Trypsin Inhibitor, Kazal Pancreatic

"Trypsin Inhibitor, Kazal Pancreatic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premataure activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.

Descriptor ID	D014359
MeSH Number(s)	D12.644.822.750.500 D12.776.124.050.850 D12.776.645.688.500
Concept/Terms	Trypsin Inhibitor, Kazal Pancreatic Trypsin Inhibitor, Kazal Pancreatic Serine Protease Inhibitor Kazal-Type 1 Serine Protease Inhibitor Kazal Type 1 Pancreatic Secretory Trypsin Inhibitor SPINK1 Trypsin Inhibitor Kazal Pancreatic Pancreatic Trypsin Secretory Inhibitor, Kazal Inhibitor, Tumor-Associated Trypsin Inhibitor, Tumor Associated Trypsin Trypsin Inhibitor, Tumor-Associated Trypsin Inhibitor, Tumor Associated Tumor-Associated Trypsin Inhibitor Tumor Associated Trypsin Inhibitor Acidic Pancreatic Trypsin Inhibitor Pancreatic Secretory Trypsin Inhibitor, Kazal Serine Peptidase Inhibitor, Kazal-Type 1 Serine Peptidase Inhibitor, Kazal Type 1 Kazal Pancreatic Trypsin Inhibitor

Below are MeSH descriptors whose meaning is more general than "Trypsin Inhibitor, Kazal Pancreatic".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Proteinase Inhibitory Proteins, Secretory [D12.644.822]
Serine Peptidase Inhibitors, Kazal Type [D12.644.822.750]
Trypsin Inhibitor, Kazal Pancreatic [D12.644.822.750.500]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Acute-Phase Proteins [D12.776.124.050]
Trypsin Inhibitor, Kazal Pancreatic [D12.776.124.050.850]
Proteinase Inhibitory Proteins, Secretory [D12.776.645]
Serine Peptidase Inhibitors, Kazal Type [D12.776.645.688]
Trypsin Inhibitor, Kazal Pancreatic [D12.776.645.688.500]

Below are MeSH descriptors whose meaning is related to "Trypsin Inhibitor, Kazal Pancreatic".

Below are MeSH descriptors whose meaning is more specific than "Trypsin Inhibitor, Kazal Pancreatic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Trypsin Inhibitor, Kazal Pancreatic" by people in this website by year, and whether "Trypsin Inhibitor, Kazal Pancreatic" was a major or minor topic of these publications.

Bar chart showing 8 publications over 5 distinct years, with a maximum of 2 publications in 2010 and 2016 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2010	0	2	2
2016	0	2	2
2018	1	1	2
2020	0	1	1

Below are the most recent publications written about "Trypsin Inhibitor, Kazal Pancreatic" by people in Profiles.

Lewis MD, Talluri J, Wilcox CM, Abberbock JN, Tang G, Conwell DL, Banks PA, Cote GA, Sherman S, Alkaade S, Gardner TB, Anderson MA, Sandhu BS, Muniraj T, Forsmark CE, Guda N, Gelrud A, Romagnuolo J, Brand R, LaRusch J, Amann ST, Slivka A, Whitcomb DC, Yadav D. Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort. Clin Gastroenterol Hepatol. 2021 02; 19(2):349-357.

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Abu-El-Haija M, Hornung L, Denson LA, Husami A, Lin TK, Matlock K, Nathan JD, Palermo JJ, Thompson T, Valencia CA, Wang X, Woo J, Zhang K, Elder D. Prevalence of abnormal glucose metabolism in pediatric acute, acute recurrent and chronic pancreatitis. PLoS One. 2018; 13(10):e0204979.

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Boortalary T, Jalaly NY, Moran RA, Makary MA, Walsh C, Lennon AM, Zaheer A, Singh VK. Metastatic Pancreatic Adenocarcinoma in a Patient With Chronic Calcific Pancreatitis and a Heterozygous SPINK1 c.194+2T>C Mutation. Pancreas. 2018 Apr; 47(4):e24-e25.

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Moran RA, Klapheke R, Jalaly NY, Makary MA, Hirose K, Goggins M, Wood L, Laheru DA, Lennon AM, Khashab MA, Singh VK. Metastatic pancreatic adenocarcinoma associated with chronic calcific pancreatitis and a heterozygous SPINK1 N34S mutation. Pancreatology. 2016 Sep-Oct; 16(5):869-72.

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Moran RA, Quesada-Vazquez N, Sinha A, de-Madaria E, Singh VK. High Penetrance of the PRSS1 A16V Mutation in a Kindred With SPINK1 N34S and CFTR TG11-5T Co-mutations. Pancreas. 2016 Jan; 45(1):e2-4.

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Schneider A, Larusch J, Sun X, Aloe A, Lamb J, Hawes R, Cotton P, Brand RE, Anderson MA, Money ME, Banks PA, Lewis MD, Baillie J, Sherman S, Disario J, Burton FR, Gardner TB, Amann ST, Gelrud A, George R, Rockacy MJ, Kassabian S, Martinson J, Slivka A, Yadav D, Oruc N, Barmada MM, Frizzell R, Whitcomb DC. Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis. Gastroenterology. 2011 Jan; 140(1):162-71.

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Nathan JD, Romac J, Peng RY, Peyton M, Rockey DC, Liddle RA. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas. 2010 Jan; 39(1):e24-30.

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Muddana V, Lamb J, Greer JB, Elinoff B, Hawes RH, Cotton PB, Anderson MA, Brand RE, Slivka A, Whitcomb DC. Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol. World J Gastroenterol. 2008 Jul 28; 14(28):4486-91.

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