Yusuf Hannun to Structure-Activity Relationship
This is a "connection" page, showing publications Yusuf Hannun has written about Structure-Activity Relationship.
Connection Strength
0.774
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Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids. Bioorg Med Chem. 2021 02 15; 32:116011.
Score: 0.170
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Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. J Lipid Res. 2019 04; 60(4):819-831.
Score: 0.148
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Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites. Bioorg Med Chem. 2018 12 15; 26(23-24):6067-6075.
Score: 0.146
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Functional analysis of ISC1 by site-directed mutagenesis. Biochemistry. 2003 Jul 01; 42(25):7855-62.
Score: 0.050
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Use of short-chain ceramides. Methods Enzymol. 2000; 312:407-20.
Score: 0.040
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Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J Biol Chem. 1995 Sep 22; 270(38):22135-42.
Score: 0.029
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Activation of a retinoblastoma-protein-dependent pathway by sphingosine. Biochem J. 1995 Sep 01; 310 ( Pt 2):453-9.
Score: 0.029
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Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols. J Lipid Res. 2015 Oct; 56(10):2019-28.
Score: 0.029
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Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem. 1993 May 05; 268(13):9255-61.
Score: 0.025
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Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15; 185(3):333-45.
Score: 0.020
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Aminoacridines, potent inhibitors of protein kinase C. J Biol Chem. 1988 Apr 15; 263(11):5124-31.
Score: 0.018
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Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents. Bioorg Med Chem. 2008 Jan 15; 16(2):1015-31.
Score: 0.017
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Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science. 1987 Feb 06; 235(4789):670-4.
Score: 0.016
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Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorg Med Chem. 2006 Nov 01; 14(21):7083-104.
Score: 0.016
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prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J. 1996 May 15; 316 ( Pt 1):25-8.
Score: 0.008
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Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry. 1989 Apr 18; 28(8):3138-45.
Score: 0.005
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Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem. 1986 Sep 25; 261(27):12610-5.
Score: 0.004
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Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci U S A. 1986 Mar; 83(5):1184-8.
Score: 0.004