individual canine airway response variability to a deep inspiration. Clin Med Insights Circ Respir Pulm Med. 2011 Feb 14; 5:7-15. PMID: 21487453.
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    76. Xiong Z, Leme AS, Ray P, Shapiro SD, Lee JS. CX3CR1+ lung mononuclear phagocytes spatially confined to the interstitium produce TNF-a and IL-6 and promote cigarette smoke-induced emphysema. J Immunol. 2011 Mar 01; 186(5):3206-14. PMID: 21278339.
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    77. Wan ES, DeMeo DL, Hersh CP, Shapiro SD, Rosiello RA, Sama SR, Fuhlbrigge AL, Foreman MG, Silverman EK. Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease (COPD). Respir Med. 2011 Apr; 105(4):588-94. PMID: 21145719.
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    78. Berndt A, Leme AS, Williams LK, Von Smith R, Savage HS, Stearns TM, Tsaih SW, Shapiro SD, Peters LL, Paigen B, Svenson KL. Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. Physiol Genomics. 2011 Jan 07; 43(1):1-11. PMID: 20823217.
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    79. Kaynar AM, Shapiro SD. NET loss of air in cystic fibrosis. Nat Med. 2010 Sep; 16(9):967-9. PMID: 20823877.
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    80. Minematsu N, Blumental-Perry A, Shapiro SD. Cigarette smoke inhibits engulfment of apoptotic cells by macrophages through inhibition of actin rearrangement. Am J Respir Cell Mol Biol. 2011 Apr; 44(4):474-82. PMID: 20525804.
      Citations:    
    81. Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med. 2010 Jul; 16(7):767-73. PMID: 20473305.
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    82. Foreman MG, Kong X, DeMeo DL, Pillai SG, Hersh CP, Bakke P, Gulsvik A, Lomas DA, Litonjua AA, Shapiro SD, Tal-Singer R, Silverman EK. Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):316-22. PMID: 20448057.
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    83. Ramsgaard L, Englert JM, Tobolewski J, Tomai L, Fattman CL, Leme AS, Kaynar AM, Shapiro SD, Enghild JJ, Oury TD. The role of the receptor for advanced glycation end-products in a murine model of silicosis. PLoS One. 2010 Mar 19; 5(3):e9604. PMID: 20333255.
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    84. Leme AS, Berndt A, Williams LK, Tsaih SW, Szatkiewicz JP, Verdugo R, Paigen B, Shapiro SD. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics. 2010 Apr; 283(4):317-26. PMID: 20143096.
      Citations:    
    85. Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med. 2010 Feb; 16(2):219-23. PMID: 20081861.
      Citations:    
    86. Hunninghake GM, Cho MH, Tesfaigzi Y, Soto-Quiros ME, Avila L, Lasky-Su J, Stidley C, Melén E, Söderhäll C, Hallberg J, Kull I, Kere J, Svartengren M, Pershagen G, Wickman M, Lange C, Demeo DL, Hersh CP, Klanderman BJ, Raby BA, Sparrow D, Shapiro SD, Silverman EK, Litonjua AA, Weiss ST, Celedón JC. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009 Dec 31; 361(27):2599-608. PMID: 20018959.
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    87. Cackowski FC, Anderson JL, Patrene KD, Choksi RJ, Shapiro SD, Windle JJ, Blair HC, Roodman GD. Osteoclasts are important for bone angiogenesis. Blood. 2010 Jan 07; 115(1):140-9. PMID: 19887675.
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    88. Khatwa UA, Kleibrink BE, Shapiro SD, Subramaniam M. MMP-8 promotes polymorphonuclear cell migration through collagen barriers in obliterative bronchiolitis. J Leukoc Biol. 2010 Jan; 87(1):69-77. PMID: 19801498.
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    89. DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, Bueno R, Pillai SG, Lomas DA, Sparrow D, Shapiro SD, Criner GJ, Kim HP, Chen Z, Choi AM, Reilly J, Silverman EK. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009 Oct; 85(4):493-502. PMID: 19800047.
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    90. Houghton AM, Hartzell WO, Robbins CS, Gomis-Rüth FX, Shapiro SD. Macrophage elastase kills bacteria within murine macrophages. Nature. 2009 Jul 30; 460(7255):637-41. PMID: 19536155.
      Citations:    
    91. Peter Y, Comellas A, Levantini E, Ingenito EP, Shapiro SD. Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization. Mol Carcinog. 2009 Jun; 48(6):488-97. PMID: 18942115.
      Citations:    
    92. Punturieri A, Szabo E, Croxton TL, Shapiro SD, Dubinett SM. Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research. J Natl Cancer Inst. 2009 Apr 15; 101(8):554-9. PMID: 19351920.
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    93. Mouded M, Egea EE, Brown MJ, Hanlon SM, Houghton AM, Tsai LW, Ingenito EP, Shapiro SD. Epithelial cell apoptosis causes acute lung injury masquerading as emphysema. Am J Respir Cell Mol Biol. 2009 Oct; 41(4):407-14. PMID: 19188661.
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    94. Volonte D, Kahkonen B, Shapiro S, Di Y, Galbiati F. Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway. J Biol Chem. 2009 Feb 27; 284(9):5462-6. PMID: 19103597.
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    95. Abraham E, Adler KB, Shapiro SD, Leff AR. The ATS journals' policy on image manipulation. Proc Am Thorac Soc. 2008 Dec 15; 5(9):869. PMID: 19056709.
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    96. Nakanishi Y, Kobayashi D, Asano Y, Sakurai T, Kashimura M, Okuyama S, Yoneda Y, Shapiro SD, Takayama K. Clarithromycin prevents smoke-induced emphysema in mice. Am J Respir Crit Care Med. 2009 Feb 15; 179(4):271-8. PMID: 19060231.
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    97. Abraham E, Adler KB, Shapiro SD, Leff AR. The ATS Journals' policy on image manipulation. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):499. PMID: 18927351.
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    98. Bhattacharya S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ. Molecular biomarkers for quantitative and discrete COPD phenotypes. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):359-67. PMID: 18849563.
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    99. Shapiro SD. Lung biology research 2008: revolution in the midst of a gathering storm. Am J Respir Cell Mol Biol. 2008 Oct; 39(4):i-ii. PMID: 18787179.
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    100. Houghton AM, Mouded M, Shapiro SD. Common origins of lung cancer and COPD. Nat Med. 2008 Oct; 14(10):1023-4. PMID: 18841139.
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    101. Shapiro SD. Retraction: stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space. Am J Respir Cell Mol Biol. 2008 Sep; 39(3):380. PMID: 18695264.
      Citations:    
    102. Shapiro SD. Retraction: involvement of discoidin domain receptor 1 in the deterioration of pulmonary sarcoidosis. Am J Respir Cell Mol Biol. 2008 Sep; 39(3):380. PMID: 18695263.
      Citations:    
    103. Brown RH, Irvin CG, Allen GB, Shapiro SD, Martin WJ, Kolb MR, Hyde DM, Nieman GF, Cody DD, Ishii M, Kadlecek SJ, Driehuys B, Rizi RR, Wu AM, Weber WA, Stout DB. An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology. Proc Am Thorac Soc. 2008 Jul 15; 5(5):591-600. PMID: 18625751.
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    104. Wilson DO, Weissfeld JL, Balkan A, Schragin JG, Fuhrman CR, Fisher SN, Wilson J, Leader JK, Siegfried JM, Shapiro SD, Sciurba FC. Association of radiographic emphysema and airflow obstruction with lung cancer. Am J Respir Crit Care Med. 2008 Oct 01; 178(7):738-44. PMID: 18565949.
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    105. Robbins CS, Franco F, Mouded M, Cernadas M, Shapiro SD. Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice. J Immunol. 2008 May 15; 180(10):6623-8. PMID: 18453581.
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    106. Kaynar AM, Houghton AM, Lum EH, Pitt BR, Shapiro SD. Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):53-60. PMID: 18276796.
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    107. Shapiro SD. The use of transgenic mice for modeling airways disease. Pulm Pharmacol Ther. 2008 Oct; 21(5):699-701. PMID: 18407535.
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    108. Hirakawa H, Pierce RA, Bingol-Karakoc G, Karaaslan C, Weng M, Shi GP, Saad A, Weber E, Mariani TJ, Starcher B, Shapiro SD, Cataltepe S. Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury. Am J Respir Crit Care Med. 2007 Oct 15; 176(8):778-85. PMID: 17673697.
      Citations:    
    109. Minematsu N, Shapiro SD. To live and die in the LA (lung airway): mode of neutrophil death and progression of chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):129-30. PMID: 17634347.
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    110. Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD. CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol. 2007 Jun 15; 178(12):8090-6. PMID: 17548647.
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    111. Arredouani MS, Franco F, Imrich A, Fedulov A, Lu X, Perkins D, Soininen R, Tryggvason K, Shapiro SD, Kobzik L. Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol. 2007 May 01; 178(9):5912-20. PMID: 17442975.
      Citations:    
    112. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L45-51. PMID: 17468134.
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    113. Matute-Bello G, Wurfel MM, Lee JS, Park DR, Frevert CW, Madtes DK, Shapiro SD, Martin TR. Essential role of MMP-12 in Fas-induced lung fibrosis. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):210-21. PMID: 17446527.
      Citations:    
    114. Kreindler JL, Shapiro SD. Lung turns to AA (adenosine analogues) to dry out. Nat Med. 2007 Apr; 13(4):406-8. PMID: 17415371.
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    115. Gutiérrez-Fernández A, Inada M, Balbín M, Fueyo A, Pitiot AS, Astudillo A, Hirose K, Hirata M, Shapiro SD, Noël A, Werb Z, Krane SM, López-Otín C, Puente XS. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J. 2007 Aug; 21(10):2580-91. PMID: 17392479.
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    116. Shapiro SD. Animal models of asthma: Pro: Allergic avoidance of animal (model[s]) is not an option. Am J Respir Crit Care Med. 2006 Dec 01; 174(11):1171-3. PMID: 17110653.
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    117. Xu J, Tian J, Grumelli SM, Haley KJ, Shapiro SD. Stage-specific effects of cAMP signaling during distal lung epithelial development. J Biol Chem. 2006 Dec 15; 281(50):38894-904. PMID: 17018522.
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    118. Zhao M, Trimbeger ME, Li N, Diaz LA, Shapiro SD, Liu Z. Role of FcRs in animal model of autoimmune bullous pemphigoid. J Immunol. 2006 Sep 01; 177(5):3398-405. PMID: 16920981.
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    119. DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502. PMID: 16921128.
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    120. Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Andalcio T, Shapiro SD, Mariani TJ. Epithelial cell PPARgamma is an endogenous regulator of normal lung maturation and maintenance. Proc Am Thorac Soc. 2006 Aug; 3(6):510-1. PMID: 16921131.
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    121. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83. PMID: 16872848.
      Citations:    
    122. Houghton AM, Grisolano JL, Baumann ML, Kobayashi DK, Hautamaki RD, Nehring LC, Cornelius LA, Shapiro SD. Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res. 2006 Jun 15; 66(12):6149-55. PMID: 16778188.
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    123. Atkinson JJ, Shapiro SD. Neutrophil-mediated eosinophil transmigration: parting the Red Sea or leaving bread crumbs. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):645-6. PMID: 16707628.
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    124. Pemberton PA, Kobayashi D, Wilk BJ, Henstrand JM, Shapiro SD, Barr PJ. Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. COPD. 2006 Jun; 3(2):101-8. PMID: 17175673.
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    125. Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Tsai LW, Ingenito EP, Gonzalez F, Shapiro SD, Mariani TJ. Epithelial cell PPAR[gamma] contributes to normal lung maturation. FASEB J. 2006 Jul; 20(9):1507-9. PMID: 16720732.
      Citations:    
    126. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 2006 May; 34(5):523-6. PMID: 16618787.
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    127. Stripp BR, Shapiro SD. Stem cells in lung disease, repair, and the potential for therapeutic interventions: State-of-the-art and future challenges. Am J Respir Cell Mol Biol. 2006 May; 34(5):517-18. PMID: 16618784.
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    128. Houghton AM, Quintero PA, Perkins DL, Kobayashi DK, Kelley DG, Marconcini LA, Mecham RP, Senior RM, Shapiro SD. Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest. 2006 Mar; 116(3):753-9. PMID: 16470245.
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    129. Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64. PMID: 16358219.
      Citations:    
    130. Mahadeva R, Shapiro SD. Animal models of pulmonary emphysema. Curr Drug Targets Inflamm Allergy. 2005 Dec; 4(6):665-73. PMID: 17305522.
      Citations:    
    131. Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N. Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):15791-6. PMID: 16236725.
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    132. Pemberton PA, Cantwell JS, Kim KM, Sundin DJ, Kobayashi D, Fink JB, Shapiro SD, Barr PJ. An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. COPD. 2005 Sep; 2(3):303-10. PMID: 17146995.
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    133. Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noël A, Cataldo DD. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol. 2005 Aug 15; 175(4):2589-97. PMID: 16081833.
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    134. Weaver A, Goncalves da Silva A, Nuttall RK, Edwards DR, Shapiro SD, Rivest S, Yong VW. An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB J. 2005 Oct; 19(12):1668-70. PMID: 16081501.
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    135. Arikan MC, Shapiro SD, Mariani TJ. Induction of macrophage elastase (MMP-12) gene expression by statins. J Cell Physiol. 2005 Jul; 204(1):139-45. PMID: 15605420.
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    136. Kassim SY, Fu X, Liles WC, Shapiro SD, Parks WC, Heinecke JW. NADPH oxidase restrains the matrix metalloproteinase activity of macrophages. J Biol Chem. 2005 Aug 26; 280(34):30201-5. PMID: 15983040.
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    137. Raptis SZ, Shapiro SD, Simmons PM, Cheng AM, Pham CT. Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering. Immunity. 2005 Jun; 22(6):679-91. PMID: 15963783.
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    138. Shapiro SD. COPD unwound. N Engl J Med. 2005 May 12; 352(19):2016-9. PMID: 15888704.
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    139. Shapiro SD, Ingenito EP. The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years. Am J Respir Cell Mol Biol. 2005 May; 32(5):367-72. PMID: 15837726.
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    140. Senft AP, Korfhagen TR, Whitsett JA, Shapiro SD, LeVine AM. Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12. J Immunol. 2005 Apr 15; 174(8):4953-9. PMID: 15814723.
      Citations:    
    141. Abraham E, Shapiro SD, Leff AR. The NIH Public Access Policy and ATS journals. Am J Respir Crit Care Med. 2005 Apr 01; 171(7):671-2. PMID: 15790862.
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    142. Longo GM, Buda SJ, Fiotta N, Xiong W, Griener T, Shapiro S, Baxter BT. MMP-12 has a role in abdominal aortic aneurysms in mice. Surgery. 2005 Apr; 137(4):457-62. PMID: 15800495.
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    143. Gidday JM, Gasche YG, Copin JC, Shah AR, Perez RS, Shapiro SD, Chan PH, Park TS. Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H558-68. PMID: 15764676.
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    144. Nénan S, Planquois JM, Berna P, De Mendez I, Hitier S, Shapiro SD, Boichot E, Lagente V, Bertrand CP. Analysis of the inflammatory response induced by rhMMP-12 catalytic domain instilled in mouse airways. Int Immunopharmacol. 2005 Mar; 5(3):511-24. PMID: 15683848.
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    145. Mahadeva R, Atkinson C, Li Z, Stewart S, Janciauskiene S, Kelley DG, Parmar J, Pitman R, Shapiro SD, Lomas DA. Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. Am J Pathol. 2005 Feb; 166(2):377-86. PMID: 15681822.
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    146. Xu J, Tian J, Shapiro SD. Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression. Am J Respir Cell Mol Biol. 2005 May; 32(5):381-7. PMID: 15677768.
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    147. Leff AR, Shapiro SD, Abraham E. The unintended consequences of noble intentions to inform. Proc Am Thorac Soc. 2005; 2(1):2-3. PMID: 16113461.
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    148. Abraham E, Shapiro SD, Leff AR. The NIH Public Access Policy and ATS journals. Proc Am Thorac Soc. 2005; 2(1):1-2. PMID: 16113460.
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    149. Buckley C, Wyble CW, Borhani M, Ennis TL, Kobayashi DK, Curci JA, Shapiro SD, Thompson RW. Accelerated enlargement of experimental abdominal aortic aneurysms in a mouse model of chronic cigarette smoke exposure. J Am Coll Surg. 2004 Dec; 199(6):896-903. PMID: 15555973.
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    150. Warner RL, Lukacs NW, Shapiro SD, Bhagarvathula N, Nerusu KC, Varani J, Johnson KJ. Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen. Am J Pathol. 2004 Dec; 165(6):1921-30. PMID: 15579436.
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    151. Sabeh F, Ota I, Holmbeck K, Birkedal-Hansen H, Soloway P, Balbin M, Lopez-Otin C, Shapiro S, Inada M, Krane S, Allen E, Chung D, Weiss SJ. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol. 2004 Nov 22; 167(4):769-81. PMID: 15557125.
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    152. Shapiro SD. Smoke gets in your cells. Am J Respir Cell Mol Biol. 2004 Nov; 31(5):481-2. PMID: 15494469.
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    153. Shapiro SD, Demeo DL, Silverman EK. Smoke and mirrors: Mouse models as a reflection of human chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Nov 01; 170(9):929-31. PMID: 15504815.
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    154. Owen CA, Hu Z, Lopez-Otin C, Shapiro SD. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol. 2004 Jun 15; 172(12):7791-803. PMID: 15187163.
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    155. Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M, Nourshargh S. Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol. 2004 Apr 01; 172(7):4493-502. PMID: 15034066.
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    156. Riese RJ, Finn PW, Shapiro SD. Influenza and asthma: adding to the respiratory burden. Nat Immunol. 2004 Mar; 5(3):243-4. PMID: 14985710.
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    157. Dunsmore SE, Shapiro SD. The bone marrow leaves its scar: new concepts in pulmonary fibrosis. J Clin Invest. 2004 Jan; 113(2):180-2. PMID: 14722608.
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    158. Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol. 2003 Dec; 163(6):2329-35. PMID: 14633606.
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    159. Shapiro SD. The post-genomic red journal: charting the path from hope (not hype) to cure. Am J Respir Cell Mol Biol. 2003 Oct; 29(4):425-6. PMID: 14500252.
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    160. Balbín M, Fueyo A, Tester AM, Pendás AM, Pitiot AS, Astudillo A, Overall CM, Shapiro SD, López-Otín C. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat Genet. 2003 Nov; 35(3):252-7. PMID: 14517555.
      Citations:    
    161. Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA, Shapiro S, Weiss SJ. Matrilysin-dependent elastolysis by human macrophages. J Exp Med. 2003 Sep 15; 198(6):925-35. PMID: 12963695.
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    162. Pouladi MA, Robbins CS, Swirski FK, Cundall M, McKenzie AN, Jordana M, Shapiro SD, Stämpfli MR. Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice. Am J Respir Cell Mol Biol. 2004 Jan; 30(1):84-90. PMID: 12842850.
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    163. Dollery CM, Owen CA, Sukhova GK, Krettek A, Shapiro SD, Libby P. Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation. 2003 Jun 10; 107(22):2829-36. PMID: 12771009.
      Citations:    
    164. Owen CA, Hu Z, Barrick B, Shapiro SD. Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils. Am J Respir Cell Mol Biol. 2003 Sep; 29(3 Pt 1):283-94. PMID: 12663332.
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    165. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature. 2003 Mar 13; 422(6928):169-73. PMID: 12634787.
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    166. Pechet TV, de le Morena M, Mendeloff EN, Sweet SC, Shapiro SD, Huddleston CB. Lung transplantation in children following treatment for malignancy. J Heart Lung Transplant. 2003 Feb; 22(2):154-60. PMID: 12581763.
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    167. Shapiro SD. Immunology: Mobilizing the army. Nature. 2003 Jan 16; 421(6920):223-4. PMID: 12529625.
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    168. Churg A, Wang RD, Tai H, Wang X, Xie C, Dai J, Shapiro SD, Wright JL. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med. 2003 Apr 15; 167(8):1083-9. PMID: 12522030.
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    169. Kure T, Chang JH, Kato T, Hernández-Quintela E, Ye H, Lu PC, Matrisian LM, Gatinel D, Shapiro S, Gosheh F, Azar DT, Gosheh F. Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):137-44. PMID: 12506066.
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    170. Hornstra IK, Birge S, Starcher B, Bailey AJ, Mecham RP, Shapiro SD. Lysyl oxidase is required for vascular and diaphragmatic development in mice. J Biol Chem. 2003 Apr 18; 278(16):14387-93. PMID: 12473682.
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    171. Kerkelä E, Ala-aho R, Klemi P, Grénman S, Shapiro SD, Kähäri VM, Saarialho-Kere U. Metalloelastase (MMP-12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while that by macrophages predicts better outcome. J Pathol. 2002 Oct; 198(2):258-69. PMID: 12237887.
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    172. Shapiro SD, Owen CA. ADAM-33 surfaces as an asthma gene. N Engl J Med. 2002 Sep 19; 347(12):936-8. PMID: 12239266.
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    173. Churg A, Zay K, Shay S, Xie C, Shapiro SD, Hendricks R, Wright JL. Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice. Am J Respir Cell Mol Biol. 2002 Sep; 27(3):368-74. PMID: 12204900.
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    174. Lanone S, Zheng T, Zhu Z, Liu W, Lee CG, Ma B, Chen Q, Homer RJ, Wang J, Rabach LA, Rabach ME, Shipley JM, Shapiro SD, Senior RM, Elias JA. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest. 2002 Aug; 110(4):463-74. PMID: 12189240.
      Citations:    
    175. Weinrauch Y, Drujan D, Shapiro SD, Weiss J, Zychlinsky A. Neutrophil elastase targets virulence factors of enterobacteria. Nature. 2002 May 02; 417(6884):91-4. PMID: 12018205.
      Citations:    
    176. Mariani TJ, Reed JJ, Shapiro SD. Expression profiling of the developing mouse lung: insights into the establishment of the extracellular matrix. Am J Respir Cell Mol Biol. 2002 May; 26(5):541-8. PMID: 11970905.
      Citations:    
    177. Allport JR, Lim YC, Shipley JM, Senior RM, Shapiro SD, Matsuyoshi N, Vestweber D, Luscinskas FW. Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro. J Leukoc Biol. 2002 May; 71(5):821-8. PMID: 11994507.
      Citations:    
    178. Mariani TJ, Shapiro SD. Thomas A. Neff lecture. Application of expression profiling to the developing lung: identification of putative regulatory networks controlling matrix production. Chest. 2002 Mar; 121(3 Suppl):42S-44S. PMID: 11893680.
      Citations:    
    179. Shapiro SD. Neutrophil elastase: path clearer, pathogen killer, or just pathologic? Am J Respir Cell Mol Biol. 2002 Mar; 26(3):266-8. PMID: 11867332.
      Citations:    
    180. Mi Y, Shapiro SD, Baenziger JU. Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo. J Clin Invest. 2002 Jan; 109(2):269-76. PMID: 11805139.
      Citations:    
    181. Mendeloff EN, Meyers BF, Sundt TM, Guthrie TJ, Sweet SC, de la Morena M, Shapiro S, Balzer DT, Trulock EP, Lynch JP, Pasque MK, Cooper JD, Huddleston CB, Patterson GA. Lung transplantation for pulmonary vascular disease. Ann Thorac Surg. 2002 Jan; 73(1):209-17; discussion 217-9. PMID: 11834012.
      Citations:    
    182. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 14751561.
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    183. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 21784967.
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    184. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 16500946.
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    185. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 21979170.
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    186. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 17200183.
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    187. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 32754113.
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    188. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 26376498.
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    189. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 35279005.
      Citations:    
    190. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 29388831.
      Citations:    
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