Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification.
Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification. Cell Growth Differ. 1996 May; 7(5):551-61.
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Androstadienes
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Antineoplastic Agents
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Blotting, Northern
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Blotting, Southern
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Blotting, Western
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Breast Neoplasms
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Cell Division
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DNA, Neoplasm
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Enzyme Inhibitors
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Epidermal Growth Factor
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Epithelial Cells
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Epithelium
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ErbB Receptors
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Female
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Gene Amplification
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Gene Expression Regulation, Neoplastic
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Genes, erbB-2
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Glycoproteins
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Humans
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Insulin-Like Growth Factor I
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Mitogens
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Neuregulins
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Phosphatidylinositol 3-Kinases
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Phosphorylation
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Phosphotransferases (Alcohol Group Acceptor)
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Proto-Oncogene Proteins
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Receptor, ErbB-2
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Receptor, ErbB-3
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RNA, Messenger
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Signal Transduction
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Tumor Cells, Cultured
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Tyrosine