"Dapsone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
| Descriptor ID |
D003622
|
| MeSH Number(s) |
D02.886.590.263
|
| Concept/Terms |
Dapsone- Dapsone
- DADPS
- Sulfonyldianiline
- Diaminodiphenylsulfone
- Diaphenylsulfone
- 4,4'-Diaminophenyl Sulfone
- 4,4' Diaminophenyl Sulfone
- Sulfone, 4,4'-Diaminophenyl
|
Below are MeSH descriptors whose meaning is more general than "Dapsone".
Below are MeSH descriptors whose meaning is more specific than "Dapsone".
This graph shows the total number of publications written about "Dapsone" by people in this website by year, and whether "Dapsone" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 3 | 0 | 3 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 1 | 2 |
| 1999 | 1 | 1 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 4 | 0 | 4 |
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Below are the most recent publications written about "Dapsone" by people in Profiles.
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Effect of pro-inflammatory cytokines on the toxicity of the arylhydroxylamine metabolites of sulphamethoxazole and dapsone in normal human keratinocytes. Toxicology. 2006 Feb 01; 218(2-3):90-9.
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Lipids versus proteins as major targets of pro-oxidant, direct-acting hemolytic agents. Toxicol Sci. 2005 Nov; 88(1):274-83.
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Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes. Biochem Pharmacol. 2005 Jul 15; 70(2):275-86.
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Comparison of colchicine, dapsone, triamcinolone, and diphenhydramine therapy for the treatment of brown recluse spider envenomation: a double-blind, controlled study in a rabbit model. Arch Dermatol. 2005 May; 141(5):595-7.
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Bullous eruption: a manifestation of lupus erythematosus. Cutis. 2003 Jul; 72(1):31-7.
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Long-term suppression of chronic Sweet's syndrome with colchicine. J Am Acad Dermatol. 2002 Aug; 47(2):323-4.
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Oxidative stress, glucose-6-phosphate dehydrogenase and the red cell. Adv Exp Med Biol. 2001; 500:595-605.
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Generalized annular borderline tuberculoid leprosy and update in management of Hansen's disease. Cutis. 2000 Apr; 65(4):203-6.
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Is hydroxylamine-induced cytotoxicity a valid marker for hypersensitivity reactions to sulfamethoxazole in human immunodeficiency virus-infected individuals? J Pharmacol Exp Ther. 1999 Dec; 291(3):1356-64.
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Methemoglobin formation by hydroxylamine metabolites of sulfamethoxazole and dapsone: implications for differences in adverse drug reactions. J Pharmacol Exp Ther. 1999 Mar; 288(3):951-9.