Ophthalmoplegia, Chronic Progressive External
"Ophthalmoplegia, Chronic Progressive External" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
| Descriptor ID |
D017246
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| MeSH Number(s) |
C05.651.460.700 C10.292.562.750.250 C10.597.622.447.511 C10.668.491.500.700 C11.590.472.250 C18.452.660.560.700 C23.888.592.636.447.511
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| Concept/Terms |
Ophthalmoplegia, Chronic Progressive External- Ophthalmoplegia, Chronic Progressive External
- Graefe Disease
- Disease, Graefe
- Mitochondrial Ocular Myopathy
- Myopathy, Mitochondrial Ocular
- Ocular Myopathy, Mitochondrial
- Chronic Progressive External Ophthalmoplegia
- Graefe's Disease
- Ocular Myopathy of Von Graefe-Fuchs
- Ocular Myopathy of Von Graefe Fuchs
- Ophthalmoplegia, Progressive External
- External Ophthalmoplegia, Progressive
- Progressive External Ophthalmoplegia
- CPEO
- Ocular Muscular Dystrophy
- Dystrophy, Ocular Muscular
- Muscular Dystrophies, Ocular
- Muscular Dystrophy, Ocular
- Ocular Muscular Dystrophies
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Below are MeSH descriptors whose meaning is more general than "Ophthalmoplegia, Chronic Progressive External".
Below are MeSH descriptors whose meaning is more specific than "Ophthalmoplegia, Chronic Progressive External".
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Below are the most recent publications written about "Ophthalmoplegia, Chronic Progressive External" by people in Profiles.
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Clinical features associated with the A-->G transition at nucleotide 8344 of mtDNA ("MERRF mutation"). Neurology. 1993 Jun; 43(6):1200-6.