Pulmonary Surfactant-Associated Protein A
"Pulmonary Surfactant-Associated Protein A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
| Descriptor ID |
D037662
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| MeSH Number(s) |
D12.776.503.280.249.600 D12.776.823.100
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pulmonary Surfactant-Associated Protein A".
Below are MeSH descriptors whose meaning is more specific than "Pulmonary Surfactant-Associated Protein A".
This graph shows the total number of publications written about "Pulmonary Surfactant-Associated Protein A" by people in this website by year, and whether "Pulmonary Surfactant-Associated Protein A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 3 | 1 | 4 |
| 2007 | 2 | 1 | 3 |
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Below are the most recent publications written about "Pulmonary Surfactant-Associated Protein A" by people in Profiles.
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Innate and adaptive mediators in cystic fibrosis and allergic fungal rhinosinusitis. Am J Rhinol. 2007 Sep-Oct; 21(5):538-41.
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Mechanical ventilation down-regulates surfactant protein A and keratinocyte growth factor expression in premature rabbits. Pediatr Res. 2007 Sep; 62(3):277-82.
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Sinonasal surfactant protein A1, A2, and D gene expression in cystic fibrosis: a preliminary report. Otolaryngol Head Neck Surg. 2007 Jul; 137(1):34-8.
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Surfactant protein A and D in human sinus mucosa: a preliminary report. ORL J Otorhinolaryngol Relat Spec. 2007; 69(1):57-60.
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Immunolocalization of surfactant protein A and D in sinonasal mucosa. Am J Rhinol. 2006 Jul-Aug; 20(4):461-5.
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Identification and characterization of p63 (CKAP4/ERGIC-63/CLIMP-63), a surfactant protein A binding protein, on type II pneumocytes. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L436-46.
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Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis. Am J Physiol Lung Cell Mol Physiol. 2006 Aug; 291(2):L181-90.
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Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity. J Biol Chem. 2006 Mar 17; 281(11):7515-25.
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Surfactant protein A-polylysine conjugates for delivery of DNA to airway cells in culture. Hum Gene Ther. 1995 Jan; 6(1):31-40.
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Surfactant peptides stimulate uptake of phosphatidylcholine by isolated cells. Biochim Biophys Acta. 1989 Nov 28; 1006(2):237-45.