"Spiperone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
| Descriptor ID |
D013134
|
| MeSH Number(s) |
D02.455.426.779.800 D02.522.352.800 D04.711.800
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Spiperone".
Below are MeSH descriptors whose meaning is more specific than "Spiperone".
This graph shows the total number of publications written about "Spiperone" by people in this website by year, and whether "Spiperone" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Spiperone" by people in Profiles.
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Burris KD, Molski TF, Xu C, Ryan E, Tottori K, Kikuchi T, Yocca FD, Molinoff PB. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul; 302(1):381-9.
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Chu TC, Ogidigben MJ, Potter DE. 8OH-DPAT-Induced ocular hypotension: sites and mechanisms of action. Exp Eye Res. 1999 Aug; 69(2):227-38.
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See RE, Lynch AM, Sorg BA. Subchronic administration of clozapine, but not haloperidol or metoclopramide, decreases dopamine D2 receptor messenger RNA levels in the nucleus accumbens and caudate-putamen in rats. Neuroscience. 1996 May; 72(1):99-104.
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Mayfield RD, Randall PK, Spirduso WW, Wilcox RE. Selective D1 and D2 dopamine receptor antagonists produce differential effects on reaction time in the rat. Pharmacol Biochem Behav. 1993 Dec; 46(4):759-68.
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Mach RH, Jackson JR, Luedtke RR, Ivins KJ, Molinoff PB, Ehrenkaufer RL. Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. J Med Chem. 1992 Feb 07; 35(3):423-30.
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Austin LS, Lydiard RB, Ballenger JC, Cohen BM, Laraia MT, Zealberg JJ, Fossey MD, Ellinwood EH. Dopamine blocking activity of clomipramine in patients with obsessive-compulsive disorder. Biol Psychiatry. 1991 Aug 01; 30(3):225-32.
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Mandel RJ, Yurek DM, Randall PK. Behavioral demonstration of a reciprocal interaction between dopamine receptor subtypes in the mouse striatum: possible involvement of the striato-nigral pathway. Brain Res Bull. 1990 Aug; 25(2):285-92.
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Luedtke RR, Bush M, Mach RH, Ehrenkaufer RE, Kung HF, Molinoff PB. Antibodies with high affinity for spiroperidol--II. Cross reactivity with iodobenzamide and domperidone. Mol Immunol. 1990 Jul; 27(7):667-77.
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Severson JA, Randall PK, Wilcox RE. Single apomorphine pretreatment results in a rapid decline in high-affinity dopamine binding to the striatal dopamine D-2 receptor. Eur J Pharmacol. 1990 Apr 25; 188(4-5):283-6.
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Schonwetter BS, Luedtke RR, Kung MP, Billings J, Kung HF, Molinoff PB. Characterization of membrane-bound and soluble D2 receptors in canine caudate using [125I]IBZM. J Pharmacol Exp Ther. 1989 Jul; 250(1):110-6.