"Phytanic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 20-carbon branched chain fatty acid. In phytanic acid storage disease (REFSUM DISEASE) this lipid may comprise as much as 30% of the total fatty acids of the plasma. This is due to a phytanic acid alpha-hydroxylase deficiency.
Below are MeSH descriptors whose meaning is more general than "Phytanic Acid".
Below are MeSH descriptors whose meaning is more specific than "Phytanic Acid".
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Below are the most recent publications written about "Phytanic Acid" by people in Profiles.
Peroxisomal fatty acid oxidation and cellular redox. Methods Enzymol. 2002; 352:361-72.
Restoration of phytanic acid oxidation in Refsum disease fibroblasts from patients with mutations in the phytanoyl-CoA hydroxylase gene. FEBS Lett. 1998 Jun 05; 429(1):119-22.
Biochemistry of peroxisomes in health and disease. Mol Cell Biochem. 1997 Feb; 167(1-2):1-29.
Phytanic acid oxidation: normal activation and transport yet defective alpha-hydroxylation of phytanic acid in peroxisomes from Refsum disease and rhizomelic chondrodysplasia punctata. J Lipid Res. 1996 May; 37(5):1137-43.
Ketoconazole and other imidazole derivatives are potent inhibitors of peroxisomal phytanic acid alpha-oxidation. FEBS Lett. 1995 Dec 18; 377(2):213-6.
Phytanic acid oxidation: topographical localization of phytanoyl-CoA ligase and transport of phytanic acid into human peroxisomes. J Lipid Res. 1995 May; 36(5):986-97.
Phytanic acid alpha-oxidation in rat liver mitochondria. Biochim Biophys Acta. 1994 Dec 15; 1201(3):491-7.
Intraorganellar localization of CoASH-independent phytanic acid oxidation in human liver peroxisomes. FEBS Lett. 1993 Oct 25; 333(1-2):154-8.
Refsum disease: a defect in the alpha-oxidation of phytanic acid in peroxisomes. J Lipid Res. 1993 Oct; 34(10):1755-64.
Phytanic acid alpha-oxidation. Differential subcellular localization in rat and human tissues and its inhibition by nycodenz. J Biol Chem. 1993 May 15; 268(14):9972-9.