William David Hill

Title
InstitutionMedical University of South Carolina
DepartmentPathology and Laboratory Medicine
AddressP.O. Box MSC 908
STB 506A Office-514 & 514A Lab
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-6623
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    Collapse Biography 
    Collapse education and training
    Wake Forest University, Winston-Salem, NCBA05/1979 Psychology
    Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NCMS05/1982 Otolaryngology
    Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NCPh.D.12/1988 Anatomy
    Marine Biological Laboratory, Woods Hole, MA1983-85Summer Research Programs
    University of Pennsylvania, Dept. of Pathology and Laboratory Medicine, Philadelphia, PA1988-92NIH NRSA Fellow Neurodegenerative Disease

    Collapse Overview 
    Collapse overview
    My lab focuses on aging, in particular in relationship to stem cells and tissue function. This includes age-associated bone homeostasis, autophagy and senescence. One of the primary areas of research is age-associated changes in the epigenetic regulation of stem cells, in particular miRNAS and Hdacs. We also study the role of the cytokine CXCL12 and its proteolytic metabolites that have separate cryptic biological activity. This not only has an impact on bone biology with aging, but has implications in many other areas, such as immunology and cancer biology. We are also interested in aging effects of the Kynurenine pathway on different organ systems including musculoskeletal and CNS. Our lab has a strong clinical translational and tech transfer focus. We have a patent portfolio and have spun off a start-up drug delivery company, SheroFill, LLC.

    Over the last several years we have focused on the exciting developing role of the tryptophan metabolite Kynurenine (KYN) and it’s signaling through the aryl hydrocarbon receptor (AhR) pathway in aging and disease. We have demonstrated its importance in inhibiting bone formation with age, as well as increasing osteoclast driven bone resorption. Most recently and relevant to the current Merit Award proposal we have identified that it drives BMSC senescence while simultaneously blocking autophagy. Senescence has emerged as a critical process in osteoporosis and age-related bone loss. With our collaborators we have been developing inducible conditional KO mouse models centered on AhR, IDO-1 and now KYN pathway enzymes. We have also identified age-associated miRNA changes in directly isolated (non-cultured) human bone marrow Mesenchymal Stem Cells (BMSCs). Further, we have started to look in detail at several of these miRNAs and their effect on BMSC osteogenic potential (U.S. Patent No. 9,267,139 [see MyBibliography]). Critically we have identified overlapping miRNAs whose expression is altered by KYN and targets osteogenesis. One of these miR-29b-1-5p is among a set of “passenger” strand miRNAs that are normally degraded, but with aging have become the dominant miRNA strand via an arm-switching process tied into kynurenine signaling through the Aryl Hydrocarbon Receptor. These miRNAs target osteogenic cytokines, including SDF-1 (aka: CXCL12), multiple signaling pathways, transcription factors and extracellular matrix molecules. We have also seen that they change with age in the same manner in murine BMSCs, muscle and bone, and that their expression can be altered via nutrient signaling pathways including diets with modified aromatic amino acids, caloric restriction or leptin treatment. The role of the SDF-1/CXCR4/ACKR3 axis, and related miRNAs, on osteogenesis in aging is a major focus of my lab. With our P01 collaborators we have identified increased kynurenine levels with age as a unifying pathway that links epigenetic changes in SDF-1 targeting miRNAs, histone deacetylases, decreased SDF-1, increased BMSC lipogenesis and decreased osteogenesis with age-related bone loss. Importantly we have demonstrated that the proteolytic processing of SDF-1 generates novel bioactive metabolites. Additionally, I have experience with aging effects on in vitro and in vivo tissue repair and on epigenetic regulation of skeletal stem cells, as well as cell death and survival pathways. This has included the first demonstration of SDF-1 mediated regulation of autophagy and has resulted in a second patent application (U.S.S.N. 61/712/708). I am interested in clinical translational development of our basic science research and have started a biotech company (SpheroFill, LLC) focused on a novel porous walled hollow glass microsphere drug delivery platform for which we received US Patent No. 10,201,633 Issued 2-12-2019 and an NSF STTR award 2112233.

    Aging collaborations: In addition to the Aging Musculoskeletal P01 research group based out of Augusta University, that I have been part of for over 15 years, I have been helping to develop an MUSC Musculoskeletal Research group focused on aging. My lab has been working with the MUSC Dept of Orthopaedics & Physical Medicine collecting human bone marrow samples to isolate different stem cell populations to identify changes in genes and their regulation at different ages and from different genders, and I have been working with Amanda LaRue, Ph.D. (ACOS-Research, Ralph H. Johnson VAMC & Dept of Pathology Vice Chair for Research) since the early 2000’s on bone marrow stem cell isolation, transplantation and function especially in the context of aging and changes in epigenetic regulation with aging. I am also exploring with Chad Novince (MUSC Dental College) the potential role of the microbiome in the regulation of bone homeostasis, as well as other systems, with age. Uniquely my lab is identifying how post-translational changes to SDF-1 with age has implications with and beyond bone homeostasis - including cardiovascular, immune system regulation and cancer biology. I am currently working with MUSC endocrinologists and GPCR researchers such as Dr. Lou Luttrell, Joe Blumer (MUSC) and Brian Volkman (MCW) to understand these CXCL12 modifications and how they alter known signaling systems and generate novel cryptic ligands that target previously unrecognized signaling pathways leading to senescence and dysfunctional bone homeostasis.
    Collapse keywords
    aging, stem cells, bone, musculoskeletal, cytokines, CXCL12, CXCR4, ACKR3, DPP4, CD26, miRNAs, miR-29, miR-29b-1-5p, arm-switching, tryptophan, Kynurenine, KMO, AhR, Aryl hydrocarbon receptor, senescence, autophagy, drug delivery, osteoporosis, brain.

    Collapse Research 
    Collapse research activities and funding
    P01-AG036675-9     (Isales)May 1, 2011 - Apr 30, 2022
    NIH/NIA
    Age-induced Impairment of Nutrient Signaling Results in Bone Loss”; Project 3: “Role of SDF-1 in Age-Related changes in BMSC miRNA and Bone Loss"
    Role: Co-I Project 3 PI

    I01CX000930     (HILL, WILLIAM D)Jan 1, 2014 - Sep 30, 2019
    NIH
    Bad to the Bone: Age-related Increases in Serum SDF-1 Leads to Bone Loss with Age
    Role Description: This is a VA Merit Award (BLR&D)
    Role: Principal Investigator

    RO1NS083559     (Ergul)Apr 1, 2020 - Jan 31, 2025
    NIH/NINDS
    “Vascular injury and recovery in diabetic ischemic stroke”
    Role: Co-I

    R01AG067510     (HILL, WILLIAM D)Jul 15, 2020 - Mar 31, 2024
    NIH
    Age-Related Kynurenine Accumulation Impairs miRNA and Hdac Epigenetic Regulation of the SDF-1 Axis Resulting in Bone Loss
    Role: Principal Investigator

    STTR R43 NSF Phase I Proposal 2112233     (Wicks)Jun 1, 2021 - May 31, 2022
    NSF
    “Porous Walled Hollow Glass Microspheres (PWHGMs): A Novel Sustained Drug Delivery Platform with Unique Flexible Capabilities”
    Role: Co-I

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alhamad DW, Bensreti H, Dorn J, Hill WD, Hamrick MW, McGee-Lawrence ME. Aryl hydrocarbon receptor (AhR)-mediated signaling as a critical regulator of skeletal cell biology. J Mol Endocrinol. 2022 10 01; 69(3):R109-R124. PMID: 35900841.
      Citations:    
    2. Huan T, Nguyen S, Colicino E, Ochoa-Rosales C, Hill WD, Brody JA, Soerensen M, Zhang Y, Baldassari A, Elhadad MA, Toshiko T, Zheng Y, Domingo-Relloso A, Lee DH, Ma J, Yao C, Liu C, Hwang SJ, Joehanes R, Fornage M, Bressler J, van Meurs JBJ, Debrabant B, Mengel-From J, Hjelmborg J, Christensen K, Vokonas P, Schwartz J, Gahrib SA, Sotoodehnia N, Sitlani CM, Kunze S, Gieger C, Peters A, Waldenberger M, Deary IJ, Ferrucci L, Qu Y, Greenland P, Lloyd-Jones DM, Hou L, Bandinelli S, Voortman T, Hermann B, Baccarelli A, Whitsel E, Pankow JS, Levy D. Integrative analysis of clinical and epigenetic biomarkers of mortality. Aging Cell. 2022 06; 21(6):e13608. PMID: 35546478.
      Citations:    
    3. Howe LJ, Nivard MG, Morris TT, Hansen AF, Rasheed H, Cho Y, Chittoor G, Ahlskog R, Lind PA, Palviainen T, van der Zee MD, Cheesman R, Mangino M, Wang Y, Li S, Klaric L, Ratliff SM, Bielak LF, Nygaard M, Giannelis A, Willoughby EA, Reynolds CA, Balbona JV, Andreassen OA, Ask H, Baras A, Bauer CR, Boomsma DI, Campbell A, Campbell H, Chen Z, Christofidou P, Corfield E, Dahm CC, Dokuru DR, Evans LM, de Geus EJC, Giddaluru S, Gordon SD, Harden KP, Hill WD, Hughes A, Kerr SM, Kim Y, Kweon H, Latvala A, Lawlor DA, Li L, Lin K, Magnus P, Magnusson PKE, Mallard TT, Martikainen P, Mills MC, Njølstad PR, Overton JD, Pedersen NL, Porteous DJ, Reid J, Silventoinen K, Southey MC, Stoltenberg C, Tucker-Drob EM, Wright MJ, Hewitt JK, Keller MC, Stallings MC, Lee JJ, Christensen K, Kardia SLR, Peyser PA, Smith JA, Wilson JF, Hopper JL, Hägg S, Spector TD, Pingault JB, Plomin R, Havdahl A, Bartels M, Martin NG, Oskarsson S, Justice AE, Millwood IY, Hveem K, Naess Ø, Willer CJ, Åsvold BO, Koellinger PD, Kaprio J, Medland SE, Walters RG, Benjamin DJ, Turley P, Evans DM, Davey Smith G, Hayward C, Brumpton B, Hemani G, Davies NM. Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects. Nat Genet. 2022 05; 54(5):581-592. PMID: 35534559.
      Citations:    
    4. Ruan L, Mendhe B, Parker E, Kent A, Isales CM, Hill WD, McGee-Lawrence M, Fulzele S, Hamrick MW. Long Non-coding RNA MALAT1 Is Depleted With Age in Skeletal Muscle in vivo and MALAT1 Silencing Increases Expression of TGF-ß1 in vitro. Front Physiol. 2021; 12:742004. PMID: 35126169.
      Citations:    
    5. Natanael Perez Cordero, Patricia V. Schoenlein, Sadanand Fulzele, and William D. Hill*. G. Duque and B. Troen, ed.,. Chapter 4 "A Geroscience Approach for Osteosarcopenia: Autophagy and Senescence as Therapeutic Targets" In Osteosarcopenia. 2022.
    6. Potter ML, Smith K, Vyavahare S, Kumar S, Periyasamy-Thandavan S, Hamrick M, Isales CM, Hill WD, Fulzele S. Characterization of Differentially Expressed miRNAs by CXCL12/SDF-1 in Human Bone Marrow Stromal Cells. Biomol Concepts. 2021 Oct 13; 12(1):132-143. PMID: 34648701.
      Citations:    
    7. Vyavahare S, Kumar S, Cantu N, Kolhe R, Bollag WB, McGee-Lawrence ME, Hill WD, Hamrick MW, Isales CM, Fulzele S. Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview. Mediators Inflamm. 2021; 2021:2911578. PMID: 34621138.
      Citations:    
    8. Eisa NH, Sudharsan PT, Herrero SM, Herberg SA, Volkman BF, Aguilar-Pérez A, Kondrikov D, Elmansi AM, Reitman C, Shi X, Fulzele S, McGee-Lawrence ME, Isales CM, Hamrick MW, Johnson MH, Chen J, Hill WD. Age-associated changes in microRNAs affect the differentiation potential of human mesenchymal stem cells: Novel role of miR-29b-1-5p expression. Bone. 2021 12; 153:116154. PMID: 34403754.
      Citations:    
    9. Hill W, Caswell DR, Swanton C. Capturing cancer evolution using genetically engineered mouse models (GEMMs). Trends Cell Biol. 2021 12; 31(12):1007-1018. PMID: 34400045.
      Citations:    
    10. Yusufu I, Ding K, Smith K, Wankhade UD, Sahay B, Patterson GT, Pacholczyk R, Adusumilli S, Hamrick MW, Hill WD, Isales CM, Fulzele S. A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice. Int J Mol Sci. 2021 May 08; 22(9). PMID: 34066870.
      Citations:    
    11. Patel D, Potter M, Anaya JM, McGee-Lawrence ME, Hamrick MW, Hill WD, Isales CM, Fulzele S. Kynurenine induces an age-related phenotype in bone marrow stromal cells. Mech Ageing Dev. 2021 04; 195:111464. PMID: 33631183.
      Citations:    
    12. Elshaer SL, Park HS, Pearson L, Hill WD, Longo FM, El-Remessy AB. Modulation of p75NTR on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model. Int J Mol Sci. 2021 Jan 15; 22(2). PMID: 33467640.
      Citations:    
    13. Eisa NH, Reddy SV, Elmansi AM, Kondrikova G, Kondrikov D, Shi XM, Novince CM, Hamrick MW, McGee-Lawrence ME, Isales CM, Fulzele S, Hill WD. Kynurenine Promotes RANKL-Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway. Int J Mol Sci. 2020 Oct 26; 21(21). PMID: 33114603.
      Citations:    
    14. Potter ML, Hill WD, Isales CM, Hamrick MW, Fulzele S. MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells. Bone. 2021 01; 142:115679. PMID: 33022453.
      Citations:    
    15. Elmansi AM, Hussein KA, Herrero SM, Periyasamy-Thandavan S, Aguilar-Pérez A, Kondrikova G, Kondrikov D, Eisa NH, Pierce JL, Kaiser H, Ding KH, Walker AL, Jiang X, Bollag WB, Elsalanty M, Zhong Q, Shi XM, Su Y, Johnson M, Hunter M, Reitman C, Volkman BF, Hamrick MW, Isales CM, Fulzele S, McGee-Lawrence ME, Hill WD. Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells. Bone Rep. 2020 Jun; 12:100270. PMID: 32395570.
      Citations:    
    16. Ding K, McGee-Lawrence ME, Kaiser H, Sharma AK, Pierce JL, Irsik DL, Bollag WB, Xu J, Zhong Q, Hill W, Shi XM, Fulzele S, Kennedy EJ, Elsalanty M, Hamrick MW, Isales CM. Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity. Exp Gerontol. 2020 05; 133:110885. PMID: 32088397.
      Citations:    
    17. Pierce JL, Roberts RL, Yu K, Kendall RK, Kaiser H, Davis C, Johnson MH, Hill WD, Isales CM, Bollag WB, Hamrick MW, McGee-Lawrence ME. Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo. Exp Gerontol. 2020 02; 130:110818. PMID: 31862422.
      Citations:    
    18. Kondrikov D, Elmansi A, Bragg RT, Mobley T, Barrett T, Eisa N, Kondrikova G, Schoeinlein P, Aguilar-Perez A, Shi XM, Fulzele S, Lawrence MM, Hamrick M, Isales C, Hill W. Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway. Exp Gerontol. 2020 02; 130:110805. PMID: 31812582.
      Citations:    
    19. Dalton S, Smith K, Singh K, Kaiser H, Kolhe R, Mondal AK, Khayrullin A, Isales CM, Hamrick MW, Hill WD, Fulzele S. Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells. Exp Gerontol. 2020 02; 130:110800. PMID: 31790802.
      Citations:    
    20. Bragg R, Gilbert W, Elmansi AM, Isales CM, Hamrick MW, Hill WD, Fulzele S. Stromal cell-derived factor-1 as a potential therapeutic target for osteoarthritis and rheumatoid arthritis. Ther Adv Chronic Dis. 2019; 10:2040622319882531. PMID: 31695863.
      Citations:    
    21. Periyasamy-Thandavan S, Burke J, Mendhe B, Kondrikova G, Kolhe R, Hunter M, Isales CM, Hamrick MW, Hill WD, Fulzele S. MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells. J Gerontol A Biol Sci Med Sci. 2019 08 16; 74(9):1368-1374. PMID: 31505568.
      Citations:    
    22. Gilbert W, Bragg R, Elmansi AM, McGee-Lawrence ME, Isales CM, Hamrick MW, Hill WD, Fulzele S. Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology. Cytokine. 2019 11; 123:154783. PMID: 31336263.
      Citations:    
    23. Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, van der Lee SJ, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Böhmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Hartmann AM, Hatzimanolis A, Heiss G, Holliday EG, Joshi PK, Kähönen M, Kardia SLR, Karlsson I, Kleineidam L, Knopman DS, Kochan NA, Konte B, Kwok JB, Le Hellard S, Lee T, Lehtimäki T, Li SC, Lill CM, Liu T, Koini M, London E, Longstreth WT, Lopez OL, Loukola A, Luck T, Lundervold AJ, Lundquist A, Lyytikäinen LP, Martin NG, Montgomery GW, Murray AD, Need AC, Noordam R, Nyberg L, Ollier W, Papenberg G, Pattie A, Polasek O, Poldrack RA, Psaty BM, Reppermund S, Riedel-Heller SG, Rose RJ, Rotter JI, Roussos P, Rovio SP, Saba Y, Sabb FW, Sachdev PS, Satizabal CL, Schmid M, Scott RJ, Scult MA, Simino J, Slagboom PE, Smyrnis N, Soumaré A, Stefanis NC, Stott DJ, Straub RE, Sundet K, Taylor AM, Taylor KD, Tzoulaki I, Tzourio C, Uitterlinden A, Vitart V, Voineskos AN, Kaprio J, Wagner M, Wagner H, Weinhold L, Wen KH, Widen E, Yang Q, Zhao W, Adams HHH, Arking DE, Bilder RM, Bitsios P, Boerwinkle E, Chiba-Falek O, Corvin A, De Jager PL, Debette S, Donohoe G, Elliott P, Fitzpatrick AL, Gill M, Glahn DC, Hägg S, Hansell NK, Hariri AR, Ikram MK, Jukema JW, Vuoksimaa E, Keller MC, Kremen WS, Launer L, Lindenberger U, Palotie A, Pedersen NL, Pendleton N, Porteous DJ, Räikkönen K, Raitakari OT, Ramirez A, Reinvang I, Rudan I, Schmidt R, Schmidt H, Schofield PW, Schofield PR, Starr JM, Steen VM, Trollor JN, Turner ST, Van Duijn CM, Villringer A, Weinberger DR, Weir DR, Wilson JF, Malhotra A, McIntosh AM, Gale CR, Seshadri S, Mosley TH, Bressler J, Lencz T, Deary IJ. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2019 May 01; 10(1):2068. PMID: 31043617.
      Citations:    
    24. Awad ME, Hussein KA, Helwa I, Abdelsamid MF, Aguilar-Perez A, Mohsen I, Hunter M, Hamrick MW, Isales CM, Elsalanty M, Hill WD, Fulzele S. Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment. Stem Cells Int. 2019; 2019:3826054. PMID: 31089328.
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    25. Elmansi AM, Awad ME, Eisa NH, Kondrikov D, Hussein KA, Aguilar-Pérez A, Herberg S, Periyasamy-Thandavan S, Fulzele S, Hamrick MW, McGee-Lawrence ME, Isales CM, Volkman BF, Hill WD. What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands. Pharmacol Ther. 2019 06; 198:90-108. PMID: 30759373.
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    26. Fariyike B, Singleton Q, Hunter M, Hill WD, Isales CM, Hamrick MW, Fulzele S. Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview. Mech Ageing Dev. 2019 03; 178:9-15. PMID: 30528652.
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    27. Howie RN, Herberg S, Durham E, Grey Z, Bennfors G, Elsalanty M, LaRue AC, Hill WD, Cray JJ. Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model. Int J Oral Sci. 2018 09 03; 10(3):25. PMID: 30174329.
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    28. Ding KH, Cain M, Davis M, Bergson C, McGee-Lawrence M, Perkins C, Hardigan T, Shi X, Zhong Q, Xu J, Bollag WB, Hill W, Elsalanty M, Hunter M, Isales MC, Lopez P, Hamrick M, Isales CM. Amino acids as signaling molecules modulating bone turnover. Bone. 2018 10; 115:15-24. PMID: 29499416.
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    29. Kolhe R, Mondal AK, Pundkar C, Periyasamy-Thandavan S, Mendhe B, Hunter M, Isales CM, Hill WD, Hamrick MW, Fulzele S. Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells. Nutrients. 2018 Feb 08; 10(2). PMID: 29419776.
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    30. Refaey ME, McGee-Lawrence ME, Fulzele S, Kennedy EJ, Bollag WB, Elsalanty M, Zhong Q, Ding KH, Bendzunas NG, Shi XM, Xu J, Hill WD, Johnson MH, Hunter M, Pierce JL, Yu K, Hamrick MW, Isales CM. Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss. J Bone Miner Res. 2017 Nov; 32(11):2182-2193. PMID: 28727234.
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    31. Mohamed SA, Shalaby SM, Abdelaziz M, Brakta S, Hill WD, Ismail N, Al-Hendy A. Human Mesenchymal Stem Cells Partially Reverse Infertility in Chemotherapy-Induced Ovarian Failure. Reprod Sci. 2018 01; 25(1):51-63. PMID: 28460567.
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    32. Davis C, Dukes A, Drewry M, Helwa I, Johnson MH, Isales CM, Hill WD, Liu Y, Shi X, Fulzele S, Hamrick MW. MicroRNA-183-5p Increases with Age in Bone-Derived Extracellular Vesicles, Suppresses Bone Marrow Stromal (Stem) Cell Proliferation, and Induces Stem Cell Senescence. Tissue Eng Part A. 2017 11; 23(21-22):1231-1240. PMID: 28363268.
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    33. Carbone LD, Bužková P, Fink HA, Robbins JA, Bethel M, Hamrick MW, Hill WD. Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study. Calcif Tissue Int. 2017 06; 100(6):599-608. PMID: 28246930.
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    34. Carbone LD, Bužková P, Fink HA, Robbins JA, Bethel M, Isales CM, Hill WD. Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study. Osteoporos Int. 2017 05; 28(5):1631-1640. PMID: 28150034.
      Citations:    
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    36. Mortensen LJ, Hill WD. Skeletal stem cells for bone development, homeostasis and repair: one or many? Bonekey Rep. 2015; 4:769. PMID: 26788287.
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    37. Herberg S, Aguilar-Perez A, Howie RN, Kondrikova G, Periyasamy-Thandavan S, Elsalanty ME, Shi X, Hill WD, Cray JJ. Mesenchymal stem cell expression of SDF-1ß synergizes with BMP-2 to augment cell-mediated healing of critical-sized mouse calvarial defects. J Tissue Eng Regen Med. 2017 06; 11(6):1806-1819. PMID: 26227988.
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    38. Sangani R, Periyasamy-Thandavan S, Pathania R, Ahmad S, Kutiyanawalla A, Kolhe R, Bhattacharyya MH, Chutkan N, Hunter M, Hill WD, Hamrick M, Isales C, Fulzele S. The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis. Stem Cell Res. 2015 Sep; 15(2):312-21. PMID: 26210298.
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    39. Dukes A, Davis C, El Refaey M, Upadhyay S, Mork S, Arounleut P, Johnson MH, Hill WD, Isales CM, Hamrick MW. The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro. Nutrition. 2015 Jul-Aug; 31(7-8):1018-24. PMID: 26059377.
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    40. Periyasamy-Thandavan S, Herberg S, Arounleut P, Upadhyay S, Dukes A, Davis C, Johnson M, McGee-Lawrence M, Hamrick MW, Isales CM, Hill WD. Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells. Mol Cell Endocrinol. 2015 Jul 15; 410:64-72. PMID: 25779533.
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    41. Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, van der Lee SJ, Le Hellard S, Liu T, Marioni RE, Oldmeadow C, Postmus I, Smith AV, Smith JA, Thalamuthu A, Thomson R, Vitart V, Wang J, Yu L, Zgaga L, Zhao W, Boxall R, Harris SE, Hill WD, Liewald DC, Luciano M, Adams H, Ames D, Amin N, Amouyel P, Assareh AA, Au R, Becker JT, Beiser A, Berr C, Bertram L, Boerwinkle E, Buckley BM, Campbell H, Corley J, De Jager PL, Dufouil C, Eriksson JG, Espeseth T, Faul JD, Ford I, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Heiss G, Hofman A, Holliday EG, Huffman J, Kardia SL, Kochan N, Knopman DS, Kwok JB, Lambert JC, Lee T, Li G, Li SC, Loitfelder M, Lopez OL, Lundervold AJ, Lundqvist A, Mather KA, Mirza SS, Nyberg L, Oostra BA, Palotie A, Papenberg G, Pattie A, Petrovic K, Polasek O, Psaty BM, Redmond P, Reppermund S, Rotter JI, Schmidt H, Schuur M, Schofield PW, Scott RJ, Steen VM, Stott DJ, van Swieten JC, Taylor KD, Trollor J, Trompet S, Uitterlinden AG, Weinstein G, Widen E, Windham BG, Jukema JW, Wright AF, Wright MJ, Yang Q, Amieva H, Attia JR, Bennett DA, Brodaty H, de Craen AJ, Hayward C, Ikram MA, Lindenberger U, Nilsson LG, Porteous DJ, Räikkönen K, Reinvang I, Rudan I, Sachdev PS, Schmidt R, Schofield PR, Srikanth V, Starr JM, Turner ST, Weir DR, Wilson JF, van Duijn C, Launer L, Fitzpatrick AL, Seshadri S, Mosley TH, Deary IJ. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015 Feb; 20(2):183-92. PMID: 25644384.
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    42. El Refaey M, Watkins CP, Kennedy EJ, Chang A, Zhong Q, Ding KH, Shi XM, Xu J, Bollag WB, Hill WD, Johnson M, Hunter M, Hamrick MW, Isales CM. Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells. Mol Cell Endocrinol. 2015 Jul 15; 410:87-96. PMID: 25637715.
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    43. Sangani R, Periyasamy-Thandavan S, Kolhe R, Bhattacharyya MH, Chutkan N, Hunter M, Isales C, Hamrick M, Hill WD, Fulzele S. MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells. Mol Cell Endocrinol. 2015 Jul 15; 410:19-26. PMID: 25617715.
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    44. Lopez LM, Hill WD, Harris SE, Valdes Hernandez M, Munoz Maniega S, Bastin ME, Bailey E, Smith C, McBride M, McClure J, Graham D, Dominiczak A, Yang Q, Fornage M, Ikram MA, Debette S, Launer L, Bis JC, Schmidt R, Seshadri S, Porteous DJ, Starr J, Deary IJ, Wardlaw JM. Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke. 2015 Feb; 46(2):341-7. PMID: 25586835.
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    45. Herberg S, Kondrikova G, Hussein KA, Periyasamy-Thandavan S, Johnson MH, Elsalanty ME, Shi X, Hamrick MW, Isales CM, Hill WD. Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation. Tissue Eng Part A. 2014 Dec; 20(23-24):3212-27. PMID: 24914464.
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    46. Herberg S, Kondrikova G, Hussein KA, Johnson MH, Elsalanty ME, Shi X, Hamrick MW, Isales CM, Hill WD. Mesenchymal stem cell expression of stromal cell-derived factor-1ß augments bone formation in a model of local regenerative therapy. J Orthop Res. 2015 Feb; 33(2):174-84. PMID: 25351363.
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    47. Herberg S, Kondrikova G, Periyasamy-Thandavan S, Howie RN, Elsalanty ME, Weiss L, Campbell P, Hill WD, Cray JJ. Inkjet-based biopatterning of SDF-1ß augments BMP-2-induced repair of critical size calvarial bone defects in mice. Bone. 2014 Oct; 67:95-103. PMID: 25016095.
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    48. Refaey ME, Zhong Q, Ding KH, Shi XM, Xu J, Bollag WB, Hill WD, Chutkan N, Robbins R, Nadeau H, Johnson M, Hamrick MW, Isales CM. Impact of dietary aromatic amino acids on osteoclastic activity. Calcif Tissue Int. 2014 Aug; 95(2):174-82. PMID: 25000990.
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    49. Buckley KM, Hess DL, Sazonova IY, Periyasamy-Thandavan S, Barrett JR, Kirks R, Grace H, Kondrikova G, Johnson MH, Hess DC, Schoenlein PV, Hoda MN, Hill WD. Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke. Exp Transl Stroke Med. 2014; 6:8. PMID: 24991402.
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    50. El Refaey M, Zhong Q, Hill WD, Shi XM, Hamrick MW, Bailey L, Johnson M, Xu J, Bollag WB, Chutkan N, Isales CM. Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension. PLoS One. 2014; 9(4):e91108. PMID: 24727733.
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    51. Platt SR, Holmes SP, Howerth EW, Duberstein KJJ, Dove CR, Kinder HA, Wyatt EL, Linville AV, Lau VW, Stice SL, Hill WD, Hess DC, West FD. Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model. Exp Transl Stroke Med. 2014 Mar 23; 6(1):5. PMID: 24655785.
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    52. Herberg S, Susin C, Pelaez M, Howie RN, Moreno de Freitas R, Lee J, Cray JJ, Johnson MH, Elsalanty ME, Hamrick MW, Isales CM, Wikesjö UM, Hill WD. Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1ß cotherapy induces bone regeneration in critical-size rat calvarial defects. Tissue Eng Part A. 2014 May; 20(9-10):1444-53. PMID: 24341891.
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    53. Hill WD, Davies G, van de Lagemaat LN, Christoforou A, Marioni RE, Fernandes CP, Liewald DC, Croning MD, Payton A, Craig LC, Whalley LJ, Horan M, Ollier W, Hansell NK, Wright MJ, Martin NG, Montgomery GW, Steen VM, Le Hellard S, Espeseth T, Lundervold AJ, Reinvang I, Starr JM, Pendleton N, Grant SG, Bates TC, Deary IJ. Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins. Transl Psychiatry. 2014 Jan 07; 4:e341. PMID: 24399044.
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    54. Duberstein KJ, Platt SR, Holmes SP, Dove CR, Howerth EW, Kent M, Stice SL, Hill WD, Hess DC, West FD. Gait analysis in a pre- and post-ischemic stroke biomedical pig model. Physiol Behav. 2014 Feb 10; 125:8-16. PMID: 24286894.
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    55. Sangani R, Pandya CD, Bhattacharyya MH, Periyasamy-Thandavan S, Chutkan N, Markand S, Hill WD, Hamrick M, Isales C, Fulzele S. Knockdown of SVCT2 impairs in-vitro cell attachment, migration and wound healing in bone marrow stromal cells. Stem Cell Res. 2014 Mar; 12(2):354-63. PMID: 24365600.
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    56. Bollag WB, Hill WD. CXCR4 in epidermal keratinocytes: crosstalk within the skin. J Invest Dermatol. 2013 Nov; 133(11):2505-2508. PMID: 24129780.
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    57. Arounleut P, Bowser M, Upadhyay S, Shi XM, Fulzele S, Johnson MH, Stranahan AM, Hill WD, Isales CM, Hamrick MW. Absence of functional leptin receptor isoforms in the POUND (Lepr(db/lb)) mouse is associated with muscle atrophy and altered myoblast proliferation and differentiation. PLoS One. 2013; 8(8):e72330. PMID: 23967295.
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    58. Jensen JL, Walker M, Denike D, Matthews V, Boudreau C, Hill W, Travers A. Paramedic myocardial infarction care with fibrinolytics: a process map and hazard analysis. Prehosp Emerg Care. 2013 Oct-Dec; 17(4):429-34. PMID: 23805871.
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    59. Herberg S, Shi X, Johnson MH, Hamrick MW, Isales CM, Hill WD. Stromal cell-derived factor-1ß mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells. PLoS One. 2013; 8(3):e58207. PMID: 23472159.
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    60. Bowser M, Herberg S, Arounleut P, Shi X, Fulzele S, Hill WD, Isales CM, Hamrick MW. Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. Exp Gerontol. 2013 Feb; 48(2):290-7. PMID: 23178301.
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    61. Herberg S, Fulzele S, Yang N, Shi X, Hess M, Periyasamy-Thandavan S, Hamrick MW, Isales CM, Hill WD. Stromal cell-derived factor-1ß potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro. Tissue Eng Part A. 2013 Jan; 19(1-2):1-13. PMID: 22779446.
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    62. Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, Johnson MH, Hill WD, Ergul A, Fagan SC, Hess DC. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012 Oct; 43(10):2794-9. PMID: 22910893.
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    63. Webster SJ, Mruthinti S, Hill WD, Buccafusco JJ, Terry AV. An aqueous orally active vaccine targeted against a RAGE/AB complex as a novel therapeutic for Alzheimer's disease. Neuromolecular Med. 2012 Jun; 14(2):119-30. PMID: 22415896.
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    64. Hoda MN, Li W, Ahmad A, Ogbi S, Zemskova MA, Johnson MH, Ergul A, Hill WD, Hess DC, Sazonova IY. Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke. Exp Transl Stroke Med. 2011 Dec 16; 3(1):16. PMID: 22177314.
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    65. Wei Q, Hill WD, Su Y, Huang S, Dong Z. Heme oxygenase-1 induction contributes to renoprotection by G-CSF during rhabdomyolysis-associated acute kidney injury. Am J Physiol Renal Physiol. 2011 Jul; 301(1):F162-70. PMID: 21511696.
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    66. Hess DC, Hill WD. Cell therapy for ischaemic stroke. Cell Prolif. 2011 Apr; 44 Suppl 1:1-8. PMID: 21481036.
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    67. Alworth L, Ardayfio KL, Blickman A, Greenhill L, Hill W, Sharp P, Talmage R, Plaut VC, Goren M. Diversity in laboratory animal science: issues and initiatives. J Am Assoc Lab Anim Sci. 2010 Mar; 49(2):138-46. PMID: 20353686.
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    68. Periyasamy-Thandavan S, Jackson WH, Samaddar JS, Erickson B, Barrett JR, Raney L, Gopal E, Ganapathy V, Hill WD, Bhalla KN, Schoenlein PV. Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells. Autophagy. 2010 Jan; 6(1):19-35. PMID: 20110775.
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    69. Kirkpatrick B, Nguyen L, Kondrikova G, Herberg S, Hill WD. Stability of human stromal-derived factor-1alpha (CXCL12alpha) after blood sampling. Ann Clin Lab Sci. 2010; 40(3):257-60. PMID: 20689138.
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    70. Wu YD, Chien CH, Chao YJ, Hamrick MW, Hill WD, Yu JC, Li X. Granulocyte colony-stimulating factor administration alters femoral biomechanical properties in C57BL/6 mice. J Biomed Mater Res A. 2008 Dec 15; 87(4):972-9. PMID: 18257084.
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    71. Zhang W, Ou G, Hamrick M, Hill W, Borke J, Wenger K, Chutkan N, Yu J, Mi QS, Isales CM, Shi XM. Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells. J Bone Miner Res. 2008 Jul; 23(7):1118-28. PMID: 18435580.
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    72. Ding KH, Shi XM, Zhong Q, Kang B, Xie D, Bollag WB, Bollag RJ, Hill W, Washington W, Mi QS, Insogna K, Chutkan N, Hamrick M, Isales CM. Impact of glucose-dependent insulinotropic peptide on age-induced bone loss. J Bone Miner Res. 2008 Apr; 23(4):536-43. PMID: 18072880.
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    73. Perry RT, Gearhart DA, Wiener HW, Harrell LE, Barton JC, Kutlar A, Kutlar F, Ozcan O, Go RC, Hill WD. Hemoglobin binding to A beta and HBG2 SNP association suggest a role in Alzheimer's disease. Neurobiol Aging. 2008 Feb; 29(2):185-93. PMID: 17157413.
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    74. Khan MM, Hadman M, De Sevilla LM, Mahesh VB, Buccafusco J, Hill WD, Brann DW. Cloning, distribution, and colocalization of MNAR/PELP1 with glucocorticoid receptors in primate and nonprimate brain. Neuroendocrinology. 2006; 84(5):317-29. PMID: 17142998.
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    75. Fagan SC, Kozak A, Hill WD, Pollock DM, Xu L, Johnson MH, Ergul A, Hess DC. Hypertension after experimental cerebral ischemia: candesartan provides neurovascular protection. J Hypertens. 2006 Mar; 24(3):535-9. PMID: 16467657.
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    76. Miller JT, Bartley JH, Wimborne HJ, Walker AL, Hess DC, Hill WD, Carroll JE. The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury. BMC Neurosci. 2005 Oct 31; 6:63. PMID: 16259636.
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    77. Bartley J, Soltau T, Wimborne H, Kim S, Martin-Studdard A, Hess D, Hill W, Waller J, Carroll J. BrdU-positive cells in the neonatal mouse hippocampus following hypoxic-ischemic brain injury. BMC Neurosci. 2005 Mar 02; 6:15. PMID: 15743533.
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    78. Shaw G, Yang C, Zhang L, Cook P, Pike B, Hill WD. Characterization of the bovine neurofilament NF-M protein and cDNA sequence, and identification of in vitro and in vivo calpain cleavage sites. Biochem Biophys Res Commun. 2004 Dec 10; 325(2):619-25. PMID: 15530438.
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    79. Mruthinti S, Buccafusco JJ, Hill WD, Waller JL, Jackson TW, Zamrini EY, Schade RF. Autoimmunity in Alzheimer's disease: increased levels of circulating IgGs binding Abeta and RAGE peptides. Neurobiol Aging. 2004 Sep; 25(8):1023-32. PMID: 15212827.
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    80. Xu L, Fagan SC, Waller JL, Edwards D, Borlongan CV, Zheng J, Hill WD, Feuerstein G, Hess DC. Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats. BMC Neurol. 2004 Apr 26; 4:7. PMID: 15109399.
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    81. Hess DC, Hill WD, Carroll JE, Borlongan CV. Do bone marrow cells generate neurons? Arch Neurol. 2004 Apr; 61(4):483-5. PMID: 15096394.
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    82. Hess DC, Abe T, Hill WD, Studdard AM, Carothers J, Masuya M, Fleming PA, Drake CJ, Ogawa M. Hematopoietic origin of microglial and perivascular cells in brain. Exp Neurol. 2004 Apr; 186(2):134-44. PMID: 15026252.
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    83. Mruthinti S, Hill WD, Swamy-Mruthinti S, Buccafusco JJ. Relationship between the induction of RAGE cell-surface antigen and the expression of amyloid binding sites. J Mol Neurosci. 2003; 20(3):223-32. PMID: 14501001.
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    84. Terry AV, Hill WD, Parikh V, Evans DR, Waller JL, Mahadik SP. Differential effects of chronic haloperidol and olanzapine exposure on brain cholinergic markers and spatial learning in rats. Psychopharmacology (Berl). 2002 Dec; 164(4):360-8. PMID: 12457265.
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    85. Hess DC, Hill WD, Martin-Studdard A, Carothers J, Brailer J, Carroll J. Blood into brain after stroke. Trends Mol Med. 2002 Sep; 8(9):452-3. PMID: 12223318.
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    86. Terry AV, Hill WD, Parikh V, Waller JL, Evans DR, Mahadik SP. Differential effects of haloperidol, risperidone, and clozapine exposure on cholinergic markers and spatial learning performance in rats. Neuropsychopharmacology. 2003 Feb; 28(2):300-9. PMID: 12589383.
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    87. Hess DC, Hill WD, Martin-Studdard A, Carroll J, Brailer J, Carothers J. Bone marrow as a source of endothelial cells and NeuN-expressing cells After stroke. Stroke. 2002 May; 33(5):1362-8. PMID: 11988616.
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    88. Casanova MF, Hill WD, Pourdihimi B. Senile plaques exert no mass lesion effect on surrounding neurons. J Neurosci Methods. 2001 Sep 30; 110(1-2):125-33. PMID: 11564532.
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    89. Hill WD, Hess DC, Carroll JE, Wakade CG, Howard EF, Chen Q, Cheng C, Martin-Studdard A, Waller JL, Beswick RA. The NF-kappaB inhibitor diethyldithiocarbamate (DDTC) increases brain cell death in a transient middle cerebral artery occlusion model of ischemia. Brain Res Bull. 2001 Jun; 55(3):375-86. PMID: 11489345.
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    90. Beswick RA, Zhang H, Marable D, Catravas JD, Hill WD, Webb RC. Long-term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response. Hypertension. 2001 Feb; 37(2 Pt 2):781-6. PMID: 11230373.
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    91. Chorsky RL, Yaghmai F, Hill WD, Stopa EG. Alzheimer's disease: a review concerning immune response and microischemia. Med Hypotheses. 2001 Jan; 56(1):124-7. PMID: 11133269.
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    92. Carroll JE, Hess DC, Howard EF, Hill WD. Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury? Neuroreport. 2000 Jun 26; 11(9):R1-4. PMID: 10884021.
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    93. Hess DC, Howard E, Cheng C, Carroll J, Hill WD, Hsu CY. Hypertonic mannitol loading of NF-kappaB transcription factor decoys in human brain microvascular endothelial cells blocks upregulation of ICAM-1. Stroke. 2000 May; 31(5):1179-86. PMID: 10797183.
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    94. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 21287590.
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    95. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 14977065.
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    96. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 26220769.
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    97. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 14748564.
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    98. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 15004018.
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    99. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 12433693.
      Citations:    
    100. Tompkins MM, Hill WD. Contribution of somal Lewy bodies to neuronal death. Brain Res. 1997 Nov 14; 775(1-2):24-9. PMID: 9439824.
      Citations:    
    101. Tompkins MM, Basgall EJ, Zamrini E, Hill WD. Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am J Pathol. 1997 Jan; 150(1):119-31. PMID: 9006329.
      Citations:    
    102. Crino PB, Martin JA, Hill WD, Greenberg B, Lee VM, Trojanowski JQ. Beta-Amyloid peptide and amyloid precursor proteins in olfactory mucosa of patients with Alzheimer's disease, Parkinson's disease, and Down syndrome. Ann Otol Rhinol Laryngol. 1995 Aug; 104(8):655-61. PMID: 7639477.
      Citations:    
    103. Lee JH, Goedert M, Hill WD, Lee VM, Trojanowski JQ. Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord. Exp Neurol. 1993 May; 121(1):93-105. PMID: 8495714.
      Citations:    
    104. Hill WD, Arai M, Cohen JA, Trojanowski JQ. Neurofilament mRNA is reduced in Parkinson's disease substantia nigra pars compacta neurons. J Comp Neurol. 1993 Mar 15; 329(3):328-36. PMID: 8459049.
      Citations:    
    105. Arai H, Lee VM, Hill WD, Greenberg BD, Trojanowski JQ. Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. Brain Res. 1992 Jul 10; 585(1-2):386-90. PMID: 1511324.
      Citations:    
    106. Trojanowski JQ, Newman PD, Hill WD, Lee VM. Human olfactory epithelium in normal aging, Alzheimer's disease, and other neurodegenerative disorders. J Comp Neurol. 1991 Aug 15; 310(3):365-76. PMID: 1723988.
      Citations:    
    107. Schmidt ML, Murray J, Lee VM, Hill WD, Wertkin A, Trojanowski JQ. Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies. Am J Pathol. 1991 Jul; 139(1):53-65. PMID: 1713021.
      Citations:    
    108. Hill WD, Lee VM, Hurtig HI, Murray JM, Trojanowski JQ. Epitopes located in spatially separate domains of each neurofilament subunit are present in Parkinson's disease Lewy bodies. J Comp Neurol. 1991 Jul 01; 309(1):150-60. PMID: 1716646.
      Citations:    
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