Dr. Sonne's primary research focus has been the pharmacotherapy of addiction and co-occurring disorders. She has served as the Principal Investigator of a number of federally funded trials for the treatment of substance use disorders, including trials for opioid dependence, stimulant dependence, and cigarette smoking. She has also received grant support from pharmaceutical companies to study the treatment of PTSD, PTSD and substance abuse, and comorbid alcohol dependence and anxiety or depression. Dr. Sonne serves as the national project director for a multi-site trial on the treatment of marijuana dependence. She is currently Chair of one of the Institutional Review Boards at MUSC and is also the Associate Director of the Regulatory Knowledge and Support Core of MUSC's South Carolina Clinical and Translational Research Institute.