"alpha-Macroglobulins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
| Descriptor ID |
D000511
|
| MeSH Number(s) |
D12.776.124.050.080 D12.776.124.790.106.100 D12.776.124.790.720.100 D12.776.377.715.085.100 D12.776.377.715.647.100
|
| Concept/Terms |
alpha-Macroglobulins- alpha-Macroglobulins
- alpha Macroglobulins
- 45S RNP
- RNP, 45S
- alpha-Macrofetoproteins
- alpha Macrofetoproteins
Slow alpha 2-Macroglobulins- Slow alpha 2-Macroglobulins
- Slow alpha 2 Macroglobulins
- alpha 2-Macroglobulins, Slow
- Slow alpha 2-Globulin
- Slow alpha 2 Globulin
- alpha 2-Globulin, Slow
alpha 1-Acute Phase Protein- alpha 1-Acute Phase Protein
- alpha 1 Acute Phase Protein
- Acute-Phase alpha 1-Protein
- Acute Phase alpha 1 Protein
- alpha 1-Protein, Acute-Phase
|
Below are MeSH descriptors whose meaning is more general than "alpha-Macroglobulins".
Below are MeSH descriptors whose meaning is more specific than "alpha-Macroglobulins".
This graph shows the total number of publications written about "alpha-Macroglobulins" by people in this website by year, and whether "alpha-Macroglobulins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "alpha-Macroglobulins" by people in Profiles.
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Hou W, Janech MG, Sobolesky PM, Bland AM, Samsuddin S, Alazawi W, Syn WK. Proteomic screening of plasma identifies potential noninvasive biomarkers associated with significant/advanced fibrosis in patients with nonalcoholic fatty liver disease. Biosci Rep. 2020 01 31; 40(1).
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Gomez IG, Tang J, Wilson CL, Yan W, Heinecke JW, Harlan JM, Raines EW. Metalloproteinase-mediated Shedding of Integrin ß2 promotes macrophage efflux from inflammatory sites. J Biol Chem. 2012 Feb 10; 287(7):4581-9.
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Patel K, Nelson DR, Rockey DC, Afdhal NH, Smith KM, Oh E, Hettinger K, Vallée M, Dev A, Smith-Riggs M, McHutchison JG. Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C. Clin Gastroenterol Hepatol. 2008 Feb; 6(2):242-7.
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Mikhailenko I, Battey FD, Migliorini M, Ruiz JF, Argraves K, Moayeri M, Strickland DK. Recognition of alpha 2-macroglobulin by the low density lipoprotein receptor-related protein requires the cooperation of two ligand binding cluster regions. J Biol Chem. 2001 Oct 19; 276(42):39484-91.
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Crawford F, Town T, Freeman M, Schinka J, Gold M, Duara R, Mullan M. The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample. Neurosci Lett. 1999 Aug 06; 270(3):133-6.
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Williams SE, Kounnas MZ, Argraves KM, Argraves WS, Strickland DK. The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the receptor-associated protein. An overview. Ann N Y Acad Sci. 1994 Sep 10; 737:1-13.
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Strickland DK, Ashcom JD, Williams S, Battey F, Behre E, McTigue K, Battey JF, Argraves WS. Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. J Biol Chem. 1991 Jul 15; 266(20):13364-9.
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Greenberg CS, Dobson JV, Miraglia CC. Regulation of plasma factor XIII binding to fibrin in vitro. Blood. 1985 Nov; 66(5):1028-34.
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Harpel PC, Lewin MF, Kaplan AP. Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes. J Biol Chem. 1985 Apr 10; 260(7):4257-63.
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Lushbaugh WB, Kairalla AB, Hofbauer AF, Arnaud P, Cantey JR, Pittman FE. Inhibition of Entamoeba histolytica cytotoxin by alpha 1 antiprotease and alpha 2 macroglobulin. Am J Trop Med Hyg. 1981 May; 30(3):575-85.