"Ethacrynic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
| Descriptor ID |
D004976
|
| MeSH Number(s) |
D02.241.081.018.386.682.300 D02.241.511.316.682.200
|
| Concept/Terms |
Ethacrynic Acid- Ethacrynic Acid
- Acid, Ethacrynic
- Etacrynic Acid
- Acid, Etacrynic
- Ethacrinic Acid
- Acid, Ethacrinic
|
Below are MeSH descriptors whose meaning is more general than "Ethacrynic Acid".
Below are MeSH descriptors whose meaning is more specific than "Ethacrynic Acid".
This graph shows the total number of publications written about "Ethacrynic Acid" by people in this website by year, and whether "Ethacrynic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 1 | 2 |
| 1994 | 1 | 2 | 3 |
| 1995 | 1 | 1 | 2 |
| 1996 | 2 | 0 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ethacrynic Acid" by people in Profiles.
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Tew KD, O'Brien M, Laing NM, Shen H. Coordinate changes in expression of protective genes in drug-resistant cells. Chem Biol Interact. 1998 Apr 24; 111-112:199-211.
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Shen H, Kauvar L, Tew KD. Importance of glutathione and associated enzymes in drug response. Oncol Res. 1997; 9(6-7):295-302.
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Ciaccio PJ, Tew KD. Adaptive response to glutathione S-transferase inhibitors. Br J Cancer Suppl. 1996 Jul; 27:S93-8.
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Ciaccio PJ, Shen H, Kruh GD, Tew KD. Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells. Biochem Biophys Res Commun. 1996 May 06; 222(1):111-5.
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Shen H, Ranganathan S, Kuzmich S, Tew KD. Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells. Biochem Pharmacol. 1995 Oct 12; 50(8):1233-8.
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Ciaccio PJ, Shen H, Jaiswal AK, Lyttle MH, Tew KD. Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors. Mol Pharmacol. 1995 Oct; 48(4):639-47.
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Lacreta FP, Brennan JM, Nash SL, Comis RL, Tew KD, O'Dwyer PJ. Pharmakokinetics and bioavailability study of ethacrynic acid as a modulator of drug resistance in patients with cancer. J Pharmacol Exp Ther. 1994 Sep; 270(3):1186-91.
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Ciaccio PJ, Tew KD. cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase. Biochim Biophys Acta. 1994 Jun 28; 1186(1-2):129-32.
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Ciaccio PJ, Jaiswal AK, Tew KD. Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. J Biol Chem. 1994 Jun 03; 269(22):15558-62.
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Cotton P. Focus in glaucoma may change from keeping fluid out to letting fluid out. JAMA. 1993 Jun 02; 269(21):2711.