"Mevalonic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.
| Descriptor ID |
D008798
|
| MeSH Number(s) |
D02.241.511.579
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Mevalonic Acid".
Below are MeSH descriptors whose meaning is more specific than "Mevalonic Acid".
This graph shows the total number of publications written about "Mevalonic Acid" by people in this website by year, and whether "Mevalonic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1997 | 2 | 0 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2016 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mevalonic Acid" by people in Profiles.
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Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N-glycosylation Abundance and Branching. Cancer Res. 2021 05 15; 81(10):2625-2635.
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Chamber-specific differences in human cardiac fibroblast proliferation and responsiveness toward simvastatin. Am J Physiol Cell Physiol. 2016 08 01; 311(2):C330-9.
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Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. J Immunol. 2016 Feb 15; 196(4):1461-70.
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Cholesterol and the development of clear-cell renal carcinoma. Curr Opin Pharmacol. 2012 Dec; 12(6):742-50.
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Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. Am J Pathol. 2012 Sep; 181(3):993-1006.
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Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. Neuroscience. 2012 Jan 27; 202:1-9.
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Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol Pharmacol. 2008 May; 73(5):1381-93.
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Simvastatin protection against acute immune-mediated glomerulonephritis in mice. Kidney Int. 2006 Feb; 69(3):457-63.
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Rho/ROCK pathway as a target of tumor therapy. J Neurosci Res. 2006 Feb 01; 83(2):243-55.
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Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis. Mol Carcinog. 2004 Sep; 41(1):39-53.