Igor Roninson to Humans
This is a "connection" page, showing publications Igor Roninson has written about Humans.
Connection Strength
0.682
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Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition. Cells. 2019 11 09; 8(11).
Score: 0.026
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Identifying Cancers Impacted by CDK8/19. Cells. 2019 08 03; 8(8).
Score: 0.025
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CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res. 2018 12 01; 78(23):6594-6606.
Score: 0.024
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CDK8/19 Mediator kinases potentiate induction of transcription by NF?B. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):10208-10213.
Score: 0.022
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Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer. Curr Cancer Drug Targets. 2015; 15(8):739-49.
Score: 0.018
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Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13799-804.
Score: 0.016
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A subunit of coatomer protein complex offers a novel tumor-specific target through a surprising mechanism. Autophagy. 2011 Dec; 7(12):1551-2.
Score: 0.015
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Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ? 2 renders tumor cells dependent on its paralogous gene COPZ1. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12449-54.
Score: 0.014
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Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7377-82.
Score: 0.013
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Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. Aging (Albany NY). 2009 May; 1(5):470-80.
Score: 0.012
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p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. Oncogene. 2007 Oct 18; 26(48):6954-8.
Score: 0.011
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p21 (CDKN1A) is a negative regulator of p53 stability. Cell Cycle. 2007 Jun 15; 6(12):1468-71.
Score: 0.011
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Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells. Cancer Res. 2006 Dec 01; 66(23):11370-80.
Score: 0.011
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Cell cycle arrest drastically extends the duration of gene silencing after transient expression of short hairpin RNA. Cell Cycle. 2006 Oct; 5(20):2390-5.
Score: 0.010
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Agonist and antagonist of retinoic acid receptors cause similar changes in gene expression and induce senescence-like growth arrest in MCF-7 breast carcinoma cells. Cancer Res. 2006 Sep 01; 66(17):8749-61.
Score: 0.010
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Seeking favors from nature. Cancer Biol Ther. 2005 Jul; 4(7):794-9.
Score: 0.010
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Induction of transcription by p21Waf1/Cip1/Sdi1: role of NFkappaB and effect of non-steroidal anti-inflammatory drugs. Cell Cycle. 2004 Jul; 3(7):931-40.
Score: 0.009
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Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activity. Cancer Res. 2004 May 01; 64(9):2956-61.
Score: 0.009
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Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene. 2004 Apr 12; 23(16):2919-33.
Score: 0.009
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Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements. Cancer Cell. 2003 Jul; 4(1):41-53.
Score: 0.008
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Tumor cell senescence in cancer treatment. Cancer Res. 2003 Jun 01; 63(11):2705-15.
Score: 0.008
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Genetic suppressor elements in the characterization and identification of tumor suppressor genes. Methods Mol Biol. 2003; 222:413-36.
Score: 0.008
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Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in?vitro and in?vivo. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2201073119.
Score: 0.008
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Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett. 2002 May 08; 179(1):1-14.
Score: 0.008
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A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics. J Med Chem. 2022 02 24; 65(4):3420-3433.
Score: 0.008
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Retinoid-induced growth arrest of breast carcinoma cells involves co-activation of multiple growth-inhibitory genes. Cancer Biol Ther. 2002 Jan-Feb; 1(1):24-7.
Score: 0.007
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Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):389-94.
Score: 0.007
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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat. 2001 Oct; 4(5):303-13.
Score: 0.007
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Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry. 2001 Apr 10; 40(14):4312-22.
Score: 0.007
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P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. Biochemistry. 2001 Apr 10; 40(14):4323-31.
Score: 0.007
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Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein. Biochemistry. 2001 Apr 10; 40(14):4332-9.
Score: 0.007
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The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs. Cells. 2021 01 12; 10(1).
Score: 0.007
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Pleiotropic resistance to DNA-interactive drugs is associated with increased expression of genes involved in DNA replication, repair, and stress response. Cancer Res. 2000 Sep 15; 60(18):5027-30.
Score: 0.007
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Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res. 2000 May 15; 60(10):2576-8.
Score: 0.007
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p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene. 2000 Apr 20; 19(17):2165-70.
Score: 0.007
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Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4291-6.
Score: 0.007
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Characterizing CDK8/19 Inhibitors through a NF?B-Dependent Cell-Based Assay. Cells. 2019 10 06; 8(10).
Score: 0.006
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Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene. 1999 Aug 26; 18(34):4808-18.
Score: 0.006
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A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 1999 Aug 01; 59(15):3761-7.
Score: 0.006
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Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. Science. 2019 02 15; 363(6428):753-756.
Score: 0.006
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A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication. Somat Cell Mol Genet. 1999 Jan; 25(1):9-26.
Score: 0.006
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Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer. Oncogene. 2018 08; 37(35):4792-4808.
Score: 0.006
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Internal ribosomal entry site-containing retroviral vectors with green fluorescent protein and drug resistance markers. Hum Gene Ther. 1998 May 20; 9(8):1233-6.
Score: 0.006
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Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E1973-E1982.
Score: 0.006
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Isolation of altered-function mutants and genetic suppressor elements of multidrug transporter P-glycoprotein by expression selection from retroviral libraries. Methods Enzymol. 1998; 292:225-48.
Score: 0.006
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P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):12908-13.
Score: 0.006
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Drug resistance conferred by MDR1 expression in spheroids formed by glioblastoma cell lines. Anticancer Res. 1997 Sep-Oct; 17(5A):3321-7.
Score: 0.006
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Applications of green fluorescent protein as a marker of retroviral vectors. Somat Cell Mol Genet. 1997 Sep; 23(5):325-40.
Score: 0.006
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Efficient recovery and regeneration of integrated retroviruses. Nucleic Acids Res. 1997 Jul 15; 25(14):2940-2.
Score: 0.005
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Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. 2017 Feb 21; 8(8):12558-12575.
Score: 0.005
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Isolation of genetic suppressor elements (GSEs) from random fragment cDNA libraries in retroviral vectors. Methods Mol Biol. 1997; 69:221-40.
Score: 0.005
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Inducible retroviral vectors regulated by lac repressor in mammalian cells. Gene. 1996 Dec 12; 183(1-2):137-42.
Score: 0.005
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Effects of infection rate and selection pressure on gene expression from an internal promoter of a double gene retroviral vector. Somat Cell Mol Genet. 1996 Jul; 22(4):291-309.
Score: 0.005
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Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nat Cell Biol. 2016 07; 18(7):777-89.
Score: 0.005
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Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate. Int J Cancer. 1996 Mar 01; 65(5):613-9.
Score: 0.005
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P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1238-42.
Score: 0.005
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Genetic suppressor elements: new tools for molecular oncology--thirteenth Cornelius P. Rhoads Memorial Award Lecture. Cancer Res. 1995 Sep 15; 55(18):4023-8.
Score: 0.005
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Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells. Oncotarget. 2015 May 30; 6(15):13088-104.
Score: 0.005
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Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3744-8.
Score: 0.004
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Variable effects of sodium butyrate on the expression and function of the MDR1 (P-glycoprotein) gene in colon carcinoma cell lines. Int J Cancer. 1993 Sep 09; 55(2):297-302.
Score: 0.004
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Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J Natl Cancer Inst. 1993 Apr 21; 85(8):632-9.
Score: 0.004
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Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3231-5.
Score: 0.004
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Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood. 1992 Dec 01; 80(11):2735-9.
Score: 0.004
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Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas. J Natl Cancer Inst. 1992 Oct 07; 84(19):1486-91.
Score: 0.004
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From amplification to function: the case of the MDR1 gene. Mutat Res. 1992 May; 276(3):151-61.
Score: 0.004
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Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544.
Score: 0.004
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Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem. 2012 Mar 23; 287(13):9845-9854.
Score: 0.004
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The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem Pharmacol. 1992 Jan 09; 43(1):95-102.
Score: 0.004
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TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells. Aging (Albany NY). 2012 Jan; 4(1):28-39.
Score: 0.004
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Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncol Res. 1992; 4(7):281-90.
Score: 0.004
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Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells. Cell Cycle. 2011 Oct 15; 10(20):3505-14.
Score: 0.004
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Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7386-90.
Score: 0.004
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Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell. 1991 Jul 12; 66(1):85-94.
Score: 0.004
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Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis. Cancer Res. 1991 May 15; 51(10):2720-6.
Score: 0.004
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Molecular remodeling of potassium channels in fibroblasts from centenarians: a marker of longevity? Mech Ageing Dev. 2010 Nov-Dec; 131(11-12):674-81.
Score: 0.003
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Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc Natl Acad Sci U S A. 1990 09; 87(18):7160-4.
Score: 0.003
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Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7225-9.
Score: 0.003
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Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem. 1990 Jan 05; 265(1):506-14.
Score: 0.003
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Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro. Br J Cancer. 2009 Dec 01; 101(11):1900-8.
Score: 0.003
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Analysis of gene amplification in human tumor cells by in-gel DNA renaturation assay. Nihon Ketsueki Gakkai Zasshi. 1989 Dec; 52(8):1463-70.
Score: 0.003
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Structure and expression of the human MDR (P-glycoprotein) gene family. Mol Cell Biol. 1989 Sep; 9(9):3808-20.
Score: 0.003
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Association of Ki-ras with amplified DNA sequences, detected in human ovarian carcinomas by a modified in-gel renaturation assay. Cancer Res. 1989 Apr 01; 49(7):1693-7.
Score: 0.003
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mRNA phenotyping by enzymatic amplification of randomly primed cDNA. Nucleic Acids Res. 1988 Nov 11; 16(21):10366.
Score: 0.003
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Regulation of Sp1 by cell cycle related proteins. Cell Cycle. 2008 Sep 15; 7(18):2856-67.
Score: 0.003
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Analysis of gene amplification in human tumor cell lines. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6846-50.
Score: 0.003
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Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell. 2008 Oct; 7(5):609-21.
Score: 0.003
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An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell. 1988 May 20; 53(4):519-29.
Score: 0.003
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Localization of the human multiple drug resistance gene, MDR1, to 7q21.1. Hum Genet. 1987 Oct; 77(2):142-4.
Score: 0.003
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Effect of target secondary structure on RNAi efficiency. RNA. 2007 Oct; 13(10):1631-40.
Score: 0.003
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Molecular mechanism of multidrug resistance in tumor cells. Clin Physiol Biochem. 1987; 5(3-4):140-51.
Score: 0.003
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The STAT3 oncogene as a predictive marker of drug resistance. Trends Mol Med. 2007 Jan; 13(1):4-11.
Score: 0.003
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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell. 1986 Nov 07; 47(3):381-9.
Score: 0.003
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Detection of amplified sequences in mammalian DNA by in-gel renaturation and SINE hybridization. Somat Cell Mol Genet. 1986 Nov; 12(6):611-23.
Score: 0.003
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Proteomic analysis of factors released from p21-overexpressing tumour cells. Proteomics. 2006 Jul; 6(13):3739-53.
Score: 0.003
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Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4538-42.
Score: 0.003
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Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1. Cancer Res. 2005 Oct 01; 65(19):8927-35.
Score: 0.002
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Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gels. Nucleic Acids Res. 1983 Aug 25; 11(16):5413-31.
Score: 0.002
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Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein. Int J Oncol. 2000 Sep; 17(3):579-86.
Score: 0.002
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Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells. Oncogene. 1999 Jan 14; 18(2):377-84.
Score: 0.002
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Isolation of efficient antivirals: genetic suppressor elements against HIV-1. Gene Ther. 1999 Jan; 6(1):130-7.
Score: 0.002
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Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response. Cancer Res. 1998 Aug 01; 58(15):3423-8.
Score: 0.001
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Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains. J Biol Chem. 1998 Apr 24; 273(17):10132-8.
Score: 0.001
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Activation of the LRP (lung resistance-related protein) gene by short-term exposure of human leukemia cells to phorbol ester and cytarabine. Oncol Res. 1998; 10(4):185-92.
Score: 0.001
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Evaluation of newer prognostic markers for adult soft tissue sarcomas. J Clin Oncol. 1997 Oct; 15(10):3249-57.
Score: 0.001
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60-Hz electric fields inhibit protein kinase C activity and multidrug resistance gene (MDR1) up-regulation. Radiat Res. 1997 Mar; 147(3):369-75.
Score: 0.001
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Identification of p53 genetic suppressor elements which confer resistance to cisplatin. Oncogene. 1997 Jan 16; 14(2):185-93.
Score: 0.001
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Inhibition of cytarabine-induced MDR1 (P-glycoprotein) gene activation in human tumor cells by fatty acid-polyethylene glycol-fatty acid diesters, novel inhibitors of P-glycoprotein function. Int J Cancer. 1996 Oct 09; 68(2):245-50.
Score: 0.001
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Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis. Cancer Lett. 1996 Oct 01; 107(1):73-81.
Score: 0.001
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Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes. Exp Hematol. 1996 Aug; 24(10):1258-64.
Score: 0.001
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Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein. J Biol Chem. 1996 Jan 26; 271(4):1877-83.
Score: 0.001
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Resistance to taxol chemotherapy produced in mouse marrow cells by safety-modified retroviruses containing a human MDR-1 transcription unit. Gene Ther. 1995 Jun; 2(4):279-84.
Score: 0.001
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Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. Biochemistry. 1995 Jan 10; 34(1):32-9.
Score: 0.001
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Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein. Int J Cancer. 1993 Sep 30; 55(3):478-84.
Score: 0.001
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MDR-1 expression in metastatic malignant melanoma. J Surg Res. 1993 Jun; 54(6):621-4.
Score: 0.001
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Chromosome 7 long arm deletion in myeloid disorders: a narrow breakpoint region in 7q22 defined by molecular mapping. Blood. 1989 Jan; 73(1):230-4.
Score: 0.001
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Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. Mol Cell Biol. 1989 Jan; 9(1):109-15.
Score: 0.001
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Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells. Jpn J Cancer Res. 1987 Dec; 78(12):1415-9.
Score: 0.001
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Decreased expression of the amplified mdr1 gene in revertants of multidrug-resistant human myelogenous leukemia K562 occurs without loss of amplified DNA. Mol Cell Biol. 1987 Dec; 7(12):4549-52.
Score: 0.001
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RFLPs associated with MDR2, a member of the human multidrug resistance gene family mapped to chromosome 7. Nucleic Acids Res. 1987 Aug 11; 15(15):6305.
Score: 0.001
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The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J Biol Chem. 1987 Jan 15; 262(2):505-8.
Score: 0.001
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The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun. 1986 Dec 30; 141(3):956-62.
Score: 0.001
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Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Mol Cell Biol. 1986 Nov; 6(11):4039-45.
Score: 0.001
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Localization of multidrug resistance-associated DNA sequences to human chromosome 7. Somat Cell Mol Genet. 1986 Jul; 12(4):415-20.
Score: 0.001
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Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science. 1986 May 02; 232(4750):643-5.
Score: 0.001
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Acquisition and loss of amplified genes: dramatic effects of hormones, tumor promoters and cytotoxic drugs. Princess Takamatsu Symp. 1983; 14:235-54.
Score: 0.001
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Physical mapping of human adenovirus type 7 DNA using a simple and sensitive method of terminal labeling. Gene. 1982 May; 18(2):123-31.
Score: 0.000