Fluorouracil

"Fluorouracil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

Descriptor ID	D005472
MeSH Number(s)	D03.383.742.698.875.404
Concept/Terms	Fluorouracil Fluorouracil 5FU 5-FU 5-Fluorouracil 5 Fluorouracil Fluoruracil 5-FU Lederle 5-FU Lederle 5 FU Lederle 5-FU Medac 5-FU Medac 5 FU Medac 5-HU Hexal 5-HU Hexal 5 HU Hexal Adrucil Adrucil Carac Carac Efudix Efudix Fluoro-Uracile ICN Fluoro Uracile ICN Efudex Fluoroplex Fluoroplex Flurodex Fluorouracil Mononitrate Fluorouracil Mononitrate Fluorouracil Monopotassium Salt Fluorouracil Monopotassium Salt Fluorouracil Monosodium Salt Fluorouracil Monosodium Salt Fluorouracil Potassium Salt Fluorouracil Potassium Salt Fluorouracil-GRY Fluorouracil-GRY Fluorouracil GRY Fluorouracile Dakota Fluorouracile Dakota Dakota, Fluorouracile Fluorouracilo Ferrer Far Fluorouracilo Ferrer Far Fluracedyl Fluracedyl Haemato-FU Haemato-FU Haemato FU Neofluor Neofluor Onkofluor Onkofluor Ribofluor Ribofluor 5-Fluorouracil-Biosyn 5-Fluorouracil-Biosyn 5 Fluorouracil Biosyn

Below are MeSH descriptors whose meaning is more general than "Fluorouracil".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]
Pyrimidinones [D03.383.742.698]
Uracil [D03.383.742.698.875]
Fluorouracil [D03.383.742.698.875.404]

Below are MeSH descriptors whose meaning is related to "Fluorouracil".

Below are MeSH descriptors whose meaning is more specific than "Fluorouracil".

Fluorouracil
Capecitabine
Tegafur

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Fluorouracil" by people in this website by year, and whether "Fluorouracil" was a major or minor topic of these publications.

Bar chart showing 75 publications over 29 distinct years, with a maximum of 5 publications in 1993 and 1995

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	0	5	5
1994	0	3	3
1995	0	5	5
1996	0	3	3
1997	1	0	1
1998	1	2	3
1999	4	0	4
2000	2	1	3
2001	0	4	4
2002	2	1	3
2003	1	1	2
2004	2	2	4
2005	0	1	1
2006	1	2	3
2007	0	2	2
2008	0	1	1
2009	0	2	2
2010	0	2	2
2011	1	3	4
2012	1	1	2
2013	1	0	1
2014	2	1	3
2015	1	2	3
2016	0	1	1
2017	1	2	3
2018	0	1	1
2019	1	0	1
2020	1	1	2
2021	0	3	3

Below are the most recent publications written about "Fluorouracil" by people in Profiles.

Eisen DB, Asgari MM, Bennett DD, Connolly SM, Dellavalle RP, Freeman EE, Goldenberg G, Leffell DJ, Peschin S, Sligh JE, Wu PA, Frazer-Green L, Malik S, Schlesinger TE. Guidelines of care for the management of actinic keratosis: Executive summary. J Am Acad Dermatol. 2021 10; 85(4):945-955.

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Eisen DB, Asgari MM, Bennett DD, Connolly SM, Dellavalle RP, Freeman EE, Goldenberg G, Leffell DJ, Peschin S, Sligh JE, Wu PA, Frazer-Green L, Malik S, Schlesinger TE. Guidelines of care for the management of actinic keratosis. J Am Acad Dermatol. 2021 10; 85(4):e209-e233.

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Ghatak S, Hascall VC, Markwald RR, Misra S. FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells. Int J Mol Sci. 2021 Jan 13; 22(2).

View in: PubMed
Elston DM. Medical therapy for keratoacanthomas. J Am Acad Dermatol. 2020 11; 83(5):1544-1545.

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Janakiraman H, Zhu Y, Becker SA, Wang C, Cross A, Curl E, Lewin D, Hoffman BJ, Warren GW, Hill EG, Timmers C, Findlay VJ, Camp ER. Modeling rectal cancer to advance neoadjuvant precision therapy. Int J Cancer. 2020 09 01; 147(5):1405-1418.

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Sougiannis AT, VanderVeen BN, Enos RT, Velazquez KT, Bader JE, Carson M, Chatzistamou I, Walla M, Pena MM, Kubinak JL, Nagarkatti M, Carson JA, Murphy EA. Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota. Brain Behav Immun. 2019 08; 80:44-55.

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Touchefeu Y, Guimbaud R, Louvet C, Dahan L, Samalin E, Barbier E, Le Malicot K, Cohen R, Gornet JM, Aparicio T, Nguyen S, Azzedine A, Etienne PL, Phelip JM, Hammel P, Chapelle N, Sefrioui D, Mineur L, Lepage C, Bouche O. Prognostic factors in patients treated with second-line chemotherapy for advanced gastric cancer: results from the randomized prospective phase III FFCD-0307 trial. Gastric Cancer. 2019 05; 22(3):577-586.

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Mohana M, Thomas Muthiah P, McMillen CD. Supramolecular architectures in two 1:1 cocrystals of 5-fluorouracil with 5-bromothiophene-2-carboxylic acid and thiophene-2-carboxylic acid. Acta Crystallogr C Struct Chem. 2017 Jun 01; 73(Pt 6):481-485.

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Sengupta N, Reardon DC, Gerard PD, Baldwin WS. Exchange of polar lipids from adults to neonates in Daphnia magna: Perturbations in sphingomyelin allocation by dietary lipids and environmental toxicants. PLoS One. 2017; 12(5):e0178131.

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Symmans WF, Wei C, Gould R, Yu X, Zhang Y, Liu M, Walls A, Bousamra A, Ramineni M, Sinn B, Hunt K, Buchholz TA, Valero V, Buzdar AU, Yang W, Brewster AM, Moulder S, Pusztai L, Hatzis C, Hortobagyi GN. Long-Term Prognostic Risk After Neoadjuvant Chemotherapy Associated With Residual Cancer Burden and Breast Cancer Subtype. J Clin Oncol. 2017 Apr 01; 35(10):1049-1060.

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