"Didanosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
- 2',3' Dideoxyinosine
- ddI (Antiviral)
Below are MeSH descriptors whose meaning is more general than "Didanosine".
Below are MeSH descriptors whose meaning is more specific than "Didanosine".
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Below are the most recent publications written about "Didanosine" by people in Profiles.
Biddle AK, Simpson KN. Modeling the use of triple combination therapy in five countries: nevirapine, Zidovudine, and Didanosine. Value Health. 2000 May-Jun; 3(3):186-201.
Cotton P. FDA 'pushing envelope' on AIDS drug. JAMA. 1991 Aug 14; 266(6):757-8.
Cotton P. Surrogate markers of disease studied as means of determining AIDS drugs' effectiveness. JAMA. 1990 Nov 14; 264(18):2362, 2365.