Yongxia Wu

Title
InstitutionMedical University of South Carolina
DepartmentMicro And Immuno - Research And PI
AddressP.O. Box MSC 955
HO356
Hollings Cancer Center - 86 Jonathan Lucas St.
Phone843-792-8787
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bastian D, Sui X, Choi HJ, Wu Y, Tian L, Yang K, Liu C, Liu Y, Yu XZ. The Absence of IL-12R?2 Expression on Recipient Nonhematopoietic Cells Diminishes Acute Graft-versus-Host Disease in the Gastrointestinal Tract. J Immunol. 2023 02 15; 210(4):486-495. PMID: 36548465; PMCID: PMC9938950.
      Citations:    Fields:    Translation:Animals
    2. Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G. The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. Nat Commun. 2023 01 03; 14(1):1. PMID: 36596776; PMCID: PMC9810714.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Schutt SD, Wu Y, Kharel A, Bastian D, Choi HJ, Hanief Sofi M, Mealer C, McDaniel Mims B, Nguyen H, Liu C, Helke K, Cui W, Zhang X, Ben-David Y, Yu XZ. The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host disease. J Clin Invest. 2022 11 01; 132(21). PMID: 36074578; PMCID: PMC9621143.
      Citations:    Fields:    Translation:HumansCells
    4. Tian L, Wu Y, Choi HJ, Sui X, Li X, Sofi MH, Kassir MF, Chen X, Mehrotra S, Ogretmen B, Yu XZ. S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission. Cell Mol Immunol. 2022 Nov; 19(11):1235-1250. PMID: 36071219; PMCID: PMC9622814.
      Citations: 3     Fields:    Translation:HumansCells
    5. Wu Y, Mealer C, Schutt S, Wilson CL, Bastian D, Sofi MH, Zhang M, Luo Z, Choi HJ, Yang K, Tian L, Nguyen H, Helke K, Schnapp LM, Wang H, Yu XZ, Wu Y, Mealer C, Schutt S, Wilson CL, Bastian D, Sofi MH, Zhang M, Luo Z, Choi HJ, Yang K, Tian L, Nguyen H, Helke K, Schnapp LM, Wang H, Yu XZ. MicroRNA-31 regulates T-cell metabolism via HIF1a and promotes chronic GVHD pathogenesis in mice. Blood Adv. 2022 05 24; 6(10):3036-3052. PMID: 35073581; PMCID: PMC9131913.
      Citations:    
    6. Sofi MH, Tian L, Schutt S, Khan I, Choi HJ, Wu Y, Bastian D, Ticer T, Kassir MF, Atilgan FC, Kim J, Sui X, Zivkovic A, Mehrotra S, O'Bryan JP, Stark H, Martin PJ, Ogretmen B, Yu XZ, Sofi MH, Tian L, Schutt S, Khan I, Choi HJ, Wu Y, Bastian D, Ticer T, Kassir MF, Atilgan FC, Kim J, Sui X, Zivkovic A, Mehrotra S, O'Bryan JP, Stark H, Martin PJ, Ogretmen B, Yu XZ. Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway. Leukemia. 2022 07; 36(7):1907-1915. PMID: 35513703; PMCID: PMC9256768.
      Citations: 4     Fields:    Translation:HumansCells
    7. Luo Z, Health SL, Li M, Yang H, Wu Y, Collins M, Deeks SG, Martin JN, Scott A, Jiang W, Luo Z, Health SL, Li M, Yang H, Wu Y, Collins M, Deeks SG, Martin JN, Scott A, Jiang W. Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV. EBioMedicine. 2022 Jun; 80:104037. PMID: 35500539; PMCID: PMC9065923.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    8. Wu Y, Fu J, Wang H, Yu XZ, Wu Y, Fu J, Wang H, Yu XZ. Donor T-Cell Repertoire Profiling in Recipient Lymphoid and Parenchyma Organs Reveals GVHD Pathogenesis at Clonal Levels After Bone Marrow Transplantation in Mice. Front Immunol. 2021; 12:778996. PMID: 34950143; PMCID: PMC8688739.
      Citations:    
    9. Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf BJ, Huang L, Yu J, Scott A, Mcrae-Clark A, Hamlett ED, Jiang W, Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf BJ, Huang L, Yu J, Scott A, Mcrae-Clark A, Hamlett ED, Jiang W. Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases ?-amyloid protein production in the brain. EBioMedicine. 2021 Dec; 74:103701. PMID: 34826801; PMCID: PMC8626580.
      Citations:    
    10. Choi HJ, Tang CA, Tian L, Wu Y, Sofi MH, Ticer T, Schutt SD, Hu CA, Yu XZ, Choi HJ, Tang CA, Tian L, Wu Y, Sofi MH, Ticer T, Schutt SD, Hu CA, Yu XZ. XBP-1s Promotes B Cell Pathogenicity in Chronic GVHD by Restraining the Activity of Regulated IRE-1a-Dependent Decay. Front Immunol. 2021; 12:705484. PMID: 34659198; PMCID: PMC8517405.
      Citations:    
    11. Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H, Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H. Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia. J Clin Invest. 2021 08 16; 131(16). PMID: 34255748; PMCID: PMC8363288.
      Citations:    
    12. Bastian D, Sui X, Nguyen HD, Wu Y, Schutt S, Tian L, Sofi MH, Liu Y, Martin P, Bartee E, Yu XZ, Bastian D, Sui X, Nguyen HD, Wu Y, Schutt S, Tian L, Sofi MH, Liu Y, Martin P, Bartee E, Yu XZ. Interleukin-23 receptor signaling by interleukin-39 potentiates T cell pathogenicity in acute graft-versus-host disease. Am J Transplant. 2021 11; 21(11):3538-3549. PMID: 33934505.
      Citations:    
    13. Sofi MH, Wu Y, Ticer T, Schutt S, Bastian D, Choi HJ, Tian L, Mealer C, Liu C, Westwater C, Armeson KE, Alekseyenko AV, Yu XZ, Sofi MH, Wu Y, Ticer T, Schutt S, Bastian D, Choi HJ, Tian L, Mealer C, Liu C, Westwater C, Armeson KE, Alekseyenko AV, Yu XZ. A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD. JCI Insight. 2021 02 08; 6(3). PMID: 33554953; PMCID: PMC7934839.
      Citations:    
    14. Wu Y, Tang CA, Mealer C, Bastian D, Hanief Sofi M, Tian L, Schutt S, Choi HJ, Ticer T, Zhang M, Sui X, Huang L, Mellor AL, Hu CA, Yu XZ, Wu Y, Tang CA, Mealer C, Bastian D, Hanief Sofi M, Tian L, Schutt S, Choi HJ, Ticer T, Zhang M, Sui X, Huang L, Mellor AL, Hu CA, Yu XZ. STING negatively regulates allogeneic T-cell responses by constraining antigen-presenting cell function. Cell Mol Immunol. 2021 03; 18(3):632-643. PMID: 33500563; PMCID: PMC8027033.
      Citations:    
    15. Nguyen H, Alawieh A, Bastian D, Kuril S, Dai M, Daenthanasanmak A, Zhang M, Iamsawat S, Schutt SD, Wu Y, Sleiman MM, Shetty A, Atkinson C, Sun S, Varela JC, Tomlinson S, Yu XZ, Nguyen H, Alawieh A, Bastian D, Kuril S, Dai M, Daenthanasanmak A, Zhang M, Iamsawat S, Schutt SD, Wu Y, Sleiman MM, Shetty A, Atkinson C, Sun S, Varela JC, Tomlinson S, Yu XZ. Targeting the Complement Alternative Pathway Permits Graft Versus Leukemia Activity while Preventing Graft Versus Host Disease. Clin Cancer Res. 2020 07 01; 26(13):3481-3490. PMID: 31919135; PMCID: PMC7334060.
      Citations:    
    16. Bastian D, Wu Y, Betts BC, Yu XZ, Bastian D, Wu Y, Betts BC, Yu XZ. The IL-12 Cytokine and Receptor Family in Graft-vs.-Host Disease. Front Immunol. 2019; 10:988. PMID: 31139181; PMCID: PMC6518430.
      Citations:    
    17. Luo Z, Li M, Wu Y, Meng Z, Martin L, Zhang L, Ogunrinde E, Zhou Z, Qin S, Wan Z, Westerink MAJ, Warth S, Liu H, Jin P, Stroncek D, Li QZ, Wang E, Wu X, Heath SL, Li Z, Alekseyenko AV, Jiang W, Luo Z, Li M, Wu Y, Meng Z, Martin L, Zhang L, Ogunrinde E, Zhou Z, Qin S, Wan Z, Westerink MAJ, Warth S, Liu H, Jin P, Stroncek D, Li QZ, Wang E, Wu X, Heath SL, Li Z, Alekseyenko AV, Jiang W. Systemic translocation of Staphylococcus drives autoantibody production in HIV disease. Microbiome. 2019 02 14; 7(1):25. PMID: 30764863; PMCID: PMC6376754.
      Citations:    
    18. Wu Y, Yu XZ, Wu Y, Yu XZ. Modelling CAR-T therapy in humanized mice. EBioMedicine. 2019 Feb; 40:25-26. PMID: 30665855; PMCID: PMC6413350.
      Citations:    
    19. Bastian D, Liu Y, Wu Y, Schutt S, Nguyen HD, Daenthanasanmak A, Sofi MH, Zhang M, Iamsuwat S, Yu XZ, Bastian D, Liu Y, Wu Y, Schutt S, Nguyen HD, Daenthanasanmak A, Sofi MH, Zhang M, Iamsuwat S, Yu XZ. IL-27 Receptor Signaling on T cells Augments GVHD Severity through Enhancing Th1 Responses. J Immunol Res Ther. 2018; 3(1):151-157. PMID: 30906912; PMCID: PMC6426137.
      Citations:    
    20. Wu Y, Schutt S, Paz K, Zhang M, Flynn RP, Bastian D, Sofi MH, Nguyen H, Dai M, Liu C, Chang YJ, Blazar BR, Yu XZ, Wu Y, Schutt S, Paz K, Zhang M, Flynn RP, Bastian D, Sofi MH, Nguyen H, Dai M, Liu C, Chang YJ, Blazar BR, Yu XZ. MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice. Blood. 2018 04 26; 131(17):1974-1986. PMID: 29530952; PMCID: PMC5921962.
      Citations:    
    21. Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CC, Yu XZ, Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CC, Yu XZ. Inhibition of the IRE-1a/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice. Blood Adv. 2018 02 27; 2(4):414-427. PMID: 29483082; PMCID: PMC5858472.
      Citations:    
    22. Wu Y, Yu XZ, Wu Y, Yu XZ. IL-17A ? Th17 in GvHD. Cell Mol Immunol. 2018 03; 15(3):282-283. PMID: 27796285; PMCID: PMC5843611.
      Citations:    
    23. Heinrichs J, Li J, Nguyen H, Wu Y, Bastian D, Daethanasanmak A, Sofi MH, Schutt S, Liu C, Jin J, Betts B, Anasetti C, Yu XZ, Heinrichs J, Li J, Nguyen H, Wu Y, Bastian D, Daethanasanmak A, Sofi MH, Schutt S, Liu C, Jin J, Betts B, Anasetti C, Yu XZ. CD8(+) Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4(+) Tregs in mice. Oncoimmunology. 2016 Jun; 5(6):e1146842. PMID: 27471614; PMCID: PMC4938369.
      Citations:    
    24. Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, Yu XZ, Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, Yu XZ. T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice. J Immunol. 2016 Apr 01; 196(7):3168-79. PMID: 26903480; PMCID: PMC4799777.
      Citations:    
    25. Orr RK, Hoehn JL, Col NF, Schutt SD, Fu J, Nguyen H, Bastian D, Heinrichs J, Wu Y, Liu C, McDonald DG, Pidala J, Yu XZ. Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice. PLoS One. 2015; 10(9):e0137641. PMID: 26348529; PMCID: PMC4562702.
      Citations:    
    26. Wu Y, Heinrichs J, Bastian D, Fu J, Nguyen H, Schutt S, Liu Y, Jin J, Liu C, Li QJ, Xia C, Yu XZ, Wu Y, Heinrichs J, Bastian D, Fu J, Nguyen H, Schutt S, Liu Y, Jin J, Liu C, Li QJ, Xia C, Yu XZ. MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice. Blood. 2015 Sep 10; 126(11):1314-23. PMID: 26138686; PMCID: PMC4566810.
      Citations:    
    27. Orr RK, Hoehn JL, Col NF, Wu Y, Bastian D, Schutt S, Nguyen H, Fu J, Heinrichs J, Xia C, Yu XZ. Essential Role of Interleukin-12/23p40 in the Development of Graft-versus-Host Disease in Mice. Biol Blood Marrow Transplant. 2015 Jul; 21(7):1195-204. PMID: 25846718; PMCID: PMC4466028.
      Citations:    
    28. Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K, Bastian D, McDonald DG, Anasetti C, Yu XZ, Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K, Bastian D, McDonald DG, Anasetti C, Yu XZ. T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function. J Immunol. 2015 Jan 01; 194(1):388-97. PMID: 25404360; PMCID: PMC4314960.
      Citations:    
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