Glycogen Synthase Kinase 3 beta

"Glycogen Synthase Kinase 3 beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycogen synthase kinase-3 type enzyme that functions in ENERGY METABOLISM; EMBRYONIC DEVELOPMENT; and NEUROGENESIS. It is also involved in PROTEIN BIOSYNTHESIS and regulates cell growth and proliferation as a component of the WNT SIGNALING PATHWAY and other signaling pathways. Certain polymorphisms in the GSK3B gene have been associated with PARKINSON DISEASE; ALZHEIMER DISEASE; and BIPOLAR DISORDER.

Descriptor ID	D000071679
MeSH Number(s)	D05.500.117.875.500 D08.811.913.696.620.682.700.429.500.500 D08.811.913.696.620.682.700.646.625.500 D12.644.360.300.500.500 D12.776.476.081.875.500 D12.776.476.300.500.500
Concept/Terms	Glycogen Synthase Kinase 3 beta Glycogen Synthase Kinase 3 beta GSK-3beta GSK 3beta GSK3beta GSK3B Protein

Below are MeSH descriptors whose meaning is more general than "Glycogen Synthase Kinase 3 beta".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Axin Signaling Complex [D05.500.117]
Glycogen Synthase Kinase 3 [D05.500.117.875]
Glycogen Synthase Kinase 3 beta [D05.500.117.875.500]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.429.500]
Glycogen Synthase Kinase 3 beta [D08.811.913.696.620.682.700.429.500.500]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.646.625]
Glycogen Synthase Kinase 3 beta [D08.811.913.696.620.682.700.646.625.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Glycogen Synthase Kinases [D12.644.360.300]
Glycogen Synthase Kinase 3 [D12.644.360.300.500]
Glycogen Synthase Kinase 3 beta [D12.644.360.300.500.500]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Axin Signaling Complex [D12.776.476.081]
Glycogen Synthase Kinase 3 [D12.776.476.081.875]
Glycogen Synthase Kinase 3 beta [D12.776.476.081.875.500]
Glycogen Synthase Kinases [D12.776.476.300]
Glycogen Synthase Kinase 3 [D12.776.476.300.500]
Glycogen Synthase Kinase 3 beta [D12.776.476.300.500.500]

Below are MeSH descriptors whose meaning is related to "Glycogen Synthase Kinase 3 beta".

Below are MeSH descriptors whose meaning is more specific than "Glycogen Synthase Kinase 3 beta".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Glycogen Synthase Kinase 3 beta" by people in this website by year, and whether "Glycogen Synthase Kinase 3 beta" was a major or minor topic of these publications.

Bar chart showing 27 publications over 16 distinct years, with a maximum of 3 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	2	2
2004	0	2	2
2005	0	1	1
2006	0	2	2
2007	0	2	2
2008	0	2	2
2009	0	1	1
2010	0	1	1
2011	0	3	3
2012	0	1	1
2014	0	2	2
2015	0	2	2
2017	0	2	2
2018	1	1	2
2020	0	1	1
2021	0	1	1

Below are the most recent publications written about "Glycogen Synthase Kinase 3 beta" by people in Profiles.

Shu Y, Hassan F, Ostrowski MC, Mehta KD. Role of hepatic PKCß in nutritional regulation of hepatic glycogen synthesis. JCI Insight. 2021 10 08; 6(19).

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Dimou A, Nasarre C, Peterson YK, Pagano R, Gooz M, Nasarre P, Drabkin HA, Armeson KE, Gibney BC, Gemmill RM, Denlinger CE. Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non-small cell lung cancer. J Thorac Cardiovasc Surg. 2021 08; 162(2):463-473.

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Coant N, García-Barros M, Zhang Q, Obeid LM, Hannun YA. AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018 07; 37(28):3852-3863.

View in: PubMed
Xin Y, Bai Y, Jiang X, Zhou S, Wang Y, Wintergerst KA, Cui T, Ji H, Tan Y, Cai L. Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway. Redox Biol. 2018 05; 15:405-417.

View in: PubMed
Lee HW, Arif E, Altintas MM, Quick K, Maheshwari S, Plezia A, Mahmood A, Reiser J, Nihalani D, Gupta V. High-content screening assay-based discovery of paullones as novel podocyte-protective agents. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F280-F292.

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Zhou S, Yin X, Jin J, Tan Y, Conklin DJ, Xin Y, Zhang Z, Sun W, Cui T, Cai J, Zheng Y, Cai L. Intermittent hypoxia-induced cardiomyopathy and its prevention by Nrf2 and metallothionein. Free Radic Biol Med. 2017 11; 112:224-239.

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Das A, Miller R, Lee P, Holden CA, Lindhorst SM, Jaboin J, Vandergrift WA, Banik NL, Giglio P, Varma AK, Raizer JJ, Patel SJ. A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/ß-catenin signaling pathway. Tumour Biol. 2015 Sep; 36(9):7027-34.

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Suo D, Park J, Young S, Makita T, Deppmann CD. Coronin-1 and calcium signaling governs sympathetic final target innervation. J Neurosci. 2015 Mar 04; 35(9):3893-902.

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Le Grand M, Rovini A, Bourgarel-Rey V, Honore S, Bastonero S, Braguer D, Carre M. ROS-mediated EB1 phosphorylation through Akt/GSK3ß pathway: implication in cancer cell response to microtubule-targeting agents. Oncotarget. 2014 May 30; 5(10):3408-23.

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McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol. 2014 Jun; 134(6):1725-1734.

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