Cytochrome P-450 CYP1A1

"Cytochrome P-450 CYP1A1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.

Descriptor ID	D019363
MeSH Number(s)	D08.244.453.005.332 D08.244.453.100.500 D08.811.682.690.708.170.010.277 D08.811.682.690.708.170.020.500 D12.776.422.220.453.010.332 D12.776.422.220.453.100.500
Concept/Terms	Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 Cytochrome P 450 CYP1A1 EROD Ethoxyresorufin Dealkylase Ethylresorufin O-Deethylase CYP1A1 Protein 7-Ethoxyresorufin O-Deethylase CYP1A1 Cytochrome P450 IA1 Ethoxyresorufin O-Deethylase CYP 1A1

Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP1A1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Aryl Hydrocarbon Hydroxylases [D08.244.453.005]
Cytochrome P-450 CYP1A1 [D08.244.453.005.332]
Cytochrome P450 Family 1 [D08.244.453.100]
Cytochrome P-450 CYP1A1 [D08.244.453.100.500]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Aryl Hydrocarbon Hydroxylases [D08.811.682.690.708.170.010]
Cytochrome P-450 CYP1A1 [D08.811.682.690.708.170.010.277]
Cytochrome P450 Family 1 [D08.811.682.690.708.170.020]
Cytochrome P-450 CYP1A1 [D08.811.682.690.708.170.020.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Aryl Hydrocarbon Hydroxylases [D12.776.422.220.453.010]
Cytochrome P-450 CYP1A1 [D12.776.422.220.453.010.332]
Cytochrome P450 Family 1 [D12.776.422.220.453.100]
Cytochrome P-450 CYP1A1 [D12.776.422.220.453.100.500]

Below are MeSH descriptors whose meaning is related to "Cytochrome P-450 CYP1A1".

Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP1A1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cytochrome P-450 CYP1A1" by people in this website by year, and whether "Cytochrome P-450 CYP1A1" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 1996 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	1	1
2007	1	0	1
2009	1	0	1
2010	1	1	2
2012	0	1	1
2014	0	1	1
2016	1	0	1
2017	1	0	1

Below are the most recent publications written about "Cytochrome P-450 CYP1A1" by people in Profiles.

Hale MD, Galligan TM, Rainwater TR, Moore BC, Wilkinson PM, Guillette LJ, Parrott BB. AHR and CYP1A expression link historical contamination events to modern day developmental effects in the American alligator. Environ Pollut. 2017 Nov; 230:1050-1061.

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Parada H, Steck SE, Cleveland RJ, Teitelbaum SL, Neugut AI, Santella RM, Gammon MD. Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence. Ann Epidemiol. 2017 03; 27(3):208-214.e1.

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Spink BC, Bloom MS, Wu S, Sell S, Schneider E, Ding X, Spink DC. Analysis of the AHR gene proximal promoter GGGGC-repeat polymorphism in lung, breast, and colon cancer. Toxicol Appl Pharmacol. 2015 Jan 01; 282(1):30-41.

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Singh NP, Singh UP, Guan H, Nagarkatti P, Nagarkatti M. Prenatal exposure to TCDD triggers significant modulation of microRNA expression profile in the thymus that affects consequent gene expression. PLoS One. 2012; 7(9):e45054.

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Singh NP, Singh US, Nagarkatti M, Nagarkatti PS. Resveratrol (3,5,4'-trihydroxystilbene) protects pregnant mother and fetus from the immunotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Nutr Food Res. 2011 Feb; 55(2):209-19.

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Vibhuti A, Arif E, Mishra A, Deepak D, Singh B, Rahman I, Mohammad G, Pasha MA. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. Clin Chim Acta. 2010 Apr 02; 411(7-8):474-80.

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Chi AC, Appleton K, Henriod JB, Krayer JW, Marlow NM, Bandyopadhyay D, Sigmon RC, Kurtz DT. Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa. Oral Oncol. 2009 Nov; 45(11):980-5.

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Montie EW, Fair PA, Bossart GD, Mitchum GB, Houde M, Muir DC, Letcher RJ, McFee WE, Starczak VR, Stegeman JJ, Hahn ME. Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States. Aquat Toxicol. 2008 Feb 18; 86(3):397-412.

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Lecavalier P, Chu I, Yagminas A, Villeneuve DC, Poon R, Feeley M, Håkansson H, Ahlborg UG, Valli VE, Bergman A, Seegal RF, Kennedy SW. Subchronic toxicity of 2,2',3,3',4,4'-hexachlorobiphenyl in rats. J Toxicol Environ Health. 1997 Jun 27; 51(3):265-77.

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Chu I, Villeneuve DC, Yagminas A, Lecavalier P, Poon R, Håkansson H, Ahlborg UG, Valli VE, Kennedy SW, Bergman A, Seegal RF, Feeley M. Toxicity of 2,4,4'-trichlorobiphenyl in rats following 90-day dietary exposure. J Toxicol Environ Health. 1996 Oct 25; 49(3):301-18.

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