Steven W Kubalak

Title
InstitutionMedical University of South Carolina
DepartmentRegenerative Medicine and Cell Biology
AddressP.O. Box MSC 508
BSB 615C
Basic Science Building - 173 Ashley Ave.
Phone843-792-0624
Fax843-792-0664
ORCID ORCID Icon0000-0002-5557-2781 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Wisconsin Green Bay, Green Bay, WIBS1985Biology
    Medical University of South Carolina, Charleston , SCPhD1991Pharmacology
    Medical University of South Carolina, Charleston, SC1992Pharmacology
    University of California San Diego, San Diego, CA1996Cardiac Development

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Laswi M, Lesperance R, Kaye A, Bauman Z, Hansen A, Achay J, Kubalak S, Eriksson E. Redefining the costal margin: A pilot study. J Trauma Acute Care Surg. 2022 Dec 01; 93(6):762-766. PMID: 36121266.
      Citations:    Fields:    Translation:Humans
    2. Kwon JH, Hill M, Gerry B, Kubalak SW, Mohiuddin M, Kavarana MN, Rajab TK, Kwon JH, Hill M, Gerry B, Kubalak SW, Mohiuddin M, Kavarana MN, Rajab TK. Surgical techniques for aortic valve xenotransplantation. J Cardiothorac Surg. 2021 Dec 28; 16(1):358. PMID: 34961532; PMCID: PMC8714421.
      Citations:    
    3. Ross GA, Ashenburg NG, Wynn WD, McCarthy JJ, Clendening AM, Presley BC, Kubalak SW, Barnes RM, Ross GA, Ashenburg NG, Wynn WD, McCarthy JJ, Clendening AM, Presley BC, Kubalak SW, Barnes RM. Intra-Articular Catheter Placement: A Novel Approach for Simulating Ankle Effusions in Cadaver Models. West J Emerg Med. 2019 01; 20(1):92-93. PMID: 30643607; PMCID: PMC6324721.
      Citations:    
    4. Robichaux JP, Fuseler JW, Patel SS, Kubalak SW, Hartstone-Rose A, Ramsdell AF, Ramsdell AF, Robichaux JP, Fuseler JW, Patel SS, Kubalak SW, Hartstone-Rose A, Ramsdell AF. Left-right analysis of mammary gland development in retinoid X receptor-a+/- mice. Philos Trans R Soc Lond B Biol Sci. 2016 12 19; 371(1710). PMID: 27821527; PMCID: PMC5104514.
      Citations:    
    5. Hoover LL, Kubalak SW, Hoover LL, Kubalak SW. Holding their own: the noncanonical roles of Smad proteins. Sci Signal. 2008 Nov 18; 1(46):pe48. PMID: 19018011; PMCID: PMC2913314.
      Citations:    
    6. Hoover LL, Burton EG, O'Neill ML, Brooks BA, Sreedharan S, Dawson NA, Kubalak SW, Hoover LL, Burton EG, O'Neill ML, Brooks BA, Sreedharan S, Dawson NA, Kubalak SW. Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation. Biochim Biophys Acta. 2008 Dec; 1783(12):2279-86. PMID: 18773928; PMCID: PMC2596883.
      Citations:    
    7. Hoover LL, Burton EG, Brooks BA, Kubalak SW, Hoover LL, Burton EG, Brooks BA, Kubalak SW. The expanding role for retinoid signaling in heart development. ScientificWorldJournal. 2008 Feb 25; 8:194-211. PMID: 18661045; PMCID: PMC2559957.
      Citations:    
    8. Snarr BS, O'Neal JL, Chintalapudi MR, Wirrig EE, Phelps AL, Kubalak SW, Wessels A, Snarr BS, O'Neal JL, Chintalapudi MR, Wirrig EE, Phelps AL, Kubalak SW, Wessels A. Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development. Circ Res. 2007 Nov 09; 101(10):971-4. PMID: 17947796.
      Citations:    
    9. Menick DR, Renaud L, Buchholz A, Müller JG, Zhou H, Kappler CS, Kubalak SW, Conway SJ, Xu L, Menick DR, Renaud L, Buchholz A, M?ller JG, Zhou H, Kappler CS, Kubalak SW, Conway SJ, Xu L. Regulation of Ncx1 gene expression in the normal and hypertrophic heart. Ann N Y Acad Sci. 2007 Mar; 1099:195-203. PMID: 17446459; PMCID: PMC3096001.
      Citations:    
    10. Xu L, Renaud L, Müller JG, Baicu CF, Bonnema DD, Zhou H, Kappler CS, Kubalak SW, Zile MR, Conway SJ, Menick DR, Xu L, Renaud L, M?ller JG, Baicu CF, Bonnema DD, Zhou H, Kappler CS, Kubalak SW, Zile MR, Conway SJ, Menick DR. Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation. J Biol Chem. 2006 Nov 10; 281(45):34430-40. PMID: 16966329; PMCID: PMC3096005.
      Citations:    
    11. Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P, Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18455-60. PMID: 16352730; PMCID: PMC1317903.
      Citations:    
    12. Hewett KW, Norman LW, Sedmera D, Barker RJ, Justus C, Zhang J, Kubalak SW, Gourdie RG, Hewett KW, Norman LW, Sedmera D, Barker RJ, Justus C, Zhang J, Kubalak SW, Gourdie RG. Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation. Cardiovasc Res. 2005 Aug 15; 67(3):548-60. PMID: 15907824; PMCID: PMC3096008.
      Citations:    
    13. Jenkins SJ, Hutson DR, Kubalak SW, Jenkins SJ, Hutson DR, Kubalak SW. Analysis of the proepicardium-epicardium transition during the malformation of the RXRalpha-/- epicardium. Dev Dyn. 2005 Jul; 233(3):1091-101. PMID: 15861408; PMCID: PMC3094707.
      Citations:    
    14. Eisenberg LM, Kubalak SW, Eisenberg CA, Eisenberg LM, Kubalak SW, Eisenberg CA. Stem cells and the formation of the myocardium in the vertebrate embryo. Anat Rec A Discov Mol Cell Evol Biol. 2004 Jan; 276(1):2-12. PMID: 14699629; PMCID: PMC3096003.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Sedmera D, Reckova M, DeAlmeida A, Coppen SR, Kubalak SW, Gourdie RG, Thompson RP, Sedmera D, Reckova M, DeAlmeida A, Coppen SR, Kubalak SW, Gourdie RG, Thompson RP. Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system. Anat Rec A Discov Mol Cell Evol Biol. 2003 Sep; 274(1):773-7. PMID: 12923887.
      Citations: 46     Fields:    Translation:AnimalsCells
    16. Pashmforoush M, Pomiès P, Peterson KL, Kubalak S, Ross J, Hefti A, Aebi U, Beckerle MC, Chien KR, Pashmforoush M, Pomi?s P, Peterson KL, Kubalak S, Ross J, Hefti A, Aebi U, Beckerle MC, Chien KR. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med. 2001 May; 7(5):591-7. PMID: 11329061.
      Citations: 65     Fields:    Translation:Animals
    17. Nguyên-Trân VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR, Nguy?n-Tr?n VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR. A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Cell. 2000 Sep 01; 102(5):671-82. PMID: 11007485.
      Citations: 30     Fields:    Translation:Animals
    18. Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, Calabro A, Kubalak S, Klewer SE, McDonald JA, Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, Calabro A, Kubalak S, Klewer SE, McDonald JA. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J Clin Invest. 2000 Aug; 106(3):349-60. PMID: 10930438; PMCID: PMC314332.
      Citations: 342     Fields:    Translation:AnimalsCells
    19. Doevendans PA, Kubalak SW, An RH, Becker DK, Chien KR, Kass RS, Doevendans PA, Kubalak SW, An RH, Becker DK, Chien KR, Kass RS. Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes. J Mol Cell Cardiol. 2000 May; 32(5):839-51. PMID: 10775488.
      Citations: 18     Fields:    Translation:AnimalsCells
    20. Doevendans PA, Bronsaer R, Lozano PR, Kubalak S, van Bilsen M, Doevendans PA, Bronsaer R, Lozano PR, Kubalak S, van Bilsen M. The murine atrial myosin light chain-2 gene: a member of an evolutionarily conserved family of contractile proteins. Cytogenet Cell Genet. 2000; 90(3-4):248-52. PMID: 11124527.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Hertig CM, Kubalak SW, Wang Y, Chien KR, Hertig CM, Kubalak SW, Wang Y, Chien KR. Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis. J Biol Chem. 1999 Dec 24; 274(52):37362-9. PMID: 10601306.
      Citations: 36     Fields:    Translation:Animals
    22. Gourdie RG, Kubalak S, Mikawa T, Gourdie RG, Kubalak S, Mikawa T. Conducting the embryonic heart: orchestrating development of specialized cardiac tissues. Trends Cardiovasc Med. 1999 Jan-Feb; 9(1-2):18-26. PMID: 10189963.
      Citations: 18     Fields:    Translation:HumansAnimals
    23. Gruber PJ, Kubalak SW, Chien KR, Gruber PJ, Kubalak SW, Chien KR. Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos. Development. 1998 Nov; 125(22):4427-38. PMID: 9778502.
      Citations: 6     Fields:    Translation:AnimalsCells
    24. Chen J, Kubalak SW, Chien KR, Chen J, Kubalak SW, Chien KR. Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development. 1998 May; 125(10):1943-9. PMID: 9550726.
      Citations: 102     Fields:    Translation:Animals
    25. Orr RK, Hoehn JL, Col NF, Ruiz-Lozano P, Smith SM, Perkins G, Kubalak SW, Boss GR, Sucov HM, Evans RM, Chien KR. Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos. Development. 1998 Feb; 125(3):533-44. PMID: 9425147.
      Citations: 13     Fields:    Translation:AnimalsCells
    26. Chen J, Kubalak SW, Minamisawa S, Price RL, Becker KD, Hickey R, Ross J, Chien KR, Chen J, Kubalak SW, Minamisawa S, Price RL, Becker KD, Hickey R, Ross J, Chien KR. Selective requirement of myosin light chain 2v in embryonic heart function. J Biol Chem. 1998 Jan 09; 273(2):1252-6. PMID: 9422794.
      Citations: 78     Fields:    Translation:Animals
    27. Zhang J, Sato M, Duzic E, Kubalak SW, Lanier SM, Webb JG, Zhang J, Sato M, Duzic E, Kubalak SW, Lanier SM, Webb JG. Adenylyl cyclase isoforms and vasopressin enhancement of agonist-stimulated cAMP in vascular smooth muscle cells. Am J Physiol. 1997 Aug; 273(2 Pt 2):H971-80. PMID: 9277517.
      Citations: 6     Fields:    Translation:AnimalsCells
    28. Gruber PJ, Kubalak SW, Pexieder T, Sucov HM, Evans RM, Chien KR, Gruber PJ, Kubalak SW, Pexieder T, Sucov HM, Evans RM, Chien KR. RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. J Clin Invest. 1996 Sep 15; 98(6):1332-43. PMID: 8823298; PMCID: PMC507559.
      Citations: 38     Fields:    Translation:AnimalsCells
    29. An RH, Davies MP, Doevendans PA, Kubalak SW, Bangalore R, Chien KR, Kass RS, An RH, Davies MP, Doevendans PA, Kubalak SW, Bangalore R, Chien KR, Kass RS. Developmental changes in beta-adrenergic modulation of L-type Ca2+ channels in embryonic mouse heart. Circ Res. 1996 Mar; 78(3):371-8. PMID: 8593695.
      Citations: 14     Fields:    Translation:AnimalsCells
    30. Davies MP, An RH, Doevendans P, Kubalak S, Chien KR, Kass RS, Davies MP, An RH, Doevendans P, Kubalak S, Chien KR, Kass RS. Developmental changes in ionic channel activity in the embryonic murine heart. Circ Res. 1996 Jan; 78(1):15-25. PMID: 8603498.
      Citations: 42     Fields:    Translation:AnimalsCells
    31. Sucov HM, Lou J, Gruber PJ, Kubalak SW, Dyson E, Gumeringer CL, Lee RY, Moles SA, Chien KR, Giguere V, Evans RM, Sucov HM, Lou J, Gruber PJ, Kubalak SW, Dyson E, Gumeringer CL, Lee RY, Moles SA, Chien KR, Giguere V, Evans RM. The molecular genetics of retinoic acid receptors: cardiovascular and limb development. Biochem Soc Symp. 1996; 62:143-56. PMID: 8971347.
      Citations: 2     Fields:    Translation:Animals
    32. Dyson E, Sucov HM, Kubalak SW, Schmid-Schönbein GW, DeLano FA, Evans RM, Ross J, Chien KR, Dyson E, Sucov HM, Kubalak SW, Schmid-Sch?nbein GW, DeLano FA, Evans RM, Ross J, Chien KR. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice. Proc Natl Acad Sci U S A. 1995 Aug 01; 92(16):7386-90. PMID: 7638202; PMCID: PMC41344.
      Citations: 43     Fields:    Translation:Animals
    33. Kubalak SW, Miller-Hance WC, O'Brien TX, Dyson E, Chien KR, Kubalak SW, Miller-Hance WC, O'Brien TX, Dyson E, Chien KR. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem. 1994 Jun 17; 269(24):16961-70. PMID: 8207020.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    34. Hunter JJ, Zhu H, Lee KJ, Kubalak S, Chien KR, Hunter JJ, Zhu H, Lee KJ, Kubalak S, Chien KR. Targeting gene expression to specific cardiovascular cell types in transgenic mice. Hypertension. 1993 Oct; 22(4):608-17. PMID: 8406667.
      Citations: 1     Fields:    Translation:Animals
    35. Kubalak SW, Webb JG, Kubalak SW, Webb JG. Angiotensin II enhancement of hormone-stimulated cAMP formation in cultured vascular smooth muscle cells. Am J Physiol. 1993 Jan; 264(1 Pt 2):H86-96. PMID: 8381612.
      Citations: 6     Fields:    Translation:AnimalsCells
    36. Kubalak SW, Newman WH, Webb JG, Kubalak SW, Newman WH, Webb JG. Differential effect of pertussis toxin on adenosine and muscarinic inhibition of cyclic AMP accumulation in canine ventricular myocytes. J Mol Cell Cardiol. 1991 Feb; 23(2):199-205. PMID: 1648626.
      Citations: 1     Fields:    Translation:AnimalsCells
    37. Oehlenschlager WF, Kubalak SW, Currie MG, Oehlenschlager WF, Kubalak SW, Currie MG. A rapid and economical method of preparing radioiodinated cyclic nucleotide derivatives for use in radioimmunoassays. J Immunoassay. 1990; 11(1):109-18. PMID: 2159027.
      Citations: 1     Fields:    
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