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    • LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.
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LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol. 2020 02; 22(2):246-256.

View in: PubMed

subject areas
  • Animals
  • Colonic Neoplasms
  • CRISPR-Cas Systems
  • Female
  • Gene Editing
  • Gene Expression Regulation, Developmental
  • HCT116 Cells
  • HEK293 Cells
  • HeLa Cells
  • Heterografts
  • Humans
  • Liver
  • MCF-7 Cells
  • Mechanistic Target of Rapamycin Complex 1
  • Mice
  • Mice, Nude
  • Mice, Transgenic
  • Myocardium
  • Neurofibromin 2
  • Organ Size
  • Ras Homolog Enriched in Brain Protein
  • Regulatory-Associated Protein of mTOR
  • Signal Transduction
  • Tumor Suppressor Proteins

authors with profiles
  • Wenjian Gan
  • Shasha Yin