Besim Ogretmen to Humans
This is a "connection" page, showing publications Besim Ogretmen has written about Humans.
Connection Strength
0.869
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Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis. Cell Rep. 2022 12 06; 41(10):111742.
Score: 0.033
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Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients. Sci Rep. 2021 07 09; 11(1):14232.
Score: 0.030
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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T?cell response. Cell Rep. 2021 05 04; 35(5):109076.
Score: 0.029
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Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. Sci Adv. 2019 09; 5(9):eaax1978.
Score: 0.026
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The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction. FASEB J. 2019 06; 33(6):7647-7666.
Score: 0.025
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Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis. J Biol Chem. 2019 01 11; 294(2):502-519.
Score: 0.025
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Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3. J Biol Chem. 2018 06 22; 293(25):9784-9800.
Score: 0.024
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Mechanisms of Ceramide-Dependent Cancer Cell Death. Adv Cancer Res. 2018; 140:1-25.
Score: 0.023
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Sphingolipid metabolism in cancer signalling and therapy. Nat Rev Cancer. 2018 Jan; 18(1):33-50.
Score: 0.023
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TGF-? receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Sci Signal. 2017 Oct 24; 10(502).
Score: 0.023
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HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. EMBO Mol Med. 2017 08; 9(8):1030-1051.
Score: 0.023
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Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML. Blood. 2016 10 13; 128(15):1944-1958.
Score: 0.021
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Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Sci Signal. 2015 Jun 16; 8(381):ra58.
Score: 0.019
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Ceramide induced mitophagy and tumor suppression. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt B):2834-45.
Score: 0.019
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Autophagy paradox and ceramide. Biochim Biophys Acta. 2014 May; 1841(5):783-92.
Score: 0.017
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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med. 2013 01; 5(1):105-21.
Score: 0.016
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Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol. 2012 Oct; 8(10):831-8.
Score: 0.016
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Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med. 2012 Aug; 4(8):761-75.
Score: 0.016
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Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102.
Score: 0.016
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Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells. EMBO Mol Med. 2012 Feb; 4(2):78-92.
Score: 0.015
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Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. J Biol Chem. 2011 Dec 09; 286(49):42446-42458.
Score: 0.015
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Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C18-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. 2011 Sep 15; 17(18):6097-105.
Score: 0.015
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Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 2011 Jun 02; 117(22):5941-52.
Score: 0.015
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Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J. 2010 Jan; 24(1):296-308.
Score: 0.013
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Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J. 2009 Mar; 23(3):751-63.
Score: 0.012
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Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett. 2007 Oct 18; 256(1):101-11.
Score: 0.011
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Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. FASEB J. 2007 Oct; 21(12):3386-97.
Score: 0.011
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Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J Biol Chem. 2007 Apr 13; 282(15):10922-34.
Score: 0.011
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Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther. 2007 Feb; 6(2):712-22.
Score: 0.011
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Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther. 2006 Jun; 317(3):1188-99.
Score: 0.010
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Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem J. 2006 Jan 15; 393(Pt 2):513-21.
Score: 0.010
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Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. J Biol Chem. 2005 Aug 12; 280(32):28867-76.
Score: 0.010
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Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem. 2004 Oct 22; 279(43):44311-9.
Score: 0.009
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Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004 Aug; 4(8):604-16.
Score: 0.009
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Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 2004 Feb 13; 279(7):6152-62.
Score: 0.009
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Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. Arch Biochem Biophys. 2003 Nov 15; 419(2):110-9.
Score: 0.009
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Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor, in relapsed and/or refractory multiple myeloma. Ann Hematol. 2023 Feb; 102(2):369-383.
Score: 0.008
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S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission. Cell Mol Immunol. 2022 Nov; 19(11):1235-1250.
Score: 0.008
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Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6. Nat Commun. 2022 08 19; 13(1):4880.
Score: 0.008
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Sphingolipid metabolism in T cell responses after allogeneic hematopoietic cell transplantation. Front Immunol. 2022; 13:904823.
Score: 0.008
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Polyploid giant cancer cells are dependent on cholesterol for progeny formation through amitotic division. Sci Rep. 2022 05 27; 12(1):8971.
Score: 0.008
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Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway. Leukemia. 2022 07; 36(7):1907-1915.
Score: 0.008
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Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem. 2002 Apr 12; 277(15):12960-9.
Score: 0.008
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Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. J Biol Chem. 2022 02; 298(2):101492.
Score: 0.008
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Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem. 2001 Aug 31; 276(35):32506-14.
Score: 0.007
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Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem. 2001 Jul 06; 276(27):24901-10.
Score: 0.007
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Immunoprecipitation of human telomerase reverse transcriptase with telomerase activity. Anal Biochem. 2001 Apr 01; 291(1):166-9.
Score: 0.007
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
Score: 0.007
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Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer. Cells. 2020 12 15; 9(12).
Score: 0.007
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Identification and characterization of the MDR1 promoter-enhancing factor 1 (MEF1) in the multidrug resistant HL60/VCR human acute myeloid leukemia cell line. Biochemistry. 2000 Jan 11; 39(1):194-204.
Score: 0.007
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Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease. J Clin Invest. 2019 05 02; 129(7):2760-2774.
Score: 0.006
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Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma. Nat Commun. 2019 03 21; 10(1):1296.
Score: 0.006
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Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region. Biochemistry. 1999 Feb 16; 38(7):2189-99.
Score: 0.006
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Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells. JCI Insight. 2018 12 20; 3(24).
Score: 0.006
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Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer. PLoS One. 2018; 13(10):e0205077.
Score: 0.006
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Molecular mechanisms of loss of beta 2-microglobulin expression in drug-resistant breast cancer sublines and its involvement in drug resistance. Biochemistry. 1998 Aug 18; 37(33):11679-91.
Score: 0.006
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Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis. Sci Rep. 2017 Nov 14; 7(1):15552.
Score: 0.006
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A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017 Aug 15; 23(16):4642-4650.
Score: 0.006
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S.?pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol Cell. 2017 Feb 16; 65(4):699-714.e6.
Score: 0.005
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Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells. Oncogene. 1997 Jan 30; 14(4):499-506.
Score: 0.005
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Site-directed mutagenesis by unique site elimination using filamentous phage-derived ssDNA templates for plasmids that are resistant to denaturation. Biotechniques. 1996 Aug; 21(2):209-13.
Score: 0.005
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CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. J Biol Chem. 2016 08 05; 291(32):16586-96.
Score: 0.005
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
Score: 0.005
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Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. J Biol Chem. 2015 May 22; 290(21):13157-67.
Score: 0.005
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Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol. 2015 Apr; 62(4):879-88.
Score: 0.005
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Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. Blood. 2014 Sep 18; 124(12):1915-25.
Score: 0.005
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Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells. PLoS One. 2014; 9(7):e102314.
Score: 0.005
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Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Mol Cancer Ther. 2014 Jan; 13(1):154-64.
Score: 0.004
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PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest. 2013 Oct; 123(10):4144-57.
Score: 0.004
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Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells. Cancer Biol Ther. 2013 Nov; 14(11):1039-49.
Score: 0.004
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Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood. 2013 Sep 12; 122(11):1923-34.
Score: 0.004
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Effects of staining of RNA with ethidium bromide before electrophoresis on performance of northern blots. Biotechniques. 1993 Jun; 14(6):932-5.
Score: 0.004
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Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6. J Biol Chem. 2013 May 03; 288(18):12880-90.
Score: 0.004
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Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Res. 2010 Aug 01; 70(15):6313-24.
Score: 0.003
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PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Res. 2010 Feb 01; 70(3):1120-9.
Score: 0.003
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Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation. J Mol Biol. 2009 Dec 11; 394(4):789-803.
Score: 0.003
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Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. Oncogene. 2009 Feb 26; 28(8):1132-41.
Score: 0.003
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Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem. 2007 Jun 08; 282(23):16718-28.
Score: 0.003
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Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem. 2006 Dec 01; 281(48):36793-802.
Score: 0.003
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Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant. Oncogene. 2002 Aug 01; 21(33):5160-74.
Score: 0.002
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De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem. 2002 Apr 12; 277(15):12587-95.
Score: 0.002
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Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem. 2001 Sep 21; 276(38):35258-64.
Score: 0.002
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Mini-preparation of total RNA for RT-PCR from cultured human cells. Biotechniques. 1995 Sep; 19(3):374-6.
Score: 0.001