Milrinone

"Milrinone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.

Descriptor ID	D020105
MeSH Number(s)	D02.092.080.085.543 D03.383.725.050.085.543
Concept/Terms	Milrinone Milrinone Win-47203 Win-47203 Win 47203 Win47203 Primacor Primacor Corotrope Corotrope Corotrop Milrinone Lactate Milrinone Lactate Lactate, Milrinone

Below are MeSH descriptors whose meaning is more general than "Milrinone".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amines [D02.092]
Aminopyridines [D02.092.080]
Amrinone [D02.092.080.085]
Milrinone [D02.092.080.085.543]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyridines [D03.383.725]
Aminopyridines [D03.383.725.050]
Amrinone [D03.383.725.050.085]
Milrinone [D03.383.725.050.085.543]

Below are MeSH descriptors whose meaning is related to "Milrinone".

Below are MeSH descriptors whose meaning is more specific than "Milrinone".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Milrinone" by people in this website by year, and whether "Milrinone" was a major or minor topic of these publications.

Bar chart showing 11 publications over 11 distinct years, with a maximum of 1 publications in 1995 and 2002 and 2003 and 2004 and 2006 and 2010 and 2014 and 2016 and 2017 and 2019 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
2002	1	0	1
2003	1	0	1
2004	1	0	1
2006	1	0	1
2010	1	0	1
2014	1	0	1
2016	1	0	1
2017	1	0	1
2019	1	0	1
2020	0	1	1

Below are the most recent publications written about "Milrinone" by people in Profiles.

Silverman DN, Houston BA, Tedford RJ. Old Drug, New Trick? Oral Milrinone for Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2020 07 07; 9(13):e017170.

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Hornik CP, Yogev R, Mourani PM, Watt KM, Sullivan JE, Atz AM, Speicher D, Al-Uzri A, Adu-Darko M, Payne EH, Gelber CE, Lin S, Harper B, Melloni C, Cohen-Wolkowiez M, Gonzalez D. Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents. J Clin Pharmacol. 2019 12; 59(12):1606-1619.

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Abramov D, Haglund NA, Di Salvo TG. Effect of Milrinone Infusion on Pulmonary Vasculature and Stroke Work Indices: A Single-Center Retrospective Analysis in 69 Patients Awaiting Cardiac Transplantation. Am J Cardiovasc Drugs. 2017 Aug; 17(4):335-342.

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Halliday M, Kavarana M, Ebeling M, Kiger J. Milrinone use for hemodynamic instability in patent ductus arteriosus ligation. J Matern Fetal Neonatal Med. 2017 Mar; 30(5):529-533.

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Costello JM, Dunbar-Masterson C, Allan CK, Gauvreau K, Newburger JW, McGowan FX, Wessel DL, Mayer JE, Salvin JW, Dionne RE, Laussen PC. Impact of empiric nesiritide or milrinone infusion on early postoperative recovery after Fontan surgery: a randomized, double-blind, placebo-controlled trial. Circ Heart Fail. 2014 Jul; 7(4):596-604.

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Kumar VH, Swartz DD, Rashid N, Lakshminrusimha S, Ma C, Ryan RM, Morin FC. Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension. J Appl Physiol (1985). 2010 Sep; 109(3):677-84.

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Rashid N, Morin FC, Swartz DD, Ryan RM, Wynn KA, Wang H, Lakshminrusimha S, Kumar VH. Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation. Pediatr Res. 2006 Nov; 60(5):624-9.

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Bailey JM, Hoffman TM, Wessel DL, Nelson DP, Atz AM, Chang AC, Kulik TJ, Spray TL, Akbary A, Miller RP, Wernovsky G. A population pharmacokinetic analysis of milrinone in pediatric patients after cardiac surgery. J Pharmacokinet Pharmacodyn. 2004 Feb; 31(1):43-59.

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Hoffman TM, Wernovsky G, Atz AM, Kulik TJ, Nelson DP, Chang AC, Bailey JM, Akbary A, Kocsis JF, Kaczmarek R, Spray TL, Wessel DL. Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation. 2003 Feb 25; 107(7):996-1002.

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Hoffman TM, Wernovsky G, Atz AM, Bailey JM, Akbary A, Kocsis JF, Nelson DP, Chang AC, Kulik TJ, Spray TL, Wessel DL. Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study. Prophylactic Intravenous Use of Milrinone After Cardiac Operation in Pediatrics. Am Heart J. 2002 Jan; 143(1):15-21.

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