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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 Jan 28; 115(4):824-33.

View in: PubMed

subject areas
  • Animals
  • Apoptosis
  • Benzylidene Compounds
  • Cell Division
  • Cell Line, Tumor
  • Extracellular Signal-Regulated MAP Kinases
  • G1 Phase
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Jurkat Cells
  • MAP Kinase Signaling System
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Phosphorylation
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-myc
  • Proto-Oncogene Proteins c-pim-1
  • Thiazolidinediones
  • TOR Serine-Threonine Kinases

authors with profiles
  • Elizabeth G. Hill
  • Wenxue Wang
  • Charles D. Smith
  • Andrew S Kraft