"Prions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
Descriptor ID |
D011328
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MeSH Number(s) |
D12.776.785
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Prions".
Below are MeSH descriptors whose meaning is more specific than "Prions".
This graph shows the total number of publications written about "Prions" by people in this website by year, and whether "Prions" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Prions" by people in Profiles.
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The structural basis of yeast prion strain variants. Nature. 2007 Sep 13; 449(7159):233-7.
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Bad news and good news: what the dentist needs to know about transmissible spongiform encephalopathies. Quintessence Int. 1998 May; 29(5):319-21.
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Beta-Amyloid peptide and amyloid precursor proteins in olfactory mucosa of patients with Alzheimer's disease, Parkinson's disease, and Down syndrome. Ann Otol Rhinol Laryngol. 1995 Aug; 104(8):655-61.
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Slow virus diseases. Annu Rev Microbiol. 1974; 28(0):231-4.