Masahiro Kono

Title
InstitutionMedical University of South Carolina
DepartmentOphthalmology
AddressP.O. Box MSC 676
714
167 Ashley Ave.
Phone843-792-6676
ORCID ORCID Icon0000-0001-7377-1664 Additional info
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    Collapse Biography 
    Collapse education and training
    Massachusetts Institute of Technology, Cambridge, MABS06/1986Chemistry
    University of Illinois at Urbana-Champaign, Urbana, ILPhD10/1994Biophysics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Luo DG, Silverman D, Frederiksen R, Adhikari R, Cao LH, Oatis JE, Kono M, Cornwall MC, Yau KW, Luo DG, Silverman D, Frederiksen R, Adhikari R, Cao LH, Oatis JE, Kono M, Cornwall MC, Yau KW. Apo-Opsin and Its Dark Constitutive Activity across Retinal Cone Subtypes. Curr Biol. 2020 12 21; 30(24):4921-4931.e5. PMID: 33065015; PMCID: PMC8561704.
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    2. Chen C, Kono M, Koutalos Y, Chen C, Kono M, Koutalos Y. Photooxidation mediated by 11-cis and all-trans retinal in single isolated mouse rod photoreceptors. Photochem Photobiol Sci. 2020 Oct 14; 19(10):1300-1307. PMID: 32812970; PMCID: PMC7559207.
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    3. Hanneken A, Neikirk T, Johnson J, Kono M, Hanneken A, Neikirk T, Johnson J, Kono M. Biochemical Measurements of Free Opsin in Macular Degeneration Eyes: Examining the 11-CIS Retinal Deficiency Hypothesis of Delayed Dark Adaptation (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc. 2017 Aug; 115:T1. PMID: 28900371; PMCID: PMC5572981.
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    4. Crouch RK, Koutalos Y, Kono M, Schey K, Ablonczy Z, Crouch RK, Koutalos Y, Kono M, Schey K, Ablonczy Z. A2E and Lipofuscin. Prog Mol Biol Transl Sci. 2015; 134:449-63. PMID: 26310170.
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    5. Kono M, Kono M. Cone Health and Retinoids. Prog Mol Biol Transl Sci. 2015; 134:465-76. PMID: 26310171.
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    6. Tam BM, Noorwez SM, Kaushal S, Kono M, Moritz OL, Tam BM, Noorwez SM, Kaushal S, Kono M, Moritz OL. Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa. J Neurosci. 2014 Oct 01; 34(40):13336-48. PMID: 25274813; PMCID: PMC4180472.
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    7. Isayama T, Chen Y, Kono M, Fabre E, Slavsky M, DeGrip WJ, Ma JX, Crouch RK, Makino CL, Isayama T, Chen Y, Kono M, Fabre E, Slavsky M, DeGrip WJ, Ma JX, Crouch RK, Makino CL. Coexpression of three opsins in cone photoreceptors of the salamander Ambystoma tigrinum. J Comp Neurol. 2014 Jul 01; 522(10):2249-65. PMID: 24374736; PMCID: PMC3997598.
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    8. Crouch RK, Kono M, Crouch RK, Kono M. Ligand control of g protein-coupled receptor activity: new insights. Chem Biol. 2014 Mar 20; 21(3):309-10. PMID: 24655920.
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    9. Bandyopadhyay M, Kono M, Rohrer B, Bandyopadhyay M, Kono M, Rohrer B. Explant cultures of Rpe65-/- mouse retina: a model to investigate cone opsin trafficking. Mol Vis. 2013; 19:1149-57. PMID: 23734084; PMCID: PMC3669539.
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    10. Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK, Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK. New insights into retinoid metabolism and cycling within the retina. Prog Retin Eye Res. 2013 Jan; 32:48-63. PMID: 23063666; PMCID: PMC3746031.
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    11. Fan J, Crouch RK, Kono M, Fan J, Crouch RK, Kono M. Light prevents exogenous 11-cis retinal from maintaining cone photoreceptors in chromophore-deficient mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2412-6. PMID: 21228385; PMCID: PMC3081252.
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    12. Kono M, Crouch RK, Kono M, Crouch RK. Probing human red cone opsin activity with retinal analogues. J Nat Prod. 2011 Mar 25; 74(3):391-4. PMID: 21314100; PMCID: PMC3064742.
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    13. Kono M, Crouch RK, Kono M, Crouch RK. In vitro assays of rod and cone opsin activity: retinoid analogs as agonists and inverse agonists. Methods Mol Biol. 2010; 652:85-94. PMID: 20552423; PMCID: PMC3694563.
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    14. Kono M, Kono M. Assays for inverse agonists in the visual system. Methods Enzymol. 2010; 485:213-24. PMID: 21050919; PMCID: PMC3697084.
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    15. Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K, Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, M?ller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26; 48(20):4294-304. PMID: 19348429; PMCID: PMC2710298.
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    16. Ala-Laurila P, Cornwall MC, Crouch RK, Kono M, Ala-Laurila P, Cornwall MC, Crouch RK, Kono M. The action of 11-cis-retinol on cone opsins and intact cone photoreceptors. J Biol Chem. 2009 Jun 12; 284(24):16492-16500. PMID: 19386593; PMCID: PMC2713570.
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    17. Kono M, Goletz PW, Crouch RK, Kono M, Goletz PW, Crouch RK. 11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle. Biochemistry. 2008 Jul 15; 47(28):7567-71. PMID: 18563917; PMCID: PMC2561911.
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    18. McKee TD, Lewis MR, Kono M, McKee TD, Lewis MR, Kono M. Engineering a "steric doorstop" in rhodopsin: converting an inverse agonist to an agonist. Biochemistry. 2007 Oct 30; 46(43):12248-52. PMID: 17918963.
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    19. Lewis MR, Kono M, Lewis MR, Kono M. Rhodopsin deactivation is affected by mutations of Tyrl91. Photochem Photobiol. 2006 Nov-Dec; 82(6):1442-6. PMID: 16906791.
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    20. Ablonczy Z, Kono M, Knapp DR, Crouch RK, Ablonczy Z, Kono M, Knapp DR, Crouch RK. Palmitylation of cone opsins. Vision Res. 2006 Dec; 46(27):4493-501. PMID: 16989884; PMCID: PMC2025682.
      Citations:    
    21. Kono M, Kono M. Constitutive activity of a UV cone opsin. FEBS Lett. 2006 Jan 09; 580(1):229-32. PMID: 16368093; PMCID: PMC1661692.
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    22. Sutton RB, Vishnivetskiy SA, Robert J, Hanson SM, Raman D, Knox BE, Kono M, Navarro J, Gurevich VV, Sutton RB, Vishnivetskiy SA, Robert J, Hanson SM, Raman D, Knox BE, Kono M, Navarro J, Gurevich VV. Crystal structure of cone arrestin at 2.3A: evolution of receptor specificity. J Mol Biol. 2005 Dec 16; 354(5):1069-80. PMID: 16289201.
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    23. Kono M, Crouch RK, Oprian DD, Kono M, Crouch RK, Oprian DD. A dark and constitutively active mutant of the tiger salamander UV pigment. Biochemistry. 2005 Jan 18; 44(2):799-804. PMID: 15641808.
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    24. Kim JM, Altenbach C, Kono M, Oprian DD, Hubbell WL, Khorana HG, Kim JM, Altenbach C, Kono M, Oprian DD, Hubbell WL, Khorana HG. Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12508-13. PMID: 15306683; PMCID: PMC515088.
      Citations:    
    25. Das J, Crouch RK, Ma JX, Oprian DD, Kono M, Das J, Crouch RK, Ma JX, Oprian DD, Kono M. Role of the 9-methyl group of retinal in cone visual pigments. Biochemistry. 2004 May 11; 43(18):5532-8. PMID: 15122919.
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    26. Darden AG, Wu BX, Znoiko SL, Hazard ES, Kono M, Crouch RK, Ma JX, Darden AG, Wu BX, Znoiko SL, Hazard ES, Kono M, Crouch RK, Ma JX. A novel Xenopus SWS2, P434 visual pigment: structure, cellular location, and spectral analyses. Mol Vis. 2003 May 16; 9:191-9. PMID: 12764253.
      Citations: 3     Fields:    Translation:AnimalsCells
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