"Dantrolene" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
| Descriptor ID |
D003620
|
| MeSH Number(s) |
D03.383.129.308.432.555.287
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dantrolene".
Below are MeSH descriptors whose meaning is more specific than "Dantrolene".
This graph shows the total number of publications written about "Dantrolene" by people in this website by year, and whether "Dantrolene" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dantrolene" by people in Profiles.
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Pathophysiology and Treatment of Malignant Hyperthermia. Adv Emerg Nurs J. 2021 Apr-Jun 01; 43(2):102-110.
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Management of a Patient With a History of Nonanesthesia-Related Malignant Hyperthermia Undergoing Laparoscopic Cholecystectomy: A Case Report. A A Pract. 2018 Sep 01; 11(5):137-139.
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Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016 12 01; 25(23):5126-5141.
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Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J Neurosci. 2000 Feb 15; 20(4):1358-64.
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General anesthesia in a malignant hyperthermia susceptible patient. J Oral Med. 1987 Jan-Mar; 42(1):22-4, 66.