Adam J. Smolka

Title
InstitutionMedical University of South Carolina
DepartmentMedicine
AddressP.O. Box MSC 637
912
96 Jonathan Lucas St.
Phone843-792-3527
Fax843-792-2358
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    Dr. Smolka is Professor of Medicine in the Division of Gastroenterology and Hepatology at the Medical University of South Carolina. He earned his PhD in Physiology and Biophysics in 1982 at the University of Alabama, Birmingham. Following postdoctoral studies at the University of California, Los Angeles, he was appointed Assistant Professor in the Department of Medicine at UCLA in 1984. Dr. Smolka was appointed Associate Professor in the Department of Anatomy and Cell Biology at MUSC in 1992, and tenured full Professor in the Department of Medicine at MUSC in 1998.

    Dr. Smolka is Course Director of the First Year Curriculum in the MUSC College of Graduate Studies and chair of the College Curriculum Committee. He is a member and fellow
    of the American Gastroenterological Association, American Physiological Association, American Association for the Advancement of Science, American Society for Cell Biology, and the Parietal Cell Club. Additionally, he is a member of Hollings Cancer Center at MUSC, and a past Universities Space Research Association Scholar and member of the NASA Biotechnology Fundamentals Study Section.

    Dr. Smolka’s current research interests include pathophysiology of Helicobacter pylori infection of the gastric mucosa, molecular structure-function relationships in the gastric proton pump, and proteomic analysis of esophageal cancers. Previous research at NASA Marshall Space Flight Center, Huntsville, Alabama, focused on bioseparations technology, including microgravity cell electrophoresis (a sample of his blood was processed in earth orbit on Skylab II), and modification of cell electrophoretic mobility using synthetic polymeric microspheres. Dr. Smolka has published extensively (60 papers, 15 book chapters, and 70 abstracts), and since 1984 has been Principal Investigator on five major National Institutes of Health grant awards, and one NASA award.
    Collapse keywords
    Pathophysiology of Helicobacter pylori, Biochemistry and cell biology of gastric acid secretion, Pharmacological inhibition of acid secretion

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yao X, Smolka AJ. Gastric Parietal Cell Physiology and Helicobacter pylori-Induced Disease. Gastroenterology. 2019 06; 156(8):2158-2173. PMID: 30831083.
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    2. Smolka AJ, Schubert ML. Helicobacter pylori-Induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease. Curr Top Microbiol Immunol. 2017; 400:227-252. PMID: 28124156.
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    3. Gonçalves O, Castro LF, Smolka AJ, Fontainhas A, Wilson JM. The Gastric Phenotype in the Cypriniform Loaches: A Case of Reinvention? PLoS One. 2016; 11(10):e0163696. PMID: 27783698.
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    4. Mak MA, Smolka A, Kowalski J, Kuc A, Klausa F, Kremens K, Jarek D, Bachowski R, Skiba J. Can cardiopulmonary bypass system with blood priming become a new standard in coronary surgery? Kardiol Pol. 2016; 74(8):726-732. PMID: 26898969.
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    5. Hammond CE, Beeson C, Suarez G, Peek RM, Backert S, Smolka AJ. Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 01; 309(3):G193-201. PMID: 26045613.
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    6. Smolka AJ, Halushka PV, Garrett-Mayer E. The faculty costs to educate a biomedical sciences graduate student. CBE Life Sci Educ. 2015 Mar 02; 14(1):ar3. PMID: 25673355.
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    7. Schwacke J, Millar TP, Hammond CE, Saha A, Hoffman BJ, Romagnuolo J, Hill EG, Smolka AJ. Discrimination of normal and esophageal cancer plasma proteomes by MALDI-TOF mass spectrometry. Dig Dis Sci. 2015 Jun; 60(6):1645-54. PMID: 25577268.
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    8. Zhang YM, Noto JM, Hammond CE, Barth JL, Argraves WS, Backert S, Peek RM, Smolka AJ. Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase a-subunit gene expression by miRNA. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 01; 306(7):G606-13. PMID: 24503769.
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    9. Nguyen N, Kozer-Gorevich N, Gliddon BL, Smolka AJ, Clayton AH, Gleeson PA, van Driel IR. Independent trafficking of the KCNQ1 K+ channel and H+-K+-ATPase in gastric parietal cells from mice. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G157-66. PMID: 23154976.
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    10. Smolka AJ, Backert S. How Helicobacter pylori infection controls gastric acid secretion. J Gastroenterol. 2012 Jun; 47(6):609-18. PMID: 22565637.
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    11. Mueller D, Tegtmeyer N, Brandt S, Yamaoka Y, De Poire E, Sgouras D, Wessler S, Torres J, Smolka A, Backert S. c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains. J Clin Invest. 2012 Apr; 122(4):1553-66. PMID: 22378042.
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    12. Song P, Groos S, Riederer B, Feng Z, Krabbenhöft A, Manns MP, Smolka A, Hagen SJ, Neusch C, Seidler U. Kir4.1 channel expression is essential for parietal cell control of acid secretion. J Biol Chem. 2011 Apr 22; 286(16):14120-8. PMID: 21367857.
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    13. Saha A, Hammond CE, Beeson C, Peek RM, Smolka AJ. Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa. Gut. 2010 Jul; 59(7):874-81. PMID: 20581234.
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    14. Tegtmeyer N, Hartig R, Delahay RM, Rohde M, Brandt S, Conradi J, Takahashi S, Smolka AJ, Sewald N, Backert S. A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation. J Biol Chem. 2010 Jul 23; 285(30):23515-26. PMID: 20507990.
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    15. Saha A, Backert S, Hammond CE, Gooz M, Smolka AJ. Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology. 2010 Jul; 139(1):239-48. PMID: 20303353.
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    16. Song P, Groos S, Riederer B, Feng Z, Krabbenhöft A, Smolka A, Seidler U. KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion. J Physiol. 2009 Aug 01; 587(Pt 15):3955-65. PMID: 19491250.
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    17. Saha A, Hammond CE, Gooz M, Smolka AJ. The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G977-86. PMID: 18772363.
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    18. Saha A, Hammond CE, Trojanowska M, Smolka AJ. Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G795-807. PMID: 18202112.
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    19. Lapierre LA, Avant KM, Caldwell CM, Ham AJ, Hill S, Williams JA, Smolka AJ, Goldenring JR. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1249-62. PMID: 17255364.
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    20. Saha A, Hammond CE, Gooz M, Smolka AJ. IL-1beta modulation of H,K-ATPase alpha-subunit gene transcription in Helicobacter pylori infection. Am J Physiol Gastrointest Liver Physiol. 2007 Apr; 292(4):G1055-61. PMID: 17204545.
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    21. Karpievitch YV, Hill EG, Smolka AJ, Morris JS, Coombes KR, Baggerly KA, Almeida JS. PrepMS: TOF MS data graphical preprocessing tool. Bioinformatics. 2007 Jan 15; 23(2):264-5. PMID: 17121773.
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    22. Göõz M, Tóth M, Vakkuri O, Göõz P, Smolka AJ, de Châtel R, Szalay KS. Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells. Life Sci. 2004 Mar 12; 74(17):2111-28. PMID: 14969716.
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    23. Gööz M, Shaker M, Gööz P, Smolka AJ. Interleukin 1beta induces gastric epithelial cell matrix metalloproteinase secretion and activation during Helicobacter pylori infection. Gut. 2003 Sep; 52(9):1250-6. PMID: 12912854.
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    24. Yang GY, Liao J, Cassai ND, Smolka AJ, Sidhu GS. Parietal cell carcinoma of gastric cardia: immunophenotype and ultrastructure. Ultrastruct Pathol. 2003 Mar-Apr; 27(2):87-94. PMID: 12746199.
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    25. Göõz M, Göõz P, Smolka AJ. Epithelial and bacterial metalloproteinases and their inhibitors in H. pylori infection of human gastric cells. Am J Physiol Gastrointest Liver Physiol. 2001 Sep; 281(3):G823-32. PMID: 11518695.
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    26. Smolka AJ, Larsen KA, Hammond CE. Location of a cytoplasmic epitope for monoclonal antibody HK 12.18 on H,K-ATPase alpha subunit. Biochem Biophys Res Commun. 2000 Jul 14; 273(3):942-7. PMID: 10891352.
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    27. Göõz M, Hammond CE, Larsen K, Mukhin YV, Smolka AJ. Inhibition of human gastric H(+)-K(+)-ATPase alpha-subunit gene expression by Helicobacter pylori. Am J Physiol Gastrointest Liver Physiol. 2000 Jun; 278(6):G981-91. PMID: 10859229.
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    28. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 9227635.
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    29. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 116687.
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    30. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 2452803.
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    31. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 9551404.
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    32. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 15028114.
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    33. Smolka AJ, Larsen KA, Schweinfest CW, Hammond CE. H,K-ATPase alpha subunit C-terminal membrane topology: epitope tags in the insect cell expression system. Biochem J. 1999 Jun 15; 340 ( Pt 3):601-11. PMID: 10359643.
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    34. Harris AW, Walker MM, Smolka A, Waller JM, Baron JH, Misiewicz JJ. Parietal cells in the duodenal bulb and their relation to Helicobacter pylori infection. J Clin Pathol. 1996 Apr; 49(4):309-12. PMID: 8655707.
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    35. Lacy ER, Cowart KS, King JS, DelValle J, Smolka AJ. Epithelial response of the rat gastric mucosa to chronic superficial injury. Yale J Biol Med. 1996 Mar-Apr; 69(2):105-18. PMID: 9112742.
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    36. Walker MM, Smolka A, Waller JM, Evans DJ. Identification of parietal cells in gastric body mucosa with HMFG-2 monoclonal antibody. J Clin Pathol. 1995 Sep; 48(9):832-4. PMID: 7490316.
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    37. Wingo CS, Smolka AJ. Function and structure of H-K-ATPase in the kidney. Am J Physiol. 1995 Jul; 269(1 Pt 2):F1-16. PMID: 7631822.
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    38. Tyagarajan K, Chow DC, Smolka A, Forte JG. Structural interactions between alpha- and beta-subunits of the gastric H,K-ATPase. Biochim Biophys Acta. 1995 May 24; 1236(1):105-13. PMID: 7794938.
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    39. Callaghan JM, Tan SS, Khan MA, Curran KA, Campbell WG, Smolka AJ, Toh BH, Gleeson PA, Wingo CS, Cain BD, et al. Renal expression of the gene encoding the gastric H(+)-K(+)-ATPase beta-subunit. Am J Physiol. 1995 Mar; 268(3 Pt 2):F363-74. PMID: 7900835.
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    40. Swenson ER, Fine AD, Maren TH, Reale E, Lacy ER, Smolka AJ. Physiological and immunocytochemical evidence for a putative H-K-ATPase in elasmobranch renal acid secretion. Am J Physiol. 1994 Oct; 267(4 Pt 2):F639-45. PMID: 7943360.
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    41. Smolka AJ, Lacy ER, Luciano L, Reale E. Identification of gastric H,K-ATPase in an early vertebrate, the Atlantic stingray Dasyatis sabina. J Histochem Cytochem. 1994 Oct; 42(10):1323-32. PMID: 7930514.
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    42. Soroka CJ, Chew CS, Hanzel DK, Smolka A, Modlin IM, Goldenring JR. Characterization of membrane and cytoskeletal compartments in cultured parietal cells: immunofluorescence and confocal microscopic examination. Eur J Cell Biol. 1993 Feb; 60(1):76-87. PMID: 8385019.
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    43. Burman P, Kämpe O, Kraaz W, Lööf L, Smolka A, Karlsson A, Karlsson-Parra A. A study of autoimmune gastritis in the postpartum period and at a 5-year follow-up. Gastroenterology. 1992 Sep; 103(3):934-42. PMID: 1323500.
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    44. Smolka A, Swiger KM. Site-directed antibodies as topographical probes of the gastric H,K-ATPase alpha-subunit. Biochim Biophys Acta. 1992 Jul 08; 1108(1):75-85. PMID: 1643082.
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    45. Smolka A, Alverson L, Fritz R, Swiger K, Swiger R. Gastric H,K-ATPase topography: amino acids 888-907 are cytoplasmic. Biochem Biophys Res Commun. 1991 Nov 14; 180(3):1356-64. PMID: 1659414.
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    46. Wingo CS, Madsen KM, Smolka A, Tisher CC. H-K-ATPase immunoreactivity in cortical and outer medullary collecting duct. Kidney Int. 1990 Nov; 38(5):985-90. PMID: 2176257.
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    47. Okamoto CT, Karpilow JM, Smolka A, Forte JG. Isolation and characterization of gastric microsomal glycoproteins. Evidence for a glycosylated beta-subunit of the H+/K(+)-ATPase. Biochim Biophys Acta. 1990 Mar 01; 1037(3):360-72. PMID: 1690026.
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    48. Smolka A, Donaldson RM. Monoclonal antibodies to human intrinsic factor. Gastroenterology. 1990 Mar; 98(3):607-14. PMID: 2298366.
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    49. Smolka A, Sachs G, Lorentzon P. Cell-free synthesis of rat and rabbit gastric proton pump. Gastroenterology. 1989 Oct; 97(4):873-81. PMID: 2550309.
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    50. Helander HF, Anderson D, Helander KG, Smolka A, Sachs G. Immunocytochemical studies of gastric H+,K+-ATPase in the developing rat. Scand J Gastroenterol. 1989 Sep; 24(7):863-9. PMID: 2529628.
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    51. Thomas HA, Machen TE, Smolka A, Baron R, Kopito RR. Identification of a 185-kDa band 3-related polypeptide in oxyntic cells. Am J Physiol. 1989 Sep; 257(3 Pt 1):C537-44. PMID: 2551174.
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    52. Hanzel DK, Urushidani T, Usinger WR, Smolka A, Forte JG. Immunological localization of an 80-kDa phosphoprotein to the apical membrane of gastric parietal cells. Am J Physiol. 1989 Jun; 256(6 Pt 1):G1082-9. PMID: 2472073.
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    53. Chew CS, Ljungström M, Smolka A, Brown MR. Primary culture of secretagogue-responsive parietal cells from rabbit gastric mucosa. Am J Physiol. 1989 Jan; 256(1 Pt 1):G254-63. PMID: 2536239.
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    54. Smolka A, Weinstein WM. Immunoassay of pig and human gastric proton pump. Gastroenterology. 1986 Mar; 90(3):532-9. PMID: 2417911.
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    55. Peerce BE, Smolka A, Sachs G. Isolation of pepsinogen granules from rabbit gastric mucosa. J Biol Chem. 1984 Jul 25; 259(14):9255-62. PMID: 6235223.
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    56. Smolka A, Helander HF, Sachs G. Monoclonal antibodies against gastric H+ + K+ ATPase. Am J Physiol. 1983 Oct; 245(4):G589-96. PMID: 6312812.
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    57. Rabon E, Cuppoletti J, Malinowska D, Smolka A, Helander HF, Mendlein J, Sachs G. Proton secretion by the gastric parietal cell. J Exp Biol. 1983 Sep; 106:119-33. PMID: 6317787.
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    58. Faller L, Jackson R, Malinowska D, Mukidjam E, Rabon E, Saccomani G, Sachs G, Smolka A. Mechanistic aspects of gastric (H+ + K+)-ATPase. Ann N Y Acad Sci. 1982; 402:146-63. PMID: 6301328.
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    59. Faller LD, Malinowska DH, Rabon E, Smolka A, Sachs G. Mechanistic studies of the gastric (H+ + K)-ATPase. Prog Clin Biol Res. 1981; 73:153-74. PMID: 6275397.
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    60. Kopwillem A, Merriman WG, Cuddeback RM, Smolka AJ, Bier M. Serum protein fractionation by isotachophoresis using amino acid spacers. J Chromatogr. 1976 Mar 03; 118(1):34-46. PMID: 1249172.
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    61. Smolka AJ, Logan EF. Recovery of immunoglobulin G from Cohn fraction II + 3 by forced flow electrophoresis. Prep Biochem. 1972; 2(4):329-45. PMID: 4117266.
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