Neural Tube Defects

"Neural Tube Defects" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)

Descriptor ID	D009436
MeSH Number(s)	C10.500.680 C16.131.666.680
Concept/Terms	Neural Tube Defects Neural Tube Defects Defect, Neural Tube Defects, Neural Tube Neural Tube Defect Developmental Neural Tube Defects Neural Tube Developmental Defects Developmental Defects, Neural Tube Craniorachischisis Craniorachischisis Craniorachischises Diastematomyelia Diastematomyelia Diastematomyelias Tethered Cord Syndrome Tethered Cord Syndrome Tethered Cord Syndromes Occult Spinal Dysraphism Sequence Tethered Spinal Cord Syndrome Occult Spinal Dysraphism Dysraphism, Occult Spinal Dysraphisms, Occult Spinal Occult Spinal Dysraphisms Spinal Dysraphism, Occult Spinal Dysraphisms, Occult Iniencephaly Iniencephaly Iniencephalies Neurenteric Cyst Neurenteric Cyst Cyst, Neurenteric Cysts, Neurenteric Neurenteric Cysts Neuroenteric Cyst Cyst, Neuroenteric Cysts, Neuroenteric Neuroenteric Cysts Spinal Cord Myelodysplasia Spinal Cord Myelodysplasia Myelodysplasia, Spinal Cord Myelodysplasias, Spinal Cord Spinal Cord Myelodysplasias Acrania Acrania Acranias Exencephaly Exencephaly Exencephalies

Below are MeSH descriptors whose meaning is more general than "Neural Tube Defects".

Diseases [C]
Nervous System Diseases [C10]
Nervous System Malformations [C10.500]
Neural Tube Defects [C10.500.680]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Congenital Abnormalities [C16.131]
Nervous System Malformations [C16.131.666]
Neural Tube Defects [C16.131.666.680]

Below are MeSH descriptors whose meaning is related to "Neural Tube Defects".

Below are MeSH descriptors whose meaning is more specific than "Neural Tube Defects".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Neural Tube Defects" by people in this website by year, and whether "Neural Tube Defects" was a major or minor topic of these publications.

Bar chart showing 20 publications over 17 distinct years, with a maximum of 2 publications in 2012 and 2015 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1996	1	0	1
1997	1	0	1
2000	1	0	1
2003	1	0	1
2005	0	1	1
2006	0	1	1
2008	1	0	1
2010	1	0	1
2011	1	0	1
2012	1	1	2
2013	1	0	1
2015	2	0	2
2016	0	1	1
2018	1	1	2
2019	1	0	1
2021	1	0	1

Below are the most recent publications written about "Neural Tube Defects" by people in Profiles.

Lepage N, Wyatt P, Ashwood ER, Best RG, Long T, Palomaki GE. Prenatal serum screening for Down syndrome and neural tube defects in the United States: Changes in utilization patterns from 2012 to 2020. J Med Screen. 2021 12; 28(4):405-410.

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Palomaki GE, Bupp C, Gregg AR, Norton ME, Oglesbee D, Best RG. Laboratory screening and diagnosis of open neural tube defects, 2019 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2020 03; 22(3):462-474.

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Rogers LM, Cordero AM, Pfeiffer CM, Hausman DB, Tsang BL, De-Regil LM, Rosenthal J, Razzaghi H, Wong EC, Weakland AP, Bailey LB. Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues. Ann N Y Acad Sci. 2018 11; 1431(1):35-57.

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Spellicy CJ, Norris J, Bend R, Bupp C, Mester P, Reynolds T, Dean J, Peng Y, Alexov E, Schwartz CE, Stevenson RS, J Friez M. Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects. Eur J Hum Genet. 2018 03; 26(3):420-427.

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Pfeiffer CM, Sternberg MR, Hamner HC, Crider KS, Lacher DA, Rogers LM, Bailey RL, Yetley EA. Applying inappropriate cutoffs leads to misinterpretation of folate status in the US population. Am J Clin Nutr. 2016 12; 104(6):1607-1615.

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Cordero AM, Crider KS, Rogers LM, Cannon MJ, Berry RJ. Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects: World Health Organization guidelines. MMWR Morb Mortal Wkly Rep. 2015 Apr 24; 64(15):421-3.

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Taylor CM, Atkinson C, Penfold C, Bhattacharya S, Campbell D, Davey Smith G, Leary S, Ness A. Folic acid in pregnancy and mortality from cancer and cardiovascular disease: further follow-up of the Aberdeen folic acid supplementation trial. J Epidemiol Community Health. 2015 Aug; 69(8):789-94.

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McMahon DM, Liu J, Zhang H, Torres ME, Best RG. Maternal obesity, folate intake, and neural tube defects in offspring. Birth Defects Res A Clin Mol Teratol. 2013 Feb; 97(2):115-22.

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Mooney JF, Glazier SS, Barfield WR. Concurrent orthopedic and neurosurgical procedures in pediatric patients with spinal deformity. J Pediatr Orthop B. 2012 Nov; 21(6):602-5.

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Singh CK, Kumar A, LaVoie HA, DiPette DJ, Singh US. Resveratrol prevents impairment in activation of retinoic acid receptors and MAP kinases in the embryos of a rodent model of diabetic embryopathy. Reprod Sci. 2012 Sep; 19(9):949-61.

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