Imran Khan

Title
InstitutionMedical University of South Carolina
DepartmentPharmacology Allocation & Reserves
AddressP.O. Box MSC 509
Basic Science Building - 173 Ashley Ave.
Phone843-792-8975
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Whaby M, Wallon L, Mazzei M, Khan I, Teng KW, Koide S, O'Bryan JP. Mutations in the a4-a5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association. J Biol Chem. 2022 Nov 02; 102661. PMID: 36334633.
      Citations:    Fields:    
    2. Sofi MH, Tian L, Schutt S, Khan I, Choi HJ, Wu Y, Bastian D, Ticer T, Kassir MF, Atilgan FC, Kim J, Sui X, Zivkovic A, Mehrotra S, O'Bryan JP, Stark H, Martin PJ, Ogretmen B, Yu XZ, Sofi MH, Tian L, Schutt S, Khan I, Choi HJ, Wu Y, Bastian D, Ticer T, Kassir MF, Atilgan FC, Kim J, Sui X, Zivkovic A, Mehrotra S, O'Bryan JP, Stark H, Martin PJ, Ogretmen B, Yu XZ. Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway. Leukemia. 2022 07; 36(7):1907-1915. PMID: 35513703; PMCID: PMC9256768.
      Citations: 4     Fields:    Translation:HumansCells
    3. Khan I, Koide A, Zuberi M, Ketavarapu G, Denbaum E, Teng KW, Rhett JM, Spencer-Smith R, Hobbs GA, Camp ER, Koide S, O'Bryan JP, Khan I, Koide A, Zuberi M, Ketavarapu G, Denbaum E, Teng KW, Rhett JM, Spencer-Smith R, Hobbs GA, Camp ER, Koide S, O'Bryan JP. Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants. Cell Rep. 2022 02 08; 38(6):110322. PMID: 35139380; PMCID: PMC8936000.
      Citations:    
    4. Whaby M, Khan I, O'Bryan JP, Whaby M, Khan I, O'Bryan JP. Targeting the "undruggable" RAS with biologics. Adv Cancer Res. 2022; 153:237-266. PMID: 35101232; PMCID: PMC9627686.
      Citations:    
    5. Khan I, MarElia-Bennet C, Lefler J, Zuberi M, Denbaum E, Koide A, Connor DM, Broome AM, P├ęcot T, Timmers C, Ostrowski MC, Koide S, O'Bryan JP, Khan I, Marelia-Bennet C, Lefler J, Zuberi M, Denbaum E, Koide A, Connor DM, Broome AM, P?cot T, Timmers C, Ostrowski MC, Koide S, O'Bryan JP. Targeting the KRAS a4-a5 allosteric interface inhibits pancreatic cancer tumorigenesis. Small GTPases. 2022 Jan; 13(1):114-127. PMID: 33949915; PMCID: PMC9707541.
      Citations:    
    6. Khan I, O'Bryan JP, Khan I, O'Bryan JP. Probing RAS Function with Monobodies. Methods Mol Biol. 2021; 2262:281-302. PMID: 33977484; PMCID: PMC8121162.
      Citations:    
    7. Zuberi M, Khan I, O'Bryan JP, Zuberi M, Khan I, O'Bryan JP. Inhibition of RAS: proven and potential vulnerabilities. Biochem Soc Trans. 2020 10 30; 48(5):1831-1841. PMID: 32869838; PMCID: PMC7875515.
      Citations:    
    8. Rhett JM, Khan I, O'Bryan JP, Rhett JM, Khan I, O'Bryan JP. Biology, pathology, and therapeutic targeting of RAS. Adv Cancer Res. 2020; 148:69-146. PMID: 32723567; PMCID: PMC7393484.
      Citations:    
    9. Khan I, Rhett JM, O'Bryan JP, Khan I, Rhett JM, O'Bryan JP. Therapeutic targeting of RAS: New hope for drugging the "undruggable". Biochim Biophys Acta Mol Cell Res. 2020 02; 1867(2):118570. PMID: 31678118; PMCID: PMC6937383.
      Citations:    
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