T-Lymphocytes, Cytotoxic

"T-Lymphocytes, Cytotoxic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.

Descriptor ID	D013602
MeSH Number(s)	A11.118.637.555.283.875 A11.118.637.555.567.550.500.200 A11.118.637.555.567.569.220.200 A11.118.637.555.567.569.500.200 A15.145.229.637.555.283.875 A15.145.229.637.555.567.550.500.200 A15.145.229.637.555.567.569.220.200 A15.145.229.637.555.567.569.500.200 A15.382.490.555.283.875 A15.382.490.555.567.550.500.200 A15.382.490.555.567.569.220.200 A15.382.490.555.567.569.500.200
Concept/Terms	T-Lymphocytes, Cytotoxic T-Lymphocytes, Cytotoxic Cytotoxic T-Lymphocyte T Lymphocytes, Cytotoxic T-Lymphocyte, Cytotoxic Cell-Mediated Lympholytic Cells Cell Mediated Lympholytic Cells Cell, Cell-Mediated Lympholytic Cell-Mediated Lympholytic Cell Cells, Cell-Mediated Lympholytic Lympholytic Cell, Cell-Mediated Lympholytic Cells, Cell-Mediated Cytotoxic T-Lymphocytes Cytotoxic T Lymphocytes TC2 Cells TC2 Cells Cell, TC2 Cells, TC2 TC2 Cell TC1 Cells TC1 Cells Cell, TC1 Cells, TC1 TC1 Cell

Below are MeSH descriptors whose meaning is more general than "T-Lymphocytes, Cytotoxic".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Cytokine-Induced Killer Cells [A11.118.637.555.283]
T-Lymphocytes, Cytotoxic [A11.118.637.555.283.875]
Lymphocytes [A11.118.637.555.567]
Lymphocyte Subsets [A11.118.637.555.567.550]
T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
T-Lymphocytes, Cytotoxic [A11.118.637.555.567.550.500.200]
T-Lymphocytes [A11.118.637.555.567.569]
CD8-Positive T-Lymphocytes [A11.118.637.555.567.569.220]
T-Lymphocytes, Cytotoxic [A11.118.637.555.567.569.220.200]
T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
T-Lymphocytes, Cytotoxic [A11.118.637.555.567.569.500.200]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Cytokine-Induced Killer Cells [A15.145.229.637.555.283]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.283.875]
Lymphocytes [A15.145.229.637.555.567]
Lymphocyte Subsets [A15.145.229.637.555.567.550]
T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.550.500.200]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD8-Positive T-Lymphocytes [A15.145.229.637.555.567.569.220]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.569.220.200]
T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.569.500.200]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Cytokine-Induced Killer Cells [A15.382.490.555.283]
T-Lymphocytes, Cytotoxic [A15.382.490.555.283.875]
Lymphocytes [A15.382.490.555.567]
Lymphocyte Subsets [A15.382.490.555.567.550]
T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
T-Lymphocytes, Cytotoxic [A15.382.490.555.567.550.500.200]
T-Lymphocytes [A15.382.490.555.567.569]
CD8-Positive T-Lymphocytes [A15.382.490.555.567.569.220]
T-Lymphocytes, Cytotoxic [A15.382.490.555.567.569.220.200]
T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
T-Lymphocytes, Cytotoxic [A15.382.490.555.567.569.500.200]

Below are MeSH descriptors whose meaning is related to "T-Lymphocytes, Cytotoxic".

Below are MeSH descriptors whose meaning is more specific than "T-Lymphocytes, Cytotoxic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "T-Lymphocytes, Cytotoxic" by people in this website by year, and whether "T-Lymphocytes, Cytotoxic" was a major or minor topic of these publications.

Bar chart showing 49 publications over 22 distinct years, with a maximum of 5 publications in 1998

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	0	2	2
1994	0	2	2
1995	0	2	2
1996	0	1	1
1997	2	0	2
1998	1	4	5
1999	1	2	3
2001	0	1	1
2002	0	1	1
2003	2	2	4
2004	2	1	3
2005	1	1	2
2006	3	0	3
2008	1	0	1
2009	2	1	3
2010	1	1	2
2011	0	1	1
2014	2	0	2
2016	2	0	2
2018	2	1	3
2020	3	0	3
2021	1	0	1

Below are the most recent publications written about "T-Lymphocytes, Cytotoxic" by people in Profiles.

Iwanowycz S, Ngoi S, Li Y, Hill M, Koivisto C, Parrish M, Guo B, Li Z, Liu B. Type 2 dendritic cells mediate control of cytotoxic T cell resistant tumors. JCI Insight. 2021 09 08; 6(17).

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Rohan VS, Soliman KM, Alqassieh A, Alkhader D, Patel N, Nadig SN. Renal allograft surveillance with allospecific T-cytotoxic memory cells. Ren Fail. 2020 Nov; 42(1):1152-1156.

View in: PubMed
Perugino CA, Kaneko N, Maehara T, Mattoo H, Kers J, Allard-Chamard H, Mahajan VS, Liu H, Della-Torre E, Murphy SJH, Ghebremichael M, Wallace ZS, Bolster MB, Harvey LM, Mylvaganam G, Tuncay Y, Liang L, Montesi SB, Zhang X, Tinju A, Mochizuki K, Munemura R, Sakamoto M, Moriyama M, Nakamura S, Yosef N, Stone JH, Pillai S. CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease. J Allergy Clin Immunol. 2021 01; 147(1):368-382.

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Haque A, Samantaray S, Knaryan VH, Capone M, Hossain A, Matzelle D, Chandran R, Shields DC, Farrand AQ, Boger HA, Banik NL. Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease. Exp Neurol. 2020 08; 330:113315.

View in: PubMed
Kojo S, Yasmin N, Muroi S, Tenno M, Taniuchi I. Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene. Nat Commun. 2018 09 05; 9(1):3593.

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Wada H, Yasmin N, Kakugawa K, Ohno-Oishi M, Nieke S, Miyamoto C, Muroi S, Taniuchi I. Requirement for intron structures in activating the Cd8a locus. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):3440-3445.

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Scheffel MJ, Scurti G, Wyatt MM, Garrett-Mayer E, Paulos CM, Nishimura MI, Voelkel-Johnson C. N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner. Cancer Immunol Immunother. 2018 Apr; 67(4):691-702.

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Banerjee A, Thyagarajan K, Chatterjee S, Chakraborty P, Kesarwani P, Soloshchenko M, Al-Hommrani M, Andrijauskaite K, Moxley K, Janakiraman H, Scheffel MJ, Helke K, Armenson K, Palanisamy V, Rubinstein MP, Mayer EG, Cole DJ, Paulos CM, Nishimura MI, Mehrotra S. Lack of p53 Augments Antitumor Functions in Cytolytic T Cells. Cancer Res. 2016 09 15; 76(18):5229-5240.

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Liu W, Chen M, Li X, Zhao B, Hou J, Zheng H, Qiu L, Li Z, Meng S. Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response. PLoS One. 2016; 11(5):e0155202.

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Jacks SM, Taylor BR, Rogers RP, Ralston JS, Metcalf JS, Lazarchick J. Rapid deterioration in a patient with primary aggressive cutaneous epidermotropic CD8+ cytotoxic T-cell ('Berti') lymphoma after administration of adalimumab. J Am Acad Dermatol. 2014 Sep; 71(3):e86-7.

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