A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)

Descriptor ID	D004830
MeSH Number(s)	C10.228.140.490.375.290
Concept/Terms	Epilepsy, Tonic-Clonic Epilepsy, Tonic-Clonic Epilepsies, Tonic-Clonic Epilepsy, Tonic Clonic Tonic-Clonic Epilepsies Tonic-Clonic Epilepsy Epilepsy, Grand Mal Grand Mal Epilepsy Epilepsy, Major Major Epilepsies Major Epilepsy Grand Mal Seizure Disorder Major Motor Seizure Disorder Tonic-Clonic Seizure Syndrome Seizure Syndrome, Tonic-Clonic Seizure Syndromes, Tonic-Clonic Syndrome, Tonic-Clonic Seizure Syndromes, Tonic-Clonic Seizure Tonic Clonic Seizure Syndrome Tonic-Clonic Seizure Syndromes Seizure Disorder, Major Motor Seizure Disorder, Tonic Clonic Tonic Clonic Convulsions Convulsion, Tonic Clonic Convulsions, Tonic Clonic Tonic Clonic Convulsion Tonic-Clonic Convulsion Disorder Convulsion Disorder, Tonic-Clonic Convulsion Disorders, Tonic-Clonic Disorder, Tonic-Clonic Convulsion Disorders, Tonic-Clonic Convulsion Tonic Clonic Convulsion Disorder Tonic-Clonic Convulsion Disorders Tonic-Clonic Convulsion Syndrome Convulsion Syndrome, Tonic-Clonic Convulsion Syndromes, Tonic-Clonic Syndrome, Tonic-Clonic Convulsion Syndromes, Tonic-Clonic Convulsion Tonic Clonic Convulsion Syndrome Tonic-Clonic Convulsion Syndromes Tonic-Clonic Seizure Disorder Disorder, Tonic-Clonic Seizure Disorders, Tonic-Clonic Seizure Seizure Disorder, Tonic-Clonic Seizure Disorders, Tonic-Clonic Tonic Clonic Seizure Disorder Tonic-Clonic Seizure Disorders Convulsions, Grand Mal Convulsion, Grand Mal Grand Mal Convulsion Grand Mal Convulsions Seizure Disorder, Grand Mal Epilepsy, Tonic-Clonic, Symptomatic Epilepsy, Tonic-Clonic, Symptomatic Symptomatic Tonic-Clonic Epilepsy Epilepsies, Symptomatic Tonic-Clonic Epilepsy, Symptomatic Tonic-Clonic Symptomatic Tonic Clonic Epilepsy Symptomatic Tonic-Clonic Epilepsies Tonic-Clonic Epilepsies, Symptomatic Tonic-Clonic Epilepsy, Symptomatic Cryptogenic Tonic-Clonic Epilepsy Cryptogenic Tonic-Clonic Epilepsy Cryptogenic Tonic Clonic Epilepsy Cryptogenic Tonic-Clonic Epilepsies Epilepsies, Cryptogenic Tonic-Clonic Epilepsy, Cryptogenic Tonic-Clonic Tonic-Clonic Epilepsies, Cryptogenic Tonic-Clonic Epilepsy, Cryptogenic Epilepsy, Tonic-Clonic, Cryptogenic Epilepsy, Tonic-Clonic, Familial Epilepsy, Tonic-Clonic, Familial Familial Tonic-Clonic Epilepsy Epilepsies, Familial Tonic-Clonic Epilepsy, Familial Tonic-Clonic Familial Tonic Clonic Epilepsy Familial Tonic-Clonic Epilepsies Tonic-Clonic Epilepsies, Familial Tonic-Clonic Epilepsy, Familial

Below are MeSH descriptors whose meaning is more general than "Epilepsy, Tonic-Clonic".

Below are MeSH descriptors whose meaning is related to "Epilepsy, Tonic-Clonic".

Below are MeSH descriptors whose meaning is more specific than "Epilepsy, Tonic-Clonic".