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    • Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.
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Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma. Nat Commun. 2019 03 21; 10(1):1296.

View in: PubMed

subject areas
  • Animals
  • Antineoplastic Agents
  • Benzeneacetamides
  • Cell Line, Tumor
  • Cyclin D1
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6
  • Drug Resistance, Neoplasm
  • Drug Synergism
  • Energy Metabolism
  • Esophageal Neoplasms
  • F-Box Proteins
  • Gene Expression Regulation, Neoplastic
  • Glutaminase
  • Glutamine
  • Humans
  • Hypoglycemic Agents
  • Male
  • Mechanistic Target of Rapamycin Complex 1
  • Metformin
  • Mice
  • Molecular Targeted Therapy
  • Phenformin
  • Protein Kinase Inhibitors
  • Retinoblastoma Protein
  • Signal Transduction
  • Thiadiazoles
  • Xenograft Model Antitumor Assays

authors with profiles
  • Natalia V. Oleinik
  • Besim Ogretmen
  • Craig Cano Beeson