Hypoxanthine Phosphoribosyltransferase
"Hypoxanthine Phosphoribosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
| Descriptor ID |
D007041
|
| MeSH Number(s) |
D08.811.913.400.725.450
|
| Concept/Terms |
Hypoxanthine Phosphoribosyltransferase- Hypoxanthine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine
- IMP Pyrophosphorylase
- Pyrophosphorylase, IMP
- HGPRT
- HPRT
- HPRTase
- Hypoxanthine-Guanine Phosphoribosyltransferase
- Hypoxanthine Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine-Guanine
- Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Guanine
|
Below are MeSH descriptors whose meaning is more general than "Hypoxanthine Phosphoribosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Hypoxanthine Phosphoribosyltransferase".
This graph shows the total number of publications written about "Hypoxanthine Phosphoribosyltransferase" by people in this website by year, and whether "Hypoxanthine Phosphoribosyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hypoxanthine Phosphoribosyltransferase" by people in Profiles.
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Genotype-phenotype correlations in neurogenetics: Lesch-Nyhan disease as a model disorder. Brain. 2014 May; 137(Pt 5):1282-303.
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Gene targeting in the mouse: advances in introduction of transgenes into the genome by homologous recombination. Endocrine. 2002 Dec; 19(3):229-38.
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Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation. BMC Biotechnol. 2001; 1:12.
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IL-12-mediated increases in protection elicited by pneumococcal and meningococcal conjugate vaccines. Vaccine. 2001 Feb 28; 19(15-16):2020-8.
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Isolation and characterization of mutant cell lines defective in transforming growth factor beta signaling. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):7655-60.