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    • The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
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The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nat Med. 2003 Feb; 9(2):220-4.

View in: PubMed

subject areas
  • Animals
  • Base Sequence
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System
  • DNA Primers
  • DNA-Binding Proteins
  • Electrophoretic Mobility Shift Assay
  • Enhancer Elements, Genetic
  • Enzyme Induction
  • Hepatocyte Nuclear Factor 4
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Phosphoproteins
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid
  • Transcription Factors
  • Tumor Cells, Cultured
  • Xenobiotics

authors with profiles
  • Stephen Alexander Duncan