Bruce M. Frankel

Title
InstitutionMedical University of South Carolina
DepartmentNeurosurgery
AddressP.O. Box MSC 606
301 CSB
96 Jonathan Lucas St.
Phone843-792-2423
Fax843-792-9279
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    Collapse Biography 
    Collapse education and training
    Boston University, Boston, MABA05/1990Biology
    Syracuse Upstate Medical University, Syracuse, NYMD06/1994Medicine
    Syracuse Upstate Medical University, Syracuse, NYMD07/1995General Surgery (internship)
    Syracuse Upstate Medical University, Syracuse, NYMD07/2001Neurosurgery (resident)
    Collapse awards and honors
    1994Alpha Omega Alpha, Syracuse Upstate Medical University
    2014 - 2020Americas Top Doctors, Medical University of South Carolina

    Collapse Overview 
    Collapse keywords
    Brain Tumor, Spine Tumor, Metastatic Epidural Spinal Cord Compression, Pituitary Tumor, Complex Spine Surgery, Minimally Invasive Spine Surgery, Endoscopic Spine Surgery

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Research 
    Collapse research activities and funding
    R01FD003542     (FRANKEL, BRUCE MICHAEL)Sep 1, 2009 - Aug 31, 2013
    NIH
    P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Das A, Gunasekaran A, Stephens HR, Mark J, Lindhorst SM, Cachia D, Patel SJ, Frankel BM. Establishing a Standardized Method for the Effective Intraoperative Collection and Biological Preservation of Brain Tumor Tissue Samples Using a Novel Tissue Preservation System: A Pilot Study. World Neurosurg. 2022 05; 161:e61-e74. PMID: 35032716.
      Citations:    
    2. Tharp P, King RW, Frankel BM, Wooster MD. Thoracic Endovascular Aortic Repair for Iatrogenic Injury of the Thoracic Aorta. J Endovasc Ther. 2022 10; 29(5):813-817. PMID: 34894824.
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    3. Porto GBF, Cisewski SE, Wolgamott L, Frankel BM. Clinical outcomes for patients with lateral lumbar radiculopathy treated by percutaneous endoscopic transforaminal discectomy versus tubular microdiscectomy: A retrospective review. Clin Neurol Neurosurg. 2021 Sep; 208:106848. PMID: 34339898.
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    4. Alshareef M, Klapthor G, Alawieh A, Lowe S, Frankel B. Evaluation of open and minimally invasive spinal surgery for the treatment of thoracolumbar metastatic epidural spinal cord compression: a systematic review. Eur Spine J. 2021 10; 30(10):2906-2914. PMID: 34052895.
      Citations:    
    5. Frankel BM, Cachia D, Patel SJ, Das A. Analysis of the P53N a Novel Protein Encoded on Chromosome 22q12.1-12.3 in Glioblastomas and Ependymomas Specimens. J Mol Neurosci. 2021 Aug; 71(8):1714-1722. PMID: 33595778.
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    6. Alshareef M, Lowe S, Park Y, Frankel B. Utility of intraoperative ultrasonography for resection of pituitary adenomas: a comparative retrospective study. Acta Neurochir (Wien). 2021 06; 163(6):1725-1734. PMID: 33403430.
      Citations:    
    7. Alshareef MA, Klapthor G, Lowe SR, Barley J, Cachia D, Frankel BM. Strategies for posterior-only minimally invasive surgery in thoracolumbar metastatic epidural spinal cord compression. Surg Neurol Int. 2020; 11:462. PMID: 33408947.
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    8. Frankel BM, Cachia D, Patel SJ, Das A. Targeting Subventricular Zone Progenitor Cells with Intraventricular Liposomal Encapsulated Cytarabine in Patients with Secondary Glioblastoma : A Report of Two Cases. SN Compr Clin Med. 2020 Jun; 2(6):836-843. PMID: 32704621.
      Citations:    
    9. Mark Semler, Bruce M. Frankel, Joe Ruscito -. Expandable Vertebral Body Replacement Device and Method U.S. Patent No.: 10,653,530. 2020.
    10. Frankel BM, Cachia D, Patel SJ, Das A. Analysis of P78: A Novel Cytoplasmic Membrane-Associated Protein Encoded on Chromosome 19q13.3 in Glioma Specimens. J Mol Neurosci. 2020 Sep; 70(9):1415-1424. PMID: 32367506.
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    11. Frankel BM, Cachia D, Patel SJ, Das A. . Analysis of P(78): A Novel Cytoplasmic Membrane-Associated Protein Encoded on Chromosome 19q13.3 in Glioma Specimens. Journal of Molecular Neuroscience. 2020; 18(70):1415-1424.
    12. Henderson F, Hubbard ZS, Jones S, Barley J, Frankel B. Endoscopic decompression of epidural spinal metastasis causing lumbar radiculopathy through a transforaminal approach: report of two cases. AME Case Rep. 2020; 4:2. PMID: 32206748.
      Citations:    
    13. Henderson F, Hubbard ZS, Jones S, Barley J, Frankel BM . Endoscopic decompression of epidural spinal metastasis causing lumbar radiculopathy through a transforaminal approach: report of two cases. AME Case Rep. 2020; 2(4).
    14. Frankel BM, Cachia D, Patel SJ, Das A. (2020) 2020. Targeting Subventricular Zone Progenitor Cells with Intraventricular Liposomal Encapsulated Cytarabine in Patients with Secondary Glioblastoma: A Report of Two Cases. SN Comprehensive Clinical Medicine. 2020; 6(2):836-843.
    15. Bruce M. Frankel, Randall Baraso, and Thomas Oko . Ultrasound and Detachable Instrument for Procedures U.S. Patent No.: 10,117,564. 2018.
    16. Cachia D, Johnson DR, Kaufmann TJ, Lowe S, Andersen S, Olar A, Cooper SL, Frankel BM, Gilbert MR. Case-based review: ependymomas in adults. Neurooncol Pract. 2018 Aug; 5(3):142-153. PMID: 31386035.
      Citations:    
    17. Mark Semler, Bruce M. Frankel . Expandable Vertebral Body Replacement Device and Method United States Patent No.: 9,889,018. 2018.
    18. Mark Semler, Bruce M. Frankel . Expandable Vertebral Body Replacement Device and Method U.S. Patent no: 9,775,719. 2017.
    19. Bruce M. Frankel . A Percutaneous Rod to Rod Cross Connector U.S. Patent no: 9,603,634. 2017.
    20. Bruce M. Frankel . Percutaneous Modular Head-to-Head Cross Connector U.S. Patent no: 9,439,684. 2016.
    21. Buchholz AL, Frankel BM. Response. J Neurosurg Spine. 2016 Apr; 24(4):672. PMID: 27482580.
      Citations:    
    22. Mark Semler and Bruce Frankel . Anti-Splay Apparatus. U.S. Patent no: 9,149,315. 2015.
    23. Bruce M. Frankel . Percutaneous Modular Head-to-Head Cross Connector U.S. Patent no: 9,023,087. 2015.
    24. Buchholz AL, Morgan SL, Robinson LC, Frankel BM. Minimally invasive percutaneous screw fixation of traumatic spondylolisthesis of the axis. J Neurosurg Spine. 2015 May; 22(5):459-65. PMID: 25723118.
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    25. Bruce M. Frankel, Mark Semler . A Skeletal Bone Fixation Rod U.S. Patent no: D722,698. 2015.
    26. Mark Semler and Bruce Frankel . Anti-Splay Apparatus U.S. Patent no: 8,828,006. 2014.
    27. Kosnik-Infinger L, Glazier SS, Frankel BM. Response. J Neurosurg Pediatr. 2014 Jan; 13(1):43-4. PMID: 24520577.
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    28. Frankel B, Krishna V, Vandergrift A, Bauer DC, Nicholas J. Natural history and risk factors for adjacent vertebral fractures in the fracture intervention trial. Spine (Phila Pa 1976). 2013 Dec 01; 38(25):2201-7. PMID: 24285276.
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    29. Kosnik-Infinger L, Glazier SS, Frankel BM. Occipital condyle to cervical spine fixation in the pediatric population. J Neurosurg Pediatr. 2014 Jan; 13(1):45-53. PMID: 24206344.
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    30. Randall Baraso, Bruce M. Frankel, Kazutoshi Tsuchida, and Hiroaki Wakabayashi . Ultrasound Systems and Methods for Orthopedic Applications U.S. Patent no: 8,343,056. 2013.
    31. Bruce M. Frankel, Scott Koysh, and Natalie Hunter . Fenestrated Bone Tap and Method U.S. Patent no: 8, 303,598. 2012.
    32. Randall Baraso, Bruce M. Frankel, Kazutoshi Tsuchida, and Hiroaki Wakabayashi U.S. Patent no: 8,206,306. Ultrasound Systems and Methods for Orthopedic Applications. 2012.
    33. Frankel BM, Krishna V. Meta-analysis: vertebroplasty for vertebral compression fracture ineffective in improving pain and function. Evid Based Med. 2012 Oct; 17(5):142-3. PMID: 22044795.
      Citations:    
    34. DePalma MJ, Ketchum JM, Frankel BM, Frey ME. Percutaneous vertebroplasty for osteoporotic vertebral compression fractures in the nonagenarians: a prospective study evaluating pain reduction and new symptomatic fracture rate. Spine (Phila Pa 1976). 2011 Feb 15; 36(4):277-82. PMID: 20975625.
      Citations:    
    35. Shukla BS, Giglio P, Couch JE, Hasija N, Krishna V, Frankel BM, Welsh CT. Concomitant lymphoma and cryptococcosis in a patient with acquired immune deficiency syndrome. Am J Med Sci. 2010 Oct; 340(4):340-2. PMID: 20739871.
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    36. Frankel B, Bloch DA. Sham or scam: a critical assessment of recent vertebroplasty trials. Neurosurgery. 2010 Aug; 67(2):E521. PMID: 20644394.
      Citations:    
    37. Frankel BM, Hanley M, Vandergrift A, Monroe T, Morgan S, Rumboldt Z. Posterior occipitocervical (C0-3) fusion using polyaxial occipital condyle to cervical spine screw and rod fixation: a radiographic and cadaveric analysis. J Neurosurg Spine. 2010 May; 12(5):509-16. PMID: 20433299.
      Citations:    
    38. Bruce M. Frankel and Scott Koysh . Fenestrated Bone Tap and Method U.S. Patent no: 7,699,852. 2010.
    39. Wise SK, Harvey RJ, Patel SJ, Frankel BM, Schlosser RJ. Endoscopic repair of skull base defects presenting with pneumocephalus. J Otolaryngol Head Neck Surg. 2009 Aug; 38(4):509-16. PMID: 19755094.
      Citations:    
    40. Wise SK, Harvey RJ, Neal JG, Patel SJ, Frankel BM, Schlosser RJ. Factors contributing to failure in endoscopic skull base defect repair. Am J Rhinol Allergy. 2009 Mar-Apr; 23(2):185-91. PMID: 19401047.
      Citations:    
    41. Harvey RJ, Smith JE, Wise SK, Patel SJ, Frankel BM, Schlosser RJ. Intracranial complications before and after endoscopic skull base reconstruction. Am J Rhinol. 2008 Sep-Oct; 22(5):516-21. PMID: 18954512.
      Citations:    
    42. Ryken TC. Frankel B. Julien T. Olson JJ. . Surgical management of newly diagnosed glioblastoma in adults: role of cytoreductive surgery. Journal of Neuro-Oncology. 2008; 3(89):271-86.
    43. Buric J, Rigobello M, Frankel B, Hooper D. Five Year Follow-Up on Intradiscal Ozone Injection for Disc Herniation. Orthopaedic Product News . 2008; May-June.
    44. Frankel BM, Jones T, Wang C. Segmental polymethylmethacrylate-augmented pedicle screw fixation in patients with bone softening caused by osteoporosis and metastatic tumor involvement: a clinical evaluation. Neurosurgery. 2007 Sep; 61(3):531-7; discussion 537-8. PMID: 17881965.
      Citations:    
    45. Frankel BM, D'Agostino S, Wang C. A biomechanical cadaveric analysis of polymethylmethacrylate-augmented pedicle screw fixation. J Neurosurg Spine. 2007 Jul; 7(1):47-53. PMID: 17633487.
      Citations:    
    46. Frankel BM, Monroe T, Wang C. Percutaneous vertebral augmentation: an elevation in adjacent-level fracture risk in kyphoplasty as compared with vertebroplasty. Spine J. 2007 Sep-Oct; 7(5):575-82. PMID: 17905320.
      Citations:    
    47. Frankel B. Letter to the Editor: The Acute Care Surgery Curriculum. Neurotrauma and Critical Care News. 2007; (Spring):2-3.
    48. C., Zhou Q., Weimar J.D., Frankel B., Robertson J.H., Pourmotabbed T. . Up-regulation of neuropoiesis generating glial progenitors that infiltrate rat intracranial glioma. Journal of Neuro-Oncology. 2005; 3(71):245-255.
    49. Liu D, Schelper RL, Carter DA, Poiesz BJ, Shrimpton AE, Frankel BM, Hutchison RE. Primary central nervous system cytotoxic/suppressor T-cell lymphoma: report of a unique case and review of the literature. Am J Surg Pathol. 2003 May; 27(5):682-8. PMID: 12717253.
      Citations:    
    50. Fuller CE, Frankel B, Smith M, Rodziewitz G, Landas SK, Caruso R, Schelper R. Suprasellar monomorphous pilomyxoid neoplasm: an ultastructural analysis. Clin Neuropathol. 2001 Nov-Dec; 20(6):256-62. PMID: 11758781.
      Citations:    
    51. Frankel B, Longo SL, Kyle M, Canute GW, Ryken TC. Tumor Fas (APO-1/CD95) up-regulation results in increased apoptosis and survival times for rats with intracranial malignant gliomas. Neurosurgery. 2001 Jul; 49(1):168-75; discussion 175-6. PMID: 11440439.
      Citations:    
    52. Frankel B., Longo S.L., Kyle M., Canute G.W., Ryken T.C. Tumor Fas (APO-1/CD95) up-regulation results in increased apoptosis and survival times for rats with intracranial malignant gliomas. Neurosurgery. 2001; 1(49):168-176.
    53. Ryken T.C., Frankel B., Longo S.L., Sibenaller Z. . Interaction of Fas and Fas ligand in a rat 36b10 glioma model. Neurosurgical Focus. 2000; 4(8):Article 3.
    54. Julien T., Frankel B., Traynelis V., Ryken T.C. Evidence-based analysis of odontoid fracture management. Neurosurgical Focus. 2000; 6(8):Article 1.
    55. Frankel B., Longo S.L., Canute G.W. . Soluble Fas-Ligand (sFasL) in human astrocytoma cyst fluid is cytotoxic to T-Cells: Another potential means of immune evasion. Journal of Neuro-Oncology. 2000; (48):21-26.
    56. Julien T., Frankel B., Longo S.L., Kyle M., Gibson S., Shillitoe E., Ryken T.C. Antisense-mediated inhibition of the bcl-2 gene induces apoptosis in human malignant glioma. Surgical Neurology. 2000; (53):360-369.
    57. Ryken T.C., Julien T., Frankel B., Canute G.W., Haller J., Rosenbaum A. . Image-injected frameless stereotactic approach to the anterior craniovertebral junction. Neurosurgical Focus. 1999; 6(6):9.
    58. Frankel B., Longo S.L., Rodziewicz G.S., Hodge C.J. Antisense oligonucleotide induced inhibition of ACTH release from cultured human corticotrophs. Journal of Neurosurgery. 1999; (91):261-267.
    59. Frankel B., Longo S.L., Ryken T.C. Co-expression of Fas and Fas ligand in human non-astrocytic glial tumors. Acta Neuropathologica. 1999; (98):363-366.
    60. Frankel B., Longo S.L., Ryken T.C. Human astrocytomas co-expressing Fas and Fas ligand also produce TGFß2 and Bcl-2. Journal of Neuro-Oncology. 1999; (44):205-212.
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