"Phytanic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 20-carbon branched chain fatty acid. In phytanic acid storage disease (REFSUM DISEASE) this lipid may comprise as much as 30% of the total fatty acids of the plasma. This is due to a phytanic acid alpha-hydroxylase deficiency.
| Descriptor ID |
D010831
|
| MeSH Number(s) |
D02.455.849.291.515
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Phytanic Acid".
Below are MeSH descriptors whose meaning is more specific than "Phytanic Acid".
This graph shows the total number of publications written about "Phytanic Acid" by people in this website by year, and whether "Phytanic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 2 | 0 | 2 |
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phytanic Acid" by people in Profiles.
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Peroxisomal fatty acid oxidation and cellular redox. Methods Enzymol. 2002; 352:361-72.
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Restoration of phytanic acid oxidation in Refsum disease fibroblasts from patients with mutations in the phytanoyl-CoA hydroxylase gene. FEBS Lett. 1998 Jun 05; 429(1):119-22.
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Biochemistry of peroxisomes in health and disease. Mol Cell Biochem. 1997 Feb; 167(1-2):1-29.
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Phytanic acid oxidation: normal activation and transport yet defective alpha-hydroxylation of phytanic acid in peroxisomes from Refsum disease and rhizomelic chondrodysplasia punctata. J Lipid Res. 1996 May; 37(5):1137-43.
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Ketoconazole and other imidazole derivatives are potent inhibitors of peroxisomal phytanic acid alpha-oxidation. FEBS Lett. 1995 Dec 18; 377(2):213-6.
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Phytanic acid oxidation: topographical localization of phytanoyl-CoA ligase and transport of phytanic acid into human peroxisomes. J Lipid Res. 1995 May; 36(5):986-97.
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Phytanic acid alpha-oxidation in rat liver mitochondria. Biochim Biophys Acta. 1994 Dec 15; 1201(3):491-7.
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Intraorganellar localization of CoASH-independent phytanic acid oxidation in human liver peroxisomes. FEBS Lett. 1993 Oct 25; 333(1-2):154-8.
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Refsum disease: a defect in the alpha-oxidation of phytanic acid in peroxisomes. J Lipid Res. 1993 Oct; 34(10):1755-64.
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Phytanic acid alpha-oxidation. Differential subcellular localization in rat and human tissues and its inhibition by nycodenz. J Biol Chem. 1993 May 15; 268(14):9972-9.