Sodium-Hydrogen Exchanger 3
"Sodium-Hydrogen Exchanger 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sodium-hydrogen antiporter expressed primarily by EPITHELIAL CELLS in the kidneys, it localizes to the apical membrane of the PROXIMAL KIDNEY TUBULE, where it functions in sodium and water reabsorption and possibly calcium homeostasis. It also is expressed in heart, brain, and lung tissues and is resistant to AMILORIDE inhibition.
| Descriptor ID |
D000074083
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| MeSH Number(s) |
D12.776.157.530.450.162.775.750 D12.776.157.530.937.703.750 D12.776.543.550.190.775.750 D12.776.543.585.450.162.775.750 D12.776.543.585.937.828.750
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| Concept/Terms |
Sodium-Hydrogen Exchanger 3- Sodium-Hydrogen Exchanger 3
- Sodium Hydrogen Exchanger 3
- Na(+)-H(+) Exchanger 3
- Solute Carrier Family 9 Member 3
- NHE-3 Protein
- NHE 3 Protein
- SLC9A3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Sodium-Hydrogen Exchanger 3".
Below are MeSH descriptors whose meaning is more specific than "Sodium-Hydrogen Exchanger 3".
This graph shows the total number of publications written about "Sodium-Hydrogen Exchanger 3" by people in this website by year, and whether "Sodium-Hydrogen Exchanger 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sodium-Hydrogen Exchanger 3" by people in Profiles.
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The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II. Am J Physiol Renal Physiol. 2016 08 01; 311(2):F343-51.
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Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice. Am J Physiol Renal Physiol. 2012 Dec 01; 303(11):F1495-502.
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Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea. J Pediatr Gastroenterol Nutr. 2011 Nov; 53(5):474-7.
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Effect of metabolic acidosis on neonatal proximal tubule acidification. Am J Physiol Regul Integr Comp Physiol. 2010 Nov; 299(5):R1360-8.
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slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon. J Biol Chem. 2006 Dec 08; 281(49):37962-71.
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Identification of mRNA transcripts and immunohistochemical localization of Na/H exchanger isoforms in gerbil inner ear. Hear Res. 1998 Sep; 123(1-2):1-9.