Zinc Finger Protein GLI1

"Zinc Finger Protein GLI1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcriptional activator and oncogene protein that contains two CYS2-HIS2 ZINC FINGERS. Two isoforms are expressed; both regulate the expression of specific genes during development of craniofacial features, digits, the CENTRAL NERVOUS SYSTEM; and the GASTROINTESTINAL TRACT. They also regulate SONIC HEDGEHOG PROTEIN signaling and cell proliferation.

Descriptor ID	D000071676
MeSH Number(s)	D12.776.260.755.850 D12.776.624.664.700.989 D12.776.930.900.700
Concept/Terms	Zinc Finger Protein GLI1 Zinc Finger Protein GLI1 Oncogene GLI Protein GLI Protein, Oncogene Glioma-Associated Oncogene Protein Glioma Associated Oncogene Protein Oncogene Protein, Glioma-Associated Gli Protein Gli1 Protein

Below are MeSH descriptors whose meaning is more general than "Zinc Finger Protein GLI1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Trans-Activators [D12.776.260.755]
Zinc Finger Protein GLI1 [D12.776.260.755.850]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Zinc Finger Protein GLI1 [D12.776.624.664.700.989]
Transcription Factors [D12.776.930]
Trans-Activators [D12.776.930.900]
Zinc Finger Protein GLI1 [D12.776.930.900.700]

Below are MeSH descriptors whose meaning is related to "Zinc Finger Protein GLI1".

Below are MeSH descriptors whose meaning is more specific than "Zinc Finger Protein GLI1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Zinc Finger Protein GLI1" by people in this website by year, and whether "Zinc Finger Protein GLI1" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	0	1	1
2014	0	1	1
2016	1	0	1
2018	0	2	2
2019	0	1	1
2022	0	1	1

Below are the most recent publications written about "Zinc Finger Protein GLI1" by people in Profiles.

Swiderska-Syn M, Mir-Pedrol J, Oles A, Schleuger O, Salvador AD, Greiner SM, Seward C, Yang F, Babcock BR, Shen C, Wynn DT, Sanchez-Mejias A, Gershon TR, Martin V, McCrea HJ, Lindsey KG, Krieg C, Rodriguez-Blanco J. Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse. Sci Adv. 2022 07 22; 8(29):eabj9138.

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Penas C, Maloof ME, Stathias V, Long J, Tan SK, Mier J, Fang Y, Valdes C, Rodriguez-Blanco J, Chiang CM, Robbins DJ, Liebl DJ, Lee JK, Hatten ME, Clarke J, Ayad NG. Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis. Nat Commun. 2019 07 10; 10(1):3028.

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Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ. A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma. Clin Cancer Res. 2019 02 15; 25(4):1379-1388.

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Rudolph M, Sizemore ST, Lu Y, Teng KY, Basree MM, Reinbolt R, Timmers CD, Leone G, Ostrowski MC, Majumder S, Ramaswamy B. A hedgehog pathway-dependent gene signature is associated with poor clinical outcomes in Luminal A breast cancer. Breast Cancer Res Treat. 2018 Jun; 169(3):457-467.

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Wu M, Ingram L, Tolosa EJ, Vera RE, Li Q, Kim S, Ma Y, Spyropoulos DD, Beharry Z, Huang J, Fernandez-Zapico ME, Cai H. Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. J Biol Chem. 2016 Dec 02; 291(49):25749-25760.

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Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ. The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers. J Biol Chem. 2014 Dec 19; 289(51):35494-502.

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Singh S, Wang Z, Liang Fei D, Black KE, Goetz JA, Tokhunts R, Giambelli C, Rodriguez-Blanco J, Long J, Lee E, Briegel KJ, Bejarano PA, Dmitrovsky E, Capobianco AJ, Robbins DJ. Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity. Cancer Res. 2011 Jul 01; 71(13):4454-63.

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