John O'Bryan to Animals
This is a "connection" page, showing publications John O'Bryan has written about Animals.
Connection Strength
0.993
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Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants. Cell Rep. 2022 02 08; 38(6):110322.
Score: 0.060
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Targeting the KRAS a4-a5 allosteric interface inhibits pancreatic cancer tumorigenesis. Small GTPases. 2022 Jan; 13(1):114-127.
Score: 0.057
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Inhibition of RAS: proven and potential vulnerabilities. Biochem Soc Trans. 2020 10 30; 48(5):1831-1841.
Score: 0.055
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Biology, pathology, and therapeutic targeting of RAS. Adv Cancer Res. 2020; 148:69-146.
Score: 0.054
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Pharmacological targeting of RAS: Recent success with direct inhibitors. Pharmacol Res. 2019 01; 139:503-511.
Score: 0.048
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Direct inhibition of RAS: Quest for the Holy Grail? Semin Cancer Biol. 2019 02; 54:138-148.
Score: 0.045
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Inhibition of RAS function through targeting an allosteric regulatory site. Nat Chem Biol. 2017 Jan; 13(1):62-68.
Score: 0.042
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Intersectin scaffold proteins and their role in cell signaling and endocytosis. Biochim Biophys Acta Mol Cell Res. 2017 Jan; 1864(1):23-30.
Score: 0.042
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Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2?) isoform contributes to neuroblastoma tumorigenesis. Cancer Lett. 2015 Apr 10; 359(2):262-8.
Score: 0.037
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Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase. Mol Cell Biol. 2014 Jan; 34(2):271-9.
Score: 0.034
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Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways. Int J Mol Sci. 2013 Apr 10; 14(4):7829-52.
Score: 0.033
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A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2?) regulation. PLoS One. 2012; 7(9):e45360.
Score: 0.031
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Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. PLoS One. 2012; 7(4):e36023.
Score: 0.030
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Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene. 2012 Nov 15; 31(46):4828-34.
Score: 0.030
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Cardiac-specific expression of the tetracycline transactivator confers increased heart function and survival following ischemia reperfusion injury. PLoS One. 2012; 7(1):e30129.
Score: 0.030
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Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction. Mol Cell Biol. 2012 Feb; 32(4):817-25.
Score: 0.030
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Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26; 22(15):767-72.
Score: 0.029
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Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway. Mol Cell Biol. 2007 Nov; 27(22):7906-17.
Score: 0.022
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Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. Hum Mol Genet. 2007 Aug 01; 16(15):1862-71.
Score: 0.022
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Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling. Mol Pharmacol. 2006 Nov; 70(5):1643-53.
Score: 0.021
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Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK. J Biol Chem. 2003 Nov 21; 278(47):47038-45.
Score: 0.017
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The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination. Curr Biol. 2002 Jul 09; 12(13):1112-6.
Score: 0.015
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Neuroblastoma differentiation in?vivo excludes cranial tumors. Dev Cell. 2021 10 11; 56(19):2752-2764.e6.
Score: 0.015
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Mitogenesis and endocytosis: What's at the INTERSECTIoN? Oncogene. 2001 Oct 01; 20(44):6300-8.
Score: 0.015
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The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2. Nat Commun. 2021 05 25; 12(1):3091.
Score: 0.014
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Selective and noncovalent targeting of RAS mutants for inhibition and degradation. Nat Commun. 2021 05 11; 12(1):2656.
Score: 0.014
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Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function. Am J Physiol Cell Physiol. 2020 11 01; 319(5):C933-C944.
Score: 0.014
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Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways. J Biol Chem. 2000 Sep 01; 275(35):27414-20.
Score: 0.014
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The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor. J Biol Chem. 1998 Aug 07; 273(32):20431-7.
Score: 0.012
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Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2018 03; 38(3):529-541.
Score: 0.011
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Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice. J Pediatr Hematol Oncol. 2017 11; 39(8):e413-e418.
Score: 0.011
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A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):2729-34.
Score: 0.010
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Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity. J Biol Chem. 2015 May 08; 290(19):12058-67.
Score: 0.009
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UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy. Cell Signal. 2015 May; 27(5):908-22.
Score: 0.009
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The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage. J Biol Chem. 1995 Jan 13; 270(2):551-7.
Score: 0.009
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Down syndrome: genes, model systems, and progress towards pharmacotherapies and clinical trials for cognitive deficits. Cytogenet Genome Res. 2013; 141(4):260-71.
Score: 0.008
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axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct; 11(10):5016-31.
Score: 0.007
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Cooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-Src. Mol Pharmacol. 2011 Oct; 80(4):665-72.
Score: 0.007
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N-type Ca2+ channels as scaffold proteins in the assembly of signaling molecules for GABAB receptor effects. J Biol Chem. 2004 Jun 04; 279(23):24649-58.
Score: 0.004
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Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr Biol. 2002 Jan 08; 12(1):27-33.
Score: 0.004
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The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell. 2001 Jul; 1(1):63-72.
Score: 0.004
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The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Neuron. 2000 Dec; 28(3):819-33.
Score: 0.003
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Intersectin can regulate the Ras/MAP kinase pathway independent of its role in endocytosis. J Biol Chem. 2000 Sep 22; 275(38):29894-9.
Score: 0.003
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Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity. J Biol Chem. 1999 Oct 22; 274(43):30410-8.
Score: 0.003
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Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. J Biol Chem. 1999 May 28; 274(22):15671-7.
Score: 0.003
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Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells. Eur J Neurosci. 1998 Jun; 10(6):1995-2008.
Score: 0.003
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Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family. J Biol Chem. 1996 Nov 15; 271(46):29049-59.
Score: 0.003