Receptors, Adrenergic, alpha
"Receptors, Adrenergic, alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
| Descriptor ID |
D011942
|
| MeSH Number(s) |
D12.776.543.750.670.300.300.300 D12.776.543.750.695.150.300.300 D12.776.543.750.720.330.300.300
|
| Concept/Terms |
Receptors, Adrenergic, alpha- Receptors, Adrenergic, alpha
- Adrenergic alpha-Receptors
- Adrenergic alpha Receptors
- alpha-Receptors, Adrenergic
- alpha-Adrenergic Receptors
- alpha Adrenergic Receptors
- Receptor, Adrenergic, alpha
- Receptors, alpha-Adrenergic
- Receptors, alpha Adrenergic
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Adrenergic, alpha".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Biogenic Amine [D12.776.543.750.670]
- Receptors, Catecholamine [D12.776.543.750.670.300]
- Receptors, Adrenergic [D12.776.543.750.670.300.300]
- Receptors, Adrenergic, alpha [D12.776.543.750.670.300.300.300]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Catecholamine [D12.776.543.750.695.150]
- Receptors, Adrenergic [D12.776.543.750.695.150.300]
- Receptors, Adrenergic, alpha [D12.776.543.750.695.150.300.300]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Catecholamine [D12.776.543.750.720.330]
- Receptors, Adrenergic [D12.776.543.750.720.330.300]
- Receptors, Adrenergic, alpha [D12.776.543.750.720.330.300.300]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Adrenergic, alpha".
This graph shows the total number of publications written about "Receptors, Adrenergic, alpha" by people in this website by year, and whether "Receptors, Adrenergic, alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 3 | 0 | 3 |
| 1995 | 0 | 2 | 2 |
| 1996 | 2 | 0 | 2 |
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 0 | 2 |
| 2000 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Adrenergic, alpha" by people in Profiles.
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Pierce KL, Maudsley S, Daaka Y, Luttrell LM, Lefkowitz RJ. Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1489-94.
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Haastrup AT, Stepniakowski KT, Goodfriend TL, Egan BM. Intralipid enhances alpha1-adrenergic receptor mediated pressor sensitivity. Hypertension. 1998 Oct; 32(4):693-8.
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Akhter SA, Luttrell LM, Rockman HA, Iaccarino G, Lefkowitz RJ, Koch WJ. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science. 1998 Apr 24; 280(5363):574-7.
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Stepniakowski KT, Lu G, Miller GD, Egan BM. Fatty acids, not insulin, modulate alpha1-adrenergic reactivity in dorsal hand veins. Hypertension. 1997 Nov; 30(5):1150-5.
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Stepniakowski KT, Sallee FR, Goodfriend TL, Zhang Z, Egan BM. Fatty acids enhance neurovascular reflex responses by effects on alpha 1-adrenoceptors. Am J Physiol. 1996 Jun; 270(6 Pt 2):R1340-6.
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Piascik MT, Soltis EE, Piascik MM, Macmillan LB. Alpha-adrenoceptors and vascular regulation: molecular, pharmacologic and clinical correlates. Pharmacol Ther. 1996; 72(3):215-41.
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Zhou MD, Sucov HM, Evans RM, Chien KR. Retinoid-dependent pathways suppress myocardial cell hypertrophy. Proc Natl Acad Sci U S A. 1995 Aug 01; 92(16):7391-5.
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Kjeldsen SE, Weder AB, Egan B, Neubig R, Zweifler AJ, Julius S. Effect of circulating epinephrine on platelet function and hematocrit. Hypertension. 1995 May; 25(5):1096-105.
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Neahring JM, Stepniakowski K, Greene AS, Egan BM. Insulin does not reduce forearm alpha-vasoreactivity in obese hypertensive or lean normotensive men. Hypertension. 1993 Oct; 22(4):584-90.
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Del Monte F, Mynett JR, Sugden PH, Poole-Wilson PA, Harding SE. Subcellular mechanism of the species difference in the contractile response of ventricular myocytes to endothelin-1. Cardioscience. 1993 Sep; 4(3):185-91.