Calcium Channels, L-Type

"Calcium Channels, L-Type" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.

Descriptor ID	D020746
MeSH Number(s)	D12.776.157.530.400.150.400 D12.776.543.550.450.150.400 D12.776.543.585.400.150.400
Concept/Terms	Calcium Channels, L-Type Calcium Channels, L-Type Calcium Channels, L Type L-Type VDCC L Type VDCC VDCC, L-Type L-Type Calcium Channel Calcium Channel, L-Type L Type Calcium Channel L-Type Voltage-Dependent Calcium Channels L Type Voltage Dependent Calcium Channels L-Type Calcium Channels L Type Calcium Channels Long-Lasting Calcium Channels Calcium Channels, Long-Lasting Long Lasting Calcium Channels Receptors, Dihydropyridine Receptors, Dihydropyridine L-Type VDCC alpha-1 Subunit L Type VDCC alpha 1 Subunit Dihydropyridine Receptor Receptor, Dihydropyridine Dihydropyridine Receptors L-Type VDCC delta Subunit L-Type VDCC delta Subunit L Type VDCC delta Subunit L-Type VDCC alpha-2 Subunit L-Type VDCC alpha-2 Subunit L Type VDCC alpha 2 Subunit L-Type VDCC beta Subunit L-Type VDCC beta Subunit L Type VDCC beta Subunit L-Type VDCC gamma Subunit L-Type VDCC gamma Subunit L Type VDCC gamma Subunit

Below are MeSH descriptors whose meaning is more general than "Calcium Channels, L-Type".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Calcium Channels [D12.776.157.530.400.150]
Calcium Channels, L-Type [D12.776.157.530.400.150.400]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Calcium Channels [D12.776.543.550.450.150]
Calcium Channels, L-Type [D12.776.543.550.450.150.400]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Calcium Channels [D12.776.543.585.400.150]
Calcium Channels, L-Type [D12.776.543.585.400.150.400]

Below are MeSH descriptors whose meaning is related to "Calcium Channels, L-Type".

Below are MeSH descriptors whose meaning is more specific than "Calcium Channels, L-Type".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calcium Channels, L-Type" by people in this website by year, and whether "Calcium Channels, L-Type" was a major or minor topic of these publications.

Bar chart showing 29 publications over 16 distinct years, with a maximum of 3 publications in 2003 and 2009 and 2010 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	2	2
2000	0	2	2
2002	0	2	2
2003	2	1	3
2004	2	0	2
2005	0	1	1
2006	0	2	2
2007	1	0	1
2009	2	1	3
2010	1	2	3
2011	1	0	1
2012	1	0	1
2013	1	0	1
2014	1	2	3
2015	0	1	1

Below are the most recent publications written about "Calcium Channels, L-Type" by people in Profiles.

Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA. Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging. 2016 Feb; 38:141-150.

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Genewsky A, Jost I, Busch C, Huber C, Stindl J, Skerka C, Zipfel PF, Rohrer B, Strauß O. Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium. Pflugers Arch. 2015 Oct; 467(10):2179-91.

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Spencer S, Brown RM, Quintero GC, Kupchik YM, Thomas CA, Reissner KJ, Kalivas PW. a2d-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse. J Neurosci. 2014 Jun 18; 34(25):8605-11.

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Rohrer B, Kunchithapautham K, Genewsky A, Strauß O. Prolonged SRC kinase activation, a mechanism to turn transient, sublytic complement activation into a sustained pathological condition in retinal pigment epithelium cells. Adv Exp Med Biol. 2014; 801:221-7.

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Scaringi JA, Rosa AO, Morad M, Cleemann L. A new method to detect rapid oxygen changes around cells: how quickly do calcium channels sense oxygen in cardiomyocytes? J Appl Physiol (1985). 2013 Dec; 115(12):1855-61.

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Rosa AO, Movafagh S, Cleemann L, Morad M. Hypoxic regulation of cardiac Ca2+ channel: possible role of haem oxygenase. J Physiol. 2012 Sep 01; 590(17):4223-37.

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Movafagh S, Cleemann L, Morad M. Regulation of cardiac Ca(2+) channel by extracellular Na(+). Cell Calcium. 2011 Mar; 49(3):162-73.

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Das A, Smith JA, Gibson C, Varma AK, Ray SK, Banik NL. Estrogen receptor agonists and estrogen attenuate TNF-a-induced apoptosis in VSC4.1 motoneurons. J Endocrinol. 2011 Feb; 208(2):171-82.

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Movafagh S, Morad M. L-type calcium channel as a cardiac oxygen sensor. Ann N Y Acad Sci. 2010 Feb; 1188:153-8.

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Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, Treves S, Dirksen RT, Meissner G, Muntoni F, Jungbluth H. Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene. Neuromuscul Disord. 2010 Mar; 20(3):166-73.

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