"Hemoglobin, Sickle" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
| Descriptor ID |
D006451
|
| MeSH Number(s) |
D12.776.124.400.463.588 D12.776.422.316.762.426.588
|
| Concept/Terms |
Deoxyhemoglobin S- Deoxyhemoglobin S
- Deoxygenated Sickle Hemoglobin
- Hemoglobin, Deoxygenated Sickle
- Sickle Hemoglobin, Deoxygenated
|
Below are MeSH descriptors whose meaning is more general than "Hemoglobin, Sickle".
Below are MeSH descriptors whose meaning is more specific than "Hemoglobin, Sickle".
This graph shows the total number of publications written about "Hemoglobin, Sickle" by people in this website by year, and whether "Hemoglobin, Sickle" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 1 | 0 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Hemoglobin, Sickle" by people in Profiles.
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Voxelotor for the treatment of sickle cell disease in pediatric patients. Expert Rev Hematol. 2022 06; 15(6):485-492.
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Safety and efficacy of voxelotor in pediatric patients with sickle cell disease aged 4 to 11?years. Pediatr Blood Cancer. 2022 08; 69(8):e29716.
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A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease. N Engl J Med. 2019 08 08; 381(6):509-519.
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Multifunctional magnetic rotator for micro and nanorheological studies. Rev Sci Instrum. 2012 Jun; 83(6):065110.
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Chronic transfusion practices for prevention of primary stroke in children with sickle cell anemia and abnormal TCD velocities. Am J Hematol. 2012 Apr; 87(4):428-30.
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Effect of chronic transfusion therapy on progression of neurovascular pathology in pediatric patients with sickle cell anemia. Blood Cells Mol Dis. 2011 Aug 15; 47(2):125-8.
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Associations of multi-locus polymorphisms in an immune network with susceptibility to uncomplicated Plasmodium falciparum malaria in Daraweesh village, Eastern Sudan. Infect Genet Evol. 2011 Oct; 11(7):1674-81.
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Impact of chronic transfusion on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemia. J Pediatr. 2001 Dec; 139(6):785-9.
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Laboratory recognition of a rare hemoglobinopathy: hemoglobins SS and SG(Philadelphia) associated with alpha-thalassemia-2. Arch Pathol Lab Med. 1999 Oct; 123(10):963-6.
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Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998 Jul 02; 339(1):5-11.