Protein Disulfide-Isomerases
"Protein Disulfide-Isomerases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Sulfur-sulfur bond isomerases that catalyze the rearrangement of disulfide bonds within proteins during folding. Specific protein disulfide-isomerase isoenzymes also occur as subunits of PROCOLLAGEN-PROLINE DIOXYGENASE.
| Descriptor ID |
D019704
|
| MeSH Number(s) |
D08.811.399.475.800.550
|
| Concept/Terms |
Protein Disulfide-Isomerases- Protein Disulfide-Isomerases
- Disulfide-Isomerases, Protein
- Protein Disulfide Isomerases
- Disulfide Isomerase
- Isomerase, Disulfide
- Glycosylation Site-Binding Protein
- Glycosylation Site Binding Protein
- Protein, Glycosylation Site-Binding
- Site-Binding Protein, Glycosylation
- Trypanothione-Glutathione Thioltransferase
- Thioltransferase, Trypanothione-Glutathione
- Trypanothione Glutathione Thioltransferase
- Protein Disulfide-Isomerase
- Disulfide-Isomerase, Protein
- Sulfhydryl-Disulfide Interchange Enzyme
- Enzyme, Sulfhydryl-Disulfide Interchange
- Interchange Enzyme, Sulfhydryl-Disulfide
- Sulfhydryl Disulfide Interchange Enzyme
- Thiol-Disulfide Transhydrogenase
- Thiol Disulfide Transhydrogenase
- Transhydrogenase, Thiol-Disulfide
- Disulfide Interchange Enzyme
- Enzyme, Disulfide Interchange
- Interchange Enzyme, Disulfide
- Protein Disulfide Isomerase
- Disulfide Isomerase, Protein
- Isomerase, Protein Disulfide
|
Below are MeSH descriptors whose meaning is more general than "Protein Disulfide-Isomerases".
Below are MeSH descriptors whose meaning is more specific than "Protein Disulfide-Isomerases".
This graph shows the total number of publications written about "Protein Disulfide-Isomerases" by people in this website by year, and whether "Protein Disulfide-Isomerases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Protein Disulfide-Isomerases" by people in Profiles.
-
Robinson RM, Basar AP, Reyes L, Duncan RM, Li H, Dolloff NG. PDI inhibitor LTI6426 enhances panobinostat efficacy in preclinical models of multiple myeloma. Cancer Chemother Pharmacol. 2022 05; 89(5):643-653.
-
Duncan RM, Reyes L, Moats K, Robinson RM, Murphy SA, Kaur B, Stessman HAF, Dolloff NG. ATF3 Coordinates Antitumor Synergy between Epigenetic Drugs and Protein Disulfide Isomerase Inhibitors. Cancer Res. 2020 08 15; 80(16):3279-3291.
-
Hurst KE, Lawrence KA, Reyes Angeles L, Ye Z, Zhang J, Townsend DM, Dolloff N, Thaxton JE. Endoplasmic Reticulum Protein Disulfide Isomerase Shapes T Cell Efficacy for Adoptive Cellular Therapy of Tumors. Cells. 2019 11 26; 8(12).
-
Robinson RM, Reyes L, Duncan RM, Bian H, Strobel ED, Hyman SL, Reitz AB, Dolloff NG. Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor. Eur J Med Chem. 2020 Jan 15; 186:111906.
-
Robinson RM, Reyes L, Duncan RM, Bian H, Reitz AB, Manevich Y, McClure JJ, Champion MM, Chou CJ, Sharik ME, Chesi M, Bergsagel PL, Dolloff NG. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 04; 33(4):1011-1022.
-
Manuel AM, Walla MD, Faccenda A, Martin SL, Tanis RM, Piroli GG, Adam J, Kantor B, Mutus B, Townsend DM, Frizzell N. Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes. Antioxid Redox Signal. 2017 Dec 01; 27(16):1281-1296.
-
Kenche H, Ye ZW, Vedagiri K, Richards DM, Gao XH, Tew KD, Townsend DM, Blumental-Perry A. Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase. J Biol Chem. 2016 Feb 26; 291(9):4763-78.
-
Kenche H, Baty CJ, Vedagiri K, Shapiro SD, Blumental-Perry A. Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. FASEB J. 2013 Mar; 27(3):965-77.
-
Uys JD, Xiong Y, Townsend DM. Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase. Methods Enzymol. 2011; 490:321-32.
-
Townsend DM, Manevich Y, He L, Xiong Y, Bowers RR, Hutchens S, Tew KD. Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response. Cancer Res. 2009 Oct 01; 69(19):7626-34.